Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats

British Journal of Pharmacology

Volumn 132, Issue 7, 2001, Pages 1509-1523

  Hannon, J P ^a   Tigani, B ^a   Williams, I ^a   Mazzoni, L ^a   Fozard, J R ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Adenosine; Airway hyperresponsiveness; Bradykinin; Capsaicin; Compound 48 80; Disodium cromoglycate; Ketanserin; Mast cell mediators; Methacholine; Methysergide

Indexed keywords

ADENOSINE; ALLERGEN; ATROPINE; BRADYKININ; CAPSAICIN; COMPOUND 48-80; CROMOGLYCATE DISODIUM; KETANSERIN; METHACHOLINE; METHYSERGIDE; OVALBUMIN; SEROTONIN;

ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RESPONSE; HISTAMINE BLOOD LEVEL; HISTOLOGY; MALE; MAST CELL DEGRANULATION; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RAT; SENSITIZATION; SEROTONIN BLOOD LEVEL; SEROTONIN RELEASE; VAGOTOMY;

EID: 0035066699     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703961     Document Type: Article

References (69)

1. Dissimilarity in methacholine and adenosine 5′-monophosphate responsiveness 3 and 24 h after allergen challenge
2. Adenosine-receptor mediated bronchoconstriction and bronchial hyperresponsiveness in an allergic rabbit model
3. 1 receptor
4. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo
5. 5-Hydroxytryptamine in mast cells
6. Cromones
7. Airway hyperresponsiveness in asthma: Not just a matter of airway inflammation
8. Clinical features of bronchial hyperresponsiveness
9. Airway responsiveness
10. 5-hydroxytryptamine and non-vascular smooth muscle contraction and relaxation
11. Role of 5-HT2 receptors in serotonin-induced contractions of non-vascular smooth muscle
12. Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects
13. Nedocromil sodium and sodium cromoglycate: Pharmacology and putative modes of action
14. Characterisation of adenosine receptors involved in adenosine-induced bronchoconstriction in allergic rabbits
15. Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitised Brown Norway rats
16. Allergen-induced airway hyperresponsiveness in Brown Norway rat: Role of parasympathetic mechanisms
17. 2B receptors: A novel therapeutic target in asthma?
18. Adenosine, mast cells and asthma
19. Mechanisms and modulation of capsaicin activity on airway afferent nerves
20. Adenosine receptor ligands: Potential as therapeutic agents in asthma and COPD
21. Species differences in adenosine induced bronchoconstrictor responses
22. The hypotensive action of 5-hydroxytryptamine (5-HT) in anaesthetised and pithed rats
23. Mechanism of the hypotensive effect of ketanserin
24. 3 receptor activation in rats
25. Expression of Th-2 cytokines interleukin-4 and -5 and of Th-1 cytokine interferongamma in ovalbumin-exposed sensitised Brown-Norway rats
26. + T-cells induces airway inflammation and hyperresponsiveness in Brown Norway rats
27. 3 receptor-mediated hypotension in the anaesthetised rat
28. Mechanism of airway hyperreactivity to adenosine induced by allergen challenge in actively sensitised Brown Norway rats
29. The receptor mediating airway hyperreactivity to adenosine induced by allergen challenge in actively sensitised Brown Norway rats
30. Capsaicin: Cellular targets, mechanisms of action and selectivity for thin sensory neurons
31. 1 receptors
32. 5-Hydroxytryptamine receptors
33. The role of adenosine in asthma
34. 3 receptors
35. Inhibition by disodium cromoglycate in vitro of anaphylactically induced histamine release from rat peritoneal mast cells
36. An in vitro study of various drugs on central and peripheral airways of the rat: A comparison with human airways
37. Adenosine
38. 6-2-(4-aminopheny-1)ethyladenosine induces bronchospasm in BDE rats by a neurally mediated mechanism involving cells resembling mast cells
39. 2 receptors
40. 4
41. Adenosine-induced contractions of the isolated rat trachea are mediated by 5-hydroxytryptamine
42. DNA antisense therapy for asthma in an animal model
43. Selective airway responsiveness in asthma
44. Sodium cromoglycate, a tachykinin antagonist?
45. Compound 48/80: A potent histamine liberator
46. Characterisation of the adenosine receptors in airways
47. An animal model of adenosine-induced bronchoconstriction
48. Genetic control of indirect airway responsiveness in the rat
49. The influence of antigen dose on IgE production in different rat strains
50. Mechanisms of adenosine-induced bronchoconstriction: An animal model
51. Genetic factor in non-specific bronchial reactivity in rats
52. Development of specific antibody and in vivo response to antigen in different rat strains: Effect of dexamethasone and importance of endogenous corticosteroid
53. Adenosine and the airways in asthma
54. Adenosine bronchoprovocation: A promising marker of allergic inflammation in asthma?
55. Differential release of histamine and 5-hydroxytryptamine from rat mast cells: The contribution of amine uptake to the apparent pattern of secretion
56. The activity of amitryptyline as a differential inhibitor of amine secretion from rat peritoneal mast cells: The contribution of amine uptake
57. Comparison of histamine and 5-hydroxytryptamine content and secretion in rat mast cells isolated from different anatomical locations
58. Comparison of post-secretory mechanisms to the observed pattern of histamine and 5-hydroxytryptamine secretion from peritoneal rat mast cells in response to compound 48/80
59. 3 receptors promote degranulation of rat mast cells both in vitro and in vivo
60. Cytokine expression in the presence or absence of late airway responses after allergen challenge of sensitised animals
61. Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat
62. Quantitation of eosinophil and neutrophil infiltration into rat lung by specific assays for eosinophil peroxidase and myeloperoxidase. Application in a Brown Norway rat model of allergic pulmonary inflammation
63. Effect of cromolyn on adenosine-induced airway microvascular leakage in sensitised rats
64. Model of bronchial allergic inflammation in the Brown-Norway rat. Pharmacological modulation
65. Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitised guinea-pigs
66. Analysis of the bronchoconstrictor responses to adenosine receptor agonists in sensitised guinea-pig lungs and trachea
67. IgE production, antigen-induced airway inflammation and airway hyperreactivity in the Brown Norway rat: The effects of ricin
68. Definitions and clinical classification
69. Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea