Transcriptional activity of the islet β cell factor Pdx1 Is augmented by lysine methylation catalyzed by the methyltransferase Set7/9

Journal of Biological Chemistry

Volumn 290, Issue 15, 2015, Pages 9812-9822

  Maganti, Aarthi V ^a   Maier, Bernhard ^b   Tersey, Sarah A ^b   Sampley, Megan L ^c   Mosley, Amber L ^a   Özcan, Sabire ^c   Pachaiyappan, Boobalan ^d   Woster, Patrick M ^d   Hunter, Chad S ^e,f   Stein, Roland ^e   Mirmira, Raghavendra G ^a,b  

^a Department of Cellular and Integrative Physiology ^*  (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINO ACIDS; CATALYSIS; CYTOLOGY; GENE ENCODING; GENE EXPRESSION; GENES; GLUCOSE; MAMMALS; MASS SPECTROMETRY; METHYLATION; SPECTROMETRY; TRANSCRIPTION;

BETA CELL FUNCTIONS; GLUCOSE-STIMULATED INSULIN SECRETIONS; IMMUNOPRECIPITATION ASSAYS; LUCIFERASE REPORTER ASSAYS; MASS SPECTROMETRIC ANALYSIS; MUTATIONAL ANALYSIS; STRUCTURAL ELEMENTS; TRANSCRIPTIONAL ACTIVITY;

CELLS;

DNA; GLUCOSE; INSULIN; LYSINE; METHYLTRANSFERASE; TRANSCRIPTION FACTOR PDX 1; HISTONE LYSINE METHYLTRANSFERASE; HOMEODOMAIN PROTEIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; PROTEIN BINDING; TRANSACTIVATOR PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; DNA BINDING; GENE CONTROL; GENE TARGETING; GENETIC CODE; GLUCOSE INTOLERANCE; IMMUNOPRECIPITATION; IN VITRO STUDY; INSULIN RELEASE; LUCIFERASE ASSAY; MASS SPECTROMETRY; METHYLATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TERTIARY STRUCTURE; 3T3 CELL LINE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; GENETIC TRANSCRIPTION; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOBLOTTING; KNOCKOUT MOUSE; METABOLISM; MOLECULAR GENETICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TUMOR CELL LINE;

MUS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; HEK293 CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOBLOTTING; INSULIN-SECRETING CELLS; LYSINE; METHYLATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 84927145879     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.616219     Document Type: Article

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