Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice

Bone

Volumn 56, Issue 1, 2013, Pages 48-54

  Stange, Richard ^a   Kronenberg, Daniel ^a   Timmen, Melanie ^a   Everding, Jens ^a   Hidding, Heriburg ^a   Eckes, Beate ^b   Hansen, Uwe ^a   Holtkamp, Michael ^c   Karst, Uwe ^c   Pap, Thomas ^a   Raschke, Michael J ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Aging; Bone metabolism; Collagen type I; Collagen binding integrins; Osteoporosis

Indexed keywords

ALKALINE PHOSPHATASE; ALPHA2 INTEGRIN; COLLAGEN TYPE 1; VERY LATE ACTIVATION ANTIGEN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE AGE; BONE DEFECT; BONE STRUCTURE; CONTROLLED STUDY; CORTICAL THICKNESS (BONE); FEMALE; FEMUR; MOLECULAR DYNAMICS; MORPHOMETRICS; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PHENOTYPE; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRABECULAR BONE; WILD TYPE;

AGING; BONE METABOLISM; COLLAGEN TYPE I; COLLAGEN-BINDING INTEGRINS; OSTEOPOROSIS;

AGING; ANIMALS; BIOLOGICAL MARKERS; BIOMECHANICAL PHENOMENA; BONE RESORPTION; CALCIFICATION, PHYSIOLOGIC; CELL COUNT; CELL DIFFERENTIATION; COLLAGEN TYPE I; DISSECTION; FEMALE; FEMUR; FIBRILLAR COLLAGENS; GENE EXPRESSION REGULATION; INTEGRIN ALPHA2BETA1; MICE; MICE, INBRED C57BL; OSTEOBLASTS; RNA, MESSENGER;

EID: 84879324134     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.05.003     Document Type: Article

References (30)

1. Morgan M.R., Humphries M.J., Bass M.D. Synergistic control of cell adhesion by integrins and syndecans. Nat Rev Mol Cell Biol 2007, 8:957-969.
2. Meighan C.M., Schwarzbauer J.E. Temporal and spatial regulation of integrins during development. Curr Opin Cell Biol 2008, 20:520-524.
3. Streuli C.H., Akhtar N. Signal co-operation between integrins and other receptor systems. Biochem J 2009, 418:491-506.
4. Legate K.R., Wickstrom S.A., Fassler R. Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 2009, 23:397-418.
5. Larsen M., Artym V.V., Green J.A., Yamada K.M. The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr Opin Cell Biol 2006, 18:463-471.
6. Harburger D.S., Calderwood D.A. Integrin signalling at a glance. J Cell Sci 2009, 122:159-163.
7. Humphries J.D., Byron A., Humphries M.J. Integrin ligands at a glance. J Cell Sci 2006, 119:3901-3903.
8. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 2002, 110:673-687.
9. Barczyk M., Carracedo S., Gullberg D. Integrins. Cell Tissue Res 2010, 339:269-280.
10. Gullberg D., Gehlsen K.R., Turner D.C., Ahlen K., Zijenah L.S., Barnes M.J., et al. Analysis of alpha 1 beta 1, alpha 2 beta 1 and alpha 3 beta 1 integrins in cell-collagen interactions: identification of conformation dependent alpha 1 beta 1 binding sites in collagen type I. EMBO J 1992, 11:3865-3873.
11. Tulla M., Pentikainen O.T., Viitasalo T., Kapyla J., Impola U., Nykvist P., et al. Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I, and alpha 10I domains. J Biol Chem 2001, 276:48206-48212.
12. Jokinen J., Dadu E., Nykvist P., Kapyla J., White D.J., Ivaska J., et al. Integrin-mediated cell adhesion to type I collagen fibrils. J Biol Chem 2004, 279:31956-31963.
13. Bailey A.J. Changes in bone collagen with age and disease. J Musculoskelet Neuronal Interact 2002, 2:529-531.
14. Malaval L., Liu F., Roche P., Aubin J.E. Kinetics of osteoprogenitor proliferation and osteoblast differentiation in vitro. J Cell Biochem 1999, 74:616-627.
15. Wu J.E., Santoro S.A. Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. Dev Dyn 1994, 199:292-314.
16. Mizuno M., Fujisawa R., Kuboki Y. Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction. J Cell Physiol 2000, 184:207-213.
17. Xiao G., Wang D., Benson M.D., Karsenty G., Franceschi R.T. Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem 1998, 273:32988-32994.
18. Riikonen T., Westermarck J., Koivisto L., Broberg A., Kahari V.M., Heino J. Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression. J Biol Chem 1995, 270:13548-13552.
19. Ivaska J., Reunanen H., Westermarck J., Koivisto L., Kahari V.M., Heino J. Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail. J Cell Biol 1999, 147:401-416.
20. Holtkoetter O., Nieswandt B., Smyth N., Muller W., Hafner M., Schulte V., et al. Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem 2002, 277:10789-10794.
21. Blumbach K., Niehoff A., Belgardt B.F., Ehlen H.W., Schmitz M., Hallinger R., et al. Dwarfism in mice lacking collagen-binding integrins alpha2beta1 and alpha11beta1 is caused by severely diminished IGF-1 levels. J Biol Chem 2011.
22. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
23. Schmidmaier G., Wildemann B., Cromme F., Kandziora F., Haas N.P., Raschke M. Bone morphogenetic protein-2 coating of titanium implants increases biomechanical strength and accelerates bone remodeling in fracture treatment: a biomechanical and histological study in rats. Bone 2002, 30:816-822.
24. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
25. Bellows C.G., Aubin J.E., Heersche J.N., Antosz M.E. Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations. Calcif Tissue Int 1986, 38:143-154.
26. Syed F.A., Modder U.I., Roforth M., Hensen I., Fraser D.G., Peterson J.M., et al. Effects of chronic estrogen treatment on modulating age-related bone loss in female mice. J Bone Miner Res 2010, 25:2438-2446.
27. Floerkemeier T., Witte F., Nellesen J., Thorey F., Windhagen H., Wellmann M. Repetitive recombinant human bone morphogenetic protein 2 injections improve the callus microarchitecture and mechanical stiffness in a sheep model of distraction osteogenesis. Orthop Rev (Pavia) 2012, 4:e13.
28. Pereira R.F., Hume E.L., Halford K.W., Prockop D.J. Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age-dependent phenotype of human osteogenesis imperfecta. J Bone Miner Res 1995, 10:1837-1843.
29. Silva M.J., Brodt M.D., Wopenka B., Thomopoulos S., Williams D., Wassen M.H., et al. Decreased collagen organization and content are associated with reduced strength of demineralized and intact bone in the SAMP6 mouse. J Bone Miner Res 2006, 21:78-88.
30. Graham H.K., Holmes D.F., Watson R.B., Kadler K.E. Identification of collagen fibril fusion during vertebrate tendon morphogenesis. The process relies on unipolar fibrils and is regulated by collagen-proteoglycan interaction. J Mol Biol 2000, 295:891-902.