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Volumn 112, Issue , 2015, Pages 273-300

Epithelial-mesenchymal transitions: From cell plasticity to concept elasticity

Author keywords

Cadherin; Carcinoma; Epithelial mesenchymal transition; Gastrulation; Metastable phenotype; Migration; Morphogenesis; Neural crest cells

Indexed keywords

ANIMAL; CELL ADHESION; CELL MOTION; CELL PLASTICITY; DISEASE COURSE; ELASTICITY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; NEOPLASMS; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

EID: 84926135569     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.ctdb.2014.11.021     Document Type: Chapter
Times cited : (141)

References (152)
  • 1
    • 79955685108 scopus 로고    scopus 로고
    • MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells
    • Abell A.N., Jordan N.V., Huang W., Prat A., Midland A.A., Johnson N.L., et al. MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells. Cell Stem Cell 2011, 8(5):525-537.
    • (2011) Cell Stem Cell , vol.8 , Issue.5 , pp. 525-537
    • Abell, A.N.1    Jordan, N.V.2    Huang, W.3    Prat, A.4    Midland, A.A.5    Johnson, N.L.6
  • 2
    • 84907342688 scopus 로고    scopus 로고
    • Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis
    • Aceto N., Bardia A., Miyamoto D.T., Donaldson M.C., Wittner B.S., Spencer J.A., et al. Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell 2014, 158(5):1110-1122.
    • (2014) Cell , vol.158 , Issue.5 , pp. 1110-1122
    • Aceto, N.1    Bardia, A.2    Miyamoto, D.T.3    Donaldson, M.C.4    Wittner, B.S.5    Spencer, J.A.6
  • 3
    • 84876954094 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis
    • Akalay I., Janji B., Hasmim M., Noman M.Z., Andre F., De Cremoux P., et al. Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis. Cancer Research 2013, 73(8):2418-2427.
    • (2013) Cancer Research , vol.73 , Issue.8 , pp. 2418-2427
    • Akalay, I.1    Janji, B.2    Hasmim, M.3    Noman, M.Z.4    Andre, F.5    De Cremoux, P.6
  • 5
    • 0036668283 scopus 로고    scopus 로고
    • Early induction of neural crest cells: Lessons learned from frog, fish and chick
    • Aybar M.J., Mayor R. Early induction of neural crest cells: Lessons learned from frog, fish and chick. Current Opinion in Genetics & Development 2002, 12(4):452-458.
    • (2002) Current Opinion in Genetics & Development , vol.12 , Issue.4 , pp. 452-458
    • Aybar, M.J.1    Mayor, R.2
  • 6
    • 70350012437 scopus 로고    scopus 로고
    • A twist of insight-The role of Twist-family bHLH factors in development
    • Barnes R.M., Firulli A.B. A twist of insight-The role of Twist-family bHLH factors in development. International Journal of Developmental Biology 2009, 53(7):909-924.
    • (2009) International Journal of Developmental Biology , vol.53 , Issue.7 , pp. 909-924
    • Barnes, R.M.1    Firulli, A.B.2
  • 7
    • 25144451812 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition (EMT) and colorectal cancer progression
    • Bates R.C., Mercurio A.M. The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biology & Therapy 2005, 4(4):365-370.
    • (2005) Cancer Biology & Therapy , vol.4 , Issue.4 , pp. 365-370
    • Bates, R.C.1    Mercurio, A.M.2
  • 8
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • Batlle E., Sancho E., Franci C., Dominguez D., Monfar M., Baulida J., et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature Cell Biology 2000, 2(2):84-89.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3    Dominguez, D.4    Monfar, M.5    Baulida, J.6
  • 10
    • 0023074411 scopus 로고
    • Changes in intermediate filament composition during neurogenesis
    • Bennett G.S. Changes in intermediate filament composition during neurogenesis. Current Topics in Developmental Biology 1987, 21:151-183.
    • (1987) Current Topics in Developmental Biology , vol.21 , pp. 151-183
    • Bennett, G.S.1
  • 12
    • 84864367866 scopus 로고    scopus 로고
    • Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT)
    • Biamonti G., Bonomi S., Gallo S., Ghigna C. Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT). Cellular and Molecular Life Sciences 2012, 69(15):2515-2526.
    • (2012) Cellular and Molecular Life Sciences , vol.69 , Issue.15 , pp. 2515-2526
    • Biamonti, G.1    Bonomi, S.2    Gallo, S.3    Ghigna, C.4
  • 13
    • 0029240438 scopus 로고
    • E-cadherin as a tumor (invasion) suppressor gene
    • Birchmeier W. E-cadherin as a tumor (invasion) suppressor gene. Bioessays 1995, 17(2):97-99.
    • (1995) Bioessays , vol.17 , Issue.2 , pp. 97-99
    • Birchmeier, W.1
  • 14
    • 0024461004 scopus 로고
    • Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells
    • Boyer B., Tucker G.C., Valles A.M., Franke W.W., Thiery J.P. Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells. Journal of Cell Biology 1989, 109(4Pt. 1):1495-1509.
    • (1989) Journal of Cell Biology , vol.109 , Issue.4 , pp. 1495-1509
    • Boyer, B.1    Tucker, G.C.2    Valles, A.M.3    Franke, W.W.4    Thiery, J.P.5
  • 15
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not-Routes towards metastasis
    • Brabletz T. To differentiate or not-Routes towards metastasis. Nature Reviews Cancer 2012, 12(6):425-436.
    • (2012) Nature Reviews Cancer , vol.12 , Issue.6 , pp. 425-436
    • Brabletz, T.1
  • 16
    • 79952227361 scopus 로고    scopus 로고
    • CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    • Brown R.L., Reinke L.M., Damerow M.S., Perez D., Chodosh L.A., Yang J., et al. CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. Journal of Clinical Investigation 2011, 121(3):1064-1074.
    • (2011) Journal of Clinical Investigation , vol.121 , Issue.3 , pp. 1064-1074
    • Brown, R.L.1    Reinke, L.M.2    Damerow, M.S.3    Perez, D.4    Chodosh, L.A.5    Yang, J.6
  • 17
    • 84855359334 scopus 로고    scopus 로고
    • A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT
    • Bryant J.L., Britson J., Balko J.M., Willian M., Timmons R., Frolov A., et al. A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT. British Journal of Cancer 2012, 106(1):148-156.
    • (2012) British Journal of Cancer , vol.106 , Issue.1 , pp. 148-156
    • Bryant, J.L.1    Britson, J.2    Balko, J.M.3    Willian, M.4    Timmons, R.5    Frolov, A.6
  • 18
    • 84871998076 scopus 로고    scopus 로고
    • An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
    • Byers L.A., Diao L., Wang J., Saintigny P., Girard L., Peyton M., et al. An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clinical Cancer Research 2013, 19(1):279-290.
    • (2013) Clinical Cancer Research , vol.19 , Issue.1 , pp. 279-290
    • Byers, L.A.1    Diao, L.2    Wang, J.3    Saintigny, P.4    Girard, L.5    Peyton, M.6
  • 19
    • 77955484344 scopus 로고    scopus 로고
    • Twist-ing cell fate: Mechanistic insights into the role of twist in lineage specification/differentiation and tumorigenesis
    • Cakouros D., Raices R.M., Gronthos S., Glackin C.A. Twist-ing cell fate: Mechanistic insights into the role of twist in lineage specification/differentiation and tumorigenesis. Journal of Cellular Biochemistry 2010, 110(6):1288-1298.
    • (2010) Journal of Cellular Biochemistry , vol.110 , Issue.6 , pp. 1288-1298
    • Cakouros, D.1    Raices, R.M.2    Gronthos, S.3    Glackin, C.A.4
  • 20
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A., Perez-Moreno M.A., Rodrigo I., Locascio A., Blanco M.J., del Barrio M.G., et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biology 2000, 2(2):76-83.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    del Barrio, M.G.6
  • 21
    • 84885377160 scopus 로고    scopus 로고
    • A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma
    • Caramel J., Papadogeorgakis E., Hill L., Browne G.J., Richard G., Wierinckx A., et al. A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma. Cancer Cell 2013, 24(4):466-480.
    • (2013) Cancer Cell , vol.24 , Issue.4 , pp. 466-480
    • Caramel, J.1    Papadogeorgakis, E.2    Hill, L.3    Browne, G.J.4    Richard, G.5    Wierinckx, A.6
  • 22
    • 0035167812 scopus 로고    scopus 로고
    • The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
    • Carver E.A., Jiang R., Lan Y., Oram K.F., Gridley T. The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Molecular and Cellular Biology 2001, 21(23):8184-8188.
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.23 , pp. 8184-8188
    • Carver, E.A.1    Jiang, R.2    Lan, Y.3    Oram, K.F.4    Gridley, T.5
  • 23
    • 78651401992 scopus 로고    scopus 로고
    • Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis
    • Casas E., Kim J., Bendesky A., Ohno-Machado L., Wolfe C.J., Yang J. Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Research 2011, 71(1):245-254.
    • (2011) Cancer Research , vol.71 , Issue.1 , pp. 245-254
    • Casas, E.1    Kim, J.2    Bendesky, A.3    Ohno-Machado, L.4    Wolfe, C.J.5    Yang, J.6
  • 24
    • 79952283482 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    • Chang C.J., Chao C.H., Xia W., Yang J.Y., Xiong Y., Li C.W., et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nature Cell Biology 2011, 13(3):317-323.
    • (2011) Nature Cell Biology , vol.13 , Issue.3 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3    Yang, J.Y.4    Xiong, Y.5    Li, C.W.6
  • 25
    • 33746056119 scopus 로고    scopus 로고
    • Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity
    • Chen X., Gumbiner B.M. Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity. Journal of Cell Biology 2006, 174(2):301-313.
    • (2006) Journal of Cell Biology , vol.174 , Issue.2 , pp. 301-313
    • Chen, X.1    Gumbiner, B.M.2
  • 26
    • 0035963314 scopus 로고    scopus 로고
    • Mechanisms of inactivation of E-cadherin in breast carcinoma: Modification of the two-hit hypothesis of tumor suppressor gene
    • Cheng C.W., Wu P.E., Yu J.C., Huang C.S., Yue C.T., Wu C.W., et al. Mechanisms of inactivation of E-cadherin in breast carcinoma: Modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 2001, 20(29):3814-3823.
    • (2001) Oncogene , vol.20 , Issue.29 , pp. 3814-3823
    • Cheng, C.W.1    Wu, P.E.2    Yu, J.C.3    Huang, C.S.4    Yue, C.T.5    Wu, C.W.6
  • 27
    • 77952490843 scopus 로고    scopus 로고
    • Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells
    • Cho K.B., Cho M.K., Lee W.Y., Kang K.W. Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells. Cancer Letters 2010, 293(2):230-239.
    • (2010) Cancer Letters , vol.293 , Issue.2 , pp. 230-239
    • Cho, K.B.1    Cho, M.K.2    Lee, W.Y.3    Kang, K.W.4
  • 28
    • 0033079605 scopus 로고    scopus 로고
    • The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
    • Christofori G., Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends in Biochemical Sciences 1999, 24(2):73-76.
    • (1999) Trends in Biochemical Sciences , vol.24 , Issue.2 , pp. 73-76
    • Christofori, G.1    Semb, H.2
  • 29
    • 84873094470 scopus 로고    scopus 로고
    • Insights into cancer metastasis from a clinicopathologic perspective: Epithelial-Mesenchymal Transition is not a necessary step
    • Chui M.H. Insights into cancer metastasis from a clinicopathologic perspective: Epithelial-Mesenchymal Transition is not a necessary step. International Journal of Cancer 2013, 132(7):1487-1495.
    • (2013) International Journal of Cancer , vol.132 , Issue.7 , pp. 1487-1495
    • Chui, M.H.1
  • 31
    • 77954861745 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer
    • Creighton C.J., Chang J.C., Rosen J.M. Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. Journal of Mammary Gland Biology and Neoplasia 2010, 15(2):253-260.
    • (2010) Journal of Mammary Gland Biology and Neoplasia , vol.15 , Issue.2 , pp. 253-260
    • Creighton, C.J.1    Chang, J.C.2    Rosen, J.M.3
  • 32
    • 0029034061 scopus 로고
    • Expression and functional role of E- and P-cadherins in mouse mammary ductal morphogenesis and growth
    • Daniel C.W., Strickland P., Friedmann Y. Expression and functional role of E- and P-cadherins in mouse mammary ductal morphogenesis and growth. Developmental Biology 1995, 169(2):511-519.
    • (1995) Developmental Biology , vol.169 , Issue.2 , pp. 511-519
    • Daniel, C.W.1    Strickland, P.2    Friedmann, Y.3
  • 33
    • 84856015098 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition, cancer stem cells and treatment resistance
    • Dave B., Mittal V., Tan N.M., Chang J.C. Epithelial-mesenchymal transition, cancer stem cells and treatment resistance. Breast Cancer Research 2012, 14(1):202.
    • (2012) Breast Cancer Research , vol.14 , Issue.1 , pp. 202
    • Dave, B.1    Mittal, V.2    Tan, N.M.3    Chang, J.C.4
  • 34
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B., Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nature Reviews Cancer 2013, 13(2):97-110.
    • (2013) Nature Reviews Cancer , vol.13 , Issue.2 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 36
    • 33644984369 scopus 로고    scopus 로고
    • Desmocollin 3 is required for pre-implantation development of the mouse embryo
    • Den Z., Cheng X., Merched-Sauvage M., Koch P.J. Desmocollin 3 is required for pre-implantation development of the mouse embryo. Journal of Cell Science 2006, 119(Pt. 3):482-489.
    • (2006) Journal of Cell Science , vol.119 , pp. 482-489
    • Den, Z.1    Cheng, X.2    Merched-Sauvage, M.3    Koch, P.J.4
  • 37
    • 5444267235 scopus 로고    scopus 로고
    • N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling
    • Derycke L.D., Bracke M.E. N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. International Journal of Developmental Biology 2004, 48(5-6):463-476.
    • (2004) International Journal of Developmental Biology , vol.48 , Issue.5-6 , pp. 463-476
    • Derycke, L.D.1    Bracke, M.E.2
  • 38
    • 80054784515 scopus 로고    scopus 로고
    • The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer
    • Dhasarathy A., Phadke D., Mav D., Shah R.R., Wade P.A. The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS One 2011, 6(10):e26514.
    • (2011) PLoS One , vol.6 , Issue.10 , pp. e26514
    • Dhasarathy, A.1    Phadke, D.2    Mav, D.3    Shah, R.R.4    Wade, P.A.5
  • 39
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
    • DiMeo T.A., Anderson K., Phadke P., Fan C., Perou C.M., Naber S., et al. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Research 2009, 69(13):5364-5373.
    • (2009) Cancer Research , vol.69 , Issue.13 , pp. 5364-5373
    • DiMeo, T.A.1    Anderson, K.2    Phadke, P.3    Fan, C.4    Perou, C.M.5    Naber, S.6
  • 40
    • 84912123252 scopus 로고    scopus 로고
    • Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development
    • Dong C.Y., Liu X.Y., Wang N., Wang L.N., Yang B.X., Ren Q., et al. Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development. Stem Cells 2014, 32(12):3173-3182.
    • (2014) Stem Cells , vol.32 , Issue.12 , pp. 3173-3182
    • Dong, C.Y.1    Liu, X.Y.2    Wang, N.3    Wang, L.N.4    Yang, B.X.5    Ren, Q.6
  • 41
    • 84876434755 scopus 로고    scopus 로고
    • Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer
    • Dong C., Yuan T., Wu Y., Wang Y., Fan T.W., Miriyala S., et al. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell 2013, 23(3):316-331.
    • (2013) Cancer Cell , vol.23 , Issue.3 , pp. 316-331
    • Dong, C.1    Yuan, T.2    Wu, Y.3    Wang, Y.4    Fan, T.W.5    Miriyala, S.6
  • 43
    • 0020451945 scopus 로고
    • Distribution of fibronectin in the early phase of avian cephalic neural crest cell migration
    • Duband J.L., Thiery J.P. Distribution of fibronectin in the early phase of avian cephalic neural crest cell migration. Developmental Biology 1982, 93(2):308-323.
    • (1982) Developmental Biology , vol.93 , Issue.2 , pp. 308-323
    • Duband, J.L.1    Thiery, J.P.2
  • 45
    • 84864866755 scopus 로고    scopus 로고
    • Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium
    • Ewald A.J., Huebner R.J., Palsdottir H., Lee J.K., Perez M.J., Jorgens D.M., et al. Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. Journal of Cell Science 2012, 125(Pt. 11):2638-2654.
    • (2012) Journal of Cell Science , vol.125 , pp. 2638-2654
    • Ewald, A.J.1    Huebner, R.J.2    Palsdottir, H.3    Lee, J.K.4    Perez, M.J.5    Jorgens, D.M.6
  • 46
    • 81855182066 scopus 로고    scopus 로고
    • Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal
    • Fang X., Cai Y., Liu J., Wang Z., Wu Q., Zhang Z., et al. Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene 2011, 30(47):4707-4720.
    • (2011) Oncogene , vol.30 , Issue.47 , pp. 4707-4720
    • Fang, X.1    Cai, Y.2    Liu, J.3    Wang, Z.4    Wu, Q.5    Zhang, Z.6
  • 47
    • 75749146306 scopus 로고    scopus 로고
    • Plasticity of cell migration: A multiscale tuning model
    • Friedl P., Wolf K. Plasticity of cell migration: A multiscale tuning model. Journal of Cell Biology 2010, 188(1):11-19.
    • (2010) Journal of Cell Biology , vol.188 , Issue.1 , pp. 11-19
    • Friedl, P.1    Wolf, K.2
  • 48
    • 0031215023 scopus 로고    scopus 로고
    • The epithelial cell default-phenotype hypothesis and its implications for cancer
    • Frisch S.M. The epithelial cell default-phenotype hypothesis and its implications for cancer. Bioessays 1997, 19:705-709.
    • (1997) Bioessays , vol.19 , pp. 705-709
    • Frisch, S.M.1
  • 49
    • 84875587594 scopus 로고    scopus 로고
    • Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis
    • Frisch S.M., Schaller M., Cieply B. Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. Journal of Cell Science 2013, 126(Pt. 1):21-29.
    • (2013) Journal of Cell Science , vol.126 , pp. 21-29
    • Frisch, S.M.1    Schaller, M.2    Cieply, B.3
  • 51
    • 84866334922 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial-mesenchymal transition: A link between cancer and inflammation
    • Fuxe J., Karlsson M.C. TGF-beta-induced epithelial-mesenchymal transition: A link between cancer and inflammation. Seminars in Cancer Biology 2012, 22(5-6):455-461.
    • (2012) Seminars in Cancer Biology , vol.22 , Issue.5-6 , pp. 455-461
    • Fuxe, J.1    Karlsson, M.C.2
  • 52
    • 84867115486 scopus 로고    scopus 로고
    • Microenvironmental regulation of epithelial-mesenchymal transitions in cancer
    • Gao D., Vahdat L.T., Wong S., Chang J.C., Mittal V. Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Research 2012, 72(19):4883-4889.
    • (2012) Cancer Research , vol.72 , Issue.19 , pp. 4883-4889
    • Gao, D.1    Vahdat, L.T.2    Wong, S.3    Chang, J.C.4    Mittal, V.5
  • 53
    • 79960423794 scopus 로고    scopus 로고
    • Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas
    • Geradts J., de Herreros A.G., Su Z., Burchette J., Broadwater G., Bachelder R.E. Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas. Human Pathology 2011, 42(8):1125-1131.
    • (2011) Human Pathology , vol.42 , Issue.8 , pp. 1125-1131
    • Geradts, J.1    de Herreros, A.G.2    Su, Z.3    Burchette, J.4    Broadwater, G.5    Bachelder, R.E.6
  • 54
    • 70449526719 scopus 로고    scopus 로고
    • Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility
    • Giampieri S., Manning C., Hooper S., Jones L., Hill C.S., Sahai E. Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nature Cell Biology 2009, 11(11):1287-1296.
    • (2009) Nature Cell Biology , vol.11 , Issue.11 , pp. 1287-1296
    • Giampieri, S.1    Manning, C.2    Hooper, S.3    Jones, L.4    Hill, C.S.5    Sahai, E.6
  • 55
    • 84859822323 scopus 로고    scopus 로고
    • EMT and oxidative stress: A bidirectional interplay affecting tumor malignancy
    • Giannoni E., Parri M., Chiarugi P. EMT and oxidative stress: A bidirectional interplay affecting tumor malignancy. Antioxidants & Redox Signaling 2012, 16(11):1248-1263.
    • (2012) Antioxidants & Redox Signaling , vol.16 , Issue.11 , pp. 1248-1263
    • Giannoni, E.1    Parri, M.2    Chiarugi, P.3
  • 56
    • 77954865524 scopus 로고    scopus 로고
    • Cell polarity in motion: Redefining mammary tissue organization through EMT and cell polarity transitions
    • Godde N.J., Galea R.C., Elsum I.A., Humbert P.O. Cell polarity in motion: Redefining mammary tissue organization through EMT and cell polarity transitions. Journal of Mammary Gland Biology and Neoplasia 2010, 15(2):149-168.
    • (2010) Journal of Mammary Gland Biology and Neoplasia , vol.15 , Issue.2 , pp. 149-168
    • Godde, N.J.1    Galea, R.C.2    Elsum, I.A.3    Humbert, P.O.4
  • 57
    • 79957610057 scopus 로고    scopus 로고
    • The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization
    • Goossens S., Janzen V., Bartunkova S., Yokomizo T., Drogat B., Crisan M., et al. The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization. Blood 2011, 117(21):5620-5630.
    • (2011) Blood , vol.117 , Issue.21 , pp. 5620-5630
    • Goossens, S.1    Janzen, V.2    Bartunkova, S.3    Yokomizo, T.4    Drogat, B.5    Crisan, M.6
  • 58
    • 0020358296 scopus 로고
    • Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells
    • Greenburg G., Hay E.D. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. Journal of Cell Biology 1982, 95(1):333-339.
    • (1982) Journal of Cell Biology , vol.95 , Issue.1 , pp. 333-339
    • Greenburg, G.1    Hay, E.D.2
  • 59
    • 84857817163 scopus 로고    scopus 로고
    • Slug and Sox9 cooperatively determine the mammary stem cell state
    • Guo W., Keckesova Z., Donaher J.L., Shibue T., Tischler V., Reinhardt F., et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 2012, 148(5):1015-1028.
    • (2012) Cell , vol.148 , Issue.5 , pp. 1015-1028
    • Guo, W.1    Keckesova, Z.2    Donaher, J.L.3    Shibue, T.4    Tischler, V.5    Reinhardt, F.6
  • 60
    • 59149085104 scopus 로고    scopus 로고
    • Regulated adhesion as a driving force of gastrulation movements
    • Hammerschmidt M., Wedlich D. Regulated adhesion as a driving force of gastrulation movements. Development 2008, 135(22):3625-3641.
    • (2008) Development , vol.135 , Issue.22 , pp. 3625-3641
    • Hammerschmidt, M.1    Wedlich, D.2
  • 61
    • 0022621979 scopus 로고
    • Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development
    • Hatta K., Takeichi M. Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature 1986, 320(6061):447-449.
    • (1986) Nature , vol.320 , Issue.6061 , pp. 447-449
    • Hatta, K.1    Takeichi, M.2
  • 63
    • 53449094858 scopus 로고    scopus 로고
    • Back and forth between cell fate specification and movement during vertebrate gastrulation
    • Heisenberg C.P., Solnica-Krezel L. Back and forth between cell fate specification and movement during vertebrate gastrulation. Current Opinion in Genetics & Development 2008, 18(4):311-316.
    • (2008) Current Opinion in Genetics & Development , vol.18 , Issue.4 , pp. 311-316
    • Heisenberg, C.P.1    Solnica-Krezel, L.2
  • 65
    • 77951900538 scopus 로고    scopus 로고
    • Beyond epithelial to mesenchymal transition: A novel role for the transcription factor Snail in inflammation and wound healing
    • Hotz B., Visekruna A., Buhr H.J., Hotz H.G. Beyond epithelial to mesenchymal transition: A novel role for the transcription factor Snail in inflammation and wound healing. Journal of Gastrointestinal Surgery 2010, 14(2):388-397.
    • (2010) Journal of Gastrointestinal Surgery , vol.14 , Issue.2 , pp. 388-397
    • Hotz, B.1    Visekruna, A.2    Buhr, H.J.3    Hotz, H.G.4
  • 66
    • 79956049096 scopus 로고    scopus 로고
    • RB1 and p53 at the crossroad of EMT and triple-negative breast cancer
    • Jiang Z., Jones R., Liu J.C., Deng T., Robinson T., Chung P.E., et al. RB1 and p53 at the crossroad of EMT and triple-negative breast cancer. Cell Cycle 2011, 10(10):1563-1570.
    • (2011) Cell Cycle , vol.10 , Issue.10 , pp. 1563-1570
    • Jiang, Z.1    Jones, R.2    Liu, J.C.3    Deng, T.4    Robinson, T.5    Chung, P.E.6
  • 67
    • 79954579633 scopus 로고    scopus 로고
    • EMT: A new vision of hypoxia promoting cancer progression
    • Jiang J., Tang Y.L., Liang X.H. EMT: A new vision of hypoxia promoting cancer progression. Cancer Biology & Therapy 2011, 11(8):714-723.
    • (2011) Cancer Biology & Therapy , vol.11 , Issue.8 , pp. 714-723
    • Jiang, J.1    Tang, Y.L.2    Liang, X.H.3
  • 68
    • 79951871973 scopus 로고    scopus 로고
    • An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer
    • Katz E., Dubois-Marshall S., Sims A.H., Gautier P., Caldwell H., Meehan R.R., et al. An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. PLoS One 2011, 6(2):e17083.
    • (2011) PLoS One , vol.6 , Issue.2 , pp. e17083
    • Katz, E.1    Dubois-Marshall, S.2    Sims, A.H.3    Gautier, P.4    Caldwell, H.5    Meehan, R.R.6
  • 69
    • 24644445739 scopus 로고    scopus 로고
    • Cell migration during gastrulation
    • Keller R. Cell migration during gastrulation. Current Opinion in Cell Biology 2005, 17(5):533-541.
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.5 , pp. 533-541
    • Keller, R.1
  • 70
    • 84860367807 scopus 로고    scopus 로고
    • What is bad in cancer is good in the embryo: Importance of EMT in neural crest development
    • Kerosuo L., Bronner-Fraser M. What is bad in cancer is good in the embryo: Importance of EMT in neural crest development. Seminars in Cell & Developmental Biology 2012, 23(3):320-332.
    • (2012) Seminars in Cell & Developmental Biology , vol.23 , Issue.3 , pp. 320-332
    • Kerosuo, L.1    Bronner-Fraser, M.2
  • 71
    • 0032414392 scopus 로고    scopus 로고
    • The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation
    • Kim S.H., Yamamoto A., Bouwmeester T., Agius E., Robertis E.M. The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation. Development 1998, 125(23):4681-4690.
    • (1998) Development , vol.125 , Issue.23 , pp. 4681-4690
    • Kim, S.H.1    Yamamoto, A.2    Bouwmeester, T.3    Agius, E.4    Robertis, E.M.5
  • 72
    • 0023218503 scopus 로고
    • Distribution of basement membrane antigens in cryopreserved early embryonic hearts
    • Kitten G.T., Markwald R.R., Bolender D.L. Distribution of basement membrane antigens in cryopreserved early embryonic hearts. Anatomical Record 1987, 217(4):379-390.
    • (1987) Anatomical Record , vol.217 , Issue.4 , pp. 379-390
    • Kitten, G.T.1    Markwald, R.R.2    Bolender, D.L.3
  • 73
    • 65649153358 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: A cancer researcher's conceptual friend and foe
    • Klymkowsky M.W., Savagner P. Epithelial-mesenchymal transition: A cancer researcher's conceptual friend and foe. American Journal of Pathology 2009, 174(5):1588-1593.
    • (2009) American Journal of Pathology , vol.174 , Issue.5 , pp. 1588-1593
    • Klymkowsky, M.W.1    Savagner, P.2
  • 74
    • 70349859809 scopus 로고    scopus 로고
    • Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells
    • Kurrey N.K., Jalgaonkar S.P., Joglekar A.V., Ghanate A.D., Chaskar P.D., Doiphode R.Y., et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 2009, 27(9):2059-2068.
    • (2009) Stem Cells , vol.27 , Issue.9 , pp. 2059-2068
    • Kurrey, N.K.1    Jalgaonkar, S.P.2    Joglekar, A.V.3    Ghanate, A.D.4    Chaskar, P.D.5    Doiphode, R.Y.6
  • 77
    • 79955420293 scopus 로고    scopus 로고
    • Cancer theory faces doubts
    • Ledford H. Cancer theory faces doubts. Nature 2011, 472(7343):273.
    • (2011) Nature , vol.472 , Issue.7343 , pp. 273
    • Ledford, H.1
  • 78
    • 84866341656 scopus 로고    scopus 로고
    • A comparison of epithelial-to-mesenchymal transition and re-epithelialization
    • Leopold P.L., Vincent J., Wang H. A comparison of epithelial-to-mesenchymal transition and re-epithelialization. Seminars in Cancer Biology 2012, 22(5-6):471-483.
    • (2012) Seminars in Cancer Biology , vol.22 , Issue.5-6 , pp. 471-483
    • Leopold, P.L.1    Vincent, J.2    Wang, H.3
  • 79
    • 14644399248 scopus 로고    scopus 로고
    • Gastrulation movements: The logic and the nuts and bolts
    • Leptin M. Gastrulation movements: The logic and the nuts and bolts. Developmental Cell 2005, 8(3):305-320.
    • (2005) Developmental Cell , vol.8 , Issue.3 , pp. 305-320
    • Leptin, M.1
  • 81
    • 84865839326 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Insights from development
    • Lim J., Thiery J.P. Epithelial-mesenchymal transitions: Insights from development. Development 2012, 139(19):3471-3486.
    • (2012) Development , vol.139 , Issue.19 , pp. 3471-3486
    • Lim, J.1    Thiery, J.P.2
  • 82
    • 84869199718 scopus 로고    scopus 로고
    • Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy
    • Lin C.C., Cheng T.L., Tsai W.H., Tsai H.J., Hu K.H., Chang H.C., et al. Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy. Science Reports 2012, 2:785.
    • (2012) Science Reports , vol.2 , pp. 785
    • Lin, C.C.1    Cheng, T.L.2    Tsai, W.H.3    Tsai, H.J.4    Hu, K.H.5    Chang, H.C.6
  • 84
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133(4):704-715.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 85
    • 0028008219 scopus 로고
    • Invasion promoter versus invasion suppressor molecules: The paradigm of E-cadherin
    • Mareel M., Bracke M., Van Roy F. Invasion promoter versus invasion suppressor molecules: The paradigm of E-cadherin. Molecular Biology Reports 1994, 19(1):45-67.
    • (1994) Molecular Biology Reports , vol.19 , Issue.1 , pp. 45-67
    • Mareel, M.1    Bracke, M.2    Van Roy, F.3
  • 86
    • 0037700454 scopus 로고    scopus 로고
    • Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus
    • Marsden M., DeSimone D.W. Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus. Current Biology 2003, 13(14):1182-1191.
    • (2003) Current Biology , vol.13 , Issue.14 , pp. 1182-1191
    • Marsden, M.1    DeSimone, D.W.2
  • 87
    • 84876705952 scopus 로고    scopus 로고
    • The regulation and functional impact of actin assembly at cadherin cell-cell adhesions
    • Michael M., Yap A.S. The regulation and functional impact of actin assembly at cadherin cell-cell adhesions. Seminars in Cell & Developmental Biology 2013, 24(4):298-307.
    • (2013) Seminars in Cell & Developmental Biology , vol.24 , Issue.4 , pp. 298-307
    • Michael, M.1    Yap, A.S.2
  • 88
    • 0342264492 scopus 로고    scopus 로고
    • Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis
    • Moinfar F., Man Y.G., Arnould L., Bratthauer G.L., Ratschek M., Tavassoli F.A. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis. Cancer Research 2000, 60(9):2562-2566.
    • (2000) Cancer Research , vol.60 , Issue.9 , pp. 2562-2566
    • Moinfar, F.1    Man, Y.G.2    Arnould, L.3    Bratthauer, G.L.4    Ratschek, M.5    Tavassoli, F.A.6
  • 92
    • 51449115370 scopus 로고    scopus 로고
    • Epithelium mesenchyme transitions are crucial morphogenetic events occurring during early development
    • Landes Bioscience; Kluwer Academic, Georgetown, TX; New York, NY, P. Savagner (Ed.)
    • Morali O.G., Savagner P., Larue L. Epithelium mesenchyme transitions are crucial morphogenetic events occurring during early development. Rise and fall of epithelial phenotype: Concepts of epithelial-mesenchymal transition 2005, Landes Bioscience; Kluwer Academic, Georgetown, TX; New York, NY. P. Savagner (Ed.).
    • (2005) Rise and fall of epithelial phenotype: Concepts of epithelial-mesenchymal transition
    • Morali, O.G.1    Savagner, P.2    Larue, L.3
  • 93
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel A.P., Lievre M., Thomas C., Hinkal G., Ansieau S., Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008, 3(8):e2888.
    • (2008) PLoS One , vol.3 , Issue.8 , pp. e2888
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 94
    • 34249035916 scopus 로고    scopus 로고
    • Multiple functions of Snail family genes during palate development in mice
    • Murray S.A., Oram K.F., Gridley T. Multiple functions of Snail family genes during palate development in mice. Development 2007, 134(9):1789-1797.
    • (2007) Development , vol.134 , Issue.9 , pp. 1789-1797
    • Murray, S.A.1    Oram, K.F.2    Gridley, T.3
  • 95
    • 0034234278 scopus 로고    scopus 로고
    • Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor
    • Nabeshima K., Inoue T., Shimao Y., Okada Y., Itoh Y., Seiki M., et al. Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor. Cancer Research 2000, 60(13):3364-3369.
    • (2000) Cancer Research , vol.60 , Issue.13 , pp. 3364-3369
    • Nabeshima, K.1    Inoue, T.2    Shimao, Y.3    Okada, Y.4    Itoh, Y.5    Seiki, M.6
  • 96
    • 0031706575 scopus 로고    scopus 로고
    • Neural crest emigration from the neural tube depends on regulated cadherin expression
    • Nakagawa S., Takeichi M. Neural crest emigration from the neural tube depends on regulated cadherin expression. Development 1998, 125(15):2963-2971.
    • (1998) Development , vol.125 , Issue.15 , pp. 2963-2971
    • Nakagawa, S.1    Takeichi, M.2
  • 97
    • 56849121006 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition during gastrulation: An embryological view
    • Nakaya Y., Sheng G. Epithelial to mesenchymal transition during gastrulation: An embryological view. Development, Growth & Differentiation 2008, 50(9):755-766.
    • (2008) Development, Growth & Differentiation , vol.50 , Issue.9 , pp. 755-766
    • Nakaya, Y.1    Sheng, G.2
  • 98
    • 84887131202 scopus 로고    scopus 로고
    • EMT in developmental morphogenesis
    • Nakaya Y., Sheng G. EMT in developmental morphogenesis. Cancer Letters 2013, 341(1):9-15.
    • (2013) Cancer Letters , vol.341 , Issue.1 , pp. 9-15
    • Nakaya, Y.1    Sheng, G.2
  • 99
    • 84871648551 scopus 로고    scopus 로고
    • Slug controls stem/progenitor cell growth dynamics during mammary gland morphogenesis
    • Nassour M., Idoux-Gillet Y., Selmi A., Come C., Faraldo M.L., Deugnier M.A., et al. Slug controls stem/progenitor cell growth dynamics during mammary gland morphogenesis. PLoS One 2012, 7(12):e53498.
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e53498
    • Nassour, M.1    Idoux-Gillet, Y.2    Selmi, A.3    Come, C.4    Faraldo, M.L.5    Deugnier, M.A.6
  • 100
    • 0033230475 scopus 로고    scopus 로고
    • N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression
    • Nieman M.T., Prudoff R.S., Johnson K.R., Wheelock M.J. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. Journal of Cell Biology 1999, 147(3):631-644.
    • (1999) Journal of Cell Biology , vol.147 , Issue.3 , pp. 631-644
    • Nieman, M.T.1    Prudoff, R.S.2    Johnson, K.R.3    Wheelock, M.J.4
  • 101
    • 84866325625 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity
    • Nieto M.A., Cano A. The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity. Seminars in Cancer Biology 2012, 22(5-6):361-368.
    • (2012) Seminars in Cancer Biology , vol.22 , Issue.5-6 , pp. 361-368
    • Nieto, M.A.1    Cano, A.2
  • 102
    • 0028318730 scopus 로고
    • Control of cell behavior during vertebrate development by Slug, a zinc finger gene
    • Nieto M.A., Sargent M.G., Wilkinson D.G., Cooke J. Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science 1994, 264(5160):835-839.
    • (1994) Science , vol.264 , Issue.5160 , pp. 835-839
    • Nieto, M.A.1    Sargent, M.G.2    Wilkinson, D.G.3    Cooke, J.4
  • 103
    • 77954956275 scopus 로고    scopus 로고
    • Cellular dynamics in the early mouse embryo: From axis formation to gastrulation
    • Nowotschin S., Hadjantonakis A.K. Cellular dynamics in the early mouse embryo: From axis formation to gastrulation. Current Opinion in Genetics & Development 2010, 20(4):420-427.
    • (2010) Current Opinion in Genetics & Development , vol.20 , Issue.4 , pp. 420-427
    • Nowotschin, S.1    Hadjantonakis, A.K.2
  • 105
    • 0024508983 scopus 로고
    • Changing patterns of cytokeratins and vimentin in the early chick embryo
    • Page M. Changing patterns of cytokeratins and vimentin in the early chick embryo. Development 1989, 105(1):97-107.
    • (1989) Development , vol.105 , Issue.1 , pp. 97-107
    • Page, M.1
  • 106
    • 27144518237 scopus 로고    scopus 로고
    • A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression
    • Peinado H., Iglesias-de Del Carmen, la Cruz M., Olmeda D., Csiszar K., Fong K.S., et al. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO Journal 2005, 24(19):3446-3458.
    • (2005) EMBO Journal , vol.24 , Issue.19 , pp. 3446-3458
    • Peinado, H.1    Iglesias-de, D.C.2    la Cruz, M.3    Olmeda, D.4    Csiszar, K.5    Fong, K.S.6
  • 108
    • 79551614327 scopus 로고    scopus 로고
    • Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
    • Proia T.A., Keller P.J., Gupta P.B., Klebba I., Jones A.D., Sedic M., et al. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell 2011, 8(2):149-163.
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 149-163
    • Proia, T.A.1    Keller, P.J.2    Gupta, P.B.3    Klebba, I.4    Jones, A.D.5    Sedic, M.6
  • 109
    • 84875576976 scopus 로고    scopus 로고
    • Further evidence that E-cadherin is not a tumour suppressor gene in invasive ductal carcinoma of the breast: An immunohistochemical study
    • Rakha E.A., Teoh T.K., Lee A.H., Nolan C.C., Ellis I.O., Green A.R. Further evidence that E-cadherin is not a tumour suppressor gene in invasive ductal carcinoma of the breast: An immunohistochemical study. Histopathology 2013, 62(5):695-701.
    • (2013) Histopathology , vol.62 , Issue.5 , pp. 695-701
    • Rakha, E.A.1    Teoh, T.K.2    Lee, A.H.3    Nolan, C.C.4    Ellis, I.O.5    Green, A.R.6
  • 110
    • 0027425517 scopus 로고
    • The cytoskeleton and associated proteins during cleavage, compaction and blastocyst differentiation in the pig
    • Reima I., Lehtonen E., Virtanen I., Flechon J.E. The cytoskeleton and associated proteins during cleavage, compaction and blastocyst differentiation in the pig. Differentiation 1993, 54(1):35-45.
    • (1993) Differentiation , vol.54 , Issue.1 , pp. 35-45
    • Reima, I.1    Lehtonen, E.2    Virtanen, I.3    Flechon, J.E.4
  • 111
    • 84875054847 scopus 로고    scopus 로고
    • P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model
    • Ribeiro A.S., Sousa B., Carreto L., Mendes N., Nobre A.R., Ricardo S., et al. P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model. Journal of Pathology 2013, 229(5):705-718.
    • (2013) Journal of Pathology , vol.229 , Issue.5 , pp. 705-718
    • Ribeiro, A.S.1    Sousa, B.2    Carreto, L.3    Mendes, N.4    Nobre, A.R.5    Ricardo, S.6
  • 112
    • 84878344213 scopus 로고    scopus 로고
    • Occurrence and significance of epithelial-mesenchymal transition in breast cancer
    • Roxanis I. Occurrence and significance of epithelial-mesenchymal transition in breast cancer. Journal of Clinical Pathology 2013, 66(6):517-521.
    • (2013) Journal of Clinical Pathology , vol.66 , Issue.6 , pp. 517-521
    • Roxanis, I.1
  • 113
    • 0034798707 scopus 로고    scopus 로고
    • Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition
    • Savagner P. Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 2001, 23(10):912-923.
    • (2001) Bioessays , vol.23 , Issue.10 , pp. 912-923
    • Savagner, P.1
  • 114
    • 0031005659 scopus 로고    scopus 로고
    • The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
    • Savagner P., Yamada K.M., Thiery J.P. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. Journal of Cell Biology 1997, 137(6):1403-1419.
    • (1997) Journal of Cell Biology , vol.137 , Issue.6 , pp. 1403-1419
    • Savagner, P.1    Yamada, K.M.2    Thiery, J.P.3
  • 115
    • 84866324123 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links
    • Scheel C., Weinberg R.A. Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links. Seminars in Cancer Biology 2012, 22(5-6):396-403.
    • (2012) Seminars in Cancer Biology , vol.22 , Issue.5-6 , pp. 396-403
    • Scheel, C.1    Weinberg, R.A.2
  • 116
    • 0142211292 scopus 로고    scopus 로고
    • Mouse Snail-related transcription repressors regulate chondrocyte extracellular matrix, type II collagen and aggrecan
    • Seki K., Fujimori T., Savagner P., Hata A., Aikawa T., Ogata N., et al. Mouse Snail-related transcription repressors regulate chondrocyte extracellular matrix, type II collagen and aggrecan. Journal of Biological Chemistry 2002, 278:41862-41870.
    • (2002) Journal of Biological Chemistry , vol.278 , pp. 41862-41870
    • Seki, K.1    Fujimori, T.2    Savagner, P.3    Hata, A.4    Aikawa, T.5    Ogata, N.6
  • 119
    • 80052322960 scopus 로고    scopus 로고
    • An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype
    • Shapiro I.M., Cheng A.W., Flytzanis N.C., Balsamo M., Condeelis J.S., Oktay M.H., et al. An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genetics 2011, 7(8):e1002218.
    • (2011) PLoS Genetics , vol.7 , Issue.8 , pp. e1002218
    • Shapiro, I.M.1    Cheng, A.W.2    Flytzanis, N.C.3    Balsamo, M.4    Condeelis, J.S.5    Oktay, M.H.6
  • 120
    • 79960195435 scopus 로고    scopus 로고
    • Snail2 controls mesodermal BMP/Wnt induction of neural crest
    • Shi J., Severson C., Yang J., Wedlich D., Klymkowsky M.W. Snail2 controls mesodermal BMP/Wnt induction of neural crest. Development 2011, 138(15):3135-3145.
    • (2011) Development , vol.138 , Issue.15 , pp. 3135-3145
    • Shi, J.1    Severson, C.2    Yang, J.3    Wedlich, D.4    Klymkowsky, M.W.5
  • 122
    • 15744401970 scopus 로고    scopus 로고
    • Conserved patterns of cell movements during vertebrate gastrulation
    • Solnica-Krezel L. Conserved patterns of cell movements during vertebrate gastrulation. Current Biology 2005, 15(6):R213-R228.
    • (2005) Current Biology , vol.15 , Issue.6 , pp. R213-R228
    • Solnica-Krezel, L.1
  • 124
    • 0022924546 scopus 로고
    • The relationship between emerging neural crest cells and basement membranes in the trunk of the mouse embryo: A TEM and immunocytochemical study
    • Sternberg J., Kimber S.J. The relationship between emerging neural crest cells and basement membranes in the trunk of the mouse embryo: A TEM and immunocytochemical study. Journal of Embryology and Experimental Morphology 1986, 98:251-268.
    • (1986) Journal of Embryology and Experimental Morphology , vol.98 , pp. 251-268
    • Sternberg, J.1    Kimber, S.J.2
  • 125
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker M., Gherardi E., Perryman M., Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 1987, 327(6119):239-242.
    • (1987) Nature , vol.327 , Issue.6119 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 126
    • 77950353236 scopus 로고    scopus 로고
    • Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration
    • Sun Y., Shao L., Bai H., Wang Z.Z., Wu W.S. Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration. Blood 2010, 115(9):1709-1717.
    • (2010) Blood , vol.115 , Issue.9 , pp. 1709-1717
    • Sun, Y.1    Shao, L.2    Bai, H.3    Wang, Z.Z.4    Wu, W.S.5
  • 127
    • 84908086125 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients
    • Tan T.Z., Miow Q.H., Miki Y., Noda T., Mori S., Huang R.Y., et al. Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Molecular Medicine 2014.
    • (2014) EMBO Molecular Medicine
    • Tan, T.Z.1    Miow, Q.H.2    Miki, Y.3    Noda, T.4    Mori, S.5    Huang, R.Y.6
  • 129
    • 22244473343 scopus 로고    scopus 로고
    • The fallacy of epithelial mesenchymal transition in neoplasia
    • discussion 6000-5991
    • Tarin D., Thompson E.W., Newgreen D.F. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Research 2005, 65(14):5996-6000. discussion 6000-5991.
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 5996-6000
    • Tarin, D.1    Thompson, E.W.2    Newgreen, D.F.3
  • 130
    • 84860841774 scopus 로고    scopus 로고
    • Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration
    • Theveneau E., Mayor R. Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration. Developmental Biology 2012, 366(1):34-54.
    • (2012) Developmental Biology , vol.366 , Issue.1 , pp. 34-54
    • Theveneau, E.1    Mayor, R.2
  • 131
    • 72649091778 scopus 로고    scopus 로고
    • Metastasis: Alone or together?
    • Thiery J.P. Metastasis: Alone or together?. Current Biology 2009, 19(24):R1121-R1123.
    • (2009) Current Biology , vol.19 , Issue.24 , pp. R1121-R1123
    • Thiery, J.P.1
  • 132
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139(5):871-890.
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 134
    • 84878983107 scopus 로고    scopus 로고
    • Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming
    • Tiwari N., Tiwari V.K., Waldmeier L., Balwierz P.J., Arnold P., Pachkov M., et al. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell 2013, 23(6):768-783.
    • (2013) Cancer Cell , vol.23 , Issue.6 , pp. 768-783
    • Tiwari, N.1    Tiwari, V.K.2    Waldmeier, L.3    Balwierz, P.J.4    Arnold, P.5    Pachkov, M.6
  • 135
    • 38849093994 scopus 로고    scopus 로고
    • Direct evidence for epithelial-mesenchymal transitions in breast cancer
    • Trimboli A.J., Fukino K., de Bruin A., Wei G., Shen L., Tanner S.M., et al. Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Research 2008, 68(3):937-945.
    • (2008) Cancer Research , vol.68 , Issue.3 , pp. 937-945
    • Trimboli, A.J.1    Fukino, K.2    de Bruin, A.3    Wei, G.4    Shen, L.5    Tanner, S.M.6
  • 136
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai J.H., Donaher J.L., Murphy D.A., Chau S., Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012, 22(6):725-736.
    • (2012) Cancer Cell , vol.22 , Issue.6 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 137
    • 0026094367 scopus 로고
    • Combined effects of extracellular matrix and growth factors on NBT-II rat bladder carcinoma cell dispersion
    • Tucker G.C., Boyer B., Valles A.M., Thiery J.P. Combined effects of extracellular matrix and growth factors on NBT-II rat bladder carcinoma cell dispersion. Journal of Cell Science 1991, 100(Pt. 2):371-380.
    • (1991) Journal of Cell Science , vol.100 , pp. 371-380
    • Tucker, G.C.1    Boyer, B.2    Valles, A.M.3    Thiery, J.P.4
  • 139
    • 0037322308 scopus 로고    scopus 로고
    • Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome
    • Van de Putte T., Maruhashi M., Francis A., Nelles L., Kondoh H., Huylebroeck D., et al. Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. American Journal of Human Genetics 2003, 72(2):465-470.
    • (2003) American Journal of Human Genetics , vol.72 , Issue.2 , pp. 465-470
    • Van de Putte, T.1    Maruhashi, M.2    Francis, A.3    Nelles, L.4    Kondoh, H.5    Huylebroeck, D.6
  • 140
    • 84885352426 scopus 로고    scopus 로고
    • Origins of metastatic traits
    • Vanharanta S., Massague J. Origins of metastatic traits. Cancer Cell 2013, 24(4):410-421.
    • (2013) Cancer Cell , vol.24 , Issue.4 , pp. 410-421
    • Vanharanta, S.1    Massague, J.2
  • 141
    • 84879564968 scopus 로고    scopus 로고
    • Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development
    • Vannier C., Mock K., Brabletz T., Driever W. Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development. Journal of Biological Chemistry 2013, 288(26):18643-18659.
    • (2013) Journal of Biological Chemistry , vol.288 , Issue.26 , pp. 18643-18659
    • Vannier, C.1    Mock, K.2    Brabletz, T.3    Driever, W.4
  • 142
    • 85027953065 scopus 로고    scopus 로고
    • Ubiquitination and the Ubiquitin-Proteasome System as regulators of transcription and transcription factors in epithelial mesenchymal transition of cancer
    • Voutsadakis I.A. Ubiquitination and the Ubiquitin-Proteasome System as regulators of transcription and transcription factors in epithelial mesenchymal transition of cancer. Tumour Biology 2012, 33(4):897-910.
    • (2012) Tumour Biology , vol.33 , Issue.4 , pp. 897-910
    • Voutsadakis, I.A.1
  • 143
    • 84866320228 scopus 로고    scopus 로고
    • Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT)
    • Warzecha C.C., Carstens R.P. Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT). Seminars in Cancer Biology 2012, 22(5-6):417-427.
    • (2012) Seminars in Cancer Biology , vol.22 , Issue.5-6 , pp. 417-427
    • Warzecha, C.C.1    Carstens, R.P.2
  • 144
    • 0025119463 scopus 로고
    • Scatter factor: Molecular characteristics and effect on the invasiveness of epithelial cells
    • Weidner K.M., Behrens J., Vandekerckhove J., Birchmeier W. Scatter factor: Molecular characteristics and effect on the invasiveness of epithelial cells. Journal of Cell Biology 1990, 111(5Pt. 1):2097-2108.
    • (1990) Journal of Cell Biology , vol.111 , Issue.5 , pp. 2097-2108
    • Weidner, K.M.1    Behrens, J.2    Vandekerckhove, J.3    Birchmeier, W.4
  • 145
    • 0020627016 scopus 로고
    • Mammary ductal elongation: Differentiation of myoepithelium and basal lamina during branching morphogenesis
    • Williams J.M., Daniel C.W. Mammary ductal elongation: Differentiation of myoepithelium and basal lamina during branching morphogenesis. Developmental Biology 1983, 97(2):274-290.
    • (1983) Developmental Biology , vol.97 , Issue.2 , pp. 274-290
    • Williams, J.M.1    Daniel, C.W.2
  • 147
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • Wu W.S., Heinrichs S., Xu D., Garrison S.P., Zambetti G.P., Adams J.M., et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005, 123(4):641-653.
    • (2005) Cell , vol.123 , Issue.4 , pp. 641-653
    • Wu, W.S.1    Heinrichs, S.2    Xu, D.3    Garrison, S.P.4    Zambetti, G.P.5    Adams, J.M.6
  • 148
    • 84867371728 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression
    • Wu Z.Q., Li X.Y., Hu C.Y., Ford M., Kleer C.G., Weiss S.J. Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(41):16654-16659.
    • (2012) Proceedings of the National Academy of Sciences of the United States of America , vol.109 , Issue.41 , pp. 16654-16659
    • Wu, Z.Q.1    Li, X.Y.2    Hu, C.Y.3    Ford, M.4    Kleer, C.G.5    Weiss, S.J.6
  • 149
    • 84865169224 scopus 로고    scopus 로고
    • Epigenetic reprogramming and post-transcriptional regulation during the epithelial-mesenchymal transition
    • Wu C.Y., Tsai Y.P., Wu M.Z., Teng S.C., Wu K.J. Epigenetic reprogramming and post-transcriptional regulation during the epithelial-mesenchymal transition. Trends in Genetics 2012, 28(9):454-463.
    • (2012) Trends in Genetics , vol.28 , Issue.9 , pp. 454-463
    • Wu, C.Y.1    Tsai, Y.P.2    Wu, M.Z.3    Teng, S.C.4    Wu, K.J.5
  • 150
    • 67549101912 scopus 로고    scopus 로고
    • Unexpected functional redundancy between Twist and Slug (Snail2) and their feedback regulation of NF-kappaB via Nodal and Cerberus
    • Zhang C., Klymkowsky M.W. Unexpected functional redundancy between Twist and Slug (Snail2) and their feedback regulation of NF-kappaB via Nodal and Cerberus. Developmental Biology 2009, 331(2):340-349.
    • (2009) Developmental Biology , vol.331 , Issue.2 , pp. 340-349
    • Zhang, C.1    Klymkowsky, M.W.2
  • 151
    • 84868000009 scopus 로고    scopus 로고
    • MicroRNA control of epithelial-mesenchymal transition and metastasis
    • Zhang J., Ma L. MicroRNA control of epithelial-mesenchymal transition and metastasis. Cancer Metastasis Reviews 2012, 31(3-4):653-662.
    • (2012) Cancer Metastasis Reviews , vol.31 , Issue.3-4 , pp. 653-662
    • Zhang, J.1    Ma, L.2
  • 152
    • 84897977206 scopus 로고    scopus 로고
    • Multilayer control of the EMT master regulators
    • Zheng H., Kang Y. Multilayer control of the EMT master regulators. Oncogene 2014, 33(14):1755-1763.
    • (2014) Oncogene , vol.33 , Issue.14 , pp. 1755-1763
    • Zheng, H.1    Kang, Y.2


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