Identification, synthesis, and enzymology of non-natural glucosinolate chemopreventive candidates

ChemBioChem

Volumn 9, Issue 5, 2008, Pages 729-747

  Mays, Jared R ^a   Roska, Rachel L Weller ^a   Sarfaraz, Sami ^a   Mukhtar, Hasan ^a   Rajski, Scott R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Glucosinolates; Isothiocynates; Myrosinase; Prodrugs; Stucture activity relationships

Indexed keywords

(BIPHENYL 2 YL)METHYL GLUCOSINOLATE; 1 (ISOTHIOCYANATOMETHYL) 2 PHENYLBENZENE; 1 (ISOTHIOCYANATOMETHYL) 3 PHENYLBENZENE; 1 (ISOTHIOCYANATOMETHYL) 4 PHENOXYBENZENE; 2 ISOTHIOCYANATO 1,1 DIPHENYLETHANE; 2,2 DIPHENYLETHYL GLUCOSINOLATE; 3 (ISOTHIOCYANATOMETHYL)PYRIDINE; 3 (PYRIDYLMETHYL)ISOTHIOCYANATE; GLUCOSINOLATE; ISOTHIOCYANIC ACID DERIVATIVE; SINIGRIN; SULFORAPHANE; THIOGLUCOSIDASE; UNCLASSIFIED DRUG; GLYCOSIDASE; SULFORAFAN; THIOCYANIC ACID DERIVATIVE; WATER;

ANIMAL CELL; ARTICLE; CANCER PREVENTION; CANCER RISK; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYMOLOGY; GASTROINTESTINAL DISEASE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; CARCINOMA; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; EPITHELIUM CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; METHODOLOGY; MOLECULAR LIBRARY; MOUSE; STEREOISOMERISM; SYNTHESIS; TIME; TUMOR CELL LINE;

BRASSICA OLERACEA VAR. ITALICA;

ANIMALS; CARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOPREVENTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SCREENING ASSAYS, ANTITUMOR; EPITHELIAL CELLS; GLUCOSINOLATES; GLYCOSIDE HYDROLASES; HUMANS; HYDROLYSIS; ISOTHIOCYANATES; MICE; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; THIOCYANATES; TIME FACTORS; WATER;

EID: 43149121599     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700586     Document Type: Article

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