Detecting low level sequence variants in recombinant monoclonal antibodies

mAbs

Volumn 2, Issue 3, 2010, Pages 285-298

  Yang, Yi ^a   Strahan, Alex ^a   Li, Charlene ^a   Shen, Amy ^a   Liu, Hongbin ^a   Ouyang, Jun ^a   Katta, Viswanatham ^a   Francissen, Kathleen ^a   Zhang, Boyan ^a  

^a GENENTECH INC   (United States)

Author keywords

Cell line development; HPLC UV MS MS; Mascot error tolerant search; Recombinant monoclonal antibody; Sequence variants; Tryptic peptide mapping

Indexed keywords

MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY DETECTION; ARTICLE; MASS SPECTROMETRY; NONHUMAN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; HUMANS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; RECEPTOR, ERBB-2; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; ULTRAVIOLET RAYS;

EID: 77953677787     PISSN: 19420862     EISSN: None     Source Type: Journal    
DOI: 10.4161/mabs.2.3.11718     Document Type: Article

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