The histamine H4-receptor (H4R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice

European Journal of Immunology

Volumn 45, Issue 4, 2015, Pages 1129-1140

  Hartwig, Christina ^a   Munder, Antje ^a   Glage, Silke ^a   Wedekind, Dirk ^a   Schenk, Heiko ^a   Seifert, Roland ^a   Neumann, Detlef ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Adoptive cell transfer; Dendritic cells; Experimental allergic asthma; Histamine H4 receptor (H4R); Inflammation; Ovalbumin; T cells

Indexed keywords

EOTAXIN; GAMMA INTERFERON; HISTAMINE; HISTAMINE H4 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN; RANTES; ALLERGEN; CYTOKINE; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN P 15095; HISTAMINE RECEPTOR; HRH4 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; DENDRITIC CELL; EFFECTOR CELL; EOSINOPHIL; EXPERIMENTAL ASTHMA; FLOW CYTOMETRY; INFLAMMATION; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; T LYMPHOCYTE; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTHMA; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; CYTOLOGY; DISEASE MODEL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; LUNG LAVAGE; MAST CELL; METABOLISM; PATHOLOGY; TH2 CELL; TRANSPLANTATION;

ADOPTIVE TRANSFER; ALLERGENS; ANIMALS; ANTIGENS, CD11C; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; EOSINOPHILS; HISTAMINE; INFLAMMATION; INTERLEUKIN-5; LUNG; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; TH2 CELLS;

EID: 84927054425     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445179     Document Type: Article

References (64)

1. Schneider, E., Rolli-Derkinderen, M., Arock, M. and Dy, M., Trends in histamine research: new functions during immune responses and hematopoiesis. Trends Immunol. 2002. 23: 255-263.
2. 3 receptor. Eur. J. Pharmacol. 2003. 467: 57-65.
3. Parsons, M. E. and Ganellin, C. R., Histamine and its receptors. Br. J. Pharmacol. 2006. 147(Suppl 1): S127-S135.
4. Jutel, M., Blaser, K. and Akdis, C. A., Histamine in allergic inflammation and immune modulation. Int. Arch. Allergy Immunol. 2005. 137: 82-92.
5. 2-receptor antagonist. 1975. Br. J. Pharmacol. 2010. 160(Suppl 1): S52-S53.
6. 3 receptor antagonists in relation to epilepsy & neurodegeneration: a systemic consideration of recent progresses and perspectives. Br. J. Pharmacol. 2012. 167: 1398-1414.
7. Passani, M. B. and Blandina, P., Histamine receptors in the CNS as targets for therapeutic intervention. Trends Pharmacol. Sci. 2011. 32: 242-249.
8. Strasser, A., Wittmann, H. J., Buschauer, A., Schneider, E. H. and Seifert, R., Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs. Trends Pharmacol. Sci. 2013. 34: 13-32.
9. Akdis, C. A. and Simons, F. E., Histamine receptors are hot in immunopharmacology. Eur. J. Pharmacol. 2006. 533: 69-76.
10. Jutel, M., Watanabe, T., Akdis, M., Blaser, K. and Akdis, C. A., Immune regulation by histamine. Curr. Opin. Immunol. 2002. 14: 735-740.
11. 4 receptors reveals substantial pharmacological species variation. J. Pharmacol. Exp. Ther. 2001. 299: 121-130.
12. Amaral, M. M., Davio, C., Ceballos, A., Salamone, G., Cañones, C., Geffner, J. and Vermeulen, M., Histamine improves antigen uptake and cross-presentation by dendritic cells. J. Immunol. 2007. 179: 3425-3433.
13. Komai, M., Tanaka, H., Masuda, T., Nagao, K., Ishizaki, M., Sawada, M. and Nagai, H., Role of Th2 responses in the development of allergen-induced airway remodelling in a murine model of allergic asthma. Br. J. Pharmacol. 2003. 138: 912-920.
14. 4 receptor mediates chemotaxis and calcium mobilization of mast cells. J. Pharmacol. Exp. Ther. 2003. 305: 1212-1221.
15. 4 antagonists. J. Med. Chem. 2005. 48: 8289-8298.
16. 4 receptor: a novel modulator of inflammatory and immune disorders. Pharmacol. Ther. 2007. 113: 594-606.
17. Seifert, R., Strasser, A., Schneider, E. H., Neumann, D., Dove, S. and Buschauer, A., Molecular and cellular analysis of human histamine receptor subtypes. Trends Pharmacol. Sci. 2013. 34: 33-58.
18. Calhoun, W. J., Lavins, B. J., Minkwitz, M. C., Evans, R., Gleich, G. J. and Cohn, J., Effect of zafirlukast (Accolate) on cellular mediators of inflammation: bronchoalveolar lavage fluid findings after segmental antigen challenge. Am. J. Respir. Crit. Care Med. 1998. 157: 1381-1389.
19. Hannon, J. P., Tigani, B., Williams, I., Mazzoni, L. and Fozard, J. R., Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats. Br. J. Pharmacol. 2001. 132: 1509-1523.
20. 3 receptors: stimulation of IL-10 production. J. Immunol. 2000. 164: 2964-2970.
21. Caron, G., Delneste, Y., Roelandts, E., Duez, C., Herbault, N., Magistrelli, G., Bonnefoy, J. Y. et al., Histamine induces CD86 expression and chemokine production by human immature dendritic cells. J. Immunol. 2001. 166: 6000-6006.
22. + T cells. J. Immunol. 2006. 176: 7062-7070.
23. Szeberényi, J. B., Pállinger, E., Zsinkó, M., Pós, Z., Rothe, G., Orsó, E., Szeberényi, S. et al., Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Immunol. Lett. 2001. 76: 175-182.
24. 4 receptor on human eosinophils-role in eosinophil chemotaxis. J. Recept. Signal Transduct. Res. 2002. 22: 431-448.
25. 4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br. J. Pharmacol. 2004. 142: 161-171.
26. 4-receptor: evidence for ligand-specific receptor conformations. Biochem. Pharmacol. 2012. 84: 192-203.
27. 4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. J. Immunol. 2005. 174: 5224-5232.
28. Caron, G., Delneste, Y., Roelandts, E., Duez, C., Bonnefoy, J. Y., Pestel, J. and Jeannin, P., Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells. J. Immunol. 2001. 167: 3682-3686.
29. 4 receptors in allergic inflammation: the search for new antihistamines. Nat. Rev. Drug Discov. 2008. 7: 41-53.
30. 1 histamine receptor regulates allergic lung responses. J. Clin. Invest. 2006. 116: 1624-1632.
31. 4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation. J. Invest. Dermatol. 2010. 130: 1023-1033.
32. Beermann, S., Glage, S., Jonigk, D., Seifert, R. and Neumann, D., Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. PLoS One 2012. 7: e30285.
33. 2 receptors. Nature 2001. 413: 420-425.
34. 4 receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects. J. Pharmacol. Exp. Ther. 2014. 350: 181-187.
35. 4 receptor antagonist JNJ 39758979. J. Pharmacol. Exp. Ther. 2014. 349: 176-184.
36. 4 ligands. Mini. Rev. Med. Chem. 2004. 4: 993-1000.
37. Cohn, L., Homer, R. J., Marinov, A., Rankin, J. and Bottomly, K., Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 1997. 186: 1737-1747.
38. 4-receptor lack specificity. Naunyn-Schmiedebergs Arch. Pharmacol. 2012. 385: 125-135.
39. Anjuère, F., Martín, P., Ferrero, I., Fraga, M. L., del Hoyo, G. M., Wright, N. and Ardavín, C., Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. Blood 1999. 93: 590-598.
40. Tan, J. K. and O'Neill, H. C., Concise review: dendritic cell development in the context of the spleen microenvironment. Stem Cells 2007. 25: 2139-2145.
41. Henri, S., Vremec, D., Kamath, A., Waithman, J., Williams, S., Benoist, C., Burnham, K. et al., The dendritic cell populations of mouse lymph nodes. J. Immunol. 2001. 167: 741-748.
42. Vremec, D., Pooley, J., Hochrein, H., Wu, L. and Shortman, K., CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 2000. 164: 2978-2986.
43. Lambrecht, B. N. and Hammad, H., Taking our breath away: dendritic cells in the pathogenesis of asthma. Nat. Rev. Immunol. 2003. 3: 994-1003.
44. Shortman, K. and Liu, Y. J., Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2002. 2: 151-161.
45. 4) expressed in bone marrow. Mol. Pharmacol. 2001. 59: 420-426.
46. Mazzoni, A., Young, H. A., Spitzer, J. H., Visintin, A. and Segal, D. M., Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J. Clin. Invest. 2001. 108: 1865-1873.
47. Idzko, M., la Sala, A., Ferrari, D., Panther, E., Herouy, Y., Dichmann, S., Mockenhaupt, M. et al., Expression and function of histamine receptors in human monocyte-derived dendritic cells. J. Allergy Clin. Immunol. 2002. 109: 839-846.
48. 4 receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells. Eur. J. Pharmacol. 2011. 651: 197-204.
49. Katoh, N., Soga, F., Nara, T., Masuda, K. and Kishimoto, S., Histamine induces the generation of monocyte-derived dendritic cells that express CD14 but not CD1a. J. Invest. Dermatol. 2005. 125: 753-760.
50. Amin, K., The role of mast cells in allergic inflammation. Respir. Med. 2012. 106: 9-14.
51. Shakoory, B., Fitzgerald, S. M., Lee, S. A., Chi, D. S. and Krishnaswamy, G., The role of human mast cell-derived cytokines in eosinophil biology. J. Interferon. Cytokine Res. 2004. 24: 271-281.
52. Lei, Y., Gregory, J. A., Nilsson, G. P. and Adner, M., Insights into mast cell functions in asthma using mouse models. Pulm. Pharmacol. Ther. 2013. 26: 532-539.
53. 4 receptor in receptor activation. Naunyn Schmiedebergs Arch. Pharmacol. 2011. 384: 301-317.
54. 4 receptor. Br. J. Pharmacol. 2003. 140: 1117-1127.
55. 2-receptor in human eosinophils and neutrophils. Biochem. Pharmacol. 2012. 84: 1174-1185.
56. Mattes, J. and Foster, P. S., Regulation of eosinophil migration and Th2 cell function by IL-5 and eotaxin. Curr. Drug Targets Inflamm. Allergy 2003. 2: 169-174.
57. Pawankar, R., Nasal polyposis: an update: editorial review. Curr. Opin. Allergy Clin. Immunol. 2003. 3: 1-6.
58. Pavord, I. D., Korn, S., Howarth, P., Bleecker, E. R., Buhl, R., Keene, O. N., Ortega, H. et al., Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012. 380: 651-659.
59. Ghazi, A., Trikha, A. and Calhoun, W. J., Benralizumab-a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity-a novel approach for the treatment of asthma. Expert Opin. Biol. Ther. 2012. 12: 113-118.
60. Corren, J., Anti-interleukin-5 antibody therapy in asthma and allergies. Curr. Opin. Allergy Clin. Immunol. 2011. 11: 565-570.
61. Castro, M., Mathur, S., Hargreave, F., Boulet, L. P., Xie, F., Young, J., Wilkins, H. J. et al., Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am. J. Respir. Crit. Care Med. 2011. 184: 1125-1132.
62. Abonia, J. P. and Putnam, P. E., Mepolizumab in eosinophilic disorders. Expert Rev. Clin. Immunol. 2011. 7: 411-417.
63. Zimmermann, A. S., Burhenne, H., Kaever, V., Seifert, R. and Neumann, D., Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c. Inflamm. Res. 2011. 60: 1153-1159.
64. Stevens, W. W., Kim, T. S., Pujanauski, L. M., Hao, X. and Braciale, T. J., Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry. J. Immunol. Methods 2007. 327: 63-74.