메뉴 건너뛰기




Volumn 25, Issue 11, 2014, Pages 567-575

Integrin and cadherin signaling in bone: Role and potential therapeutic targets

Author keywords

Bone formation; Bone repair; Cadherins; Integrins; Niches; Wnt signaling

Indexed keywords

BETA CATENIN; CADHERIN; CELL ADHESION MOLECULE; INTEGRIN; WNT PROTEIN;

EID: 84927694761     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.06.009     Document Type: Review
Times cited : (117)

References (85)
  • 1
    • 79251493453 scopus 로고    scopus 로고
    • The amazing osteocyte
    • Bonewald L.F. The amazing osteocyte. J. Bone Miner. Res. 2011, 26:229-238.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 229-238
    • Bonewald, L.F.1
  • 2
    • 84865765939 scopus 로고    scopus 로고
    • Intercellular cross-talk among bone cells: new factors and pathways
    • Sims N.A., Walsh N.C. Intercellular cross-talk among bone cells: new factors and pathways. Curr. Osteoporos. Rep. 2012, 10:109-117.
    • (2012) Curr. Osteoporos. Rep. , vol.10 , pp. 109-117
    • Sims, N.A.1    Walsh, N.C.2
  • 3
    • 27944480412 scopus 로고    scopus 로고
    • Pathophysiology of age-related bone loss and osteoporosis
    • Khosla S., Riggs B.L. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol. Metab. Clin. North Am. 2005, 34:1015-1030.
    • (2005) Endocrinol. Metab. Clin. North Am. , vol.34 , pp. 1015-1030
    • Khosla, S.1    Riggs, B.L.2
  • 4
    • 84901254305 scopus 로고    scopus 로고
    • Bone cell senescence: mechanisms and perspectives
    • Marie P.J. Bone cell senescence: mechanisms and perspectives. J. Bone Miner. Res. 2014, 29:1311-1321.
    • (2014) J. Bone Miner. Res. , vol.29 , pp. 1311-1321
    • Marie, P.J.1
  • 5
    • 84907569594 scopus 로고    scopus 로고
    • Bone biology and anabolic therapies for bone: current status and future prospects
    • Martin T.J. Bone biology and anabolic therapies for bone: current status and future prospects. J. Bone Metab. 2014, 21:8-20.
    • (2014) J. Bone Metab. , vol.21 , pp. 8-20
    • Martin, T.J.1
  • 7
    • 79955528442 scopus 로고    scopus 로고
    • Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
    • Kim S.H., et al. Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. J. Endocrinol. 2009, 209:139-151.
    • (2009) J. Endocrinol. , vol.209 , pp. 139-151
    • Kim, S.H.1
  • 8
    • 84857320794 scopus 로고    scopus 로고
    • Interactions between extracellular signal-regulated kinase 1/2 and P38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity
    • Ge C., et al. Interactions between extracellular signal-regulated kinase 1/2 and P38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity. J. Bone Miner. Res. 2012, 27:538-551.
    • (2012) J. Bone Miner. Res. , vol.27 , pp. 538-551
    • Ge, C.1
  • 9
    • 80055062698 scopus 로고    scopus 로고
    • Integrin-linked kinase: not so 'pseudo' after all
    • Hannigan G.E., et al. Integrin-linked kinase: not so 'pseudo' after all. Oncogene 2011, 30:4375-4385.
    • (2011) Oncogene , vol.30 , pp. 4375-4385
    • Hannigan, G.E.1
  • 10
    • 84887217021 scopus 로고    scopus 로고
    • Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization
    • El-Hoss J., et al. Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization. Gene 2014, 533:246-252.
    • (2014) Gene , vol.533 , pp. 246-252
    • El-Hoss, J.1
  • 11
    • 84876756847 scopus 로고    scopus 로고
    • Targeting integrins to promote bone formation and repair
    • Marie P.J. Targeting integrins to promote bone formation and repair. Nat. Rev. Endocrinol. 2013, 9:288-295.
    • (2013) Nat. Rev. Endocrinol. , vol.9 , pp. 288-295
    • Marie, P.J.1
  • 12
    • 13644250768 scopus 로고    scopus 로고
    • Skeletal phenotype of growing transgenic mice that express a function-perturbing form of β1 integrin in osteoblasts
    • Globus R.K., et al. Skeletal phenotype of growing transgenic mice that express a function-perturbing form of β1 integrin in osteoblasts. Calcif. Tissue Int. 2005, 76:39-49.
    • (2005) Calcif. Tissue Int. , vol.76 , pp. 39-49
    • Globus, R.K.1
  • 13
    • 79961105781 scopus 로고    scopus 로고
    • Osteoblast mineralization requires β1 integrin/ICAP-1-dependent fibronectin deposition
    • Brunner M., et al. Osteoblast mineralization requires β1 integrin/ICAP-1-dependent fibronectin deposition. J. Cell Biol. 2011, 194:307-322.
    • (2011) J. Cell Biol. , vol.194 , pp. 307-322
    • Brunner, M.1
  • 14
    • 73249148294 scopus 로고    scopus 로고
    • Priming integrin α5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis
    • Hamidouche Z., et al. Priming integrin α5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:18587-18591.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 18587-18591
    • Hamidouche, Z.1
  • 15
    • 77953704786 scopus 로고    scopus 로고
    • Crosstalks between integrin α5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation
    • Hamidouche Z., et al. Crosstalks between integrin α5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC Cell Biol. 2010, 11:44.
    • (2010) BMC Cell Biol. , vol.11 , pp. 44
    • Hamidouche, Z.1
  • 16
    • 78650936271 scopus 로고    scopus 로고
    • WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity
    • Ono M., et al. WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity. J. Bone Miner. Res. 2011, 26:193-208.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 193-208
    • Ono, M.1
  • 17
    • 84894562060 scopus 로고    scopus 로고
    • An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells
    • Chen Q., et al. An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells 2014, 32:327-337.
    • (2014) Stem Cells , vol.32 , pp. 327-337
    • Chen, Q.1
  • 18
    • 77957765655 scopus 로고    scopus 로고
    • CYR61 regulates BMP-2-dependent osteoblast differentiation through the αvβ3 integrin/integrin-linked kinase/ERK pathway
    • Su J.L., et al. CYR61 regulates BMP-2-dependent osteoblast differentiation through the αvβ3 integrin/integrin-linked kinase/ERK pathway. J. Biol. Chem. 2010, 285:31325-31336.
    • (2010) J. Biol. Chem. , vol.285 , pp. 31325-31336
    • Su, J.L.1
  • 19
    • 84879324134 scopus 로고    scopus 로고
    • Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice
    • Stange R., et al. Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice. Bone 2013, 56:48-54.
    • (2013) Bone , vol.56 , pp. 48-54
    • Stange, R.1
  • 20
    • 80051502238 scopus 로고    scopus 로고
    • Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I
    • Popov C., et al. Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I. Cell Death Dis. 2011, 2:e186.
    • (2011) Cell Death Dis. , vol.2
    • Popov, C.1
  • 21
    • 79953066426 scopus 로고    scopus 로고
    • Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells
    • Shih Y.R., et al. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. J. Bone Miner. Res. 2011, 26:730-738.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 730-738
    • Shih, Y.R.1
  • 22
    • 70349335529 scopus 로고    scopus 로고
    • Mechanobiology of the skeleton
    • Turner C.H., et al. Mechanobiology of the skeleton. Sci. Signal. 2009, 2:pt3.
    • (2009) Sci. Signal. , vol.2
    • Turner, C.H.1
  • 23
    • 84882859988 scopus 로고    scopus 로고
    • Integrins in mechanotransduction
    • Ross T.D., et al. Integrins in mechanotransduction. Curr. Opin. Cell Biol. 2013, 25:613-618.
    • (2013) Curr. Opin. Cell Biol. , vol.25 , pp. 613-618
    • Ross, T.D.1
  • 24
    • 41649102233 scopus 로고    scopus 로고
    • Transforming growth factor-β prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling
    • Dufour C., et al. Transforming growth factor-β prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. Am. J. Physiol. Endocrinol. Metab. 2008, 294:E794-E801.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294 , pp. E794-E801
    • Dufour, C.1
  • 25
    • 80053574271 scopus 로고    scopus 로고
    • 1 integrin and PI3K/Akt signaling pathways in mandibular osteoblasts
    • 1 integrin and PI3K/Akt signaling pathways in mandibular osteoblasts. Exp. Cell Res. 2011, 317:2642-2649.
    • (2011) Exp. Cell Res. , vol.317 , pp. 2642-2649
    • Watabe, H.1
  • 26
    • 84857738933 scopus 로고    scopus 로고
    • Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels
    • Batra N., et al. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:3359-3364.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 3359-3364
    • Batra, N.1
  • 27
    • 81855196103 scopus 로고    scopus 로고
    • Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling
    • Long R.K., et al. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. J. Bone Miner. Res. 2011, 26:2948-2958.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 2948-2958
    • Long, R.K.1
  • 28
    • 84866265455 scopus 로고    scopus 로고
    • Regulation of β catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin
    • Bonnet N., et al. Regulation of β catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:15048-15053.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 15048-15053
    • Bonnet, N.1
  • 29
    • 84888340452 scopus 로고    scopus 로고
    • Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins
    • Seong J., et al. Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:19372-19377.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 19372-19377
    • Seong, J.1
  • 30
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • Robling A.G., et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J. Biol. Chem. 2008, 283:5866-5875.
    • (2008) J. Biol. Chem. , vol.283 , pp. 5866-5875
    • Robling, A.G.1
  • 31
    • 84880381959 scopus 로고    scopus 로고
    • Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process
    • Wu D., et al. Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:12096-12101.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 12096-12101
    • Wu, D.1
  • 32
    • 84891364059 scopus 로고    scopus 로고
    • Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αVβ3 integrin
    • Thi M.M., et al. Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αVβ3 integrin. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:21012-21017.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 21012-21017
    • Thi, M.M.1
  • 33
    • 77953233049 scopus 로고    scopus 로고
    • β1 integrins mediate mechanosensitive signaling pathways in osteocytes
    • Litzenberger J.B., et al. β1 integrins mediate mechanosensitive signaling pathways in osteocytes. Calcif. Tissue Int. 2010, 86:325-332.
    • (2010) Calcif. Tissue Int. , vol.86 , pp. 325-332
    • Litzenberger, J.B.1
  • 34
    • 84898627374 scopus 로고    scopus 로고
    • Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation
    • Batra N., et al. Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation. J. Biol. Chem. 2014, 289:10582-10591.
    • (2014) J. Biol. Chem. , vol.289 , pp. 10582-10591
    • Batra, N.1
  • 35
    • 0035010796 scopus 로고    scopus 로고
    • The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion
    • Gao J., et al. The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs 2001, 169:12-20.
    • (2001) Cells Tissues Organs , vol.169 , pp. 12-20
    • Gao, J.1
  • 36
    • 36849059595 scopus 로고    scopus 로고
    • Bone homing of mesenchymal stem cells by ectopic α4 integrin expression
    • Kumar S., Ponnazhagan S. Bone homing of mesenchymal stem cells by ectopic α4 integrin expression. FASEB J. 2007, 21:3917-3927.
    • (2007) FASEB J. , vol.21 , pp. 3917-3927
    • Kumar, S.1    Ponnazhagan, S.2
  • 37
    • 84858002781 scopus 로고    scopus 로고
    • Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass
    • Guan M., et al. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat. Med. 2012, 18:456-462.
    • (2012) Nat. Med. , vol.18 , pp. 456-462
    • Guan, M.1
  • 38
    • 84885090951 scopus 로고    scopus 로고
    • Reversing bone loss by directing mesenchymal stem cells to bone
    • Yao W., et al. Reversing bone loss by directing mesenchymal stem cells to bone. Stem Cells 2013, 31:2003-2014.
    • (2013) Stem Cells , vol.31 , pp. 2003-2014
    • Yao, W.1
  • 39
    • 84863661874 scopus 로고    scopus 로고
    • Peptide-based activation of α5 integrin for promoting osteogenesis
    • Fromigué O., et al. Peptide-based activation of α5 integrin for promoting osteogenesis. J. Cell. Biochem. 2012, 113:3029-3038.
    • (2012) J. Cell. Biochem. , vol.113 , pp. 3029-3038
    • Fromigué, O.1
  • 40
    • 78649603643 scopus 로고    scopus 로고
    • Extracellular matrix-mimetic adhesive biomaterials for bone repair
    • Shekaran A., Garcia A.J. Extracellular matrix-mimetic adhesive biomaterials for bone repair. J. Biomed. Mater. Res. A 2011, 96:261-272.
    • (2011) J. Biomed. Mater. Res. A , vol.96 , pp. 261-272
    • Shekaran, A.1    Garcia, A.J.2
  • 41
    • 84887329625 scopus 로고    scopus 로고
    • Osteogenic peptides in bone regeneration
    • Jabbari E. Osteogenic peptides in bone regeneration. Curr. Pharm. Des. 2013, 19:3391-3402.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 3391-3402
    • Jabbari, E.1
  • 42
    • 77955874342 scopus 로고    scopus 로고
    • Multivalent integrin-specific ligands enhance tissue healing and biomaterial integration
    • Petrie T.A., et al. Multivalent integrin-specific ligands enhance tissue healing and biomaterial integration. Sci. Transl. Med. 2010, 2:45ra60.
    • (2010) Sci. Transl. Med. , vol.2
    • Petrie, T.A.1
  • 43
    • 80052951552 scopus 로고    scopus 로고
    • Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing
    • Martino M.M., et al. Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing. Sci. Transl. Med. 2011, 3:100ra189.
    • (2011) Sci. Transl. Med. , vol.3
    • Martino, M.M.1
  • 44
    • 84856895642 scopus 로고    scopus 로고
    • Lentiviral-mediated integrin α5 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects
    • Srouji S., et al. Lentiviral-mediated integrin α5 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects. Hum. Gene Ther. 2012, 23:167-172.
    • (2012) Hum. Gene Ther. , vol.23 , pp. 167-172
    • Srouji, S.1
  • 45
    • 84864382244 scopus 로고    scopus 로고
    • Optimal intensity shock wave promotes the adhesion and migration of rat osteoblasts via integrin β1-mediated expression of phosphorylated focal adhesion kinase
    • Xu J.K., et al. Optimal intensity shock wave promotes the adhesion and migration of rat osteoblasts via integrin β1-mediated expression of phosphorylated focal adhesion kinase. J. Biol. Chem. 2012, 287:26200-26212.
    • (2012) J. Biol. Chem. , vol.287 , pp. 26200-26212
    • Xu, J.K.1
  • 46
    • 79960270517 scopus 로고    scopus 로고
    • Evolution: structural and functional diversity of cadherin at the adherens junction
    • Oda H., Takeichi M. Evolution: structural and functional diversity of cadherin at the adherens junction. J. Cell Biol. 2011, 193:1137-1146.
    • (2011) J. Cell Biol. , vol.193 , pp. 1137-1146
    • Oda, H.1    Takeichi, M.2
  • 47
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, β-catenin, and cadherin pathways
    • Nelson W.J., Nusse R. Convergence of Wnt, β-catenin, and cadherin pathways. Science 2004, 303:1483-1487.
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 48
    • 33845227116 scopus 로고    scopus 로고
    • Cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment
    • Mbalaviele G., et al. Cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment. J. Bone Miner. Res. 2006, 21:1821-1827.
    • (2006) J. Bone Miner. Res. , vol.21 , pp. 1821-1827
    • Mbalaviele, G.1
  • 49
    • 77955409133 scopus 로고    scopus 로고
    • N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms
    • Di Benedetto A., et al. N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms. J. Cell Sci. 2010, 123:2640-2648.
    • (2010) J. Cell Sci. , vol.123 , pp. 2640-2648
    • Di Benedetto, A.1
  • 50
    • 3242883440 scopus 로고    scopus 로고
    • Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis
    • Castro C.H., et al. Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis. J. Cell Sci. 2004, 117:2853-2864.
    • (2004) J. Cell Sci. , vol.117 , pp. 2853-2864
    • Castro, C.H.1
  • 51
    • 84864018515 scopus 로고    scopus 로고
    • Loss of the retinoblastoma tumor suppressor protein in murine calvaria facilitates immortalization of osteoblast-adipocyte bipotent progenitor cells characterized by low expression of N-cadherin
    • Gunduz V., et al. Loss of the retinoblastoma tumor suppressor protein in murine calvaria facilitates immortalization of osteoblast-adipocyte bipotent progenitor cells characterized by low expression of N-cadherin. Mol. Cell. Biol. 2012, 32:2561-2569.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 2561-2569
    • Gunduz, V.1
  • 52
    • 84904891746 scopus 로고    scopus 로고
    • N-Cadherin/Wnt interaction controls bone marrow mesenchymal cell fate and bone mass during aging
    • Haÿ E., et al. N-Cadherin/Wnt interaction controls bone marrow mesenchymal cell fate and bone mass during aging. J. Cell. Physiol. 2014, 10.1002/jcp.24629.
    • (2014) J. Cell. Physiol.
    • Haÿ, E.1
  • 53
    • 67749120363 scopus 로고    scopus 로고
    • Activity of the β-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion
    • Maher M.T., et al. Activity of the β-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. J. Cell Biol. 2009, 186:219-228.
    • (2009) J. Cell Biol. , vol.186 , pp. 219-228
    • Maher, M.T.1
  • 54
    • 77950683362 scopus 로고    scopus 로고
    • Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling
    • Heuberger J., Birchmeier W. Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb. Perspect. Biol. 2010, 2:a002915.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2
    • Heuberger, J.1    Birchmeier, W.2
  • 55
    • 59449095748 scopus 로고    scopus 로고
    • N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/β-catenin signaling, osteoblast function, and bone formation
    • Haÿ E., et al. N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/β-catenin signaling, osteoblast function, and bone formation. Mol. Cell. Biol. 2009, 29:953-964.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 953-964
    • Haÿ, E.1
  • 56
    • 77954069774 scopus 로고    scopus 로고
    • N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling
    • Haÿ E., et al. N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling. PLoS ONE 2009, 4:e8284.
    • (2009) PLoS ONE , vol.4
    • Haÿ, E.1
  • 57
    • 84865243092 scopus 로고    scopus 로고
    • Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation
    • Haÿ E., et al. Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation. J. Bone Miner. Res. 2012, 27:1852-1863.
    • (2012) J. Bone Miner. Res. , vol.27 , pp. 1852-1863
    • Haÿ, E.1
  • 58
    • 65549114494 scopus 로고    scopus 로고
    • Non-canonical Wnt signaling and N-cadherin related β-catenin signaling play a role in mechanically induced osteogenic cell fate
    • Arnsdorf E.J., et al. Non-canonical Wnt signaling and N-cadherin related β-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS ONE 2009, 4:e5388.
    • (2009) PLoS ONE , vol.4
    • Arnsdorf, E.J.1
  • 59
    • 80054087448 scopus 로고    scopus 로고
    • N-cadherin adherens junctions mediate osteogenesis through PI3K signaling
    • Guntur A.R., et al. N-cadherin adherens junctions mediate osteogenesis through PI3K signaling. Bone 2012, 50:54-62.
    • (2012) Bone , vol.50 , pp. 54-62
    • Guntur, A.R.1
  • 60
    • 84859550605 scopus 로고    scopus 로고
    • The stem cell niche in regenerative medicine
    • Wagers A.J. The stem cell niche in regenerative medicine. Cell Stem Cell 2012, 10:362-369.
    • (2012) Cell Stem Cell , vol.10 , pp. 362-369
    • Wagers, A.J.1
  • 61
    • 79953331206 scopus 로고    scopus 로고
    • Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
    • Shiozawa Y., et al. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J. Clin. Invest. 2011, 121:1298-1312.
    • (2011) J. Clin. Invest. , vol.121 , pp. 1298-1312
    • Shiozawa, Y.1
  • 62
    • 84866373814 scopus 로고    scopus 로고
    • Targeting of adhesion molecules as a therapeutic strategy in multiple myeloma
    • Neri P., Bahlis N.J. Targeting of adhesion molecules as a therapeutic strategy in multiple myeloma. Curr. Cancer Drug Targets 2012, 12:776-796.
    • (2012) Curr. Cancer Drug Targets , vol.12 , pp. 776-796
    • Neri, P.1    Bahlis, N.J.2
  • 63
    • 0141461414 scopus 로고    scopus 로고
    • Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia
    • Matsunaga T., et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat. Med. 2003, 9:1158-1165.
    • (2003) Nat. Med. , vol.9 , pp. 1158-1165
    • Matsunaga, T.1
  • 64
    • 84894520335 scopus 로고    scopus 로고
    • Beyond E-cadherin: roles of other cadherin superfamily members in cancer
    • van Roy F. Beyond E-cadherin: roles of other cadherin superfamily members in cancer. Nat. Rev. Cancer 2014, 14:121-134.
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 121-134
    • van Roy, F.1
  • 65
    • 80355138206 scopus 로고    scopus 로고
    • N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation
    • Groen R.W., et al. N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation. Haematologica 2011, 96:1653-1661.
    • (2011) Haematologica , vol.96 , pp. 1653-1661
    • Groen, R.W.1
  • 66
    • 74949142277 scopus 로고    scopus 로고
    • Enabling stem cell therapies through synthetic stem cell-niche engineering
    • Peerani R., Zandstra P.W. Enabling stem cell therapies through synthetic stem cell-niche engineering. J. Clin. Invest. 2010, 120:60-70.
    • (2010) J. Clin. Invest. , vol.120 , pp. 60-70
    • Peerani, R.1    Zandstra, P.W.2
  • 67
    • 61849122936 scopus 로고    scopus 로고
    • Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts
    • Young S.R., et al. Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts. J. Bone Miner. Res. 2009, 24:411-424.
    • (2009) J. Bone Miner. Res. , vol.24 , pp. 411-424
    • Young, S.R.1
  • 68
    • 55349127050 scopus 로고    scopus 로고
    • FAK-mediated mechanotransduction in skeletal regeneration
    • Leucht P., et al. FAK-mediated mechanotransduction in skeletal regeneration. PLoS ONE 2007, 2:e390.
    • (2007) PLoS ONE , vol.2
    • Leucht, P.1
  • 69
    • 84866684728 scopus 로고    scopus 로고
    • Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo
    • Castillo A.B., et al. Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo. PLoS ONE 2012, 7:e43291.
    • (2012) PLoS ONE , vol.7
    • Castillo, A.B.1
  • 70
    • 65949097929 scopus 로고    scopus 로고
    • ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK
    • Khatiwala C.B., et al. ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK. J. Bone Miner. Res. 2009, 24:886-898.
    • (2009) J. Bone Miner. Res. , vol.24 , pp. 886-898
    • Khatiwala, C.B.1
  • 71
    • 71749108831 scopus 로고    scopus 로고
    • Mechanical loading regulates NFATc1 and β-catenin signaling through a GSK3β control node
    • Sen B., et al. Mechanical loading regulates NFATc1 and β-catenin signaling through a GSK3β control node. J. Biol. Chem. 2009, 284:34607-34617.
    • (2009) J. Biol. Chem. , vol.284 , pp. 34607-34617
    • Sen, B.1
  • 72
    • 84875000886 scopus 로고    scopus 로고
    • Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
    • Ding L., Morrison S.J. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 2013, 495:231-235.
    • (2013) Nature , vol.495 , pp. 231-235
    • Ding, L.1    Morrison, S.J.2
  • 73
    • 68149149784 scopus 로고    scopus 로고
    • What is the true nature of the osteoblastic hematopoietic stem cell niche?
    • Askmyr M., et al. What is the true nature of the osteoblastic hematopoietic stem cell niche?. Trends Endocrinol. Metab. 2009, 20:303-309.
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 303-309
    • Askmyr, M.1
  • 74
    • 65949115924 scopus 로고    scopus 로고
    • Role of the osteoblast lineage in the bone marrow hematopoietic niches
    • Wu J.Y., et al. Role of the osteoblast lineage in the bone marrow hematopoietic niches. J. Bone Miner. Res. 2009, 24:759-764.
    • (2009) J. Bone Miner. Res. , vol.24 , pp. 759-764
    • Wu, J.Y.1
  • 75
    • 84865362563 scopus 로고    scopus 로고
    • Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche
    • Arai F., et al. Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche. Ann. N.Y. Acad. Sci. 2012, 1266:72-77.
    • (2012) Ann. N.Y. Acad. Sci. , vol.1266 , pp. 72-77
    • Arai, F.1
  • 76
    • 77449117244 scopus 로고    scopus 로고
    • Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow
    • Hosokawa K., et al. Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow. Cell Stem Cell 2010, 6:194-198.
    • (2010) Cell Stem Cell , vol.6 , pp. 194-198
    • Hosokawa, K.1
  • 77
    • 77956038665 scopus 로고    scopus 로고
    • Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
    • Hosokawa K., et al. Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells. Blood 2010, 116:554-563.
    • (2010) Blood , vol.116 , pp. 554-563
    • Hosokawa, K.1
  • 78
    • 76749142865 scopus 로고    scopus 로고
    • N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells
    • Wein F., et al. N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells. Stem Cell Res. 2010, 4:129-139.
    • (2010) Stem Cell Res. , vol.4 , pp. 129-139
    • Wein, F.1
  • 79
    • 33846869023 scopus 로고    scopus 로고
    • Therapeutic targeting of a stem cell niche
    • Adams G.B., et al. Therapeutic targeting of a stem cell niche. Nat. Biotechnol. 2007, 25:238-243.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 238-243
    • Adams, G.B.1
  • 80
    • 70349574479 scopus 로고    scopus 로고
    • Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation
    • Dominici M., et al. Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation. Blood 2009, 114:2333-2343.
    • (2009) Blood , vol.114 , pp. 2333-2343
    • Dominici, M.1
  • 81
    • 84904439961 scopus 로고    scopus 로고
    • Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells
    • Yao H., et al. Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells. Stem Cells 2014, 10.1002/stem.1701.
    • (2014) Stem Cells
    • Yao, H.1
  • 82
    • 38949140223 scopus 로고    scopus 로고
    • Strontium can increase some osteoblasts without increasing hematopoietic stem cells
    • Lymperi S., et al. Strontium can increase some osteoblasts without increasing hematopoietic stem cells. Blood 2008, 111:1173-1181.
    • (2008) Blood , vol.111 , pp. 1173-1181
    • Lymperi, S.1
  • 83
    • 59249094358 scopus 로고    scopus 로고
    • Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance
    • Kiel M.J., et al. Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. Cell Stem Cell 2009, 4:170-179.
    • (2009) Cell Stem Cell , vol.4 , pp. 170-179
    • Kiel, M.J.1
  • 84
    • 84864063975 scopus 로고    scopus 로고
    • Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells
    • Bromberg O., et al. Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells. Blood 2012, 120:303-313.
    • (2012) Blood , vol.120 , pp. 303-313
    • Bromberg, O.1
  • 85
    • 84864053350 scopus 로고    scopus 로고
    • N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells
    • Greenbaum A.M., et al. N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. Blood 2012, 120:295-302.
    • (2012) Blood , vol.120 , pp. 295-302
    • Greenbaum, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.