Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 124-131

  Minarini, Anna ^a   Milelli, Andrea ^a   Tumiatti, Vincenzo ^a   Ferruzzi, Lorenzo ^a   Marton, Melinda Rita ^b   Turrini, Eleonora ^a   Hrelia, Patrizia ^a   Fimognari, Carmela ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY POLITEHNICA OF BUCHAREST   (Romania)

Author keywords

Anticancer; Isothiocyanates; Multi target directed ligands; Naphthalene diimides; Sulforaphane

Indexed keywords

1,4,5,8 NAPHTHALENTETRACARBOXYLIC DIIMIDE DERIVATIVE; 2 (2 AMINO ETHYL) 7 (2 DIMETHYLAMINO ETHYL)BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8 TETRAONE; 2 (2 DIMETHYLAMINO ETHYL) 7 (2 ISOTHIOCYANATO ETHYL)BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8 TETRAONE; 2,7 BIS(2 ISOTHIOCYANATO ETHYL)BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8 TETRAONE; 2,7 BIS(3 ISOTHIOCYANATO PROPYL)BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8 TETRAONE; [2 [7 (2 DIMETHYLAMINO ETHYL) 1,3,6,8 TETRAOXO 3,6,7,8 TETRAHYDRO 1H BENZO[LMN][3,8]PHENANTHROLIN 2 YL]ETHYL]CARBAMIC ACID TERT BUTYL ESTER; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; ISOTHIOCYANIC ACID; NAPHTHALENE DERIVATIVE; SULFORAPHANE; UNCLASSIFIED DRUG; VALINOMYCIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE G1 PHASE; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL SURVIVAL; FLOW CYTOMETRY; HUMANS; ISOTHIOCYANATES; JURKAT CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NAPHTHALENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84856003311     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.12.003     Document Type: Article

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