Role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity

Journal of Molecular Biology

Volumn 425, Issue 13, 2013, Pages 2279-2287

  Garriga, Damià ^a,b   Ferrer Orta, Cristina ^a   Querol Audí, Jordi ^a   Oliva, Baldo ^c   Verdaguer, Núria ^a  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

antiviral therapy; drug discovery; RNA viruses; RNA dependent RNA polymerase; viral enzymes

Indexed keywords

RNA DIRECTED DNA POLYMERASE; RNA POLYMERASE; VIRUS RNA;

ALLOSTERISM; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REPRESSION; GENE REPLICATION; HUMAN; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; RETROVIRUS; REVIEW; SITE DIRECTED MUTAGENESIS; VIRUS EXPRESSION; X RAY CRYSTALLOGRAPHY;

RNA VIRUSES;

EID: 84879074185     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.03.034     Document Type: Review

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