Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

Journal of Clinical Investigation

Volumn 120, Issue 10, 2010, Pages 3713-3721

  Claiborn, Kathryn C ^a   Sachdeva, Mira M ^a   Cannon, Corey E ^a   Groff, David N ^a   Singer, Jeffrey D ^b   Stoffers, Doris A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PORTLAND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 12; GLUCOSE REGULATED PROTEIN 78; INSULIN; PDX1 C TERMINUS INTERACTING FACTOR 1; PROTEASOME; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; CUL3 PROTEIN, MOUSE; CULLIN; GLUCOSE; HOMEODOMAIN PROTEIN; NUCLEAR PROTEIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; REPRESSOR PROTEIN; SPOP PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HETEROZYGOSITY; IMMUNOPRECIPITATION; MORPHOMETRICS; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN STABILITY; TRANSACTIVATION; UBIQUITINATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; ENDOPLASMIC RETICULUM; GENETICS; HOMEOSTASIS; HUMAN; MALE; METABOLISM; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CULLIN PROTEINS; ENDOPLASMIC RETICULUM; GLUCOSE; HOMEODOMAIN PROTEINS; HOMEOSTASIS; HUMANS; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; REPRESSOR PROTEINS; TRANS-ACTIVATORS; UBIQUITINATION;

EID: 77957825438     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI40440     Document Type: Article

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