Novel polyamine analogues: From substrates towards potential inhibitors of monoamine oxidases

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 88-101

  Bonaiuto, Emanuela ^a   Milelli, Andrea ^b   Cozza, Giorgio ^a   Tumiatti, Vincenzo ^b   Marchetti, Chiara ^b   Agostinelli, Enzo ^c,d   Fimognari, Carmela ^b   Hrelia, Patrizia ^b   Minarini, Anna ^b   Di Paolo, Maria Luisa ^a,e  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d CNR   (Italy)

^e NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

Docking studies; Inhibitors; Isothiocyanate; Monoamine oxidase (MAO); Polyamine derivatives

Indexed keywords

3 [4 (3 AMINOPROPOXY)BUTOXY] N (THIOPHEN 2 YLMETHYL) PROPAN 1 AMINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CLORGYLINE; ISATIN; MONOAMINE OXIDASE INHIBITOR; N 1 (3 AMINOPROPYL) N 4 [3 [(NAPHTHALEN 2 YLMETHYL)AMINO]PROPYL]BUTANE 1,4 DIAMINE; N 1 (3 AMINOPROPYL) N 4 [3 [(PYRIDIN 3 YLMETHYL)AMINO]PROPYL]BUTANE 1,4 DIAMINE; N 1 (3 AMINOPROPYL) N 4 [3 [(THIOPHEN 2 YLMETHYL)AMINO]PROPYL]BUTANE 1,4 DIAMINE; N 1 (3 [(THIOPHEN 2 YLMETHYL)AMINO)PROPYL]OCTANE 1,8 DIAMINE; N 1 (THIOPHEN 2 YLMETHYL)DODECANE 1,12 DIAMINE; N 1 BENZYLDODECANE 1,12 DIAMINE; N BENZYL 12 ISOTHIOCYANATO N METHYLDODECAN 1 AMINE; POLYAMINE DERIVATIVE; SELEGILINE; SULFORAPHANE; UNCLASSIFIED DRUG; VASCULAR ADHESION PROTEIN 1;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NEUROBLASTOMA;

N(1)-(3-AMINOPROPYL)-N(4)-(3-(BENZYLAMINO)PROPYL)BUTANE-1,4-DIAMINE/N(1)-BENZYL-SPERMINE; AITC; ALLYL ISOTHIOCYANATE; BD6; BENZYLAMINE; BIS-BZA-DIADO; BZA; DOCKING STUDIES; ENZYME-INHIBITOR DISSOCIATION CONSTANT/INHIBITION CONSTANT; ENZYME-SUBSTRATE COMPLEX-INHIBITOR DISSOCIATION CONSTANT; INHIBITORS; ISOTHIOCYANATE; ITC; K(IE); K(IES); K(M); MAO; MAXIMUM VELOCITY; MICHAELIS-MENTEN CONSTANT; MONOAMINE OXIDASE; MONOAMINE OXIDASE (MAO); N(1),N(12)-DIBENZYL-DODECANE-1,12-DIAMINE; P-TYRAMINE; POLYAMINE DERIVATIVES; SEMICARBAZIDE-SENSITIVE AMINE OXIDASE/VASCULAR-ADHESION-PROTEIN-1; TYRAMINE; V(MAX); VAP-1;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; POLYAMINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84885542675     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.005     Document Type: Article

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