2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

Acta Pharmacologica Sinica

Volumn 36, Issue 4, 2015, Pages 483-496

  Zhang, Jin ^a   Zhang, Li Na ^b   Chen, Dong Mei ^a   Fu, Yan Yun ^b   Zhang, Feng ^a   Yang, Ling Ling ^a   Xia, Chun Mei ^b   Jiang, Hao Wen ^a   Tang, Chun Lan ^b   Xie, Zhi Fu ^b   Yang, Fan ^a   Li, Jia ^a,b   Tang, Jie ^a   Li, Jing Ya ^b  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

2 (3 benzoylthioureido) 4,5,6,7 tetrahydrobenzo b thiophene 3 carboxylic acid; AMPK; hepatic lipid accumulation; lipogenesis; metabolic disorders; mTOR; obesity; SREBP 1c

Indexed keywords

2 (3 BENZOYLTHIOUREIDO) 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE 3 CARBOXYLIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; BENZOTHIOPHENE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; GLUCOSE; INSULIN; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; ANTIOBESITY AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TARGET OF RAPAMYCIN KINASE; THIOPHENE DERIVATIVE; THIOPHENE-3-CARBOXYLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GLUCOSE TOLERANCE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIPID DIET; LIPID METABOLISM; LIPOGENESIS; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PROMOTER REGION; RAT; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER CELL; MALE; METABOLISM; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-OBESITY AGENTS; CELLS, CULTURED; DIET, HIGH-FAT; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; OBESITY; RATS; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; THIOPHENES; TOR SERINE-THREONINE KINASES;

EID: 84926353465     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.149     Document Type: Article

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