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Volumn 50, Issue 1, 2012, Pages 54-62

N-cadherin adherens junctions mediate osteogenesis through PI3K signaling

Author keywords

N cadherin; Osteoblasts; Osterix and adherens junctions

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA CATENIN; EGTAZIC ACID; GLYCOGEN SYNTHASE KINASE 3; NERVE CELL ADHESION MOLECULE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P120;

EID: 80054087448     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.09.036     Document Type: Article
Times cited : (42)

References (30)
  • 1
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg H. Developmental regulation of the growth plate. Nature 2003, 423(6937):332.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 332
    • Kronenberg, H.1
  • 2
    • 0033402201 scopus 로고    scopus 로고
    • The genetic transformation of bone biology
    • Karsenty G. The genetic transformation of bone biology. Genes Dev 1999, 13(23):3037-3051.
    • (1999) Genes Dev , vol.13 , Issue.23 , pp. 3037-3051
    • Karsenty, G.1
  • 3
    • 0033006591 scopus 로고    scopus 로고
    • N-cadherin expression and signaling in limb mesenchymal chondrogenesis: stimulation by poly-l-lysine
    • Woodward W.A., Tuan R.S. N-cadherin expression and signaling in limb mesenchymal chondrogenesis: stimulation by poly-l-lysine. Dev Genet 1999, 24:178-187.
    • (1999) Dev Genet , vol.24 , pp. 178-187
    • Woodward, W.A.1    Tuan, R.S.2
  • 4
    • 0031977102 scopus 로고    scopus 로고
    • Human osteoblasts express a repertoire of cadherins, which are critical for bmp-2-induced osteogenic differentiation
    • Cheng S.-L., Lecanda F., Davidson M.K., Warlow P.M., Zhang S.-F., Zhang L., et al. Human osteoblasts express a repertoire of cadherins, which are critical for bmp-2-induced osteogenic differentiation. J Bone Miner Res 1998, 13:633-644.
    • (1998) J Bone Miner Res , vol.13 , pp. 633-644
    • Cheng, S.-L.1    Lecanda, F.2    Davidson, M.K.3    Warlow, P.M.4    Zhang, S.-F.5    Zhang, L.6
  • 5
    • 33845197481 scopus 로고    scopus 로고
    • Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice
    • Lai C.F., Cheng S.-L., Mbalaviele G., Donsante C., Watkins M., Radice G.L., et al. Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice. J Bone Miner Res 2006, 21:1897-1906.
    • (2006) J Bone Miner Res , vol.21 , pp. 1897-1906
    • Lai, C.F.1    Cheng, S.-L.2    Mbalaviele, G.3    Donsante, C.4    Watkins, M.5    Radice, G.L.6
  • 6
    • 33845227116 scopus 로고    scopus 로고
    • Perspective: cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment
    • Mbalaviele G., Shin C.S., Civitelli R. Perspective: cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment. J Bone Miner Res 2006, 21:1821-1827.
    • (2006) J Bone Miner Res , vol.21 , pp. 1821-1827
    • Mbalaviele, G.1    Shin, C.S.2    Civitelli, R.3
  • 7
    • 3242883440 scopus 로고    scopus 로고
    • Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis
    • Castro C.H.M., Shin C.S., Stains J.P., Cheng S.-L., Sheikh S., Mbalaviele G., et al. Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis. J Cell Sci 2004, 117:2853-2864.
    • (2004) J Cell Sci , vol.117 , pp. 2853-2864
    • Castro, C.H.M.1    Shin, C.S.2    Stains, J.P.3    Cheng, S.-L.4    Sheikh, S.5    Mbalaviele, G.6
  • 8
    • 0033680724 scopus 로고    scopus 로고
    • A dominant negative cadherin inhibits osteoblast differentiation
    • Cheng S.-L., Shin C.S., Towler D.A., Civitelli R. A dominant negative cadherin inhibits osteoblast differentiation. J Bone Miner Res 2000, 15:2362-2370.
    • (2000) J Bone Miner Res , vol.15 , pp. 2362-2370
    • Cheng, S.-L.1    Shin, C.S.2    Towler, D.A.3    Civitelli, R.4
  • 9
    • 59449095748 scopus 로고    scopus 로고
    • N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/(Baron and Rawadi)-catenin signaling, osteoblast function, and bone formation
    • Hay E., Laplantine E., Geoffroy V., Frain M., Kohler T., Muller R., et al. N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/(Baron and Rawadi)-catenin signaling, osteoblast function, and bone formation. Mol Cell Biol 2009, 29:953-964.
    • (2009) Mol Cell Biol , vol.29 , pp. 953-964
    • Hay, E.1    Laplantine, E.2    Geoffroy, V.3    Frain, M.4    Kohler, T.5    Muller, R.6
  • 10
    • 77954069774 scopus 로고    scopus 로고
    • N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling
    • Hay E., Nouraud A., Marie P.J. N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling. PLoS One 2009, 4:e8284.
    • (2009) PLoS One , vol.4
    • Hay, E.1    Nouraud, A.2    Marie, P.J.3
  • 11
    • 38349138921 scopus 로고    scopus 로고
    • EPLIN mediates linkage of the cadherin-catenin complex to F-actin and stabilizes the circumferential actin belt
    • Abe K., Takeichi M. EPLIN mediates linkage of the cadherin-catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci 2008, 105:13-19.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 13-19
    • Abe, K.1    Takeichi, M.2
  • 12
    • 0033519239 scopus 로고    scopus 로고
    • P120ctn acts as an inhibitory regulator of cadherin function in colon carcinoma cells
    • Aono S., Nakagawa S., Reynolds A.B., Takeichi M. p120ctn acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J Cell Biol 1999, 145:551-562.
    • (1999) J Cell Biol , vol.145 , pp. 551-562
    • Aono, S.1    Nakagawa, S.2    Reynolds, A.B.3    Takeichi, M.4
  • 13
    • 0026500977 scopus 로고
    • The involvement of adherens junction components in myofibrillogenesis in cultured cardiac myocytes
    • Goncharova E.J., Kam Z., Geiger B. The involvement of adherens junction components in myofibrillogenesis in cultured cardiac myocytes. Development 1992, 114:173-183.
    • (1992) Development , vol.114 , pp. 173-183
    • Goncharova, E.J.1    Kam, Z.2    Geiger, B.3
  • 14
    • 0029989193 scopus 로고    scopus 로고
    • Osteogenic protein-1-mediated insulin-like growth factor gene expression in primary cultures of rat osteoblastic cells
    • Yeh L., Adamo M., Kitten A., Olson M., Lee J. Osteogenic protein-1-mediated insulin-like growth factor gene expression in primary cultures of rat osteoblastic cells. Endocrinology 1996, 137:1921-1931.
    • (1996) Endocrinology , vol.137 , pp. 1921-1931
    • Yeh, L.1    Adamo, M.2    Kitten, A.3    Olson, M.4    Lee, J.5
  • 16
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods (San Diego, Calif.) 2001, 25:402-408.
    • (2001) Methods (San Diego, Calif.) , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 17
    • 33947535118 scopus 로고    scopus 로고
    • Direct interactions of Runx2 and canonical Wnt signaling induce FGF18
    • Reinhold M.I., Naski C.M. Direct interactions of Runx2 and canonical Wnt signaling induce FGF18. J Biol Chem 2007, 282:3653-3663.
    • (2007) J Biol Chem , vol.282 , pp. 3653-3663
    • Reinhold, M.I.1    Naski, C.M.2
  • 18
    • 0038782306 scopus 로고    scopus 로고
    • Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    • Yu K., Xu J., Liu Z., Sosic D., Shao J., Olson E.N., et al. Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 2003, 130:3063-3074.
    • (2003) Development , vol.130 , pp. 3063-3074
    • Yu, K.1    Xu, J.2    Liu, Z.3    Sosic, D.4    Shao, J.5    Olson, E.N.6
  • 19
    • 79955136750 scopus 로고    scopus 로고
    • Conditional ablation of Pten in osteoprogenitors stimulates FGF signaling
    • Guntur A.R., Reinhold M.I., Cuellar J., Naski M.C. Conditional ablation of Pten in osteoprogenitors stimulates FGF signaling. Development 2011, 138:1433-1444.
    • (2011) Development , vol.138 , pp. 1433-1444
    • Guntur, A.R.1    Reinhold, M.I.2    Cuellar, J.3    Naski, M.C.4
  • 20
    • 77955409133 scopus 로고    scopus 로고
    • N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms
    • Di Benedetto A., Watkins M., Grimston S., Salazar V., Donsante C., Mbalaviele G., et al. N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms. J Cell Sci 2010, 123:2640-2648.
    • (2010) J Cell Sci , vol.123 , pp. 2640-2648
    • Di Benedetto, A.1    Watkins, M.2    Grimston, S.3    Salazar, V.4    Donsante, C.5    Mbalaviele, G.6
  • 21
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002, 108:17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6
  • 22
    • 0032482223 scopus 로고    scopus 로고
    • Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone
    • Wendel M., Sommarin Y., Heinegård D. Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone. J Cell Biol 1998, 141:839-847.
    • (1998) J Cell Biol , vol.141 , pp. 839-847
    • Wendel, M.1    Sommarin, Y.2    Heinegård, D.3
  • 23
    • 57449116084 scopus 로고    scopus 로고
    • Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model
    • Yang W., Harris M.A., Heinrich J.G., Guo D., Bonewald L.F., Harris S.E. Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model. Bone 2009, 44:32-45.
    • (2009) Bone , vol.44 , pp. 32-45
    • Yang, W.1    Harris, M.A.2    Heinrich, J.G.3    Guo, D.4    Bonewald, L.F.5    Harris, S.E.6
  • 24
    • 55249114587 scopus 로고    scopus 로고
    • Osteoadherin is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization
    • Rehn A., Cerny R., Sugars R., Kaukua N., Wendel M. Osteoadherin is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization. Calcif Tissue Int 2008, 82:454-464.
    • (2008) Calcif Tissue Int , vol.82 , pp. 454-464
    • Rehn, A.1    Cerny, R.2    Sugars, R.3    Kaukua, N.4    Wendel, M.5
  • 25
    • 0032915423 scopus 로고    scopus 로고
    • The catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
    • Daniel J.M., Reynolds A.B. The catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol 1999, 19:3614-3623.
    • (1999) Mol Cell Biol , vol.19 , pp. 3614-3623
    • Daniel, J.M.1    Reynolds, A.B.2
  • 26
    • 78649324674 scopus 로고    scopus 로고
    • Integration of phosphatidylinositol 3-kinase, Akt kinase, and Smad signaling pathway in BMP-2-induced osterix expression
    • Mandal C., Drissi H., Ghosh Choudhury G., Ghosh-Choudhury N. Integration of phosphatidylinositol 3-kinase, Akt kinase, and Smad signaling pathway in BMP-2-induced osterix expression. Calcif Tissue Int 2010, 1-8.
    • (2010) Calcif Tissue Int , pp. 1-8
    • Mandal, C.1    Drissi, H.2    Ghosh Choudhury, G.3    Ghosh-Choudhury, N.4
  • 27
    • 0033516481 scopus 로고    scopus 로고
    • Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex
    • Pece S., Chiariello M., Murga C., Gutkind J.S. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J Biol Chem 1999, 274:19347-19351.
    • (1999) J Biol Chem , vol.274 , pp. 19347-19351
    • Pece, S.1    Chiariello, M.2    Murga, C.3    Gutkind, J.S.4
  • 28
    • 77950560401 scopus 로고    scopus 로고
    • Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of [beta]-catenin signaling
    • Zhang J., Woodhead G.J., Swaminathan S.K., Noles S.R., McQuinn E.R., Pisarek A.J., et al. Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of [beta]-catenin signaling. Dev Cell 2010, 18:472-479.
    • (2010) Dev Cell , vol.18 , pp. 472-479
    • Zhang, J.1    Woodhead, G.J.2    Swaminathan, S.K.3    Noles, S.R.4    McQuinn, E.R.5    Pisarek, A.J.6
  • 29
    • 33644982685 scopus 로고    scopus 로고
    • The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis
    • Reinhold M.I., Kapadia R.M., Liao Z., Naski C.M. The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. J Biol Chem 2006, 281(3):1381-1388.
    • (2006) J Biol Chem , vol.281 , Issue.3 , pp. 1381-1388
    • Reinhold, M.I.1    Kapadia, R.M.2    Liao, Z.3    Naski, C.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.