Transforming growth factor-β prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling

American Journal of Physiology - Endocrinology and Metabolism

Volumn 294, Issue 4, 2008, Pages

  Dufour, Cécilie ^a,b   Holy, Xavier ^c   Marie, Pierre J ^a,b,d  

^a Institut National de la Santé et de la Recherche Médicale

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Institut de Medecine Aerospatiale   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Bone loss; Integrin; Phosphatidylinositol 3 kinase; Rat

Indexed keywords

INTEGRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; BONE MASS; CELL SURVIVAL; IMMOBILIZATION; IN VIVO STUDY; MALE; MECHANICAL STRESS; NONHUMAN; OSMOTIC MINIPUMP; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BONE AND BONES; HINDLIMB SUSPENSION; MALE; MUSCLE, SKELETAL; OSTEOBLASTS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA2; UP-REGULATION;

EID: 41649102233     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00791.2007     Document Type: Article

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