A novel anti-ischemic ATP-sensitive potassium channel (KATP) opener without vasorelaxation: N-(6-aminobenzopyranyl)-N′-benzyl- N″-cyanoguanidine analogue

Journal of Medicinal Chemistry

Volumn 44, Issue 24, 2001, Pages 4207-4215

  Yoo, S E ^a   Kyu Yang Yi, ^a   Lee, S ^a   Suh, J ^a   Kim, N ^a   Byung Ho Lee, ^a   Ho Won Seo, ^a   Kim, S O ^b   Lee, D H ^b   Lim, H ^b   Hwa Sup Shin, ^c  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Dongbu Hannong Chemical Co   (South Korea)

^c Konkuk University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1,3 DIOXOLAN 2 YL) 2 METHYL 6 NITRO 4 (2 OXO 1 PYRROLIDINYL) 2H 1 BENZOPYRAN; BMS 191095; KR 31378; N (4 CHLOROPHENYL) N' CYANO N'' (6 CYANO 3,4 DIHYDRO 3 HYDROXY 2,2 DIMETHYL 2H 1 BENZOPYRAN 4 YL)GUANIDINE; N (6 AMINO 3,4 DIHYDRO 2 DIMETHOXYMETHYL 3 HYDROXY 2 METHYL 2H BENZOPYRANYL) N' BENZYL N'' CYANOGUANIDINE; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOSELECTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; EMBRYO; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; STRUCTURE ACTIVITY RELATION; VASODILATATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; AORTA; CARDIOTONIC AGENTS; CELLS, CULTURED; CEREBRAL CORTEX; GUANIDINES; ION CHANNEL GATING; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL INFARCTION; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; POTASSIUM CHANNELS; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATION;

EID: 0035935687     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010183f     Document Type: Article

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