Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 11, 2014, Pages 4019-4024

  Loenarz, Christoph ^a   Sekirnik, Rok ^a   Thalhammer, Armin ^a   Ge, Wei ^a   Spivakovsky, Ekaterina ^a   Mackeen, Mukram M ^a,b,c   McDonough, Michael A ^a   Cockman, Matthew E ^b   Kessler, Benedikt M ^b   Ratcliffe, Peter J ^b   Wolf, Alexander ^a,d   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

2 oxoglutarate oxygenase; Hypoxia; Nonsense readthrough; Ribosomal hydroxylation; Translation

Indexed keywords

AMINO ACID; CELL PROTEIN; INITIATION FACTOR 5A; MESSENGER RNA; OXYGENASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; RIBOSOMAL PROTEIN RPS23P; RIBOSOME PROTEIN; SHORT HAIRPIN RNA; TRANSLATION TERMINATION FACTOR; UNCLASSIFIED DRUG;

ACCURACY; AMINO ACID ANALYSIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; DIHYDROXYLATION; DROSOPHILA MELANOGASTER; ENZYME ACTIVE SITE; ESCHERICHIA COLI; EUKARYOTIC CELL; GREEN ALGA; HELA CELL; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; MASS SPECTROMETRY; NONHUMAN; NONSENSE MUTATION; NUCLEAR LOCALIZATION SIGNAL; OXIDATION; PRIORITY JOURNAL; PROTEIN PROCESSING; REOXYGENATION; RIBOSOME SUBUNIT; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; STOP CODON; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

2-OXOGLUTARATE OXYGENASE; HYPOXIA; NONSENSE READTHROUGH; RIBOSOMAL HYDROXYLATION; TRANSLATION;

CHLOROPHYTA; CODON, TERMINATOR; HUMANS; HYDROXYLATION; MASS SPECTROMETRY; OXYGENASES; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBOSOMAL PROTEINS; RIBOSOMES; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SPECIES SPECIFICITY;

EID: 84896519650     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1311750111     Document Type: Article

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