A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder

Biological Psychiatry

Volumn 72, Issue 11, 2012, Pages 971-977

  Adler, Lenard A ^a,b   Kroon, René A ^c   Stein, Mark ^d   Shahid, Mohammed ^e   Tarazi, Frank I ^f   Szegedi, Armin ^g   Schipper, Jacques ^c   Cazorla, Pilar ^g  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b New York Veterans Affairs Harbor Healthcare System   (United States)

^c NV ORGANON   (Netherlands)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e Merck Sharp & Dohme Limited   (United Kingdom)

^f MCLEAN HOSPITAL   (United States)

^g MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ADHD; adult; AMPA PAM; glutamate; Org 26576; translational

Indexed keywords

AMPA RECEPTOR AGONIST; ORG 26576; OXIDOPAMINE; PLACEBO; UNCLASSIFIED DRUG;

ABNORMAL THINKING; ADULT; ADULT ADHD INVESTIGATOR SYMPTOM RATING SCALE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL GLOBAL IMPRESSION SCALE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; EXPERIMENTAL MODEL; FATIGUE; FEMALE; HEADACHE; HEART PALPITATION; HUMAN; HYPERACTIVITY; INSOMNIA; LOCOMOTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MUSCLE STRAIN; NAUSEA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL; RAT; RHINOPHARYNGITIS; SIDE EFFECT; SOMNOLENCE; SYMPTOMATOLOGY; TRANSLATIONAL RESEARCH; TREATMENT OUTCOME; VERTIGO; VOMITING; XEROSTOMIA;

ADULT; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ATTENTION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CROSS-OVER STUDIES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; TREATMENT OUTCOME;

EID: 84868211415     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.05.012     Document Type: Article

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