Characterization of antibody variants during process development: The tale of incomplete processing of N-terminal secretion peptide

mAbs

Volumn 4, Issue 6, 2012, Pages 701-709

  Ambrogelly, Alexandre ^a   Liu, Yan Hui ^a   Li, Hong ^a   Mengisen, Selina ^a   Yao, Bingyi ^a   Xu, Wei ^a   Cannon Carlson, Susan ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Monoclonal antibody; Processing; Secretion leader peptide; SRP

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; PEPTIDE; PROTEIN VARIANT; SECRETION PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL CULTURE; HYDROPHOBICITY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

MONOCLONAL ANTIBODY; PROCESSING; SECRETION LEADER PEPTIDE; SRP;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; GLYCOSYLATION; HUMANS; MASS SPECTROMETRY; PROTEIN ISOFORMS; PROTEIN SORTING SIGNALS; RNA PROCESSING, POST-TRANSCRIPTIONAL;

EID: 84869809294     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.21614     Document Type: Article

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