Isothiocyanate synthetic analogs: Biological activities, structure-activity relationships and synthetic strategies

Mini-Reviews in Medicinal Chemistry

Volumn 14, Issue 12, 2014, Pages 963-977

  Milelli, Andrea ^a   Fimognari, Carmela ^a   Ticchi, Nicole ^a   Neviani, Paolo ^a   Minarini, Anna ^a   Tumiatti, Vincenzo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Chemopreventive; Isothiocyanate; Natural products; Structure activity relationships; Sulforaphane

Indexed keywords

ACRYLIC ACID METHYL ESTER; ALLYL ISOTHIOCYANATE; AMYLOID BETA PROTEIN; BENZYL ISOTHIOCYANATE; CASPASE 8; CYCLOOXYGENASE 2; HEME OXYGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOSELENOCYANATE; ISOTHIOCYANIC ACID DERIVATIVE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; NITRIC OXIDE SYNTHASE INHIBITOR; PHENETHYL ISOTHIOCYANATE; PROTEIN P53; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; TUBULIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; SULFORAFAN;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROTECTION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHEMOPROPHYLAXIS; CLINICAL TRIAL (TOPIC); CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; EPIGENETICS; GENE EXPRESSION; GENETIC REGULATION; HUMAN; IC50; LIPOPHILICITY; MELANOMA; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; CHEMISTRY; METABOLISM; NEOPLASMS; SYNTHESIS; VEGETABLE;

ANIMALS; ANTICARCINOGENIC AGENTS; BIOLOGICAL PRODUCTS; HUMANS; ISOTHIOCYANATES; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; VEGETABLES;

EID: 84926312404     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557514666141106131909     Document Type: Article

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