Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part I: Salt gradient approach

Journal of Pharmaceutical and Biomedical Analysis

Volumn 102, Issue , 2015, Pages 33-44

  Fekete, Szabolcs ^a   Beck, Alain ^b   Fekete, Jeno ^c   Guillarme, Davy ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Centre d'Immunologie Pierre Fabre   (France)

^c BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

Cetuximab; Ion exchange; Method development; Monoclonal antibody; Salt gradient

Indexed keywords

ADALIMUMAB; CETUXIMAB; NATALIZUMAB; PANITUMUMAB; RITUXIMAB; SODIUM CHLORIDE; TRASTUZUMAB; MONOCLONAL ANTIBODY;

ARTICLE; CATION EXCHANGE; CONTROLLED STUDY; DRUG IMPURITY; DRUG PURIFICATION; EQUILIBRIUM CONSTANT; FLOW RATE; ION EXCHANGE CHROMATOGRAPHY; PH; PREDICTION; PRIORITY JOURNAL; TEMPERATURE; TIME; CHEMICAL MODEL; CHEMISTRY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, ION EXCHANGE; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; SODIUM CHLORIDE; TEMPERATURE;

EID: 84908370870     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.08.035     Document Type: Article

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