Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5866-5875

  Robling, Alexander G ^a,b   Niziolek, Paul J ^b   Baldridge, Lee A ^a   Condon, Keith W ^a   Allen, Matthew R ^a   Alam, Imranul ^b   Mantila, Sara M ^b   Gluhak Heinrich, Jelica ^c   Bellido, Teresita M ^d   Harris, Stephen E ^c   Turner, Charles H ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMECHANICS; BIPED LOCOMOTION; BONE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; MODULATION; UNLOADING;

ANTAGONISTIC EFFECTS; BONE CELLS; BONE FORMATIONS; CELL POPULATIONS; CELL TYPES; IMMUNOHISTOCHEMISTRY; IN-SITU; IN-VIVO; LOADING CONDITIONS; MECHANICAL STIMULATIONS; OSTEOCYTE; OSTEOCYTES; OSTEOGENESIS; POTENT INHIBITORS; POTENTIAL MECHANISMS; PROTEIN LEVELS; SCLEROSTIN; SIGNAL OUTPUTS; STAINING INTENSITIES;

MECHANISMS;

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; SCLEROSTIN; WNT PROTEIN; BONE MORPHOGENETIC PROTEIN; LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; SOST PROTEIN, MOUSE; SOST PROTEIN, RAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE STRENGTH; CONTROLLED STUDY; FRAGILITY FRACTURE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIBIA; ULNA; ANIMAL; BIOSYNTHESIS; BONE DEVELOPMENT; CYTOLOGY; FEMALE; GENETIC MARKER; LEWIS RAT; METABOLISM; METHODOLOGY; PHYSIOLOGY; RAT; WEIGHT BEARING; WEIGHTLESSNESS;

ANIMALS; BONE MORPHOGENETIC PROTEINS; FEMALE; GENETIC MARKERS; IN SITU HYBRIDIZATION; LDL-RECEPTOR RELATED PROTEINS; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; OSTEOCYTES; OSTEOGENESIS; RATS; RATS, INBRED LEW; TIBIA; ULNA; WEIGHT-BEARING; WEIGHTLESSNESS SIMULATION; WNT PROTEINS;

EID: 41949089764     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705092200     Document Type: Article

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