1-(1,3-benzodioxol-5-yl-carbo-nyl) piperidine, a modulator of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, ameliorates exercise-induced fatigue in mice

Biological and Pharmaceutical Bulletin

Volumn 37, Issue 1, 2014, Pages 13-17

  Fan, Wutu ^a   Wu, Xianglong ^a   Pan, Yalei ^a   Li, Chenrui ^a   Niu, Yinbo ^a   Zhai, Yuankun ^a   Mei, Qibing ^a,b  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

1 (1,3 benzodioxol 5 yl carbonyl) piperidine; A amino 3 hydroxy 5 methyl 4 isoxazole propionic acid receptor modulator; Endurance capacity; Fatigue; Weight loaded forced swimming

Indexed keywords

1 (1,3 BENZODIOXOL 5 YL CARBONYL) PIPERIDINE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; CATALASE; GLUTATHIONE PEROXIDASE; GLYCOGEN; LACTIC ACID; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; ENDURANCE; ENZYME ACTIVITY; EXERCISE; EXHAUSTION; FATIGUE; FORCED SWIM TEST; GLYCOGEN LIVER LEVEL; GLYCOGEN MUSCLE LEVEL; MALE; MOUSE; NONHUMAN; UREA NITROGEN BLOOD LEVEL;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTIOXIDANTS; BLOOD UREA NITROGEN; CATALASE; DIETARY SUPPLEMENTS; DIOXOLES; FATIGUE; GLUTATHIONE PEROXIDASE; GLYCOGEN; LACTIC ACID; LIVER; MALE; MICE; MICE, INBRED STRAINS; MUSCLE, SKELETAL; PHYSICAL ENDURANCE; PIPERIDINES; RECEPTORS, AMPA; SUPEROXIDE DISMUTASE; SWIMMING;

EID: 84892581500     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b13-00399     Document Type: Article

References (23)

1. Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet, 363, 978-988 (2004)
2. Ikeuchi M, Koyama T, Takahashi J, Yazawa K. Effects of astaxanthin supplementation on exercise-induced fatigue in mice. Biol. Pharm. Bull., 29, 2106-2110 (2006)
3. Uthayathas S, Karuppagounder SS, Tamer SI, Parameshwaran K, Degim T, Suppiramaniam V, Dhanasekaran M. Evaluation of neuroprotective and anti-fatigue effects of sildenafil. Life Sci., 81, 988-992 (2007)
4. Wang L, Zhang HL, Lu R, Zhou YJ, Ma R, Lu JQ, Li XL, Chen LJ, Yao Z. The decapeptide CMS001 enhances swimming endurance in mice. Peptides, 29, 1176-1182 (2008)
5. Wiegmann DA, Stanny RR, McKay DL, Neri DF, McCardie AH. Methamphetamine effects on cognitive processing during extended wakefulness. Int. J. Aviat. Psychol., 6, 379-397 (1996)
6. Wesensten NJ, Belenky G, Thorne DR, Kautz MA, Balkin TJ. Modafinil vs. caffeine: Effects on fatigue during sleep deprivation. Aviat. Space Environ. Med., 75, 520-525 (2004)
7. Afari N, Buchwald D. Chronic fatigue syndrome: A review. Am. J. Psychiatry, 160, 221-236 (2003)
8. Arai A, Kessler M, Xiao P, Ambros-Ingerson J, Rogers G, Lynch G. A centrally active drug that modulates AMPA receptor gated currents. Brain Res., 638, 343-346 (1994)
9. Zarate CA Jr, Manji HK. The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases. Exp. Neurol., 211, 7-10 (2008)
10. Kauer JA, Malenka RC. LTP: AMPA receptors trading places. Nat. Neurosci., 9, 593-594 (2006)
11. Griffith LC, Rosbash M. Sleep: hitting the reset button. Nat. Neurosci., 11, 123-124 (2008)
12. Black MD. Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data. Psychopharmacology (Berl.), 179, 154-163 (2005)
13. Staubli U, Rogers G, Lynch G. Facilitation of glutamate receptors enhances memory. Proc. Natl. Acad. Sci. U.S.A., 91, 777-781 (1994)
14. Bigge CF, Nikam SS. AMPA receptor agonists, antagonists and modulators: Their potential for clinical utility. Exp. Opin. Ther. Patents., 7, 1099-1114 (1997)
15. Wu XL, Fan WT, Pan YL, Zhai YK, Niu YB, Li CR, Mei QB. Synthesis of 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine by a new method and its crystal structure. Chinese Journal of Synthetic Chemistry, 21, 36-40 (2013)
16. Jung KA, Han D, Kwon EK, Lee CH, Kim YE. Antifatigue effect of rubus coreanus miquel extract in mice. J. Med. Food, 10, 689-693 (2007)
17. Huang LZ, Huang BK, Ye Q, Qin LP. Bioactivity-guided fractionation for anti-fatigue property of acanthopanax senticosus. J. Ethnopharmacol., 133, 213-219 (2011)
18. Jia JM, Wu CF. Antifatigue activity of tissue culture extracts of saussurea involucrata. Pharmaceutical Biology, 46, 433-436 (2008)
19. Pedersen TH, Nielsen OB, Lamb GD, Stephenson DG. Intracellular acidosis enhances the excitability of working muscle. Science, 305, 1144-1147 (2004)
20. Morihara N, Ushijima M, Kashimoto N, Sumioka I, Nishihama T, Hayama M, Takeda H. Aged garlic extract ameliorates physical fatigue. Biol. Pharm. Bull., 29, 962-966 (2006)
21. Tharakan B, Dhanasekaran M, Manyam BV. Antioxidant and DNA protecting properties of anti-fatigue herb Trichopus zeylanicus. Phytother. Res., 19, 669-673 (2005)
22. Dohm GL, Tapscott EB, Barakat HA, Kasperek GJ. Influence of fasting on glycogen depletion in rats during exercise. J. Appl. Physiol., 55, 830-833 (1983)
23. Lynch G. AMPA receptor modulators as cognitive enhancers. Curr. Opin. Pharmacol., 4, 4-11 (2004)