The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

PLoS Pathogens

Volumn 11, Issue 3, 2015, Pages 1-23

  van der Linden, Lonneke ^a,b   Vives Adrián, Laia ^c   Selisko, Barbara ^d   Ferrer Orta, Cristina ^c   Liu, Xinran ^e   Lanke, Kjerstin ^a   Ulferts, Rachel ^a,f   De Palma, Armando M ^b   Tanchis, Federica ^g   Goris, Nesya ^h   Lefebvre, David ⁱ   De Clercq, Kris ⁱ   Leyssen, Pieter ^b   Lacroix, Céline ^b   Pürstinger, Gerhard ^g   Coutard, Bruno ^d   Canard, Bruno ^d   Boehr, David D ^e   Arnold, Jamie J ^e   Cameron, Craig E ^e   Verdaguer, Nuria ^c   Neyts, Johan ^b   van Kuppeveld, Frank J M ^a,f   more..

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^d AIX MARSEILLE UNIVERSITY   (France)

^e PENNSYLVANIA STATE UNIVERSITY   (United States)

^f UTRECHT UNIVERSITY   (Netherlands)

^g UNIVERSITY OF INNSBRUCK   (Austria)

^h Okapi Sciences NV   (Belgium)

ⁱ VETERINARY AND AGROCHEMICAL RESEARCH CENTRE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BENZONITRILE; N114 (2,2 [(4 CHLORO 1,2 PHENYLENE)BIS(OXY)]BIS(5 NITRO-BENZONITRILE)); NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS RNA; ANTIVIRUS AGENT; VIRAL PROTEIN;

ANIMAL CELL; ANTIVIRAL THERAPY; ARTICLE; CARDIOVIRUS; COXSACKIE VIRUS B3; CRYSTALLOGRAPHY; ENTEROVIRUS; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MUTATION; NONHUMAN; PICORNAVIRIDAE; POLIOMYELITIS VIRUS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RNA BINDING; RNA REPLICATION; VIRUS REPLICATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; CHLOROCEBUS AETHIOPS; ENTEROVIRUS B; ENZYMOLOGY; HELA CELL LINE; METABOLISM;

CARDIOVIRUS; COXSACKIEVIRUS; ENCEPHALOMYOCARDITIS VIRUS; ENTEROVIRUS; HUMAN ENTEROVIRUS 71; PICORNAVIRIDAE; POLIOVIRUS; RHINOVIRUS;

ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; CARDIOVIRUS; CERCOPITHECUS AETHIOPS; ENTEROVIRUS B, HUMAN; HELA CELLS; HUMANS; POLIOVIRUS; RNA REPLICASE; VIRAL PROTEINS;

EID: 84926472896     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004733     Document Type: Article

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