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Volumn 18, Issue 6, 2012, Pages 337-347

Glucosinolates and isothiocyanates in health and disease

Author keywords

[No Author keywords available]

Indexed keywords

DITHIOCARBAMIC ACID; GLUCOSINOLATE; ISOTHIOCYANIC ACID; SULFORAPHANE;

EID: 84861875282     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2012.04.003     Document Type: Review
Times cited : (506)

References (90)
  • 2
    • 77953366823 scopus 로고    scopus 로고
    • Biosynthesis of glucosinolates - gene discovery and beyond
    • Sønderby I.E., et al. Biosynthesis of glucosinolates - gene discovery and beyond. Trends Plant Sci. 2010, 15:283-290.
    • (2010) Trends Plant Sci. , vol.15 , pp. 283-290
    • Sønderby, I.E.1
  • 3
    • 78149417008 scopus 로고    scopus 로고
    • Glucosinolate-accumulating S-cells in Arabidopsis leaves and flower stalks undergo programmed cell death at early stages of differentiation
    • Koroleva O.A., et al. Glucosinolate-accumulating S-cells in Arabidopsis leaves and flower stalks undergo programmed cell death at early stages of differentiation. Plant J. 2010, 64:456-469.
    • (2010) Plant J. , vol.64 , pp. 456-469
    • Koroleva, O.A.1
  • 4
    • 0032406798 scopus 로고    scopus 로고
    • Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
    • Shapiro T.A., et al. Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol. Biomarkers Prev. 1998, 7:1091-1100.
    • (1998) Cancer Epidemiol. Biomarkers Prev. , vol.7 , pp. 1091-1100
    • Shapiro, T.A.1
  • 5
    • 0032948428 scopus 로고    scopus 로고
    • Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress
    • Getahun S.M., Chung F.L. Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol. Biomarkers Prev. 1999, 8:447-451.
    • (1999) Cancer Epidemiol. Biomarkers Prev. , vol.8 , pp. 447-451
    • Getahun, S.M.1    Chung, F.L.2
  • 6
    • 0034434321 scopus 로고    scopus 로고
    • Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli
    • Conaway C.C., et al. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr. Cancer 2000, 38:168-178.
    • (2000) Nutr. Cancer , vol.38 , pp. 168-178
    • Conaway, C.C.1
  • 7
    • 79951939298 scopus 로고    scopus 로고
    • Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men
    • Cramer J.M., Jeffery E.H. Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men. Nutr. Cancer 2011, 63:196-201.
    • (2011) Nutr. Cancer , vol.63 , pp. 196-201
    • Cramer, J.M.1    Jeffery, E.H.2
  • 8
    • 80054979844 scopus 로고    scopus 로고
    • Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design
    • Clarke J.D., et al. Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacol. Res. 2011, 64:456-463.
    • (2011) Pharmacol. Res. , vol.64 , pp. 456-463
    • Clarke, J.D.1
  • 9
    • 42149183527 scopus 로고    scopus 로고
    • Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk
    • Tang L., et al. Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk. Cancer Epidemiol. Biomarkers Prev. 2008, 17:938-944.
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 938-944
    • Tang, L.1
  • 10
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure
    • Zhang Y., et al. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:2399-2403.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 2399-2403
    • Zhang, Y.1
  • 11
    • 0030931522 scopus 로고    scopus 로고
    • Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
    • Fahey J.W., et al. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:10367-10372.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 10367-10372
    • Fahey, J.W.1
  • 12
    • 0026783989 scopus 로고
    • Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols
    • Zhang Y., et al. Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols. Anal. Biochem. 1992, 205:100-107.
    • (1992) Anal. Biochem. , vol.205 , pp. 100-107
    • Zhang, Y.1
  • 13
    • 33644688761 scopus 로고    scopus 로고
    • Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli
    • Gasper A.V., et al. Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am. J. Clin. Nutr. 2005, 82:1283-1291.
    • (2005) Am. J. Clin. Nutr. , vol.82 , pp. 1283-1291
    • Gasper, A.V.1
  • 14
    • 79955834680 scopus 로고    scopus 로고
    • Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China
    • Egner P.A., et al. Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prev. Res. (Phila.) 2011, 4:384-395.
    • (2011) Cancer Prev. Res. (Phila.) , vol.4 , pp. 384-395
    • Egner, P.A.1
  • 15
    • 0034928041 scopus 로고    scopus 로고
    • Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans
    • Shapiro T.A., et al. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol. Biomarkers Prev 2001, 10:501-508.
    • (2001) Cancer Epidemiol. Biomarkers Prev , vol.10 , pp. 501-508
    • Shapiro, T.A.1
  • 16
    • 33749165612 scopus 로고    scopus 로고
    • Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
    • Shapiro T.A., et al. Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study. Nutr. Cancer 2006, 55:53-62.
    • (2006) Nutr. Cancer , vol.55 , pp. 53-62
    • Shapiro, T.A.1
  • 17
    • 28644450910 scopus 로고    scopus 로고
    • Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
    • Kensler T.W., et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiol. Biomarkers Prev. 2005, 14:2605-2613.
    • (2005) Cancer Epidemiol. Biomarkers Prev. , vol.14 , pp. 2605-2613
    • Kensler, T.W.1
  • 18
    • 84861913629 scopus 로고    scopus 로고
    • Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora
    • Fahey J.W., et al. Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora. Cancer Prev. Res. (Phila) 2012, 5:603-611.
    • (2012) Cancer Prev. Res. (Phila) , vol.5 , pp. 603-611
    • Fahey, J.W.1
  • 19
    • 80052895923 scopus 로고    scopus 로고
    • Variation of glucoraphanin metabolism in vivo and ex vivo by human gut bacteria
    • Li F., et al. Variation of glucoraphanin metabolism in vivo and ex vivo by human gut bacteria. Br. J. Nutr. 2011, 106:408-416.
    • (2011) Br. J. Nutr. , vol.106 , pp. 408-416
    • Li, F.1
  • 20
    • 0017328782 scopus 로고
    • Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds
    • Wattenberg L.W. Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. J. Natl. Cancer Inst. 1977, 58:395-398.
    • (1977) J. Natl. Cancer Inst. , vol.58 , pp. 395-398
    • Wattenberg, L.W.1
  • 21
    • 0018143862 scopus 로고
    • Diet in the epidemiology of cancer of the colon and rectum
    • Graham S., et al. Diet in the epidemiology of cancer of the colon and rectum. J. Natl. Cancer Inst. 1978, 61:709-714.
    • (1978) J. Natl. Cancer Inst. , vol.61 , pp. 709-714
    • Graham, S.1
  • 22
    • 33846838750 scopus 로고    scopus 로고
    • Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
    • Myzak M.C., et al. Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp. Biol. Med. (Maywood) 2007, 232:227-234.
    • (2007) Exp. Biol. Med. (Maywood) , vol.232 , pp. 227-234
    • Myzak, M.C.1
  • 23
    • 80052707191 scopus 로고    scopus 로고
    • Apoptosis induction in primary human colorectal cancer cell lines and retarded tumor growth in SCID mice by sulforaphane
    • Chen M.J., et al. Apoptosis induction in primary human colorectal cancer cell lines and retarded tumor growth in SCID mice by sulforaphane. Evid. Based Complement. Alternat. Med. 2012, 2012:415231.
    • (2012) Evid. Based Complement. Alternat. Med. , vol.2012 , pp. 415231
    • Chen, M.J.1
  • 24
    • 78650323904 scopus 로고    scopus 로고
    • Anticancer activity of a broccoli derivative, sulforaphane, in Barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy
    • Qazi A., et al. Anticancer activity of a broccoli derivative, sulforaphane, in Barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy. Transl. Oncol. 2010, 3:389-399.
    • (2010) Transl. Oncol. , vol.3 , pp. 389-399
    • Qazi, A.1
  • 25
    • 79959962141 scopus 로고    scopus 로고
    • Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice
    • Kanematsu S., et al. Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice. Oncol. Rep. 2011, 26:603-608.
    • (2011) Oncol. Rep. , vol.26 , pp. 603-608
    • Kanematsu, S.1
  • 26
    • 80053643906 scopus 로고    scopus 로고
    • Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function
    • Li Y., et al. Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. Nutr. Cancer 2011, 63:1151-1159.
    • (2011) Nutr. Cancer , vol.63 , pp. 1151-1159
    • Li, Y.1
  • 27
    • 0018054313 scopus 로고
    • Biochemical studies on the mechanisms by which dietary antioxidants suppress mutagenic activity
    • Talalay P., et al. Biochemical studies on the mechanisms by which dietary antioxidants suppress mutagenic activity. Adv. Enzyme Regul. 1978, 17:23-36.
    • (1978) Adv. Enzyme Regul. , vol.17 , pp. 23-36
    • Talalay, P.1
  • 28
    • 0026589840 scopus 로고
    • Rapid detection of inducers of enzymes that protect against carcinogens
    • Prochaska H.J., et al. Rapid detection of inducers of enzymes that protect against carcinogens. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:2394-2398.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 2394-2398
    • Prochaska, H.J.1
  • 29
    • 59249103720 scopus 로고    scopus 로고
    • Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway
    • Riedl M.A., et al. Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin. Immunol. 2009, 130:244-251.
    • (2009) Clin. Immunol. , vol.130 , pp. 244-251
    • Riedl, M.A.1
  • 30
    • 79954542852 scopus 로고    scopus 로고
    • Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model
    • Harvey C.J., et al. Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Sci. Transl. Med. 2011, 3:78ra32.
    • (2011) Sci. Transl. Med. , vol.3
    • Harvey, C.J.1
  • 31
    • 72749104168 scopus 로고    scopus 로고
    • Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes
    • Navarro S.L., et al. Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes. Cancer Epidemiol. Biomarkers Prev. 2009, 18:2974-2978.
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , pp. 2974-2978
    • Navarro, S.L.1
  • 32
    • 34247473917 scopus 로고    scopus 로고
    • Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
    • Dinkova-Kostova A.T., et al. Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. Cancer Epidemiol. Biomarkers Prev. 2007, 16:847-851.
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 847-851
    • Dinkova-Kostova, A.T.1
  • 33
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa R.K., et al. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 2002, 62:5196-5203.
    • (2002) Cancer Res. , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1
  • 34
    • 49849087443 scopus 로고    scopus 로고
    • Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate
    • Traka M., et al. Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. PLoS ONE 2008, 3:e2568.
    • (2008) PLoS ONE , vol.3
    • Traka, M.1
  • 35
    • 78751703950 scopus 로고    scopus 로고
    • Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
    • Taguchi K., et al. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011, 16:123-140.
    • (2011) Genes Cells , vol.16 , pp. 123-140
    • Taguchi, K.1
  • 36
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    • Nguyen T., et al. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 2009, 284:13291-13295.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13291-13295
    • Nguyen, T.1
  • 37
    • 78650509515 scopus 로고    scopus 로고
    • Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
    • McMahon M., et al. Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:18838-18843.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 18838-18843
    • McMahon, M.1
  • 38
    • 79954489673 scopus 로고    scopus 로고
    • Modification of Keap1 cysteine residues by sulforaphane
    • Hu C., et al. Modification of Keap1 cysteine residues by sulforaphane. Chem. Res. Toxicol. 2011, 24:515-521.
    • (2011) Chem. Res. Toxicol. , vol.24 , pp. 515-521
    • Hu, C.1
  • 39
    • 84855409443 scopus 로고    scopus 로고
    • Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
    • Kensler T.W., et al. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis 2012, 33:101-107.
    • (2012) Carcinogenesis , vol.33 , pp. 101-107
    • Kensler, T.W.1
  • 40
    • 33645815069 scopus 로고    scopus 로고
    • Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis
    • Gamet-Payrastre L. Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis. Curr. Cancer Drug Targets 2006, 6:135-145.
    • (2006) Curr. Cancer Drug Targets , vol.6 , pp. 135-145
    • Gamet-Payrastre, L.1
  • 41
    • 33645825587 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    • Myzak M.C., et al. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J. 2006, 20:506-508.
    • (2006) FASEB J. , vol.20 , pp. 506-508
    • Myzak, M.C.1
  • 42
    • 33845593776 scopus 로고    scopus 로고
    • Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization
    • Jackson S.J., et al. Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization. Vasc. Pharmacol. 2007, 46:77-84.
    • (2007) Vasc. Pharmacol. , vol.46 , pp. 77-84
    • Jackson, S.J.1
  • 43
    • 79958242724 scopus 로고    scopus 로고
    • Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells
    • Hamsa T.P., et al. Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells. Drug Chem. Toxicol. 2011, 34:332-340.
    • (2011) Drug Chem. Toxicol. , vol.34 , pp. 332-340
    • Hamsa, T.P.1
  • 44
    • 33846417309 scopus 로고    scopus 로고
    • Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production
    • Thejass P., Kuttan G. Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production. Nitric Oxide 2007, 16:247-257.
    • (2007) Nitric Oxide , vol.16 , pp. 247-257
    • Thejass, P.1    Kuttan, G.2
  • 45
    • 77951210052 scopus 로고    scopus 로고
    • Dietary phenethylisothiocyanate attenuates bowel inflammation in mice
    • Dey M., et al. Dietary phenethylisothiocyanate attenuates bowel inflammation in mice. BMC Chem. Biol. 2010, 10:4.
    • (2010) BMC Chem. Biol. , vol.10 , pp. 4
    • Dey, M.1
  • 46
    • 33846094115 scopus 로고    scopus 로고
    • Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice
    • Khor T.O., et al. Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Biopharm. Drug Dispos. 2006, 27:407-420.
    • (2006) Biopharm. Drug Dispos. , vol.27 , pp. 407-420
    • Khor, T.O.1
  • 47
    • 2342535632 scopus 로고    scopus 로고
    • Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system
    • Wu L., et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:7094-7099.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 7094-7099
    • Wu, L.1
  • 48
    • 36849089479 scopus 로고    scopus 로고
    • Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
    • Talalay P., et al. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:17500-17505.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 17500-17505
    • Talalay, P.1
  • 49
    • 70450248452 scopus 로고    scopus 로고
    • Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates
    • Brown K.K., et al. Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. J. Biol. Chem. 2009, 284:32425-32433.
    • (2009) J. Biol. Chem. , vol.284 , pp. 32425-32433
    • Brown, K.K.1
  • 50
    • 79960095905 scopus 로고    scopus 로고
    • Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention
    • Healy Z.R., et al. Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention. Cancer Epidemiol. Biomarkers. Prev. 2011, 20:1516-1523.
    • (2011) Cancer Epidemiol. Biomarkers. Prev. , vol.20 , pp. 1516-1523
    • Healy, Z.R.1
  • 51
    • 42749088621 scopus 로고    scopus 로고
    • Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells
    • Kim H.J., et al. Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells. J. Allergy Clin. Immunol. 2008, 121:1255-1261.
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 1255-1261
    • Kim, H.J.1
  • 52
    • 84856059079 scopus 로고    scopus 로고
    • The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats
    • Senanayake G.V., et al. The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats. Am. J. Hypertens. 2012, 25:229-235.
    • (2012) Am. J. Hypertens. , vol.25 , pp. 229-235
    • Senanayake, G.V.1
  • 53
    • 38949114867 scopus 로고    scopus 로고
    • Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily
    • Mukherjee S., et al. Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily. J. Agric. Food Chem. 2008, 56:609-617.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 609-617
    • Mukherjee, S.1
  • 54
    • 16244378900 scopus 로고    scopus 로고
    • Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice
    • Tanito M., et al. Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice. Invest. Ophthalmol. Vis. Sci. 2005, 46:979-987.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 979-987
    • Tanito, M.1
  • 55
    • 34247558673 scopus 로고    scopus 로고
    • Delay of photoreceptor degeneration in tubby mouse by sulforaphane
    • Kong L., et al. Delay of photoreceptor degeneration in tubby mouse by sulforaphane. J. Neurochem. 2007, 101:1041-1052.
    • (2007) J. Neurochem. , vol.101 , pp. 1041-1052
    • Kong, L.1
  • 56
    • 27644587832 scopus 로고    scopus 로고
    • Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury
    • Zhao J., et al. Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury. J. Neurosci. Res. 2005, 82:499-506.
    • (2005) J. Neurosci. Res. , vol.82 , pp. 499-506
    • Zhao, J.1
  • 57
    • 34548850603 scopus 로고    scopus 로고
    • Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury
    • Zhao J., et al. Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury. J. Neurosci. 2007, 27:10240-10248.
    • (2007) J. Neurosci. , vol.27 , pp. 10240-10248
    • Zhao, J.1
  • 58
    • 66949123850 scopus 로고    scopus 로고
    • Sulforaphane improves cognitive function administered following traumatic brain injury
    • Dash P.K., et al. Sulforaphane improves cognitive function administered following traumatic brain injury. Neurosci. Lett. 2009, 460:103-107.
    • (2009) Neurosci. Lett. , vol.460 , pp. 103-107
    • Dash, P.K.1
  • 59
    • 78149399227 scopus 로고    scopus 로고
    • The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice
    • Hong Y., et al. The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice. Acta Pharmacol. Sin. 2010, 31:1421-1430.
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 1421-1430
    • Hong, Y.1
  • 60
    • 36448945858 scopus 로고    scopus 로고
    • Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage
    • Zhao X., et al. Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. Stroke 2007, 38:3280-3286.
    • (2007) Stroke , vol.38 , pp. 3280-3286
    • Zhao, X.1
  • 61
    • 72449202067 scopus 로고    scopus 로고
    • Neuroprotective role of haptoglobin after intracerebral hemorrhage
    • Zhao X., et al. Neuroprotective role of haptoglobin after intracerebral hemorrhage. J. Neurosci. 2009, 29:15819-15827.
    • (2009) J. Neurosci. , vol.29 , pp. 15819-15827
    • Zhao, X.1
  • 62
    • 79751525643 scopus 로고    scopus 로고
    • Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage
    • Chen G., et al. Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. J. Neurosci. Res. 2011, 89:515-523.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 515-523
    • Chen, G.1
  • 63
    • 77953620909 scopus 로고    scopus 로고
    • Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme
    • Ping Z., et al. Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme. Brain Res. 2010, 1343:178-185.
    • (2010) Brain Res. , vol.1343 , pp. 178-185
    • Ping, Z.1
  • 64
    • 80051549591 scopus 로고    scopus 로고
    • Transcription factor Nrf2 protects the spinal cord from inflammation produced by spinal cord injury
    • Mao L., et al. Transcription factor Nrf2 protects the spinal cord from inflammation produced by spinal cord injury. J. Surg. Res. 2011, 170:e105-e115.
    • (2011) J. Surg. Res. , vol.170
    • Mao, L.1
  • 65
    • 84863338153 scopus 로고    scopus 로고
    • Activation of the nuclear factor e2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury
    • Wang X., et al. Activation of the nuclear factor e2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury. J. Neurotrauma 2012, 29:936-945.
    • (2012) J. Neurotrauma , vol.29 , pp. 936-945
    • Wang, X.1
  • 66
    • 21844440270 scopus 로고    scopus 로고
    • Dietary approach to decrease aging-related CNS inflammation
    • Noyan-Ashraf M.H., et al. Dietary approach to decrease aging-related CNS inflammation. Nutr. Neurosci. 2005, 8:101-110.
    • (2005) Nutr. Neurosci. , vol.8 , pp. 101-110
    • Noyan-Ashraf, M.H.1
  • 67
    • 47949083810 scopus 로고    scopus 로고
    • The transcription factor Nrf2 is a therapeutic target against brain inflammation
    • Innamorato N.G., et al. The transcription factor Nrf2 is a therapeutic target against brain inflammation. J. Immunol. 2008, 181:680-689.
    • (2008) J. Immunol. , vol.181 , pp. 680-689
    • Innamorato, N.G.1
  • 68
    • 79957515007 scopus 로고    scopus 로고
    • Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism
    • Jazwa A., et al. Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism. Antioxid. Redox Signal. 2011, 14:2347-2360.
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 2347-2360
    • Jazwa, A.1
  • 69
    • 77957075817 scopus 로고    scopus 로고
    • NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain
    • Kim D., et al. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:14851-14856.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 14851-14856
    • Kim, D.1
  • 70
    • 79961090116 scopus 로고    scopus 로고
    • Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury
    • Toyama T., et al. Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury. Environ. Health Perspect. 2011, 119:1117-1122.
    • (2011) Environ. Health Perspect. , vol.119 , pp. 1117-1122
    • Toyama, T.1
  • 71
    • 80755168858 scopus 로고    scopus 로고
    • Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
    • Zheng H., et al. Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes 2011, 60:3055-3066.
    • (2011) Diabetes , vol.60 , pp. 3055-3066
    • Zheng, H.1
  • 72
    • 82155197554 scopus 로고    scopus 로고
    • Nrf2 and NF-kappaB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes
    • Negi G., et al. Nrf2 and NF-kappaB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. Curr. Neurovasc. Res. 2011, 8:294-304.
    • (2011) Curr. Neurovasc. Res. , vol.8 , pp. 294-304
    • Negi, G.1
  • 73
    • 35448991707 scopus 로고    scopus 로고
    • Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex
    • Kerns M.L., et al. Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:14460-14465.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 14460-14465
    • Kerns, M.L.1
  • 74
    • 0037188518 scopus 로고    scopus 로고
    • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    • Fahey J.W., et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:7610-7615.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 7610-7615
    • Fahey, J.W.1
  • 75
    • 67549138277 scopus 로고    scopus 로고
    • Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
    • Yanaka A., et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev. Res. (Phila.) 2009, 2:353-360.
    • (2009) Cancer Prev. Res. (Phila.) , vol.2 , pp. 353-360
    • Yanaka, A.1
  • 76
    • 0024589128 scopus 로고
    • Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate
    • Morse M.A., et al. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate. Cancer Res. 1989, 49:549-553.
    • (1989) Cancer Res. , vol.49 , pp. 549-553
    • Morse, M.A.1
  • 77
    • 0026502758 scopus 로고
    • Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice
    • Morse M.A., et al. Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice. Cancer Lett. 1992, 62:77-81.
    • (1992) Cancer Lett. , vol.62 , pp. 77-81
    • Morse, M.A.1
  • 78
    • 24944480252 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    • Conaway C.C., et al. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res. 2005, 65:8548-8557.
    • (2005) Cancer Res. , vol.65 , pp. 8548-8557
    • Conaway, C.C.1
  • 79
    • 0025846911 scopus 로고
    • Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus
    • Stoner G.D., et al. Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus. Cancer Res. 1991, 51:2063-2068.
    • (1991) Cancer Res. , vol.51 , pp. 2063-2068
    • Stoner, G.D.1
  • 80
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    • Chung F.L., et al. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 2000, 21:2287-2291.
    • (2000) Carcinogenesis , vol.21 , pp. 2287-2291
    • Chung, F.L.1
  • 81
    • 42949121566 scopus 로고    scopus 로고
    • Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC)
    • Khor T.O., et al. Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC). Mol. Carcinog. 2008, 47:321-325.
    • (2008) Mol. Carcinog. , vol.47 , pp. 321-325
    • Khor, T.O.1
  • 82
    • 0028203252 scopus 로고
    • Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
    • Zhang Y., et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:3147-3150.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 3147-3150
    • Zhang, Y.1
  • 83
    • 33746701934 scopus 로고    scopus 로고
    • Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters
    • Kuroiwa Y., et al. Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. Cancer Lett. 2006, 241:275-280.
    • (2006) Cancer Lett. , vol.241 , pp. 275-280
    • Kuroiwa, Y.1
  • 84
    • 33745393451 scopus 로고    scopus 로고
    • Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion
    • Gills J.J., et al. Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. Cancer Lett. 2006, 236:72-79.
    • (2006) Cancer Lett. , vol.236 , pp. 72-79
    • Gills, J.J.1
  • 85
    • 33748089664 scopus 로고    scopus 로고
    • Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
    • Xu C., et al. Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. Cancer Res. 2006, 66:8293-8296.
    • (2006) Cancer Res. , vol.66 , pp. 8293-8296
    • Xu, C.1
  • 86
    • 62449233418 scopus 로고    scopus 로고
    • Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells
    • Singh S.V., et al. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Res. 2009, 69:2117-2125.
    • (2009) Cancer Res. , vol.69 , pp. 2117-2125
    • Singh, S.V.1
  • 87
    • 40449129950 scopus 로고    scopus 로고
    • Inhibition of urinary bladder carcinogenesis by broccoli sprouts
    • Munday R., et al. Inhibition of urinary bladder carcinogenesis by broccoli sprouts. Cancer Res. 2008, 68:1593-1600.
    • (2008) Cancer Res. , vol.68 , pp. 1593-1600
    • Munday, R.1
  • 88
    • 33746239394 scopus 로고    scopus 로고
    • Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts
    • Dinkova-Kostova A.T., et al. Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. Cancer Lett. 2006, 240:243-252.
    • (2006) Cancer Lett. , vol.240 , pp. 243-252
    • Dinkova-Kostova, A.T.1
  • 89
    • 69949157311 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway
    • Keum Y.S., et al. Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway. Pharm. Res. 2009, 26:2324-2331.
    • (2009) Pharm. Res. , vol.26 , pp. 2324-2331
    • Keum, Y.S.1
  • 90
    • 77951114133 scopus 로고    scopus 로고
    • Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    • Dinkova-Kostova A.T., et al. Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice. Photochem. Photobiol. Sci. 2010, 9:597-600.
    • (2010) Photochem. Photobiol. Sci. , vol.9 , pp. 597-600
    • Dinkova-Kostova, A.T.1


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