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Volumn 26, Issue 1, 2011, Pages 193-208

WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity

Author keywords

BMP; CCN; CYTOKINES; GROWTH FACTORS; OSTEOPROGENITORS; WISP1

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CCN PROTEIN; MESSENGER RNA; SHORT HAIRPIN RNA; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; WNT INDUCED SECRETED PROTEIN 1;

EID: 78650936271     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.205     Document Type: Article
Times cited : (122)

References (79)
  • 1
    • 33646102224 scopus 로고    scopus 로고
    • Expression and regulation of CCN genes in murine osteoblasts
    • Parisi MS, Gazzerro E, Rydziel S, Canalis E., Expression and regulation of CCN genes in murine osteoblasts. Bone. 2006; 38: 671-677.
    • (2006) Bone. , vol.38 , pp. 671-677
    • Parisi, M.S.1    Gazzerro, E.2    Rydziel, S.3    Canalis, E.4
  • 2
    • 4344643927 scopus 로고    scopus 로고
    • WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair
    • French DM, Kaul RJ, D'Souza AL, et al. WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol. 2004; 165: 855-867.
    • (2004) Am J Pathol. , vol.165 , pp. 855-867
    • French, D.M.1    Kaul, R.J.2    D'Souza, A.L.3
  • 5
    • 59649100796 scopus 로고    scopus 로고
    • Wnt signaling controls the fate of mesenchymal stem cells
    • Ling L, Nurcombe V, Cool SM., Wnt signaling controls the fate of mesenchymal stem cells. Gene. 2009; 433: 1-7.
    • (2009) Gene. , vol.433 , pp. 1-7
    • Ling, L.1    Nurcombe, V.2    Cool, S.M.3
  • 6
    • 0037118279 scopus 로고    scopus 로고
    • Regulation of bone formation and vision by LRP5
    • Patel MS, Karsenty G., Regulation of bone formation and vision by LRP5. N Engl J Med. 2002; 346: 1572-1574.
    • (2002) N Engl J Med. , vol.346 , pp. 1572-1574
    • Patel, M.S.1    Karsenty, G.2
  • 7
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden LM, Mao J, Belsky J, et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002; 346: 1513-1521.
    • (2002) N Engl J Med. , vol.346 , pp. 1513-1521
    • Boyden, L.M.1    Mao, J.2    Belsky, J.3
  • 8
    • 34250840514 scopus 로고    scopus 로고
    • The genetics of low-density lipoprotein receptor-related protein 5 in bone: A story of extremes
    • Balemans W, Van Hul W., The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes. Endocrinology. 2007; 148: 2622-2629.
    • (2007) Endocrinology. , vol.148 , pp. 2622-2629
    • Balemans, W.1    Van Hul, W.2
  • 9
    • 59649095502 scopus 로고    scopus 로고
    • Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1
    • Blom AB, Brockbank SM, van Lent PL, et al. Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum. 2009; 60: 501-512.
    • (2009) Arthritis Rheum. , vol.60 , pp. 501-512
    • Blom, A.B.1    Brockbank, S.M.2    Van Lent, P.L.3
  • 10
    • 60249098721 scopus 로고    scopus 로고
    • Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology
    • Geyer M, Grassel S, Straub RH, et al. Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage. 2009; 17: 328-335.
    • (2009) Osteoarthritis Cartilage. , vol.17 , pp. 328-335
    • Geyer, M.1    Grassel, S.2    Straub, R.H.3
  • 11
    • 50249133597 scopus 로고    scopus 로고
    • TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function
    • Inkson CA, Ono M, Kuznetsov SA, Fisher LW, Robey PG, Young MF., TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function. J Cell Biochem. 2008; 104: 1865-1878.
    • (2008) J Cell Biochem. , vol.104 , pp. 1865-1878
    • Inkson, C.A.1    Ono, M.2    Kuznetsov, S.A.3    Fisher, L.W.4    Robey, P.G.5    Young, M.F.6
  • 13
    • 0042855012 scopus 로고    scopus 로고
    • The CCN family: A new stimulus package
    • Brigstock DR., The CCN family: a new stimulus package. J Endocrinol. 2003; 178: 169-175.
    • (2003) J Endocrinol. , vol.178 , pp. 169-175
    • Brigstock, D.R.1
  • 14
    • 53049106277 scopus 로고    scopus 로고
    • Connective tissue growth factor enhances osteoblastogenesis in vitro
    • Smerdel-Ramoya A, Zanotti S, Deregowski V, Canalis E., Connective tissue growth factor enhances osteoblastogenesis in vitro. J Biol Chem. 2008; 283: 22690-22699.
    • (2008) J Biol Chem. , vol.283 , pp. 22690-22699
    • Smerdel-Ramoya, A.1    Zanotti, S.2    Deregowski, V.3    Canalis, E.4
  • 15
    • 50449109286 scopus 로고    scopus 로고
    • Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia
    • Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Canalis E., Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Endocrinology. 2008; 149: 4374-4381.
    • (2008) Endocrinology. , vol.149 , pp. 4374-4381
    • Smerdel-Ramoya, A.1    Zanotti, S.2    Stadmeyer, L.3    Durant, D.4    Canalis, E.5
  • 17
    • 43149111611 scopus 로고    scopus 로고
    • Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene
    • Heath E, Tahri D, Andermarcher E, Schofield P, Fleming S, Boulter CA., Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene. BMC Dev Biol. 2008; 8: 18.
    • (2008) BMC Dev Biol. , vol.8 , pp. 18
    • Heath, E.1    Tahri, D.2    Andermarcher, E.3    Schofield, P.4    Fleming, S.5    Boulter, C.A.6
  • 18
    • 0038093327 scopus 로고    scopus 로고
    • Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    • Ivkovic S, Yoon BS, Popoff SN, et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003; 130: 2779-2791.
    • (2003) Development. , vol.130 , pp. 2779-2791
    • Ivkovic, S.1    Yoon, B.S.2    Popoff, S.N.3
  • 19
    • 41949091777 scopus 로고    scopus 로고
    • Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts
    • Arnott JA, Zhang X, Sanjay A, et al. Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts. Bone. 2008; 42: 871-885.
    • (2008) Bone. , vol.42 , pp. 871-885
    • Arnott, J.A.1    Zhang, X.2    Sanjay, A.3
  • 20
    • 65249088418 scopus 로고    scopus 로고
    • WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
    • Konigshoff M, Kramer M, Balsara N, et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest. 2009; 119: 772-787.
    • (2009) J Clin Invest. , vol.119 , pp. 772-787
    • Konigshoff, M.1    Kramer, M.2    Balsara, N.3
  • 21
    • 33745497854 scopus 로고    scopus 로고
    • Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer
    • Shimo T, Kubota S, Yoshioka N, et al. Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer. J Bone Miner Res. 2006; 21: 1045-1059.
    • (2006) J Bone Miner Res. , vol.21 , pp. 1045-1059
    • Shimo, T.1    Kubota, S.2    Yoshioka, N.3
  • 22
    • 34250767642 scopus 로고    scopus 로고
    • CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancer
    • Kleer CG, Zhang Y, Merajver SD., CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancer. Cells Tissues Organs. 2007; 185: 95-99.
    • (2007) Cells Tissues Organs. , vol.185 , pp. 95-99
    • Kleer, C.G.1    Zhang, Y.2    Merajver, S.D.3
  • 23
    • 59149092493 scopus 로고    scopus 로고
    • The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth
    • Bennewith KL, Huang X, Ham CM, et al. The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Res. 2009; 69: 775-784.
    • (2009) Cancer Res. , vol.69 , pp. 775-784
    • Bennewith, K.L.1    Huang, X.2    Ham, C.M.3
  • 24
    • 25444506333 scopus 로고    scopus 로고
    • Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis
    • Yang F, Tuxhorn JA, Ressler SJ, McAlhany SJ, Dang TD, Rowley DR., Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis. Cancer Res. 2005; 65: 8887-8895.
    • (2005) Cancer Res. , vol.65 , pp. 8887-8895
    • Yang, F.1    Tuxhorn, J.A.2    Ressler, S.J.3    McAlhany, S.J.4    Dang, T.D.5    Rowley, D.R.6
  • 25
    • 0034910661 scopus 로고    scopus 로고
    • Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues
    • Maillard M, Cadot B, Ball RY, et al. Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues. Mol Pathol. 2001; 54: 275-280.
    • (2001) Mol Pathol. , vol.54 , pp. 275-280
    • Maillard, M.1    Cadot, B.2    Ball, R.Y.3
  • 26
    • 0035817741 scopus 로고    scopus 로고
    • A novel variant of WISP1 lacking a von Willebrand type C module overexpressed in scirrhous gastric carcinoma
    • Tanaka S, Sugimachi K, Saeki H, et al. A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. Oncogene. 2001; 20: 5525-5532.
    • (2001) Oncogene. , vol.20 , pp. 5525-5532
    • Tanaka, S.1    Sugimachi, K.2    Saeki, H.3
  • 27
    • 33846159843 scopus 로고    scopus 로고
    • Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development
    • Kidd M, Modlin IM, Eick GN, Camp RL, Mane SM., Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development. Am J Physiol Gastrointest Liver Physiol. 2007; 292: G191-200.
    • (2007) Am J Physiol Gastrointest Liver Physiol. , vol.292
    • Kidd, M.1    Modlin, I.M.2    Eick, G.N.3    Camp, R.L.4    Mane, S.M.5
  • 28
    • 37449000249 scopus 로고    scopus 로고
    • Functional requirement of CCN2 for intramembranous bone formation in embryonic mice
    • Kawaki H, Kubota S, Suzuki A, et al. Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun. 2008; 366: 450-456.
    • (2008) Biochem Biophys Res Commun. , vol.366 , pp. 450-456
    • Kawaki, H.1    Kubota, S.2    Suzuki, A.3
  • 29
    • 33847627603 scopus 로고    scopus 로고
    • CCN family proteins and angiogenesis: From embryo to adulthood
    • Kubota S, Takigawa M., CCN family proteins and angiogenesis: from embryo to adulthood. Angiogenesis. 2007; 10: 1-11.
    • (2007) Angiogenesis. , vol.10 , pp. 1-11
    • Kubota, S.1    Takigawa, M.2
  • 30
    • 34548413245 scopus 로고    scopus 로고
    • Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor
    • Colston JT, de la Rosa SD, Koehler M, et al. Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Am J Physiol Heart Circ Physiol. 2007; 293: H1839-1846.
    • (2007) Am J Physiol Heart Circ Physiol. , vol.293
    • Colston, J.T.1    De La Rosa, S.D.2    Koehler, M.3
  • 31
    • 2242453283 scopus 로고    scopus 로고
    • Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells
    • Leu SJ, Lam SC, Lau LF., Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J Biol Chem. 2002; 277: 46248-46255.
    • (2002) J Biol Chem. , vol.277 , pp. 46248-46255
    • Leu, S.J.1    Lam, S.C.2    Lau, L.F.3
  • 32
    • 0038605567 scopus 로고    scopus 로고
    • CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family
    • Lin CG, Leu SJ, Chen N, et al. CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem. 2003; 278: 24200-24208.
    • (2003) J Biol Chem. , vol.278 , pp. 24200-24208
    • Lin, C.G.1    Leu, S.J.2    Chen, N.3
  • 33
    • 14844311198 scopus 로고    scopus 로고
    • Integrin-dependent functions of the angiogenic inducer NOV (CCN3): Implication in wound healing
    • Lin CG, Chen CC, Leu SJ, Grzeszkiewicz TM, Lau LF., Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. J Biol Chem. 2005; 280: 8229-8237.
    • (2005) J Biol Chem. , vol.280 , pp. 8229-8237
    • Lin, C.G.1    Chen, C.C.2    Leu, S.J.3    Grzeszkiewicz, T.M.4    Lau, L.F.5
  • 34
    • 38849132123 scopus 로고    scopus 로고
    • CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma
    • Vallacchi V, Daniotti M, Ratti F, et al. CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma. Cancer Res. 2008; 68: 715-723.
    • (2008) Cancer Res. , vol.68 , pp. 715-723
    • Vallacchi, V.1    Daniotti, M.2    Ratti, F.3
  • 35
    • 36348989096 scopus 로고    scopus 로고
    • The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of alphavbeta3 and alphavbeta5
    • Crockett JC, Schutze N, Tosh D, et al. The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of alphavbeta3 and alphavbeta5. Endocrinology. 2007; 148: 5761-5768.
    • (2007) Endocrinology. , vol.148 , pp. 5761-5768
    • Crockett, J.C.1    Schutze, N.2    Tosh, D.3
  • 36
    • 32344444422 scopus 로고    scopus 로고
    • CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1
    • Hoshijima M, Hattori T, Inoue M, et al. CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1. FEBS Lett. 2006; 580: 1376-1382.
    • (2006) FEBS Lett. , vol.580 , pp. 1376-1382
    • Hoshijima, M.1    Hattori, T.2    Inoue, M.3
  • 37
    • 21744435590 scopus 로고    scopus 로고
    • In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type
    • Benini S, Perbal B, Zambelli D, et al. In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type. Oncogene. 2005; 24: 4349-4361.
    • (2005) Oncogene. , vol.24 , pp. 4349-4361
    • Benini, S.1    Perbal, B.2    Zambelli, D.3
  • 38
    • 12144286634 scopus 로고    scopus 로고
    • Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways
    • Xie D, Yin D, Tong X, et al. Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways. Cancer Res. 2004; 64: 1987-1996.
    • (2004) Cancer Res. , vol.64 , pp. 1987-1996
    • Xie, D.1    Yin, D.2    Tong, X.3
  • 39
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu JG, Ketpura NI, Reversade B, De Robertis EM., Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol. 2002; 4: 599-604.
    • (2002) Nat Cell Biol. , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 40
    • 34948831652 scopus 로고    scopus 로고
    • The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling
    • Nakamura Y, Weidinger G, Liang JO, et al. The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J Clin Invest. 2007; 117: 3075-3086.
    • (2007) J Clin Invest. , vol.117 , pp. 3075-3086
    • Nakamura, Y.1    Weidinger, G.2    Liang, J.O.3
  • 41
    • 59449095447 scopus 로고    scopus 로고
    • CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes
    • Maeda A, Nishida T, Aoyama E, et al. CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem. 2009; 145: 207-216.
    • (2009) J Biochem. , vol.145 , pp. 207-216
    • Maeda, A.1    Nishida, T.2    Aoyama, E.3
  • 42
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • Canalis E, Economides AN, Gazzerro E., Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev. 2003; 24: 218-235.
    • (2003) Endocr Rev. , vol.24 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 43
    • 33744772589 scopus 로고    scopus 로고
    • Function of BMPs and BMP antagonists in adult bone
    • Abe E., Function of BMPs and BMP antagonists in adult bone. Ann N Y Acad Sci. 2006; 1068: 41-53.
    • (2006) Ann N y Acad Sci. , vol.1068 , pp. 41-53
    • Abe, E.1
  • 44
    • 36349024668 scopus 로고    scopus 로고
    • Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery
    • Bishop GB, Einhorn TA., Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery. Int Orthop. 2007; 31: 721-727.
    • (2007) Int Orthop. , vol.31 , pp. 721-727
    • Bishop, G.B.1    Einhorn, T.A.2
  • 45
    • 24044497243 scopus 로고    scopus 로고
    • Extracellular matrix proteoglycans control the fate of bone marrow stromal cells
    • Bi Y, Stuelten CH, Kilts T, et al. Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J Biol Chem. 2005; 280: 30481-30489.
    • (2005) J Biol Chem. , vol.280 , pp. 30481-30489
    • Bi, Y.1    Stuelten, C.H.2    Kilts, T.3
  • 46
    • 36549088668 scopus 로고    scopus 로고
    • A rapid and sensitive bioassay to measure bone morphogenetic protein activity
    • Zilberberg L, ten Dijke P, Sakai LY, Rifkin DB., A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol. 2007; 8: 41.
    • (2007) BMC Cell Biol. , vol.8 , pp. 41
    • Zilberberg, L.1    Ten Dijke, P.2    Sakai, L.Y.3    Rifkin, D.B.4
  • 47
    • 0036141112 scopus 로고    scopus 로고
    • WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase
    • Su F, Overholtzer M, Besser D, Levine AJ., WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev. 2002; 16: 46-57.
    • (2002) Genes Dev. , vol.16 , pp. 46-57
    • Su, F.1    Overholtzer, M.2    Besser, D.3    Levine, A.J.4
  • 48
    • 23844546987 scopus 로고    scopus 로고
    • Combinatorial gene therapy for bone regeneration: Cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4 and 7
    • Zhao M, Zhao Z, Koh JT, Jin T, Franceschi RT., Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4 and 7. J Cell Biochem. 2005; 95: 1-16.
    • (2005) J Cell Biochem. , vol.95 , pp. 1-16
    • Zhao, M.1    Zhao, Z.2    Koh, J.T.3    Jin, T.4    Franceschi, R.T.5
  • 49
    • 57449103799 scopus 로고    scopus 로고
    • The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells
    • Inkson CA, Ono M, Bi Y, Kuznetsov SA, Fisher LW, Young MF., The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells. Cells Tissues Organs. 2009; 189: 153-157.
    • (2009) Cells Tissues Organs. , vol.189 , pp. 153-157
    • Inkson, C.A.1    Ono, M.2    Bi, Y.3    Kuznetsov, S.A.4    Fisher, L.W.5    Young, M.F.6
  • 50
    • 0032900334 scopus 로고    scopus 로고
    • Efficient gene transfer into normal human skeletal cells using recombinant adenovirus and conjugated adenovirus-DNA complexes
    • Sommer B, Kuznetsov SA, Robey PG, O'Connell B, Cristiano RJ, Young MF., Efficient gene transfer into normal human skeletal cells using recombinant adenovirus and conjugated adenovirus-DNA complexes. Calcif Tissue Int. 1999; 64: 45-49.
    • (1999) Calcif Tissue Int. , vol.64 , pp. 45-49
    • Sommer, B.1    Kuznetsov, S.A.2    Robey, P.G.3    O'Connell, B.4    Cristiano, R.J.5    Young, M.F.6
  • 51
    • 17644378679 scopus 로고    scopus 로고
    • Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
    • Lin J, Patel SR, Cheng X, et al. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med. 2005; 11: 387-393.
    • (2005) Nat Med. , vol.11 , pp. 387-393
    • Lin, J.1    Patel, S.R.2    Cheng, X.3
  • 52
    • 63849258968 scopus 로고    scopus 로고
    • Role of bone morphogenetic proteins and their antagonists in healing of bone fracture
    • Dean DB, Watson JT, Moed BR, Zhang Z., Role of bone morphogenetic proteins and their antagonists in healing of bone fracture. Front Biosci. 2009; 14: 2878-2888.
    • (2009) Front Biosci. , vol.14 , pp. 2878-2888
    • Dean, D.B.1    Watson, J.T.2    Moed, B.R.3    Zhang, Z.4
  • 54
    • 0025316785 scopus 로고
    • Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix
    • Owen TA, Aronow M, Shalhoub V, et al. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol. 1990; 143: 420-430.
    • (1990) J Cell Physiol. , vol.143 , pp. 420-430
    • Owen, T.A.1    Aronow, M.2    Shalhoub, V.3
  • 55
    • 36348940945 scopus 로고    scopus 로고
    • Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation
    • Oka M, Kubota S, Kondo S, et al. Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation. J Histochem Cytochem. 2007; 55: 1245-1255.
    • (2007) J Histochem Cytochem. , vol.55 , pp. 1245-1255
    • Oka, M.1    Kubota, S.2    Kondo, S.3
  • 56
    • 33846553080 scopus 로고    scopus 로고
    • CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways
    • Minamizato T, Sakamoto K, Liu T, et al. CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways. Biochem Biophys Res Commun. 2007; 354: 567-573.
    • (2007) Biochem Biophys Res Commun. , vol.354 , pp. 567-573
    • Minamizato, T.1    Sakamoto, K.2    Liu, T.3
  • 57
    • 40949127801 scopus 로고    scopus 로고
    • Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation
    • Pi L, Ding X, Jorgensen M, et al. Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation. Hepatology. 2008; 47: 996-1004.
    • (2008) Hepatology. , vol.47 , pp. 996-1004
    • Pi, L.1    Ding, X.2    Jorgensen, M.3
  • 58
    • 66149098432 scopus 로고    scopus 로고
    • CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells
    • Tan TW, Lai CH, Huang CY, et al. CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells. J Cell Biochem. 2009; 107: 345-356.
    • (2009) J Cell Biochem. , vol.107 , pp. 345-356
    • Tan, T.W.1    Lai, C.H.2    Huang, C.Y.3
  • 59
    • 60149091505 scopus 로고    scopus 로고
    • Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells
    • Tan TW, Yang WH, Lin YT, et al. Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells. Carcinogenesis. 2009; 30: 258-268.
    • (2009) Carcinogenesis. , vol.30 , pp. 258-268
    • Tan, T.W.1    Yang, W.H.2    Lin, Y.T.3
  • 60
    • 33646821004 scopus 로고    scopus 로고
    • A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells
    • Gao R, Brigstock DR., A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells. Gut. 2006; 55: 856-862.
    • (2006) Gut. , vol.55 , pp. 856-862
    • Gao, R.1    Brigstock, D.R.2
  • 61
    • 33847257790 scopus 로고    scopus 로고
    • CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway
    • Yoshida Y, Togi K, Matsumae H, et al. CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway. Biochem Biophys Res Commun. 2007; 355: 611-618.
    • (2007) Biochem Biophys Res Commun. , vol.355 , pp. 611-618
    • Yoshida, Y.1    Togi, K.2    Matsumae, H.3
  • 62
    • 6344260672 scopus 로고    scopus 로고
    • Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions
    • Leu SJ, Chen N, Chen CC, et al. Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions. J Biol Chem. 2004; 279: 44177-44187.
    • (2004) J Biol Chem. , vol.279 , pp. 44177-44187
    • Leu, S.J.1    Chen, N.2    Chen, C.C.3
  • 63
    • 57449108288 scopus 로고    scopus 로고
    • CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition
    • Nishida T, Kondo S, Maeda A, Kubota S, Lyons KM, Takigawa M., CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone. 2009; 44: 24-31.
    • (2009) Bone. , vol.44 , pp. 24-31
    • Nishida, T.1    Kondo, S.2    Maeda, A.3    Kubota, S.4    Lyons, K.M.5    Takigawa, M.6
  • 64
    • 27744574700 scopus 로고    scopus 로고
    • Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1
    • Fontana L, Chen Y, Prijatelj P, et al. Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. Faseb J. 2005; 19: 1798-1808.
    • (2005) Faseb J. , vol.19 , pp. 1798-1808
    • Fontana, L.1    Chen, Y.2    Prijatelj, P.3
  • 65
    • 73249148294 scopus 로고    scopus 로고
    • Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis
    • Hamidouche Z, Fromigue O, Ringe J, et al. Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Natl Acad Sci U S A. 2009; 106: 18587-18591.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 18587-18591
    • Hamidouche, Z.1    Fromigue, O.2    Ringe, J.3
  • 66
    • 0242690484 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells
    • Gao R, Brigstock DR., Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res. 2003; 27: 214-220.
    • (2003) Hepatol Res. , vol.27 , pp. 214-220
    • Gao, R.1    Brigstock, D.R.2
  • 67
    • 0035798710 scopus 로고    scopus 로고
    • The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor
    • Segarini PR, Nesbitt JE, Li D, Hays LG, Yates JR 3rd, Carmichael DF., The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor. J Biol Chem. 2001; 276: 40659-40667.
    • (2001) J Biol Chem. , vol.276 , pp. 40659-40667
    • Segarini, P.R.1    Nesbitt, J.E.2    Li, D.3    Hays, L.G.4    Yates III, J.R.5    Carmichael, D.F.6
  • 68
    • 58649087137 scopus 로고    scopus 로고
    • Where Wnts went: The exploding field of Lrp5 and Lrp6 signaling in bone
    • Williams BO, Insogna KL., Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone. J Bone Miner Res. 2009; 24: 171-178.
    • (2009) J Bone Miner Res. , vol.24 , pp. 171-178
    • Williams, B.O.1    Insogna, K.L.2
  • 69
    • 0347916881 scopus 로고    scopus 로고
    • Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists
    • Avsian-Kretchmer O, Hsueh AJ., Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. Mol Endocrinol. 2004; 18: 1-12.
    • (2004) Mol Endocrinol. , vol.18 , pp. 1-12
    • Avsian-Kretchmer, O.1    Hsueh, A.J.2
  • 70
    • 33845927993 scopus 로고    scopus 로고
    • Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation
    • van Bezooijen RL, Svensson JP, Eefting D, et al. Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation. J Bone Miner Res. 2007; 22: 19-28.
    • (2007) J Bone Miner Res. , vol.22 , pp. 19-28
    • Van Bezooijen, R.L.1    Svensson, J.P.2    Eefting, D.3
  • 71
    • 4344660363 scopus 로고    scopus 로고
    • Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex
    • Winkler DG, Yu C, Geoghegan JC, et al. Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex. J Biol Chem. 2004; 279: 36293-36298.
    • (2004) J Biol Chem. , vol.279 , pp. 36293-36298
    • Winkler, D.G.1    Yu, C.2    Geoghegan, J.C.3
  • 72
    • 13244298422 scopus 로고    scopus 로고
    • Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins
    • Winkler DG, Sutherland MS, Ojala E, et al. Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins. J Biol Chem. 2005; 280: 2498-2502.
    • (2005) J Biol Chem. , vol.280 , pp. 2498-2502
    • Winkler, D.G.1    Sutherland, M.S.2    Ojala, E.3
  • 73
    • 0032819849 scopus 로고    scopus 로고
    • Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia
    • Hurvitz JR, Suwairi WM, Van Hul W, et al. Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Nat Genet. 1999; 23: 94-98.
    • (1999) Nat Genet. , vol.23 , pp. 94-98
    • Hurvitz, J.R.1    Suwairi, W.M.2    Van Hul, W.3
  • 75
    • 34248566922 scopus 로고    scopus 로고
    • The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis
    • Wang SX, Laverty S, Dumitriu M, Plaas A, Grynpas MD., The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis. Arthritis Rheum. 2007; 56: 1537-1548.
    • (2007) Arthritis Rheum. , vol.56 , pp. 1537-1548
    • Wang, S.X.1    Laverty, S.2    Dumitriu, M.3    Plaas, A.4    Grynpas, M.D.5
  • 76
    • 14944386664 scopus 로고    scopus 로고
    • Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis
    • Lavigne P, Benderdour M, Lajeunesse D, et al. Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis. Osteoarthritis Cartilage. 2005; 13: 310-317.
    • (2005) Osteoarthritis Cartilage. , vol.13 , pp. 310-317
    • Lavigne, P.1    Benderdour, M.2    Lajeunesse, D.3
  • 78
    • 56449123273 scopus 로고    scopus 로고
    • Recent developments in the biology of fracture repair
    • Kwong FN, Harris MB., Recent developments in the biology of fracture repair. J Am Acad Orthop Surg. 2008; 16: 619-625.
    • (2008) J Am Acad Orthop Surg. , vol.16 , pp. 619-625
    • Kwong, F.N.1    Harris, M.B.2
  • 79
    • 57049163000 scopus 로고    scopus 로고
    • Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing
    • Morgan EF, Mason ZD, Bishop G, et al. Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing. Bone. 2008; 43: 1031-1038.
    • (2008) Bone. , vol.43 , pp. 1031-1038
    • Morgan, E.F.1    Mason, Z.D.2    Bishop, G.3


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