Pharmacological inhibition of FTO

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  McMurray, Fiona ^a   Demetriades, Marina ^b   Aik, WeiShen ^b   Merkestein, Myrte ^c   Kramer, Holger ^c   Andrew, Daniel S ^a   Scudamore, Cheryl L ^a   Hough, Tertius A ^a   Wells, Sara ^a   Ashcroft, Frances M ^c   McDonough, Michael A ^b   Schofield, Christopher J ^b   Cox, Roger D ^a  

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; ERYTHROPOIETIN; FTO PROTEIN; OXYGENASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; [(1 CHLORO 4 HYDROXY ISOQUINOLINE 3 CARBONYL)AMINO]ACETIC ACID; (1-CHLORO-4-HYDROXYISOQUINOLINE-3-CARBONYL)AMINO)ACETIC ACID; ALPHA KETOGLUTARATE DEPENDENT DIOXYGENASE FTO; ANTIOBESITY AGENT; FTO PROTEIN, MOUSE; GLYCINE; ISOQUINOLINE DERIVATIVE; LYASE; MIXED FUNCTION OXIDASE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DENSITY; BREATHING RATE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FAT CONTENT; FTO GENE; GENE SILENCING; IC50; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; METABOLISM; PRECLINICAL STUDY;

MUS;

ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO; ANIMALS; ANTI-OBESITY AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; GLYCINE; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; MALE; MICE, INBRED C57BL; MIXED FUNCTION OXYGENASES; OBESITY; OXO-ACID-LYASES;

EID: 84927143044     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121829     Document Type: Article

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