Analysis of monoclonal antibody product heterogeneity resulting from alternate cleavage sites of signal peptide

Analytical Biochemistry

Volumn 399, Issue 2, 2010, Pages 190-195

  Kotia, Ruchi B ^a   Raghani, Anil R ^a  

^a AMGEN INC   (United States)

Author keywords

CE SDS; Monoclonal antibody; Peptide map; Signal peptide

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CAPILLARY ELECTROPHORESIS; CELL PROLIFERATION; LIQUID CHROMATOGRAPHY; MAPPING; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; SODIUM DODECYL SULFATE; SULFUR COMPOUNDS;

AMINO ACID RESIDUES; ANALYSIS AND CHARACTERIZATION; CHINESE HAMSTER OVARY CELLS; CYTOPLASMIC PROTEINS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MONOCLONAL ANTIBODIES (MAB); SIGNAL PEPTIDE; SIGNAL PEPTIDE CLEAVAGES;

PEPTIDES;

DODECYL SULFATE SODIUM; MONOCLONAL ANTIBODY; SIGNAL PEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CAPILLARY ELECTROPHORESIS; CHO CELL; CONTROLLED STUDY; FEMALE; HEAVY CHAIN; LIGHT CHAIN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN ENGINEERING; PROTEIN SYNTHESIS;

CRICETULUS GRISEUS;

EID: 77249123811     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2010.01.008     Document Type: Article

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