On-line characterization of monoclonal antibody variants by liquid chromatography-mass spectrometry operating in a two-dimensional format

Analytical Biochemistry

Volumn 419, Issue 1, 2011, Pages 17-25

  Alvarez, Melissa ^a   Tremintin, Guillaume ^b   Wang, Jennifer ^a   Eng, Marian ^a   Kao, Yung Hsiang ^a   Jeong, Justin ^a   Ling, Victor T ^a   Borisov, Oleg V ^a  

^a GENENTECH INC   (United States)

^b Dionex   (United States)

Author keywords

Ion exchange chromatography; Liquid chromatography mass spectrometry; Mass spectrometry; Monoclonal antibodies; Size exclusion chromatography; Two dimensional liquid chromatography; Variants

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; DESALINATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ION CHROMATOGRAPHY; ION EXCHANGE; LIQUIDS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; SULFUR COMPOUNDS;

HIGH-THROUGHPUT ANALYSIS; ION EXCHANGE CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; PRODUCT CHARACTERIZATIONS; RECOMBINANT MONOCLONAL ANTIBODY; TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY; VARIANTS;

SIZE EXCLUSION CHROMATOGRAPHY;

MONOCLONAL ANTIBODY;

ARTICLE; DISULFIDE BOND; GEL PERMEATION CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; ONLINE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN VARIANT; SAMPLE; TURNAROUND TIME; WORKFLOW;

EID: 80054970831     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2011.07.033     Document Type: Article

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