메뉴 건너뛰기




Volumn 69, Issue 15, 2012, Pages 2515-2526

Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT)

Author keywords

Alternative splicing; EMT; Metastasis; RNA binding proteins; Splicing factors; Tumor progression

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; HERMES ANTIGEN; RAC1 PROTEIN;

EID: 84864367866     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-0931-7     Document Type: Review
Times cited : (53)

References (91)
  • 1
    • 33745297408 scopus 로고    scopus 로고
    • New signals from the invasive front
    • DOI 10.1038/nature04872, PII NATURE04872
    • Christofori G (2006) New signals from the invasive front. Nature 441:444-450 (Pubitemid 44050139)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 444-450
    • Christofori, G.1
  • 2
    • 70450198396 scopus 로고    scopus 로고
    • Epithelialmesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelialmesenchymal transitions in development and disease. Cell 139: 871-890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 3
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • DOI 10.1016/j.devcel.2008.05.009, PII S1534580708002098
    • Yang J, Weinberg RA (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14:818-829 (Pubitemid 351757205)
    • (2008) Developmental Cell , vol.14 , Issue.6 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 4
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9:265-273
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 5
    • 0043172396 scopus 로고    scopus 로고
    • Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
    • DOI 10.1038/nrm1175
    • Grunert S, Jechlinger M, Beug H (2003) Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Natl Rev Mol Cell Biol 4:657-665 (Pubitemid 36934968)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.8 , pp. 657-665
    • Grunert, S.1    Jechlinger, M.2    Beug, H.3
  • 6
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, β-Catenin, and Cadherin pathways
    • DOI 10.1126/science.1094291
    • Nelson WJ, Nusse R (2004) Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303:1483-1487 (Pubitemid 38314410)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 9
    • 60649089997 scopus 로고    scopus 로고
    • Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells
    • Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y(2009) Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15:195-206
    • (2009) Cancer Cell , vol.15 , pp. 195-206
    • Kudo-Saito, C.1    Shirako, H.2    Takeuchi, T.3    Kawakami, Y.4
  • 11
    • 77957726684 scopus 로고    scopus 로고
    • Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene
    • Valacca C, Bonomi S, Buratti E, Pedrotti S, Baralle FE, Sette C, Ghigna C, Biamonti G (2010) Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol 191:87-99
    • (2010) J Cell Biol , vol.191 , pp. 87-99
    • Valacca, C.1    Bonomi, S.2    Buratti, E.3    Pedrotti, S.4    Baralle, F.E.5    Sette, C.6    Ghigna, C.7    Biamonti, G.8
  • 13
    • 79952227361 scopus 로고    scopus 로고
    • CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    • Brown RL, ReinkeLM,DamerowMS, Perez D, Chodosh LA, Yang J, Cheng C (2011) CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest 121:1064-1074
    • (2011) J Clin Invest , vol.121 , pp. 1064-1074
    • Brown, R.L.1    Reinke, L.M.2    Damerow, M.S.3    Perez, D.4    Chodosh, L.A.5    Yang, J.6    Cheng, C.7
  • 14
    • 66049085709 scopus 로고    scopus 로고
    • Alternative splicing and tumor progression
    • Ghigna C, Valacca C, Biamonti G (2008) Alternative splicing and tumor progression. Curr Genomics 9:556-570
    • (2008) Curr Genomics , vol.9 , pp. 556-570
    • Ghigna, C.1    Valacca, C.2    Biamonti, G.3
  • 15
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • DOI 10.1146/annurev.biochem.72.121801.161720
    • Black DL (2003) Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 72:291-336 (Pubitemid 36930448)
    • (2003) Annual Review of Biochemistry , vol.72 , pp. 291-336
    • Black, D.L.1
  • 16
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Luhrmann R (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136:701-718
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Luhrmann, R.3
  • 17
    • 33745899048 scopus 로고    scopus 로고
    • Alternative splicing: New insights from global analyses
    • DOI 10.1016/j.cell.2006.06.023, PII S0092867406008178
    • Blencowe BJ (2006) Alternative splicing: new insights from global analyses. Cell 126:37-47 (Pubitemid 44040990)
    • (2006) Cell , vol.126 , Issue.1 , pp. 37-47
    • Blencowe, B.J.1
  • 18
    • 21244439380 scopus 로고    scopus 로고
    • Regulation of apoptosis by alternative pre-mRNA splicing
    • DOI 10.1016/j.molcel.2005.05.026, PII S1097276505013754
    • Schwerk C, Schulze-Osthoff K (2005) Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 19:1-13 (Pubitemid 40884653)
    • (2005) Molecular Cell , vol.19 , Issue.1 , pp. 1-13
    • Schwerk, C.1    Schulze-Osthoff, K.2
  • 19
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • PanQ, ShaiO,Lee LJ, FreyBJ, Blencowe BJ (2008)Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 40:1413-1415
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Panq Shaiolee, L.J.1    Freybj Blencowe, B.J.2
  • 23
    • 0036337915 scopus 로고    scopus 로고
    • A genomic view of alternative splicing
    • Modrek B, Lee C (2002) A genomic view of alternative splicing. Nat Genet 30:13-19
    • (2002) Nat Genet , vol.30 , pp. 13-19
    • Modrek, B.1    Lee, C.2
  • 24
    • 49949105213 scopus 로고    scopus 로고
    • The multiple lives of NMD factors: Balancing roles in gene and genome regulation
    • Isken O, Maquat LE (2008) The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet 9: 699-712
    • (2008) Nat Rev Genet , vol.9 , pp. 699-712
    • Isken, O.1    Maquat, L.E.2
  • 25
    • 34247330971 scopus 로고    scopus 로고
    • Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements
    • DOI 10.1038/nature05676, PII NATURE05676
    • Lareau LF, Inada M, Green RE, Wengrod JC, Brenner SE (2007) Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements. Nature 446:926-929 (Pubitemid 46633161)
    • (2007) Nature , vol.446 , Issue.7138 , pp. 926-929
    • Lareau, L.F.1    Inada, M.2    Green, R.E.3    Wengrod, J.C.4    Brenner, S.E.5
  • 26
    • 33947305594 scopus 로고    scopus 로고
    • Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay
    • DOI 10.1101/gad.1525507
    • Ni JZ, Grate L, Donohue JP, Preston C, Nobida N, O'Brien G, Shiue L, Clark TA, Blume JE, Ares M Jr (2007) Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. Genes Dev 21:708-718 (Pubitemid 46440292)
    • (2007) Genes and Development , vol.21 , Issue.6 , pp. 708-718
    • Ni, J.Z.1    Grate, L.2    Donohue, J.P.3    Preston, C.4    Nobida, N.5    O'Brien, G.6    Shiue, L.7    Clark, T.A.8    Blume, J.E.9    Ares Jr., M.10
  • 29
    • 10044274340 scopus 로고    scopus 로고
    • Influence of RNA secondary structure on the pre-mRNA splicing process
    • DOI 10.1128/MCB.24.24.10505-10514.2004
    • Buratti E, Baralle FE (2004) Influence of RNA secondary structure on the pre-mRNA splicing process. Mol Cell Biol 24: 10505-10514 (Pubitemid 39603113)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.24 , pp. 10505-10514
    • Buratti, E.1    Baralle, F.E.2
  • 30
    • 79960918747 scopus 로고    scopus 로고
    • RNA structure and the mechanisms of alternative splicing
    • McManus CJ, Graveley BR (2011) RNA structure and the mechanisms of alternative splicing. Curr Opin Genet Dev 21: 373-379
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 373-379
    • McManus, C.J.1    Graveley, B.R.2
  • 31
    • 70350569286 scopus 로고    scopus 로고
    • Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches
    • Chen M, Manley JL (2009) Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Natl Rev Mol Cell Biol 10:741-754
    • (2009) Natl Rev Mol Cell Biol , vol.10 , pp. 741-754
    • Chen, M.1    Manley, J.L.2
  • 32
    • 42449098125 scopus 로고    scopus 로고
    • Splicing regulation: From a parts list of regulatory elements to an integrated splicing code
    • DOI 10.1261/rna.876308
    • Wang Z, Burge CB (2008) Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA 14: 802-813 (Pubitemid 351574901)
    • (2008) RNA , vol.14 , Issue.5 , pp. 802-813
    • Wang, Z.1    Burge, C.B.2
  • 33
    • 0028326761 scopus 로고
    • New insights into the auxiliary domains of eukaryotic RNA binding proteins
    • DOI 10.1016/0014-5793(94)80162-2
    • Biamonti G, Riva S (1994) New insights into the auxiliary domains of eukaryotic RNA-binding proteins. FEBS Lett 340:1-8 (Pubitemid 24094346)
    • (1994) FEBS Letters , vol.340 , Issue.1-2 , pp. 1-8
    • Biamonti, G.1    Riva, S.2
  • 34
    • 0034256020 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing: The logic of combinatorial control
    • DOI 10.1016/S0968-0004(00)01604-2, PII S0968000400016042
    • Smith CW, Valcarcel J (2000) Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem Sci 25:381-388 (Pubitemid 30497249)
    • (2000) Trends in Biochemical Sciences , vol.25 , Issue.8 , pp. 381-388
    • Smith, C.W.J.1    Valcarcel, J.2
  • 35
    • 78049416081 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing regulation in cancer: Pathways and programs unhinged
    • David CJ, Manley JL (2010) Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev 24:2343-2364
    • (2010) Genes Dev , vol.24 , pp. 2343-2364
    • David, C.J.1    Manley, J.L.2
  • 36
    • 62749098351 scopus 로고    scopus 로고
    • A global view of cancer-specific transcript variants by subtractive transcriptomewide analysis
    • He C, Zhou F, Zuo Z, Cheng H, Zhou R (2009) A global view of cancer-specific transcript variants by subtractive transcriptomewide analysis. PLoS One 4:e4732
    • (2009) PLoS One , vol.4
    • He, C.1    Zhou, F.2    Zuo, Z.3    Cheng, H.4    Zhou, R.5
  • 38
    • 16544378889 scopus 로고    scopus 로고
    • Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data
    • Le K,MitsourasK,RoyM,Wang Q,Xu Q,Nelson SF, LeeC (2004) Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data. Nucleic Acids Res 32:e180
    • (2004) Nucleic Acids Res , vol.32
    • Le, K.1    Mitsouras, K.2    Roy, M.3    Wang, Q.4    Xu, Q.5    Nelson, S.F.6    Lee, C.7
  • 39
    • 30944449484 scopus 로고    scopus 로고
    • Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression
    • DOI 10.1101/gad.1382806
    • Pan Q, Saltzman AL, Kim YK, Misquitta C, Shai O, Maquat LE, Frey BJ, Blencowe BJ (2006) Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev 20:153-158 (Pubitemid 43112934)
    • (2006) Genes and Development , vol.20 , Issue.2 , pp. 153-158
    • Pan, Q.1    Saltzman, A.L.2    Yoon, K.K.3    Misquitta, C.4    Shai, O.5    Maquat, L.E.6    Frey, B.J.7    Blencowe, B.J.8
  • 40
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: A MET-driven genetic programme for cancer and stem cells
    • DOI 10.1038/nrc1912, PII NRC1912
    • Boccaccio C, Comoglio PM (2006) Invasive growth: a METdriven genetic programme for cancer and stem cells. Nat Rev Cancer 6:637-645 (Pubitemid 44140861)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.8 , pp. 637-645
    • Boccaccio, C.1    Comoglio, P.M.2
  • 41
    • 35148819860 scopus 로고    scopus 로고
    • Multiple variants of the RON receptor tyrosine kinase: Biochemical properties, tumorigenic activities, and potential drug targets
    • DOI 10.1016/j.canlet.2007.08.007, PII S0304383507003667
    • Lu Y, Yao HP, Wang MH (2007) Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targets. Cancer Lett 257:157-164 (Pubitemid 47538834)
    • (2007) Cancer Letters , vol.257 , Issue.2 , pp. 157-164
    • Lu, Y.1    Yao, H.-P.2    Wang, M.-H.3
  • 42
    • 0034811891 scopus 로고    scopus 로고
    • Identification of HGF-like protein as a novel neurotrophic factor for avian dorsal root ganglion sensory neurons
    • DOI 10.1006/bbrc.2001.4819
    • Funakoshi H, Nakamura T (2001) Identification of HGF-like protein as a novel neurotrophic factor for avian dorsal root ganglion sensory neurons. Biochem Biophys Res Commun 283:606-612 (Pubitemid 32917932)
    • (2001) Biochemical and Biophysical Research Communications , vol.283 , Issue.3 , pp. 606-612
    • Funakoshi, H.1    Nakamura, T.2
  • 44
    • 18144422402 scopus 로고    scopus 로고
    • RON, a tyrosine kinase receptor involved in tumor progression and metastasis
    • DOI 10.1245/ASO.2005.08.013
    • Camp ER, Liu W, Fan F, Yang A, Somcio R, Ellis LM (2005) RON, a tyrosine kinase receptor involved in tumor progression and metastasis. Ann Surg Oncol 12:273-281 (Pubitemid 40616491)
    • (2005) Annals of Surgical Oncology , vol.12 , Issue.4 , pp. 273-281
    • Camp, E.R.1    Liu, W.2    Fan, F.3    Yang, A.4    Somcio, R.5    Ellis, L.M.6
  • 45
    • 0037448657 scopus 로고    scopus 로고
    • Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: Generation of different splicing RON variants and their oncogenic potential
    • DOI 10.1038/sj.onc.1206075
    • Zhou YQ, He C, Chen YQ, Wang D, Wang MH (2003) Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential. Oncogene 22:186-197 (Pubitemid 36174176)
    • (2003) Oncogene , vol.22 , Issue.2 , pp. 186-197
    • Zhou, Y.-Q.1    He, C.2    Chen, Y.-Q.3    Wang, D.4    Wang, M.-H.5
  • 46
    • 35148842564 scopus 로고    scopus 로고
    • Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain
    • Wang MH, Lao WF, Wang D, Luo YL, Yao HP (2007) Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain. Cancer Biol Ther 6:1121-1129 (Pubitemid 351574966)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.7 , pp. 1121-1129
    • Wang, M.-H.1    Lao, W.-F.2    Wang, D.3    Luo, Y.-L.4    Yao, H.-P.5
  • 47
    • 0029837671 scopus 로고    scopus 로고
    • A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype
    • Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996) A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol 16:5518-5526 (Pubitemid 26315071)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.10 , pp. 5518-5526
    • Collesi, C.1    Santoro, M.M.2    Gaudino, G.3    Comoglio, P.M.4
  • 51
    • 77956910480 scopus 로고    scopus 로고
    • HnRNP A2/B1 modulates epithelial-mesenchymal transition in lung cancer cell lines
    • Tauler J, Zudaire E, Liu H, Shih J, Mulshine JL (2010) hnRNP A2/B1 modulates epithelial-mesenchymal transition in lung cancer cell lines. Cancer Res 70:7137-7147
    • (2010) Cancer Res , vol.70 , pp. 7137-7147
    • Tauler, J.1    Zudaire, E.2    Liu, H.3    Shih, J.4    Mulshine, J.L.5
  • 52
    • 79959892321 scopus 로고    scopus 로고
    • Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma
    • Golan-Gerstl R, Cohen M, Shilo A, Suh SS, Bakacs A, Coppola L, Karni R (2011) Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma. Cancer Res 71:4464-4472
    • (2011) Cancer Res , vol.71 , pp. 4464-4472
    • Golan-Gerstl, R.1    Cohen, M.2    Shilo, A.3    Suh, S.S.4    Bakacs, A.5    Coppola, L.6    Karni, R.7
  • 53
    • 77957302252 scopus 로고    scopus 로고
    • Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives
    • Ghigna C, De Toledo M, Bonomi S, Valacca C, Gallo S, Apicella M, Eperon I, Tazi J, Biamonti G (2010) Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: therapeutic potential of bifunctional oligonucleotides and indole derivatives. RNA Biol 7:495-503
    • (2010) RNA Biol , vol.7 , pp. 495-503
    • Ghigna, C.1    De Toledo, M.2    Bonomi, S.3    Valacca, C.4    Gallo, S.5    Apicella, M.6    Eperon, I.7    Tazi, J.8    Biamonti, G.9
  • 55
    • 0033581944 scopus 로고    scopus 로고
    • Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors
    • Jordan P, Brazao R, Boavida MG, Gespach C, Chastre E (1999) Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. Oncogene 18:6835-6839
    • (1999) Oncogene , vol.18 , pp. 6835-6839
    • Jordan, P.1    Brazao, R.2    Boavida, M.G.3    Gespach, C.4    Chastre, E.5
  • 56
    • 11244313840 scopus 로고    scopus 로고
    • Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
    • DOI 10.1038/sj.onc.1208182
    • Singh A, Karnoub AE, Palmby TR, Lengyel E, Sondek J, Der CJ (2004) Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene 23: 9369-9380 (Pubitemid 40069669)
    • (2004) Oncogene , vol.23 , Issue.58 , pp. 9369-9380
    • Singh, A.1    Karnoub, A.E.2    Palmby, T.R.3    Lengyel, E.4    Sondek, J.5    Der, C.J.6
  • 57
    • 33744965194 scopus 로고    scopus 로고
    • Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells
    • DOI 10.1074/jbc.M513243200
    • Matos P, Jordan P (2006) RAC1, but not RAC1B, stimulates RELB-mediated gene transcription in colorectal cancer cells. J Biol Chem 281:13724-13732 (Pubitemid 43855288)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.19 , pp. 13724-13732
    • Matos, P.1    Jordan, P.2
  • 58
    • 0034659739 scopus 로고    scopus 로고
    • Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new isoform, Rac1b
    • Schnelzer A, Prechtel D, Knaus U, Dehne K, Gerhard M, Graeff H, Harbeck N, Schmitt M, Lengyel E (2000) Rac1 in human breast cancer: overexpression, mutation analysis and characterization of a new isoform, Rac1b. Oncogene 19:3013-3020 (Pubitemid 30389092)
    • (2000) Oncogene , vol.19 , Issue.26 , pp. 3013-3020
    • Schnelzer, A.1    Prechtel, D.2    Knaus, U.3    Dehne, K.4    Gerhard, M.5    Graeff, H.6    Harbeck, N.7    Schmitt, M.8    Lengyel, E.9
  • 59
    • 70350782482 scopus 로고    scopus 로고
    • Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways
    • Goncalves V, Matos P, Jordan P (2009) Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. Hum Mol Genet 18: 3696-3707
    • (2009) Hum Mol Genet , vol.18 , pp. 3696-3707
    • Goncalves, V.1    Matos, P.2    Jordan, P.3
  • 60
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127:469-480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 61
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161-174 (Pubitemid 37328786)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.3 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 67
    • 77950561915 scopus 로고    scopus 로고
    • CD44, a therapeutic target for metastasising tumours
    • Orian-Rousseau V (2010) CD44, a therapeutic target for metastasising tumours. Eur J Cancer 46:1271-1277
    • (2010) Eur J Cancer , vol.46 , pp. 1271-1277
    • Orian-Rousseau, V.1
  • 69
    • 0037069651 scopus 로고    scopus 로고
    • Signal-dependent regulation of splicing via phosphorylation of Sam68
    • DOI 10.1038/nature01153
    • Matter N, Herrlich P, Konig H (2002) Signal-dependent regulation of splicing via phosphorylation of Sam68. Nature 420:691-695 (Pubitemid 36764503)
    • (2002) Nature , vol.420 , Issue.6916 , pp. 691-695
    • Matter, N.1    Herrlich, P.2    Konig, H.3
  • 70
    • 33645220093 scopus 로고    scopus 로고
    • Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion
    • Cheng C, Sharp PA (2006) Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol 26:362-370
    • (2006) Mol Cell Biol , vol.26 , pp. 362-370
    • Cheng, C.1    Sharp, P.A.2
  • 71
  • 72
    • 33745606029 scopus 로고    scopus 로고
    • A positive feedback loop couples Ras activation and CD44 alternative splicing
    • DOI 10.1101/gad.1430906
    • Cheng C, Yaffe MB, Sharp PA (2006) A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev 20:1715-1720 (Pubitemid 43992879)
    • (2006) Genes and Development , vol.20 , Issue.13 , pp. 1715-1720
    • Cheng, C.1    Yaffe, M.B.2    Sharp, P.A.3
  • 73
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: Provocative insights from epigenomics
    • DOI 10.1038/nrg2341, PII NRG2341
    • Suzuki MM, Bird A (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9:465-476 (Pubitemid 351693975)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.6 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 74
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B (2004) The history of cancer epigenetics. Nat Rev Cancer 4:143-153 (Pubitemid 38198742)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 75
    • 30044440197 scopus 로고    scopus 로고
    • Chromatin, transcript elongation and alternative splicing
    • DOI 10.1038/nsmb0106-5
    • Kornblihtt AR (2006) Chromatin, transcript elongation and alternative splicing. Nat Struct Mol Biol 13:5-7 (Pubitemid 43049394)
    • (2006) Nature Structural and Molecular Biology , vol.13 , Issue.1 , pp. 5-7
    • Kornblihtt, A.R.1
  • 77
    • 79952364016 scopus 로고    scopus 로고
    • Histone H3 lysine 9 trimethylation and HP1c favor inclusion of alternative exons
    • Saint-André V, Batsché E, Rachez C, Muchardt C (2011) Histone H3 lysine 9 trimethylation and HP1c favor inclusion of alternative exons. Nat Struct Mol Biol 18:337-344
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 337-344
    • Saint-André, V.1    Batsché, E.2    Rachez, C.3    Muchardt, C.4
  • 78
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • DOI 10.1038/35102167
    • Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105-111 (Pubitemid 33041634)
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 80
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: From development to cancer
    • Turner N, Grose R (2010) Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 10:116-129
    • (2010) Nat Rev Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 81
    • 0027198248 scopus 로고
    • Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy
    • Yan G, Fukabori Y,McBride G, Nikolaropolous S, McKeehan WL (1993) Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Mol Cell Biol 13:4513-4522 (Pubitemid 23220358)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.8 , pp. 4513-4522
    • Yan, G.1    Fukabori, Y.2    McBride, G.3    Nikolaropolous, S.4    McKeehan, W.L.5
  • 82
    • 0036810248 scopus 로고    scopus 로고
    • RNAi-mediated PTB depletion leads to enhanced exon definition
    • Wagner EJ, Garcia-Blanco MA (2002) RNAi-mediated PTB depletion leads to enhanced exon definition. Mol Cell 10:943-994
    • (2002) Mol Cell , vol.10 , pp. 943-994
    • Wagner, E.J.1    Garcia-Blanco, M.A.2
  • 85
    • 0033835133 scopus 로고    scopus 로고
    • An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein
    • Carstens RP, Wagner EJ, Garcia-Blanco MA (2000) An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. Mol Cell Biol 20:7388-7400
    • (2000) Mol Cell Biol , vol.20 , pp. 7388-7400
    • Carstens, R.P.1    Wagner, E.J.2    Garcia-Blanco, M.A.3
  • 86
    • 50249176008 scopus 로고    scopus 로고
    • HnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc
    • Mauger DM, Lin C, Garcia-Blanco MA (2008) hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mol Cell Biol 28:5403-5419
    • (2008) Mol Cell Biol , vol.28 , pp. 5403-5419
    • Mauger, D.M.1    Lin, C.2    Garcia-Blanco, M.A.3
  • 87
    • 61649087689 scopus 로고    scopus 로고
    • ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing
    • Warzecha CC, Sato TK, Nabet B, Hogenesch JB, Carstens RP (2009) ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell 33:591-601
    • (2009) Mol Cell , vol.33 , pp. 591-601
    • Warzecha, C.C.1    Sato, T.K.2    Nabet, B.3    Hogenesch, J.B.4    Carstens, R.P.5
  • 89
    • 77951233751 scopus 로고    scopus 로고
    • Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets
    • Weise A, Bruser K, Elfert S, Wallmen B, Wittel Y, Wöhrle S, Hecht A (2010) Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res 38:1964-1981
    • (2010) Nucleic Acids Res , vol.38 , pp. 1964-1981
    • Weise, A.1    Bruser, K.2    Elfert, S.3    Wallmen, B.4    Wittel, Y.5    Wöhrle, S.6    Hecht, A.7
  • 90
    • 52249112704 scopus 로고    scopus 로고
    • EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition
    • Hirano M, Hashimoto S, Yonemura S, Sabe H, Aizawa S (2008) EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol 182:1217-1230
    • (2008) J Cell Biol , vol.182 , pp. 1217-1230
    • Hirano, M.1    Hashimoto, S.2    Yonemura, S.3    Sabe, H.4    Aizawa, S.5
  • 91
    • 54549102285 scopus 로고    scopus 로고
    • Coordinated protein sorting, targeting and distribution in polarized cells
    • Mellman I, Nelson WJ (2008) Coordinated protein sorting, targeting and distribution in polarized cells. Natl Rev Mol Cell Biol 9:833-845
    • (2008) Natl Rev Mol Cell Biol , vol.9 , pp. 833-845
    • Mellman, I.1    Nelson, W.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.