HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice

Journal of Neurochemistry

Volumn 131, Issue 2, 2014, Pages 177-189

  Chen, Ruoli L ^a,b   Ogunshola, O O ^c   Yeoh, Karkheng K ^d   Jani, Anant ^a   Papadakis, Michalis ^a   Nagel, Simon ^a,e   Schofield, Christopher I ^d   Buchan, Alastair M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b KEELE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

BBB; EPO; HIF; IOX3; Preconditioning; Stroke

Indexed keywords

2 (1 CHLORO 4 HYDROXYISOQUINOLINE 3 CARBOXAMIDO) ACETIC ACID; ACETIC ACID DERIVATIVE; GLUCOSE; HYPOXIA INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITOR; OXYGEN; PROTEIN ZO1; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN LOCALIZATION; TRANSIENT FOCAL CEREBRAL ISCHEMIA; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; METABOLISM; RAT;

MUS;

ANIMALS; BRAIN ISCHEMIA; CELLS, CULTURED; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; RATS;

EID: 84919393948     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12804     Document Type: Article

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