Reaction of antitumor hydroxymethylacylfulvene (HMAF) with thiols

Tetrahedron

Volumn 53, Issue 43, 1997, Pages 14579-14590

  McMorris, Trevor C ^a   Yu, Jian ^a   Estes, Leita A ^b   Kelner, Michael J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYMETHYLACYLFULVENE; ANTINEOPLASTIC ANTIBIOTIC; ILLUDIN M; ILLUDIN S; SESQUITERPENE DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS; TUMOR CELL LINE;

EID: 0030839510     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)01064-8     Document Type: Article

References (14)

1. Fujita, E.; Nagao, Y. Bioorganic Chemistry. 1977, 6, 287-309.
2. McMorris, T. C.; Anchel, M. J. Am. Chem. Soc. 1963, 85, 831.
3. McMorris, T. C.; Kelner, M. J.; Chadha, R. K.; Siegel, J. S.; Moon, S.; Moya, M. Tetrahedron, 1989, 45, 5433-5440.
4. McMorris, T. C.; Kelner, M. J.; Wang, W.; Moon, S.; Taetle, R. Chem. Res. Toxic. 1990, 3, 574-579.
5. Tanaka, K.; Inoue, T.; Kadota, S.; Kikuchi, T. Xenobiotica, 1992, 22, 33-39.
6. Tanaka, K.; Inoue, T.; Kanai, M.; Kikuchi, T. Xenobiotica, 1994, 24, 1237-1243.
7. McMorris, T. C.; Kelner, M. J.; Wang, W.; Estes, L. A.; Montoya, M. A.; Taetle, R. J. Org. Chem. 1992, 57, 6876-6883.
8. McMorris, T. C.; Kelner, M. J.; Wang, W.; Diaz, M. A.; Estes, L. A.; Taetle, R. Experientia. 1996, 52, 75-80.
9. McMorris, T. C.; Kelner, M. J.; Wang, W.; Yu, J.; Estes, L. A.; Taetle, R. J. Nat. Prod. 1996, 59, 896-899.
10. Kelner, M. J.; McMorris, T. C.; Estes, L. A.; Wang, W.; Samson, K. M.; Taetle, R. Investigational New Drugs. 1996, 14, 161-167.
11. MacDonald, J. R.; Muscoplat, C. C.; Dexter, D. L.; Mangold, G. L.; Chen, S. F.; Kelner, M. J.; McMorris, T. C.; Von Hoff, D. D. Cancer Res. 1997, 57, 279-283.
12. Eckhardt, S. G.; Weiss, G. R.; Kraynak, M.; Kuhn, J. G.; MacDonald, J. R.; Hanna, J.; De Moor, C.; Moczygemba, J.; Von Hoff, D. D.; Rowinsky, E. K. MGI-114-A novel mushroom derived cytotoxin: A Phase I and pharmacokinetic (PK) study in patients with advanced cancer. 88th Annual Meeting, American Association for Cancer Research, 1997, Paper number 2055.
13. Richey, H. R.; Jr. In Carbonium Ions; Olah, G. A.; Schleyer, P. v. R., Eds.; Wiley-Interscience, New York, 1972, Vol. III, Chapter 25.
14. Unpublished data provided by MGI, Pharma, Inc.