Role of the second and third extracellular loops of the histamine H 4 receptor in receptor activation

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 384, Issue 3, 2011, Pages 301-317

  Brunskole, Irena ^a   Strasser, Andrea ^a   Seifert, Roland ^b   Buschauer, Armin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Chimeric receptors; Extracellular loops; Histamine H 4 receptor; JNJ7777120; Sf9 insect cells; Steady state GTPase assay

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; 4 METHYLHISTAMINE; CLOZAPINE; GUANOSINE TRIPHOSPHATASE; HISTAMINE; HISTAMINE H4 RECEPTOR; THIOPERAMIDE; TRITIUM;

AMINO TERMINAL SEQUENCE; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; INSECT CELL; INVERSE AGONISM; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PARTIAL AGONISM; PROTEIN DOMAIN; PROTEIN EXPRESSION; SECOND EXTRACELLULAR LOOP; STEADY STATE; THIRD EXTRACELLULAR LOOP; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; DNA, COMPLEMENTARY; DOGS; DRUG INVERSE AGONISM; DRUG PARTIAL AGONISM; HISTAMINE AGONISTS; HUMANS; INSECTS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SPECIES SPECIFICITY;

EID: 80054955958     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-011-0673-3     Document Type: Article

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