메뉴 건너뛰기




Volumn , Issue , 2014, Pages 43-80

Natural Product-Derived and Natural Product-Inspired Compound Collections

Author keywords

Combinatorial chemistry; Compound library; High pressure liquid chromatography; Natural product; Pure compounds; Semisynthetic library

Indexed keywords


EID: 84926456761     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527676545.ch02     Document Type: Chapter
Times cited : (8)

References (135)
  • 1
    • 14944383798 scopus 로고    scopus 로고
    • The evolving role of natural products in drug discovery. Nature Reviews
    • Koehn, F.E. and Carter, G.T. (2005) The evolving role of natural products in drug discovery. Nature Reviews. Drug Discovery, 4, 206-220.
    • (2005) Drug Discovery , vol.4 , pp. 206-220
    • Koehn, F.E.1    Carter, G.T.2
  • 2
    • 0033759258 scopus 로고    scopus 로고
    • In the arms of Morpheus: the development of morphine for postoperative pain relief
    • Hamilton, G.R. and Baskett, T.F. (2000) In the arms of Morpheus: the development of morphine for postoperative pain relief. Canadian Journal of Anaesthesia, 47, 367-374.
    • (2000) Canadian Journal of Anaesthesia , vol.47 , pp. 367-374
    • Hamilton, G.R.1    Baskett, T.F.2
  • 3
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: end of an era or an endless frontier?
    • Li, J.W.-H. and Vederas, J.C. (2009) Drug discovery and natural products: end of an era or an endless frontier? Science, 325, 161-165.
    • (2009) Science , vol.325 , pp. 161-165
    • Li, J.W.-H.1    Vederas, J.C.2
  • 4
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: an old process or the new hope for drug discovery?
    • Newman, D.J. (2008) Natural products as leads to potential drugs: an old process or the new hope for drug discovery? Journal of Medicinal Chemistry, 51, 2589-2599.
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 2589-2599
    • Newman, D.J.1
  • 6
    • 0037208308 scopus 로고    scopus 로고
    • Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry
    • Feher, M. and Schmidt, J.M. (2003) Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. Journal of Chemical Information and Computer Sciences, 43, 218-227.
    • (2003) Journal of Chemical Information and Computer Sciences , vol.43 , pp. 218-227
    • Feher, M.1    Schmidt, J.M.2
  • 8
    • 77955705492 scopus 로고    scopus 로고
    • Bioactivity-guided navigation of chemical space
    • Bon, R.S. and Waldmann, H. (2010) Bioactivity-guided navigation of chemical space. Accounts of Chemical Research, 43, 1103-1114.
    • (2010) Accounts of Chemical Research , vol.43 , pp. 1103-1114
    • Bon, R.S.1    Waldmann, H.2
  • 10
    • 0037119336 scopus 로고    scopus 로고
    • From protein domains to drug candidates -natural products as guiding principles in the design and synthesis of compound libraries
    • Breinbauer, R., Vetter, I.R., and Waldmann, H. (2002) From protein domains to drug candidates -natural products as guiding principles in the design and synthesis of compound libraries. Angewandte Chemie -International Edition, 41, 2878-2890.
    • (2002) Angewandte Chemie -International Edition , vol.41 , pp. 2878-2890
    • Breinbauer, R.1    Vetter, I.R.2    Waldmann, H.3
  • 13
    • 71049126548 scopus 로고    scopus 로고
    • Escape from flatland: increasing saturation as an approach to improving clinical success
    • Lovering, F., Bikker, J., and Humblet, C. (2009) Escape from flatland: increasing saturation as an approach to improving clinical success. Journal of Medicinal Chemistry, 52, 6752-6756.
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 6752-6756
    • Lovering, F.1    Bikker, J.2    Humblet, C.3
  • 14
    • 70350409235 scopus 로고    scopus 로고
    • The impact of aromatic ring count on compound developability: are too many aromatic rings a liability in drug design?
    • Ritchie, T.J. and Macdonald, S.J.F. (2009) The impact of aromatic ring count on compound developability: are too many aromatic rings a liability in drug design? Drug Discovery Today, 14, 1011-1020.
    • (2009) Drug Discovery Today , vol.14 , pp. 1011-1020
    • Ritchie, T.J.1    Macdonald, S.J.F.2
  • 16
    • 34249811180 scopus 로고    scopus 로고
    • New aspects of natural products in drug discovery
    • Lam, K.S. (2007) New aspects of natural products in drug discovery. Trends in Microbiology, 6, 279-289.
    • (2007) Trends in Microbiology , vol.6 , pp. 279-289
    • Lam, K.S.1
  • 18
    • 77952836391 scopus 로고    scopus 로고
    • Principles, implementation, and application of biology-oriented synthesis (BIOS)
    • Wilk, W., Zimmermann, T.J., Kaiser, M., and Waldmann, H. (2010) Principles, implementation, and application of biology-oriented synthesis (BIOS). Biological Chemistry, 391, 491-497.
    • (2010) Biological Chemistry , vol.391 , pp. 491-497
    • Wilk, W.1    Zimmermann, T.J.2    Kaiser, M.3    Waldmann, H.4
  • 19
    • 77149161768 scopus 로고    scopus 로고
    • BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery
    • Kombarov, R., Altieri, A., Genis, D., Kirpichenok, M., Kochubey, V., Rakitina, N., and Titarenko, Z. (2010) BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery. Molecular Diversity, 14, 193-200.
    • (2010) Molecular Diversity , vol.14 , pp. 193-200
    • Kombarov, R.1    Altieri, A.2    Genis, D.3    Kirpichenok, M.4    Kochubey, V.5    Rakitina, N.6    Titarenko, Z.7
  • 21
    • 33750464876 scopus 로고    scopus 로고
    • Small molecule natural products in the discovery of therapeutic agents: the synthesis connection
    • Wilson, R.M. and Danishefsky, S.J. (2006) Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. Journal of Organic Chemistry, 71, 8329-8351.
    • (2006) Journal of Organic Chemistry , vol.71 , pp. 8329-8351
    • Wilson, R.M.1    Danishefsky, S.J.2
  • 24
    • 70349784870 scopus 로고    scopus 로고
    • Synthesis of natural product inspired compound collections
    • Kumar, K. and Waldmann, H. (2009) Synthesis of natural product inspired compound collections. Angewandte Chemie -International Edition, 48, 3224-3242.
    • (2009) Angewandte Chemie -International Edition , vol.48 , pp. 3224-3242
    • Kumar, K.1    Waldmann, H.2
  • 28
    • 60749112509 scopus 로고    scopus 로고
    • Entwicklung einer neuen Klasse von Inhibitoren der Proteintyrosinphosphatase-B aus Mycobacterium tuberculosis durch Biologie-orientierte Synthese (BIOS)
    • (Angewandte Chemie -International Edition, 47, 5973-5977)
    • Nören-Müller, A., Wilk, W., Saxena, K., Schwalbe, H., Kaiser, M., and Waldmann, H. (2008) Entwicklung einer neuen Klasse von Inhibitoren der Proteintyrosinphosphatase-B aus Mycobacterium tuberculosis durch Biologie-orientierte Synthese (BIOS). Angewandte Chemie -International Edition, 120, 6061-6066 (Angewandte Chemie -International Edition, 47, 5973-5977).
    • (2008) Angewandte Chemie -International Edition , vol.120 , pp. 6061-6066
    • Nören-müller, A.1    Wilk, W.2    Saxena, K.3    Schwalbe, H.4    Kaiser, M.5    Waldmann, H.6
  • 31
    • 0343463781 scopus 로고
    • Recent progress in the chemistry of indole alkaloids and mould metabolites
    • Saxton, J.E. (1993) Recent progress in the chemistry of indole alkaloids and mould metabolites. Natural Product Reports, 10, 349-395.
    • (1993) Natural Product Reports , vol.10 , pp. 349-395
    • Saxton, J.E.1
  • 32
    • 33746378159 scopus 로고    scopus 로고
    • Solid-phase combinatorial synthesis of aeruginosin derivatives and their biological evaluation
    • Doi, T., Hoshina, Y., Mogi, H., Yamada, Y., and Takahashi, T. (2006) Solid-phase combinatorial synthesis of aeruginosin derivatives and their biological evaluation. Journal of Combinatorial Chemistry, 4, 571-582.
    • (2006) Journal of Combinatorial Chemistry , vol.4 , pp. 571-582
    • Doi, T.1    Hoshina, Y.2    Mogi, H.3    Yamada, Y.4    Takahashi, T.5
  • 33
    • 67049134276 scopus 로고    scopus 로고
    • Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries
    • Nandy, J.P., Prakesch, M., Khadem, S., Reddy, P.T., Sharma, U., and Arya, P. (2009) Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries. Chemical Reviews, 109, 1999-2060.
    • (2009) Chemical Reviews , vol.109 , pp. 1999-2060
    • Nandy, J.P.1    Prakesch, M.2    Khadem, S.3    Reddy, P.T.4    Sharma, U.5    Arya, P.6
  • 34
    • 4344599736 scopus 로고    scopus 로고
    • Solid-phase synthesis of lamellarins Q and O
    • Marfil, M., Albericio, F., and A'lvarez, M. (2004) Solid-phase synthesis of lamellarins Q and O. Tetrahedron, 60, 8659-8668.
    • (2004) Tetrahedron , vol.60 , pp. 8659-8668
    • Marfil, M.1    Albericio, F.2    A'lvarez, M.3
  • 35
    • 43249115971 scopus 로고    scopus 로고
    • Rapid generation of macrocycles with natural-product-like side chains by multiple multicomponent macrocyclizations (MiBs)
    • Rivera, D.G., Vercillo, O.E., and Wessjohann, L.A. (2008) Rapid generation of macrocycles with natural-product-like side chains by multiple multicomponent macrocyclizations (MiBs). Organic and Biomolecular Chemistry, 6, 1787-1795.
    • (2008) Organic and Biomolecular Chemistry , vol.6 , pp. 1787-1795
    • Rivera, D.G.1    Vercillo, O.E.2    Wessjohann, L.A.3
  • 36
    • 10044265227 scopus 로고    scopus 로고
    • Domino reactions in the synthesis of heterocyclic natural products and analogs
    • Tietze, L.F. and Rackelmann, N. (2004) Domino reactions in the synthesis of heterocyclic natural products and analogs. Pure and Applied Chemistry, 76, 1967-1983.
    • (2004) Pure and Applied Chemistry , vol.76 , pp. 1967-1983
    • Tietze, L.F.1    Rackelmann, N.2
  • 37
    • 20444401576 scopus 로고    scopus 로고
    • Wanted: new multicomponent reactions for generating libraries of polycyclic natural products
    • Ulaczyk-Lesanko, A. and Hall, D.G. (2005) Wanted: new multicomponent reactions for generating libraries of polycyclic natural products. Current Opinion in Chemical Biology, 9, 266-276.
    • (2005) Current Opinion in Chemical Biology , vol.9 , pp. 266-276
    • Ulaczyk-lesanko, A.1    Hall, D.G.2
  • 38
    • 0032087839 scopus 로고    scopus 로고
    • Domino reactions for library synthesis of small molecules in combinatorial chemistry
    • Tietze, L.F. and Lieb, M.E. (1998) Domino reactions for library synthesis of small molecules in combinatorial chemistry. Current Opinion in Chemical Biology, 2, 363-371.
    • (1998) Current Opinion in Chemical Biology , vol.2 , pp. 363-371
    • Tietze, L.F.1    Lieb, M.E.2
  • 39
    • 32744467594 scopus 로고
    • Tokushima-ken Yakusouzukan
    • Murakami, K. (1984) Tokushima-ken Yakusouzukan, 102-103.
    • (1984) , pp. 102-103
    • Murakami, K.1
  • 40
    • 69949119682 scopus 로고    scopus 로고
    • Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense
    • Tanaka, N., Kashiwada, Y., Kim, S.Y., Hashida, W., Sekiya, M., and Takaishi, Y. (2009) Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense. Journal of Natural Products, 72, 1447-1452.
    • (2009) Journal of Natural Products , vol.72 , pp. 1447-1452
    • Tanaka, N.1    Kashiwada, Y.2    Kim, S.Y.3    Hashida, W.4    Sekiya, M.5    Takaishi, Y.6
  • 43
    • 41249100821 scopus 로고    scopus 로고
    • Total synthesis and revised structure of biyouyanagin A
    • (Angewandte Chemie-International Edition, 46, 4708-4711)
    • Nicolaou, K.C., Sarlah, D., and Shaw, D.M. (2007) Total synthesis and revised structure of biyouyanagin A. Angewandte Chemie -International Edition, 119, 4792-4795 (Angewandte Chemie-International Edition, 46, 4708-4711).
    • (2007) Angewandte Chemie -International Edition , vol.119 , pp. 4792-4795
    • Nicolaou, K.C.1    Sarlah, D.2    Shaw, D.M.3
  • 47
    • 7044235263 scopus 로고    scopus 로고
    • Domino reactions in organic synthesis
    • Tietze, L.F. (1996) Domino reactions in organic synthesis. Chemical Reviews, 96, 115-136.
    • (1996) Chemical Reviews , vol.96 , pp. 115-136
    • Tietze, L.F.1
  • 48
    • 70350519146 scopus 로고    scopus 로고
    • The art of total synthesis through cascade reactions
    • Nicolau, K.C. and Chen, J.S. (2009) The art of total synthesis through cascade reactions. Chemical Society Reviews, 38, 2993-3009.
    • (2009) Chemical Society Reviews , vol.38 , pp. 2993-3009
    • Nicolau, K.C.1    Chen, J.S.2
  • 52
    • 77956033933 scopus 로고    scopus 로고
    • Silver catalyzed cascade synthesis of alkaloid ring systems: concise total synthesis of fascaplysin, homofascaplysin C and analogues
    • Waldmann, H., Eberhardt, L., Wittstein, K., and Kumar, K. (2010) Silver catalyzed cascade synthesis of alkaloid ring systems: concise total synthesis of fascaplysin, homofascaplysin C and analogues. Chemical Communications, 46, 4622-4624.
    • (2010) Chemical Communications , vol.46 , pp. 4622-4624
    • Waldmann, H.1    Eberhardt, L.2    Wittstein, K.3    Kumar, K.4
  • 53
    • 34548357166 scopus 로고    scopus 로고
    • Solid-supported reagents and catch-and-release techniques in organic synthesis
    • Solinas, A. and Taddei, M. (2007) Solid-supported reagents and catch-and-release techniques in organic synthesis. Synthesis, 2409-2453.
    • (2007) Synthesis , pp. 2409-2453
    • Solinas, A.1    Taddei, M.2
  • 54
    • 24644484834 scopus 로고    scopus 로고
    • Synthesis of alkaloid natural products using solid-supported reagents and scavengers
    • Baxendale, I.R. and Ley, S.V. (2005) Synthesis of alkaloid natural products using solid-supported reagents and scavengers. Current Organic Chemistry, 9, 1521-1534.
    • (2005) Current Organic Chemistry , vol.9 , pp. 1521-1534
    • Baxendale, I.R.1    Ley, S.V.2
  • 55
    • 15444375504 scopus 로고    scopus 로고
    • Solid-supported reagents and catalysts for the preparation of large ring compounds
    • Gonthier, E. and Breinbauer, R. (2005) Solid-supported reagents and catalysts for the preparation of large ring compounds. Molecular Diversity, 9, 51-62.
    • (2005) Molecular Diversity , vol.9 , pp. 51-62
    • Gonthier, E.1    Breinbauer, R.2
  • 56
    • 34247234108 scopus 로고    scopus 로고
    • Applications of polymeric reagents in organic synthesis
    • Salimi, H., Rahimi, A., and Pourjavadi, A. (2007) Applications of polymeric reagents in organic synthesis. Monatshefte für Chemie, 138, 363-379.
    • (2007) Monatshefte für Chemie , vol.138 , pp. 363-379
    • Salimi, H.1    Rahimi, A.2    Pourjavadi, A.3
  • 58
    • 2942523508 scopus 로고    scopus 로고
    • Total synthesis of the amaryllidaceae alkaloid ({thorn})-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions
    • (Angewandte Chemie -International Edition, 41, 2194-2197)
    • Baxendale, I.R., Ley, S.V., and Piutti, C. (2002) Total synthesis of the amaryllidaceae alkaloid ({thorn})-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions. Angewandte Chemie -International Edition, 114, 2298-2301 (Angewandte Chemie -International Edition, 41, 2194-2197).
    • (2002) Angewandte Chemie -International Edition , vol.114 , pp. 2298-2301
    • Baxendale, I.R.1    Ley, S.V.2    Piutti, C.3
  • 59
    • 28444449781 scopus 로고    scopus 로고
    • Synthesis of the alkaloid natural products ({thorn})-plicane and (-)-obliquine, using polymer-supported reagents and scavengers
    • Baxendale, I.R. and Ley, S.V. (2005) Synthesis of the alkaloid natural products ({thorn})-plicane and (-)-obliquine, using polymer-supported reagents and scavengers. Industrial & Engineering Chemistry Research, 44, 8588-8592.
    • (2005) Industrial & Engineering Chemistry Research , vol.44 , pp. 8588-8592
    • Baxendale, I.R.1    Ley, S.V.2
  • 60
    • 0037025957 scopus 로고    scopus 로고
    • Total synthesis of the amaryllidaceae alkaloid ({thorn})-plicamine using solid-supported reagents
    • Baxendale, I.R., Ley, S.V., Nessib, M., and Piutti, C. (2002) Total synthesis of the amaryllidaceae alkaloid ({thorn})-plicamine using solid-supported reagents. Tetrahedron, 58, 6285-6304.
    • (2002) Tetrahedron , vol.58 , pp. 6285-6304
    • Baxendale, I.R.1    Ley, S.V.2    Nessib, M.3    Piutti, C.4
  • 61
    • 0035793878 scopus 로고    scopus 로고
    • Fluorous mixture synthesis: a fluorous-tagging strategy for the synthesis and separation of mixtures of organic compounds
    • Luo, Z., Zhang, Q., Oderaotoshi, Y., and Curran, D.P. (2001) Fluorous mixture synthesis: a fluorous-tagging strategy for the synthesis and separation of mixtures of organic compounds. Science, 291, 1766-1769.
    • (2001) Science , vol.291 , pp. 1766-1769
    • Luo, Z.1    Zhang, Q.2    Oderaotoshi, Y.3    Curran, D.P.4
  • 62
    • 2942650823 scopus 로고    scopus 로고
    • Fluorous mixture synthesis (FMS) of enantiomers, diastereomers, and compound libraries
    • Zhang, W. (2004) Fluorous mixture synthesis (FMS) of enantiomers, diastereomers, and compound libraries. Arkivoc, i, 101-109.
    • (2004) Arkivoc , vol.1 , pp. 101-109
    • Zhang, W.1
  • 63
    • 24344493479 scopus 로고    scopus 로고
    • Quasienantiomers and quasiracemates: new tools for identification, analysis, separation, and synthesis of enantiomers
    • Zhang, Q. and Curran, D.P. (2005) Quasienantiomers and quasiracemates: new tools for identification, analysis, separation, and synthesis of enantiomers. Chemistry -A European Journal, 11, 4866-4880.
    • (2005) Chemistry -A European Journal , vol.11 , pp. 4866-4880
    • Zhang, Q.1    Curran, D.P.2
  • 64
    • 0037182696 scopus 로고    scopus 로고
    • Simultaneous preparation of four truncated analogues of discodermolide by fluorous mixture synthesis
    • Curran, D.P. and Furukawa, T. (2002) Simultaneous preparation of four truncated analogues of discodermolide by fluorous mixture synthesis. Organic Letters, 4, 2233-2235.
    • (2002) Organic Letters , vol.4 , pp. 2233-2235
    • Curran, D.P.1    Furukawa, T.2
  • 65
    • 0345868588 scopus 로고    scopus 로고
    • Synthesis of sixteen stereoisomers of murisolin, murisolin A and 16,19-cis-murisolin by fluorous mixture synthesis
    • Zhang, Q., Lu, H., Richard, C., and Curran, D.P. (2004) Synthesis of sixteen stereoisomers of murisolin, murisolin A and 16,19-cis-murisolin by fluorous mixture synthesis. Journal of the American Chemical Society, 126, 36-37.
    • (2004) Journal of the American Chemical Society , vol.126 , pp. 36-37
    • Zhang, Q.1    Lu, H.2    Richard, C.3    Curran, D.P.4
  • 66
    • 4344596714 scopus 로고    scopus 로고
    • Stereoisomer libraries: total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach
    • Dandapani, S., Jeske, M., and Curran, D.P. (2004) Stereoisomer libraries: total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach. Proceedings of the National Academy of Sciences of the United States of America, 101, 12008-12012.
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , pp. 12008-12012
    • Dandapani, S.1    Jeske, M.2    Curran, D.P.3
  • 67
    • 13544273419 scopus 로고    scopus 로고
    • Fluorous mixture synthesis of 4-alkylidene cyclopentenones via a rhodium-catalyzed [2 {thorn} 2 {thorn} 1] cycloaddition of alkynyl allenes
    • Manku, S. and Curran, D.P. (2005) Fluorous mixture synthesis of 4-alkylidene cyclopentenones via a rhodium-catalyzed [2 {thorn} 2 {thorn} 1] cycloaddition of alkynyl allenes. Journal of Combinatorial Chemistry, 7, 63-68.
    • (2005) Journal of Combinatorial Chemistry , vol.7 , pp. 63-68
    • Manku, S.1    Curran, D.P.2
  • 68
    • 0037019535 scopus 로고    scopus 로고
    • Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis
    • Zhang, W., Luo, Z., Chen, C.H-.T., and Curran, D.P. (2002) Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis. Journal of the American Chemical Society, 124, 10443-10450.
    • (2002) Journal of the American Chemical Society , vol.124 , pp. 10443-10450
    • Zhang, W.1    Luo, Z.2    Chen, C.H.-T.3    Curran, D.P.4
  • 69
    • 0000979450 scopus 로고
    • 4 {thorn} 1 radical annulations with isonitriles: a simple route to cyclopenta-fused quinolones
    • Curran, D.P. and Liu, H. (1991) 4 {thorn} 1 radical annulations with isonitriles: a simple route to cyclopenta-fused quinolones. Journal of the American Chemical Society, 113, 2127-2132.
    • (1991) Journal of the American Chemical Society , vol.113 , pp. 2127-2132
    • Curran, D.P.1    Liu, H.2
  • 70
    • 0030839899 scopus 로고    scopus 로고
    • Synthesis of (S)-mappicine and mappicine ketone via radical cascade reaction of isonitriles
    • Josien, H. and Curran, D.P. (1997) Synthesis of (S)-mappicine and mappicine ketone via radical cascade reaction of isonitriles. Tetrahedron, 53, 8881-8886.
    • (1997) Tetrahedron , vol.53 , pp. 8881-8886
    • Josien, H.1    Curran, D.P.2
  • 71
    • 0034321912 scopus 로고    scopus 로고
    • Solution phase synthesis of libraries of polycyclic natural product analogue by cascade radical annulation: synthesis of a 64-member library of mappicine analogues and a 48-member library of mappicine ketone analogues
    • de Frutos, O. and Curran, D.P. (2000) Solution phase synthesis of libraries of polycyclic natural product analogue by cascade radical annulation: synthesis of a 64-member library of mappicine analogues and a 48-member library of mappicine ketone analogues. Journal of Combinatorial Chemistry, 2, 639-649.
    • (2000) Journal of Combinatorial Chemistry , vol.2 , pp. 639-649
    • de Frutos, O.1    Curran, D.P.2
  • 73
    • 0029899208 scopus 로고    scopus 로고
    • Design, synthesis, and antitumor activity of bicyclic and isomeric analogues of illudin M
    • Kinder, F.R., Jr., Wang, R.-M., Bauta, W.E., and Bair, K.W. (1996) Design, synthesis, and antitumor activity of bicyclic and isomeric analogues of illudin M. Bioorganic & Medicinal Chemistry Letters, 6, 1029-1034.
    • (1996) Bioorganic & Medicinal Chemistry Letters , vol.6 , pp. 1029-1034
    • Kinder, F.R.1    Wang, R.-M.2    Bauta, W.E.3    Bair, K.W.4
  • 76
    • 0030839510 scopus 로고    scopus 로고
    • Reaction of antitumor hydroxymethylacylfulvene (HMAF) with thiols
    • McMorris, T.C. and Yu, J. (1997) Reaction of antitumor hydroxymethylacylfulvene (HMAF) with thiols. Tetrahedron, 53, 14579-14590.
    • (1997) Tetrahedron , vol.53 , pp. 14579-14590
    • McMorris, T.C.1    Yu, J.2
  • 77
    • 0041851110 scopus 로고    scopus 로고
    • Modular, parallel synthesis of an illudinoid combinatorial library
    • Pirrung, M.C. and Liu, H. (2003) Modular, parallel synthesis of an illudinoid combinatorial library. Organic Letters, 5, 1983-1985.
    • (2003) Organic Letters , vol.5 , pp. 1983-1985
    • Pirrung, M.C.1    Liu, H.2
  • 78
    • 0028204232 scopus 로고
    • Synthetic studies toward illudins and ptaquilosin: a highly convergent approach via the dipolar cycloaddition of carbonyl ylides
    • Padwa, A., Sandanayaka, V.P., and Curtis, E.A. (1994) Synthetic studies toward illudins and ptaquilosin: a highly convergent approach via the dipolar cycloaddition of carbonyl ylides. Journal of the American Chemical Society, 116, 2667-2668.
    • (1994) Journal of the American Chemical Society , vol.116 , pp. 2667-2668
    • Padwa, A.1    Sandanayaka, V.P.2    Curtis, E.A.3
  • 79
    • 0030889926 scopus 로고    scopus 로고
    • Generation and cycloaddition behavior of spirocyclic carbonyl ylides: application to the synthesis of the pterosin family of sesquiterpenes
    • Padwa, A., Curtis, E.A., and Sandanayaka, V.P. (1997) Generation and cycloaddition behavior of spirocyclic carbonyl ylides: application to the synthesis of the pterosin family of sesquiterpenes. Journal of Organic Chemistry, 62, 1317-1325.
    • (1997) Journal of Organic Chemistry , vol.62 , pp. 1317-1325
    • Padwa, A.1    Curtis, E.A.2    Sandanayaka, V.P.3
  • 81
    • 0002369226 scopus 로고    scopus 로고
    • Recent advances in polymer-assisted solution-phase chemical library synthesis and purification
    • Flynn, D.L. and Devraj, R.V. (1998) Recent advances in polymer-assisted solution-phase chemical library synthesis and purification. Current Opinion in Drug Discovery & Development, 1, 41-50.
    • (1998) Current Opinion in Drug Discovery & Development , vol.1 , pp. 41-50
    • Flynn, D.L.1    Devraj, R.V.2
  • 82
    • 0031741510 scopus 로고    scopus 로고
    • Medicinal Chemistry Research
    • Flynn, D.L. and Devraj, R.V. (1998) Medicinal Chemistry Research, 8, 219-243.
    • (1998) , vol.8 , pp. 219-243
    • Flynn, D.L.1    Devraj, R.V.2
  • 84
    • 41149150442 scopus 로고    scopus 로고
    • Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity
    • Bolognesi, M.L., Lizzi, F., Perozzo, R., Bruno, R., and Cavalli, A. (2008) Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity. Bioorganic & Medicinal Chemistry Letters, 18, 2272-2276.
    • (2008) Bioorganic & Medicinal Chemistry Letters , vol.18 , pp. 2272-2276
    • Bolognesi, M.L.1    Lizzi, F.2    Perozzo, R.3    Bruno, R.4    Cavalli, A.5
  • 87
    • 4143102467 scopus 로고    scopus 로고
    • Multiple triclosan targets in Trypanosoma brucei
    • Paul, K.S., Bacchi, C.J., and Englund, P.T. (2004) Multiple triclosan targets in Trypanosoma brucei. Eukaryotic Cell, 3, 855-861.
    • (2004) Eukaryotic Cell , vol.3 , pp. 855-861
    • Paul, K.S.1    Bacchi, C.J.2    Englund, P.T.3
  • 91
    • 42249106818 scopus 로고    scopus 로고
    • Synthesis of a dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering (PSSC)
    • Scheck, M., Koch, M.A., and Waldmann, H. (2008) Synthesis of a dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering (PSSC). Tetrahedron, 64, 4792-4802.
    • (2008) Tetrahedron , vol.64 , pp. 4792-4802
    • Scheck, M.1    Koch, M.A.2    Waldmann, H.3
  • 93
    • 0000478940 scopus 로고
    • General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids
    • Houghten, R.A. (1985) General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proceedings of the National Academy of Sciences of the United States of America, 82, 5131-5135.
    • (1985) Proceedings of the National Academy of Sciences of the United States of America , vol.82 , pp. 5131-5135
    • Houghten, R.A.1
  • 95
    • 3843107553 scopus 로고    scopus 로고
    • A planning strategy for diversity-oriented synthesis
    • (Angewandte Chemie -International Edition, 43, 46-58)
    • Burke, M.D. and Schreiber, S.L. (2004) A planning strategy for diversity-oriented synthesis. Angewandte Chemie -International Edition, 116, 48-60. (Angewandte Chemie -International Edition, 43, 46-58).
    • (2004) Angewandte Chemie -International Edition , vol.116 , pp. 48-60
    • Burke, M.D.1    Schreiber, S.L.2
  • 96
    • 0344515366 scopus 로고    scopus 로고
    • Diversity-oriented synthesis; a challenge for synthetic chemists
    • Spring, D.R. (2003) Diversity-oriented synthesis; a challenge for synthetic chemists. Organic & Biomolecular Chemistry, 1, 3867-3870.
    • (2003) Organic & Biomolecular Chemistry , vol.1 , pp. 3867-3870
    • Spring, D.R.1
  • 97
    • 14144251136 scopus 로고    scopus 로고
    • Exploring new chemical space by stereocontrolled diversity-oriented synthesis
    • Arya, P., Joseph, R., Gan, Z.H., and Rakic, B. (2005) Exploring new chemical space by stereocontrolled diversity-oriented synthesis. Chemistry & Biology, 12, 163-180.
    • (2005) Chemistry & Biology , vol.12 , pp. 163-180
    • Arya, P.1    Joseph, R.2    Gan, Z.H.3    Rakic, B.4
  • 98
    • 0141988625 scopus 로고    scopus 로고
    • Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds
    • Liao, Y., Hu, Y., Wu, J., Zhu, Q., Donovan, M., Fathi, R., and Yang, Z. (2003) Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds. Current Medicinal Chemistry, 10, 2285-2316.
    • (2003) Current Medicinal Chemistry , vol.10 , pp. 2285-2316
    • Liao, Y.1    Hu, Y.2    Wu, J.3    Zhu, Q.4    Donovan, M.5    Fathi, R.6    Yang, Z.7
  • 101
    • 0035037065 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of single doses of ({thorn})-calanolide A, a novel, naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy, human immunodeficiency virus-negative human subjects
    • Creagh, T., Ruckle, J.L., Tolbert, D.T., Giltner, J., Eiznhamer, D.A., Dutta, B., Flavin, M.T., and Xu, Z.Q. (2001) Safety and pharmacokinetics of single doses of ({thorn})-calanolide A, a novel, naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy, human immunodeficiency virus-negative human subjects. Antimicrobial Agents and Chemotherapy, 45, 1379-1386.
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , pp. 1379-1386
    • Creagh, T.1    Ruckle, J.L.2    Tolbert, D.T.3    Giltner, J.4    Eiznhamer, D.A.5    Dutta, B.6    Flavin, M.T.7    Xu, Z.Q.8
  • 102
    • 0036867571 scopus 로고    scopus 로고
    • Safety and pharmacokinetic profile of multiple escalating doses of ({thorn})-calanolide A, a naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy HIV-negative volunteers
    • Eiznhamer, D.A., Creagh, T., Ruckle, J.L., Tolbert, D.T., Giltner, J., Dutta, B., Flavin, M.T., Jenta, T., and Xu, Z.Q. (2002) Safety and pharmacokinetic profile of multiple escalating doses of ({thorn})-calanolide A, a naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy HIV-negative volunteers. HIV Clinical Trials, 3, 435-450.
    • (2002) HIV Clinical Trials , vol.3 , pp. 435-450
    • Eiznhamer, D.A.1    Creagh, T.2    Ruckle, J.L.3    Tolbert, D.T.4    Giltner, J.5    Dutta, B.6    Flavin, M.T.7    Jenta, T.8    Xu, Z.Q.9
  • 106
    • 41749084640 scopus 로고    scopus 로고
    • Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents
    • Ma, T., Liu, L., Xue, H., Li, L., Han, C., Wang, L., Chen, Z., and Liu, G. (2008) Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents. Journal of Medicinal Chemistry, 51, 1432-1446.
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 1432-1446
    • Ma, T.1    Liu, L.2    Xue, H.3    Li, L.4    Han, C.5    Wang, L.6    Chen, Z.7    Liu, G.8
  • 107
    • 0025113459 scopus 로고
    • 4-Heterocyclyloxy-2H-1-benzopyran potassium channel activators
    • Bergmann, R., Eiermann, V., and Gericke, R. (1990) 4-Heterocyclyloxy-2H-1-benzopyran potassium channel activators. Journal of Medicinal Chemistry, 33, 2759-2767.
    • (1990) Journal of Medicinal Chemistry , vol.33 , pp. 2759-2767
    • Bergmann, R.1    Eiermann, V.2    Gericke, R.3
  • 108
    • 0038698323 scopus 로고    scopus 로고
    • Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines
    • Hiessbock, R., Wolf, C., Richter, E., Hitzler, M., Chiba, P., Kratzel, M., and Ecker, G. (1999) Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines. Journal of Medicinal Chemistry, 42, 1921-1926.
    • (1999) Journal of Medicinal Chemistry , vol.42 , pp. 1921-1926
    • Hiessbock, R.1    Wolf, C.2    Richter, E.3    Hitzler, M.4    Chiba, P.5    Kratzel, M.6    Ecker, G.7
  • 110
    • 0034684250 scopus 로고    scopus 로고
    • Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans
    • Nicolaou, K.C., Pfefferkorn, J.A., Roecker, A.J., Cao, G.-Q., Barluenga, S., and Mitchell, H.J. (2000) Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans. Journal of the American Chemical Society, 122, 9939-9953.
    • (2000) Journal of the American Chemical Society , vol.122 , pp. 9939-9953
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2    Roecker, A.J.3    Cao, G.-Q.4    Barluenga, S.5    Mitchell, H.J.6
  • 111
    • 0034684225 scopus 로고    scopus 로고
    • Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10 000-membered benzopyran library by directed split-and-pool chemistry using NanoKans and optical encoding
    • Nicolaou, K.C., Pfefferkorn, J.A., Mitchell, H.J., Roecker, A.J., Barluenga, S., Cao, G.-Q., Affleck, R.L., and Lillig, J.E. (2000) Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10 000-membered benzopyran library by directed split-and-pool chemistry using NanoKans and optical encoding. Journal of the American Chemical Society, 122, 9954-9967.
    • (2000) Journal of the American Chemical Society , vol.122 , pp. 9954-9967
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2    Mitchell, H.J.3    Roecker, A.J.4    Barluenga, S.5    Cao, G.-Q.6    Affleck, R.L.7    Lillig, J.E.8
  • 112
    • 0141795495 scopus 로고    scopus 로고
    • Construction of 6-amino-2,2-dimethyl-3,4,6-trisubstituted-2H-1-benzopyran library by solid phase synthesis
    • Gong, Y.-D., Seo, J.-S., Chon, Y.S., Hwang, J.Y., Park, J.Y., and Yoo, S.-E. (2003) Construction of 6-amino-2,2-dimethyl-3,4,6-trisubstituted-2H-1-benzopyran library by solid phase synthesis. Journal of Combinatorial Chemistry, 5, 577-589.
    • (2003) Journal of Combinatorial Chemistry , vol.5 , pp. 577-589
    • Gong, Y.-D.1    Seo, J.-S.2    Chon, Y.S.3    Hwang, J.Y.4    Park, J.Y.5    Yoo, S.-E.6
  • 113
    • 39749179651 scopus 로고    scopus 로고
    • The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp
    • Hughes, C.C., Prieto-Dave, A., Jensen, P.R., and Fenical, W. (2008) The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Organic Letters, 10, 629-631.
    • (2008) Organic Letters , vol.10 , pp. 629-631
    • Hughes, C.C.1    Prieto-dave, A.2    Jensen, P.R.3    Fenical, W.4
  • 115
    • 77954556076 scopus 로고    scopus 로고
    • Total synthesis of (±)-marinopyrrole A and its library as potential antibiotic and anticancer agents
    • Cheng, C., Pan, L., Chen, Y., Song, H., Qin, Y., and Li, R. (2010) Total synthesis of (±)-marinopyrrole A and its library as potential antibiotic and anticancer agents. Journal of Combinatorial Chemistry, 12, 541-547.
    • (2010) Journal of Combinatorial Chemistry , vol.12 , pp. 541-547
    • Cheng, C.1    Pan, L.2    Chen, Y.3    Song, H.4    Qin, Y.5    Li, R.6
  • 117
    • 2942590399 scopus 로고    scopus 로고
    • Libraries from natural product-like scaffolds
    • Boldi, A.M. (2004) Libraries from natural product-like scaffolds. Current Opinion in Chemical Biology, 8, 281-286.
    • (2004) Current Opinion in Chemical Biology , vol.8 , pp. 281-286
    • Boldi, A.M.1
  • 118
    • 4544326369 scopus 로고    scopus 로고
    • Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates
    • Taylor, S.J., Taylor, A.M., and Schreiber, S.L. (2004) Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates. Angewandte Chemie -International Edition, 43, 1681-1685.
    • (2004) Angewandte Chemie -International Edition , vol.43 , pp. 1681-1685
    • Taylor, S.J.1    Taylor, A.M.2    Schreiber, S.L.3
  • 120
    • 12344293904 scopus 로고    scopus 로고
    • Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons
    • Oguri, H. and Schreiber, S.L. (2005) Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons. Organic Letters, 7, 47-50.
    • (2005) Organic Letters , vol.7 , pp. 47-50
    • Oguri, H.1    Schreiber, S.L.2
  • 123
    • 77951837637 scopus 로고    scopus 로고
    • The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis
    • Bauer, R.A., DiBlasi, C.M., and Tan, D.S. (2010) The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis. Organic Letters, 12, 2084-2087.
    • (2010) Organic Letters , vol.12 , pp. 2084-2087
    • Bauer, R.A.1    DiBlasi, C.M.2    Tan, D.S.3
  • 127
    • 0242636003 scopus 로고    scopus 로고
    • A combinatorial synthesis of a macrosphelide library utilizing a palladium-catalyzed carbonylation on a polymer support
    • Takahashi, T., Kusaka, S.-i., Doi, T., Sunazuka, T., and Omura, S. (2003) A combinatorial synthesis of a macrosphelide library utilizing a palladium-catalyzed carbonylation on a polymer support. Angewandte Chemie -International Edition, 42, 5230-5234.
    • (2003) Angewandte Chemie -International Edition , vol.42 , pp. 5230-5234
    • Takahashi, T.1    Kusaka, S.-I.2    Doi, T.3    Sunazuka, T.4    Omura, S.5
  • 128
    • 0033949965 scopus 로고    scopus 로고
    • Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting
    • Xiao, X.-Y., Li, R., Zhuang, H., Ewing, B., and Karunaratne, K. (2000) Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting. Biotechnology and Bioengineering, 71, 44-50.
    • (2000) Biotechnology and Bioengineering , vol.71 , pp. 44-50
    • Xiao, X.-Y.1    Li, R.2    Zhuang, H.3    Ewing, B.4    Karunaratne, K.5
  • 129
    • 0029870638 scopus 로고    scopus 로고
    • Macrolide antibiotics in paediatric infectious diseases
    • Guay, D.R.P. (1996) Macrolide antibiotics in paediatric infectious diseases. Drugs, 51, 515-536.
    • (1996) Drugs , vol.51 , pp. 515-536
    • Guay, D.R.P.1
  • 134
    • 7444242717 scopus 로고    scopus 로고
    • A synthesis strategy yielding skeletally diverse small molecules combinatorially
    • Burke, M.D., Berger, E.M., and Schreiber, S.L. (2004) A synthesis strategy yielding skeletally diverse small molecules combinatorially. Journal of the American Chemical Society, 126, 14095-14104.
    • (2004) Journal of the American Chemical Society , vol.126 , pp. 14095-14104
    • Burke, M.D.1    Berger, E.M.2    Schreiber, S.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.