Characterization of the N-Terminal Heterogeneities of Monoclonal Antibodies Using In-Gel Charge Derivatization of α-Amines and LC-MS/MS

Analytical Chemistry

Volumn 87, Issue 7, 2015, Pages 3784-3790

  Ayoub, Daniel ^a   Bertaccini, Diego ^b,c   Diemer, Hélène ^b,c   Wagner Rousset, Elsa ^a   Colas, Olivier ^a   Cianférani, Sarah ^b,c   Van Dorsselaer, Alain ^b,c   Beck, Alain ^a   Schaeffer Reiss, Christine ^b,c  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHAINS; CHEMICAL DETECTION; MASS SPECTROMETRY; MOLECULAR BIOLOGY; MONOCLONAL ANTIBODIES; PEPTIDES; PROTEINS; SURFACE PLASMON RESONANCE;

CHARGE DERIVATIZATION; CHEMICAL DERIVATIZATION; N-TERMINAL SEQUENCES; POLYPEPTIDE CHAIN; POST-TRANSLATIONAL MODIFICATIONS; PRIMARY AMINO ACID; PRIMARY SEQUENCES; RECOMBINANT MONOCLONAL ANTIBODY;

ANTIBODIES;

AMIDE; GEL; MONOCLONAL ANTIBODY;

CELL LINE; CHEMISTRY; GEL; HUMAN; LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

AMIDES; ANTIBODIES, MONOCLONAL; CELL LINE; CHROMATOGRAPHY, LIQUID; GELS; HUMANS; TANDEM MASS SPECTROMETRY;

EID: 84926683413     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac504427k     Document Type: Article

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