β-elimination and peptide bond hydrolysis: Two distinct mechanisms of human IgG1 hinge fragmentation upon storage

Journal of the American Chemical Society

Volumn 129, Issue 22, 2007, Pages 6976-6977

  Cohen, Steven L ^a   Price, Colleen ^a   Vlasak, Josef ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; PEPTIDE;

ARTICLE; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH;

AMINO ACID SEQUENCE; HUMANS; HYDROLYSIS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; PEPTIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 34250182367     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0705994     Document Type: Article

References (16)

1. Cordoba, A. J.; Shyong, B.-J.; Breen, D.; Harris, R. J. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2005, 818, 115-121.
2. Liu, H.; Gaza-Bulseco, G.; Sun, J. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2006, 837, 35-43.
3. Dillon, T. M.; Bondarenko, P. V.; Rehder, D. S.; Pipes, G. D.; Kleemann, G. R.; Ricci, M. S.; J. Chromatogr. A 2006, 1120, 112-120.
4. Tous, G. I.; Wei, Z.; Feng, J.; Bilbulian, S.; Bowen, S.; Smith, J.; Strouse, R.; McGeehan, P.; Casas-Finet, J.; Schenerman, M. A. Anal. Chem. 2005, 77, 2675-2682.
5. Last, T. Antibody Characterization - Lessons Learned from Unusual Findings; 10th International Conference on Well Characterized Biologicals, 2006; IBC Life Sciences: Chantilly, VA.
6. Smith, M. A.; Easton, M.; Everett, P.; Lewis, G.; Payne, M.; Riveros-Moreno, V.; Allen, G. Int. J. Pept. Protein Res. 1996, 48, 48-55.
7. Witkop, B. Adv. Prot. Chem. 1961, 16, 221-321.
8. Patchornik, A.; Sokolovsky, M. J. Am. Chem. Soc. 1964, 86, 1206-1212.
9. Gross, E. Adv. Exptl. Med. Biol. 1977, 86B, 131-153.
10. Chan, W. C.; Bycroft, B. W.; Lian, L.-Y.; Roberts, G. C. K. FEBS Lett. 1989, 252, 29-36.
11. Friedman, M. J. Agric. Food Chem. 1999, 47, 1295-1319.
12. Nashef, A. S.; Osuga, D. T.; Lee, H. S.; Ahmed, A. I.; Whitaker, J. R.; Feeney, R. E. J. Agric. Food Chem. 1977, 25, 245-251.
13. Florence, T. M. Biochem. J. 1980, 189, 507-520.
14. Galande, A. K.; Spatola, A. F. Lett. Pept. Sci. 2002, 8, 247-251.
15. Linetsky, M.; Hill, J. M. W.; LeGrand, R. D.; Hu, F. Exptl. Eye Res. 2004, 79, 499-512.
16. Baker, M. Nat. Biotechnol. 2005, 23, 1065-1072.