Inhibition of deoxyhypusine synthase enhances islet β cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 39943-39952

  Robbins, Reiesha D ^a   Tersey, Sarah A ^b   Ogihara, Takeshi ^b   Gupta, Dhananjay ^b   Farb, Thomas B ^c   Ficorilli, James ^c   Bokvist, Krister ^c   Maier, Bernhard ^b   Mirmira, Raghavendra G ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC; BINDING PROTEINS; CASPASE-3; CELL DYSFUNCTION; CELL FUNCTIONS; CELL LINES; COLOCALIZATION; CYTOKINES; DB/DB MOUSE; DEOXYHYPUSINE SYNTHASE; ENDOPLASMIC RETICULUM STRESS; ER STRESS; GENE TRANSCRIPTIONS; GLUCOSE TOLERANCE; HOMOLOGOUS PROTEINS; IN-VITRO; INSULIN RELEASE; INSULIN RESISTANCE; KEY DETERMINANTS; THAPSIGARGINS; TRANSLATIONAL ELONGATION; TYPE 2 DIABETES MELLITUS; TYPE-2 DIABETES;

AMINO ACIDS; CELL CULTURE; CELL DEATH; GLUCOSE; INSULIN; MEDICAL PROBLEMS; PATHOLOGY; PROTEINS; TRANSCRIPTION;

ELECTRIC RESISTANCE;

1,7 DIAMINOHEPTANE; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; DEOXYHYPUSINE SYNTHASE; GLUCOSE; INITIATION FACTOR 5A; INSULIN; THAPSIGARGIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL LINE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DOWNSTREAM PROCESSING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME LOCALIZATION; GENETIC TRANSCRIPTION; GLUCOSE TOLERANCE; IN VITRO STUDY; INSULIN RELEASE; MALE; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RIBOSOME;

ANIMALS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; INSULIN-SECRETING CELLS; MICE; MICE, MUTANT STRAINS; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PEPTIDE INITIATION FACTORS; RNA-BINDING PROTEINS; THAPSIGARGIN; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

MUS;

EID: 78650053328     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.170142     Document Type: Article

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