A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

ChemMedChem

Volumn 8, Issue 2, 2013, Pages 226-230

  Chen, Haijun ^a   Wang, Cheng Z ^a   Ding, Chunyong ^a   Wild, Christopher ^a   Copits, Bryan ^b   Swanson, Geoffrey T ^b   Johnson, Kenneth M ^a   Zhou, Jia ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Bioinformatics; Biological space; Chemical space; Chemoinformatics; Drug design; Neuroprotective agents

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANIRACETAM; CENTRAL NERVOUS SYSTEM AGENTS; CS 614; CX 614; CYCLOTHIAZIDE; HJC 0122; HJC 0124; N [2 [4 (4 CYANOPHENYL)PHENYL]PROPYL] 2 PROPANESULFONAMIDE; PIRACETAM; RECEPTOR POSITIVE ALLOSTERIC MODULATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIOINFORMATICS; CHEMOINFORMATICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG STRUCTURE; IN VITRO STUDY; INFORMATION SCIENCE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ALLOSTERIC REGULATION; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; APOPTOSIS; COMPUTATIONAL BIOLOGY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RECEPTORS, AMPA;

EID: 84873873454     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200554     Document Type: Article

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