Evidence for ligand-specific conformations of the histamine H 2-receptor in human eosinophils and neutrophils

Biochemical Pharmacology

Volumn 84, Issue 9, 2012, Pages 1174-1185

  Reher, Till M ^a   Brunskole, Irena ^a,b   Neumann, Detlef ^a   Seifert, Roland ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Eosinophil; Functional selectivity; Histamine H2 receptor; Ligand specific receptor conformation; Neutrophil

Indexed keywords

4 METHYLHISTAMINE; AMTHAMINE; CYCLIC AMP; DIMAPRIT; FAMOTIDINE; GUANOSINE TRIPHOSPHATASE; HISTAMINE; HISTAMINE H2 RECEPTOR; IMPROMIDINE; TIOTIDINE; ZOLANTIDINE;

ARTICLE; CELL POPULATION; CELL VIABILITY; CONFORMATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; EOSINOPHIL; GRANULOCYTE; GRANULOCYTE FUNCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGAND SPECIFIC RECEPTOR CONFORMATION; NEUTROPHIL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BASE SEQUENCE; CYCLIC AMP; EOSINOPHILS; HISTAMINE; HISTAMINE AGONISTS; HISTAMINE H2 ANTAGONISTS; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; NEUTROPHILS; OXYGEN; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RECEPTORS, HISTAMINE H2; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 84866610509     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.08.014     Document Type: Article

References (89)

1. C.D. Sadik, N.D. Kim, and A.D. Luster Neutrophils cascading their way to inflammation Trends Immunol 32 2011 452 460
2. M.E. Rothenberg, and S.P. Hogan The eosinophil Annu Rev Immunol 24 2006 147 174
3. R. Selvatici, S. Falzarano, A. Mollica, and S. Spisani Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils Eur J Pharmacol 534 2006 1 11
4. S.G. Trivedi, and C.M. Lloyd Eosinophils in the pathogenesis of allergic airways disease Cell Mol Life Sci 64 2007 1269 1289
5. 4 receptors in allergic inflammation: the search for new antihistamines Nat Rev Drug Discov 7 2008 41 53
6. J. Monteseirín Neutrophils and asthma J Investig Allergol Clin Immunol 19 2009 340 354
7. S.W. Edwards, and M.B. Hallett Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis Immunol Today 18 1997 320 324
8. O. Soehnlein, L. Lindbom, and C. Weber Mechanisms underlying neutrophil-mediated monocyte recruitment Blood 114 2009 4613 4623
9. D. Adamko, P. Lacy, and R. Moqbel Mechanisms of eosinophil recruitment and activation Curr Allergy Asthma Rep 2 2002 107 116
10. 2-receptors Naunyn Schmiedebergs Arch Pharmacol 340 1989 671 678
11. S.H. Pincus, A.M. DiNapoli, and W.R. Schooley Superoxide production by eosinophils: activation by histamine J Invest Dermatol 79 1982 53 57
12. R. Seifert, and G. Schultz The superoxide-forming NADPH oxidase of phagocytes. An enzyme system regulated by multiple mechanisms Rev Physiol Biochem Pharmacol 117 1991 1 338
13. W.M. Nauseef Biological roles for the NOX family NADPH oxidases J Biol Chem 283 2008 16961 16965
14. M.C. Dagher, and E. Pick Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase Biochimie 89 2007 1123 1132
15. M. Yazdanbakhsh, C.M. Eckmann, L. Koenderman, A.J. Verhoeven, and D. Roos Eosinophils do respond to fMLP Blood 70 1987 379 383
16. 2-receptors involved in the regulation of NADPH oxidase? Naunyn Schmiedebergs Arch Pharmacol 341 1990 455 461
17. 3 J Biol Chem 274 1999 33259 33266
18. i-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells J Biol Chem 264 1989 21470 21473
19. B. Haribabu, R.M. Richardson, M.W. Verghese, A.J. Barr, D.V. Zhelev, and R. Snyderman Function and regulation of chemoattractant receptors Immunol Res 22 2000 271 279
20. J.F. Klinker, K. Wenzel-Seifert, and R. Seifert G-protein-coupled receptors in HL-60 human leukemia cells Gen Pharmacol 27 1996 33 54
21. K. Wong, and K. Freund Inhibition of the n-formylmethionyl-leucyl- phenylalanine induced respiratory burst in human neutrophils by adrenergic agonists and prostaglandins of the E series Can J Physiol Pharmacol 59 1981 915 920
22. 2,2′- O-dibutyryl guanosine 3′:5′-cyclic monophosphate Naunyn Schmiedebergs Arch Pharmacol 343 1991 370 376
23. T. Mitsuyama, K. Takeshige, T. Furuno, T. Tanaka, K. Hidaka, and M. Abe An inhibitor of cyclic AMP-dependent protein kinase enhances the superoxide production of human neutrophils stimulated by N-formyl-methionyl-leucyl- phenylalanine Mol Cell Biochem 145 1995 19 24
24. Z.N. Mirza, M. Kato, H. Kimura, A. Tachibana, T. Fujiu, and M. Suzuki Fenoterol inhibits superoxide anion generation by human polymorphonuclear leukocytes via beta-adrenoceptor-dependent and -independent mechanisms Ann Allergy Asthma Immunol 88 2002 494 500
25. C. Bengis-Garber, and N. Gruener Cross-talk between cAMP and formyl Met-Leu-Phe in human neutrophils: phosphorylation of a 52,000 molecular weight protein Cell Signal 4 1992 247 260
26. 2 receptor and cAMP Br J Pharmacol 141 2004 552 561
27. F.C. Liu, Y.J. Day, J.T. Liou, H.P. Yu, and H.R. Liao Splitomicin inhibits fMLP-induced superoxide anion production in human neutrophils by activate cAMP/PKA signaling inhibition of ERK pathway Eur J Pharmacol 688 2012 68 75
28. 4-receptor: evidence for ligand-specific receptor conformations Biochem Pharmacol 84 2012 192 203
29. A.A. Wadee, R. Anderson, and R. Sher In vitro effects of histamine on eosinophil migration Int Arch Allergy Appl Immunol 63 1980 322 329
30. S.J. Hill, C.R. Ganellin, H. Timmerman, J.C. Schwartz, N.P. Shankley, and J.M. Young International Union of Pharmacology. XIII. Classification of histamine receptors Pharmacol Rev 49 1997 253 278
31. R. Leurs, M.J. Smit, and H. Timmerman Molecular pharmacological aspects of histamine receptors Pharmacol Ther 66 1995 413 463
32. 2 histamine receptor to phospholipase C Mol Endocrinol 10 1996 1697 1707
33. 2 adrenergic chimeric receptors Biochem Biophys Res Commun 276 2000 539 545
34. 2 receptor ligands Mini Rev Med Chem 4 2004 941 954
35. 2-receptor antagonists and gastric acid secretion Pharmacol Ther 26 1984 221 234
36. C. Gespach, and J.P. Abita Human polymorphonuclear neutrophils. Pharmacological characterization of histamine receptors mediating the elevation of cyclic AMP Mol Pharmacol 21 1982 78 85
37. C.I. Ezeamuzie, and N. Taslim Reactive oxygen species mediate phorbol ester-stimulated cAMP response in human eosinophils Eur J Pharmacol 543 2006 174 180
38. R.A. Clark, J.A. Sandler, J.I. Gallin, and A.P. Kaplan Histamine modulation of eosinophil migration J Immunol 118 1977 137 145
39. S. Copsel, C. Garcia, F. Diez, M. Vermeulem, A. Baldi, and L.G. Bianciotti Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation J Biol Chem 286 2011 6979 6988
40. M. Rabier, M. Damon, P. Chanez, J.M. Mencia-Huerta, P. Braquet, and J. Bousquet Inhibition by histamine of platelet-activating-factor-induced neutrophil chemotaxis in bronchial asthma Int Arch Allergy Appl Immunol 89 1989 314 317
41. 2 receptors mediate the inhibitory effect of histamine on human eosinophil degranulation Br J Pharmacol 131 2000 482 488
42. R.A. Clark, J.I. Gallin, and A.P. Kaplan The selective eosinophil chemotactic activity of histamine J Exp Med 142 1975 1462 1476
43. 2 receptor do not affect the species-selective activity of guanidine-type agonists Naunyn Schmiedebergs Arch Pharmacol 376 2007 253 264
44. 4 receptor agonists J Med Chem 52 2009 6297 6313
45. 2-receptor with guanidine-type agonists Mol Pharmacol 60 2001 1210 1225
46. 2 receptors Nature 276 1978 403 405
47. R.D. Mathison, A.D. Befus, J.S. Davison, and R.C. Woodman Modulation of neutrophil function by the tripeptide feG BMC Immunol 4 2003 3
48. L. Kinast, J. von der Ohe, H. Burhenne, and R. Seifert Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool Naunyn Schmiedebergs Arch Pharmacol 385 2012 671 683
49. 2-receptor agonist. Part 1. Pharmacology Agents Actions 7 1977 31 37
50. 2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles J Med Chem 35 1992 3239 3246
51. 2-receptor agonists J Med Chem 18 1975 905 909
52. 4 receptor agonist J Pharmacol Exp Ther 314 2005 1310 1321
53. M.E. Parsons, and C.R. Ganellin Histamine and its receptors Br J Pharmacol 147 Suppl. 1 2006 S127 S135
54. S.J. Hill G protein-coupled receptors: past, present and future Br J Pharmacol 147 Suppl. 1 2006 S27 S37
55. H.O. Schild pA, a new scale for the measurement of drug antagonism Br J Pharmacol Chemother 2 1947 189 206
56. R.L. Strausberg, E.A. Feingold, L.H. Grouse, J.G. Derge, R.D. Klausner, and F.S. Collins Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 2002 16899 16903
57. 2 receptor Biochem Biophys Res Commun 178 1991 1386 1392
58. R.R. Berardi, R.M. Tankanow, and T.T. Nostrant Comparison of famotidine with cimetidine and ranitidine Clin Pharm 7 1988 271 284
59. A. Martner, F.B. Thorén, J. Aurelius, J. Söderholm, M. Brune, and K. Hellstrand Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia Expert Rev Hematol 3 2010 381 391
60. 2 receptors with an unique agonist/antagonist profile and induces functional differentiation Mol Pharmacol 42 1992 235 241
61. M. Jutel, M. Akdis, and C.A. Akdis Histamine, histamine receptors and their role in immune pathology Clin Exp Allergy 39 2009 1786 1800
62. H. Kita Eosinophils: multifaceted biological properties and roles in health and disease Immunol Rev 242 2011 161 177
63. B.E. Seligmann, M.P. Fletcher, and J.I. Gallin Histamine modulation of human neutrophil oxidative metabolism, locomotion, degranulation, and membrane potential changes J Immunol 130 1983 1902 1909
64. F. Morel, J. Doussiere, and P.V. Vignais The superoxide-generating oxidase of phagocytic cells. Physiological, molecular and pathological aspects Eur J Biochem 201 1991 523 546
65. L.R. DeChatelet, P.S. Shirley, L.C. McPhail, C.C. Huntley, H.B. Muss, and D.A. Bass Oxidative metabolism of the human eosinophil Blood 50 1977 525 535
66. D.B. Learn, and E.P. Brestel A comparison of superoxide production by human eosinophils and neutrophils Agents Actions 12 1982 485 488
67. J. Palmblad, H. Gyllenhammar, J.A. Lindgren, and C.L. Malmsten Effects of leukotrienes and f-Met-Leu-Phe on oxidative metabolism of neutrophils and eosinophils J Immunol 132 1984 3041 3045
68. M. Nagata, J.B. Sedgwick, and W.W. Busse Differential effects of granulocyte-macrophage colony-stimulating factor on eosinophil and neutrophil superoxide anion generation J Immunol 155 1995 4948 4954
69. E.M. Zoratti, J.B. Sedgwick, R.R. Vrtis, and W.W. Busse The effect of platelet-activating factor on the generation of superoxide anion in human eosinophils and neutrophils J Allergy Clin Immunol 88 1991 749 758
70. J.B. Sedgwick, R.F. Vrtis, M.F. Gourley, and W.W. Busse Stimulus-dependent differences in superoxide anion generation by normal human eosinophils and neutrophils J Allergy Clin Immunol 81 1988 876 883
71. D.C. Petreccia, W.M. Nauseef, and R.A. Clark Respiratory burst of normal human eosinophils J Leukoc Biol 41 1987 283 288
72. 2Y receptors J Allergy Clin Immunol 107 2001 849 855
73. D.J. Adamko, Y. Wu, G.J. Gleich, P. Lacy, and R. Moqbel The induction of eosinophil peroxidase release: improved methods of measurement and stimulation J Immunol Methods 291 2004 101 108
74. K. Werner, F. Schwede, H.G. Genieser, J. Geiger, and E. Butt Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides Naunyn Schmiedebergs Arch Pharmacol 384 2011 169 176
75. 1 Biochemistry 51 2012 194 204
76. B.N. Cronstein, S.B. Kramer, E.D. Rosenstein, H.M. Korchak, G. Weissmann, and R. Hirschhorn Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization Biochem J 252 1988 709 715
77. S. Galandrin, G. Oligny-Longpré, and M. Bouvier The evasive nature of drug efficacy: implications for drug discovery Trends Pharmacol Sci 28 2007 423 430
78. R. Seifert, and K. Wenzel-Seifert Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors Naunyn Schmiedebergs Arch Pharmacol 366 2002 381 416
79. B.K. Kobilka, and X. Deupi Conformational complexity of G-protein-coupled receptors Trends Pharmacol Sci 28 2007 397 406
80. T.P. Kenakin Biased signalling and allosteric machines: new vistas and challenges for drug discovery Br J Pharmacol 165 2012 1659 1669
81. N.J. Smith, and G. Milligan Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes Pharmacol Rev 62 2010 701 725
82. R. Seifert, and S. Dove Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities Mol Pharmacol 75 2009 13 18
83. E. Reiter, S. Ahn, A.K. Shukla, and R.J. Lefkowitz Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors Annu Rev Pharmacol Toxicol 52 2012 179 197
84. T. Kenakin, S. Jenkinson, and C. Watson Determining the potency and molecular mechanism of action of insurmountable antagonists J Pharmacol Exp Ther 319 2006 710 723
85. R.R. Neubig, M. Spedding, T. Kenakin, and A. Christopoulos International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology Pharmacol Rev 55 2003 597 606
86. J.G. Baker, and S.J. Hill Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates Trends Pharmacol Sci 28 2007 374 381
87. 4 receptor ligands J Pharmacol Exp Ther 334 2010 513 521
88. 4R receptors with 34 antidepressants and antipsychotics Naunyn Schmiedebergs Arch Pharmacol 385 2012 145 170
89. 50) of an enzymatic reaction Biochem Pharmacol 22 1973 3099 3108