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Volumn 16, Issue 2, 2015, Pages 249-264

Exercise improves mitochondrial and redox-regulated stress responses in the elderly: better late than never!

Author keywords

Ageing; Exercise training; Mitochondria; Nitrogen species; Reactive oxygen; Skeletal muscle; Stress responses

Indexed keywords

AEROBIC CAPACITY; AGED; AGING; BIOGENESIS; EXERCISE; HOMEOSTASIS; HUMAN; MITOCHONDRION; MUSCLE CONTRACTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REDOX STRESS; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; BIOLOGICAL MODEL; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

EID: 84925536798     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-014-9546-8     Document Type: Review
Times cited : (53)

References (146)
  • 2
    • 0036903174 scopus 로고    scopus 로고
    • Adaptations of skeletal muscle to exercise: rapid increase in transcriptional co-activator PGC-1
    • COI: 1:CAS:528:DC%2BD38Xps1Ojtbk%3D, PID: 12468452
    • Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M et al (2002) Adaptations of skeletal muscle to exercise: rapid increase in transcriptional co-activator PGC-1. FASEB J 16:1879–1886
    • (2002) FASEB J , vol.16 , pp. 1879-1886
    • Baar, K.1    Wende, A.R.2    Jones, T.E.3    Marison, M.4    Nolte, L.A.5    Chen, M.6
  • 3
    • 77955596297 scopus 로고    scopus 로고
    • Sedentary aging increases resting and exercise-induced intramuscular free radical formation
    • COI: 1:CAS:528:DC%2BC3cXhtVyksrnO, PID: 20507973
    • Bailey DM, McEneny J, Mathieu-Costello O, Henry RR, James PE, McCord JM et al (2010) Sedentary aging increases resting and exercise-induced intramuscular free radical formation. J Appl Physiol 109:449–456
    • (2010) J Appl Physiol , vol.109 , pp. 449-456
    • Bailey, D.M.1    McEneny, J.2    Mathieu-Costello, O.3    Henry, R.R.4    James, P.E.5    McCord, J.M.6
  • 4
    • 84894620403 scopus 로고    scopus 로고
    • The emerging role of p53 in exercise metabolism
    • PID: 24264057
    • Bartlett JD, Close GL, Drust B, Morton JP (2014) The emerging role of p53 in exercise metabolism. Sports Med 44:303–309
    • (2014) Sports Med , vol.44 , pp. 303-309
    • Bartlett, J.D.1    Close, G.L.2    Drust, B.3    Morton, J.P.4
  • 5
    • 69249089756 scopus 로고    scopus 로고
    • Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function
    • COI: 1:CAS:528:DC%2BD1MXhtFGrtbnI, PID: 19571205
    • Betik AC, Thomas MM, Wright KJ, Riel CD, Hepple RT (2009) Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function. Am J Physiol Regul Integr Comp Physiol 297:R744–R755
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297 , pp. 744-755
    • Betik, A.C.1    Thomas, M.M.2    Wright, K.J.3    Riel, C.D.4    Hepple, R.T.5
  • 6
    • 81355132625 scopus 로고    scopus 로고
    • Lifetime sedentary living accelerates some aspects of secondary aging
    • PID: 21836048
    • Booth FW, Laye MJ, Roberts MD (2011) Lifetime sedentary living accelerates some aspects of secondary aging. J Appl Physiol 111:1497–1504
    • (2011) J Appl Physiol , vol.111 , pp. 1497-1504
    • Booth, F.W.1    Laye, M.J.2    Roberts, M.D.3
  • 7
    • 84861183528 scopus 로고    scopus 로고
    • The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle
    • COI: 1:CAS:528:DC%2BC38XlvVyht7k%3D, PID: 22449457
    • Bori Z, Zhao Z, Kolati E, Fatouros IG, Jamurtas AZ, Dourousdos II et al (2012) The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle. Exp Gerontol 47:417–424
    • (2012) Exp Gerontol , vol.47 , pp. 417-424
    • Bori, Z.1    Zhao, Z.2    Kolati, E.3    Fatouros, I.G.4    Jamurtas, A.Z.5    Dourousdos, I.I.6
  • 8
    • 79954504166 scopus 로고    scopus 로고
    • Basic principles and emerging concepts in the redox control of transcription factors
    • COI: 1:CAS:528:DC%2BC3MXhtFWjs77J, PID: 21194351
    • Brigelius-Flohe R, Flohe L (2011) Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal 15:2335–2381
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2335-2381
    • Brigelius-Flohe, R.1    Flohe, L.2
  • 9
    • 50049091026 scopus 로고    scopus 로고
    • Repeated bouts of aerobic exercise lead to reductions in free radical generation and nuclear kB activation
    • Brooks SV, Vasilaki A, Larkin LM, McArdle A, Jackson MJ (2008) Repeated bouts of aerobic exercise lead to reductions in free radical generation and nuclear kB activation. J Physiol 596:3979–3990
    • (2008) J Physiol , vol.596 , pp. 3979-3990
    • Brooks, S.V.1    Vasilaki, A.2    Larkin, L.M.3    McArdle, A.4    Jackson, M.J.5
  • 10
    • 0036089622 scopus 로고    scopus 로고
    • Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia
    • PID: 12015381
    • Bua EA, McKeirnan SH, Wanagat J, McKenzie D, Aiken J (2002) Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia. J Appl Physiol 92:2617–2624
    • (2002) J Appl Physiol , vol.92 , pp. 2617-2624
    • Bua, E.A.1    McKeirnan, S.H.2    Wanagat, J.3    McKenzie, D.4    Aiken, J.5
  • 11
    • 33748643416 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations accumulate to detrimental levels in aged human muscle fibres
    • COI: 1:CAS:528:DC%2BD28Xpt1Sntrc%3D, PID: 16909385
    • Bua EA, Johnson J, Herbst A, Delong B, McKenzie D, Salmat S, Aiken JM (2006) Mitochondrial DNA mutations accumulate to detrimental levels in aged human muscle fibres. Am J Hum Genet 79:469–480
    • (2006) Am J Hum Genet , vol.79 , pp. 469-480
    • Bua, E.A.1    Johnson, J.2    Herbst, A.3    Delong, B.4    McKenzie, D.5    Salmat, S.6    Aiken, J.M.7
  • 12
    • 37749021969 scopus 로고    scopus 로고
    • Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans
    • COI: 1:CAS:528:DC%2BD1cXhtFaqurY%3D, PID: 17991697
    • Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, MacDonald MJ, McGee SL et al (2008) Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol 586:151–160
    • (2008) J Physiol , vol.586 , pp. 151-160
    • Burgomaster, K.A.1    Howarth, K.R.2    Phillips, S.M.3    Rakobowchuk, M.4    MacDonald, M.J.5    McGee, S.L.6
  • 13
    • 84890124303 scopus 로고    scopus 로고
    • Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite
    • COI: 1:CAS:528:DC%2BC3sXhtlCnsLjI, PID: 23872352
    • Carballal S, Bartesaghi S, Radi R (2014) Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite. Biochim Biophys Acta 1840:768–780
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 768-780
    • Carballal, S.1    Bartesaghi, S.2    Radi, R.3
  • 14
    • 27544436207 scopus 로고    scopus 로고
    • Microdialysis studies of extracellular reactive oxygen species production in skeletal muscle: factors influencing the reduction of cytochrome c and hydroxylation of salicylate
    • COI: 1:CAS:528:DC%2BD2MXhtFyksLvE, PID: 16274881
    • Close GL, Ashton T, McArdle A, Jackson MJ (2005) Microdialysis studies of extracellular reactive oxygen species production in skeletal muscle: factors influencing the reduction of cytochrome c and hydroxylation of salicylate. Free Radic Biol Med 39:1460–1467
    • (2005) Free Radic Biol Med , vol.39 , pp. 1460-1467
    • Close, G.L.1    Ashton, T.2    McArdle, A.3    Jackson, M.J.4
  • 15
    • 33947407666 scopus 로고    scopus 로고
    • Release of superoxide from skeletal muscle of adult and old mice: an experimental test of the reductive hotspot hypothesis
    • COI: 1:CAS:528:DC%2BD2sXksVWlurw%3D, PID: 17328687
    • Close GL, Kayani AC, Ashton T, McArdle A, Jackson MJ (2007) Release of superoxide from skeletal muscle of adult and old mice: an experimental test of the reductive hotspot hypothesis. Aging Cell 6:189–195
    • (2007) Aging Cell , vol.6 , pp. 189-195
    • Close, G.L.1    Kayani, A.C.2    Ashton, T.3    McArdle, A.4    Jackson, M.J.5
  • 16
    • 84878243375 scopus 로고    scopus 로고
    • PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males
    • COI: 1:CAS:528:DC%2BC38XhslKmu7vJ, PID: 23187721
    • Cobley JN, Bartlett JD, Kayani AC, Murray SW, Louhelainen J, Donovan T et al (2012) PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males. Biogerontology 13:621–631
    • (2012) Biogerontology , vol.13 , pp. 621-631
    • Cobley, J.N.1    Bartlett, J.D.2    Kayani, A.C.3    Murray, S.W.4    Louhelainen, J.5    Donovan, T.6
  • 18
    • 84895798073 scopus 로고    scopus 로고
    • Lifelong training preserves some redox-regulated adaptive responses following an acute exercise stimulus in aged human skeletal muscle
    • COI: 1:CAS:528:DC%2BC2cXntFyjsL4%3D, PID: 24525000
    • Cobley JN, Sakellariou GK, Owens DJ, Murray S, Waldron S, Gregson W et al (2014) Lifelong training preserves some redox-regulated adaptive responses following an acute exercise stimulus in aged human skeletal muscle. Free Radic Biol Med 70:23–32
    • (2014) Free Radic Biol Med , vol.70 , pp. 23-32
    • Cobley, J.N.1    Sakellariou, G.K.2    Owens, D.J.3    Murray, S.4    Waldron, S.5    Gregson, W.6
  • 19
    • 34548371839 scopus 로고    scopus 로고
    • The molecular basis of training adaptation
    • PID: 17722947
    • Coffey VG, Hawley JA (2007) The molecular basis of training adaptation. Sports Med 37:737–763
    • (2007) Sports Med , vol.37 , pp. 737-763
    • Coffey, V.G.1    Hawley, J.A.2
  • 20
    • 14944341734 scopus 로고    scopus 로고
    • Oral leucine administration stimulates protein Synthesis in rat skeletal muscle
    • COI: 1:CAS:528:DC%2BD2MXit12nsbw%3D, PID: 15735066
    • Crozier SJ, Kimball SR, Emmert SW, Anthon JC, Jefferson LS (2005) Oral leucine administration stimulates protein Synthesis in rat skeletal muscle. J Nutr 135:376–382
    • (2005) J Nutr , vol.135 , pp. 376-382
    • Crozier, S.J.1    Kimball, S.R.2    Emmert, S.W.3    Anthon, J.C.4    Jefferson, L.S.5
  • 23
    • 33947507007 scopus 로고    scopus 로고
    • Inactivation and nitration of human superoxide dismutase (SOD) by fluxes of nitric oxide and superoxide
    • COI: 1:CAS:528:DC%2BD2sXjslGksr0%3D, PID: 17395009
    • Demicheli V, Quijano C, Alvarez B, Radi R (2007) Inactivation and nitration of human superoxide dismutase (SOD) by fluxes of nitric oxide and superoxide. Free Radic Biol Med 42:1359–1368
    • (2007) Free Radic Biol Med , vol.42 , pp. 1359-1368
    • Demicheli, V.1    Quijano, C.2    Alvarez, B.3    Radi, R.4
  • 24
    • 7544233112 scopus 로고    scopus 로고
    • Effects of aging on muscle fibre type and size
    • Deschenes MR (2004) Effects of aging on muscle fibre type and size. Sport Med 34:809–824
    • (2004) Sport Med , vol.34 , pp. 809-824
    • Deschenes, M.R.1
  • 25
    • 35448960851 scopus 로고    scopus 로고
    • Functions and dysfunctions of mitochondrial dynamics
    • COI: 1:CAS:528:DC%2BD2sXhtF2qsLzE, PID: 17928812
    • Detmer SA, Chan DC (2007) Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 8:870–879
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 870-879
    • Detmer, S.A.1    Chan, D.C.2
  • 26
    • 0141566914 scopus 로고    scopus 로고
    • Invited review: aging and sarcopenia
    • Doherty TJ (2003) Invited review: aging and sarcopenia. J Appl Physiol 111:1717–1727
    • (2003) J Appl Physiol , vol.111 , pp. 1717-1727
    • Doherty, T.J.1
  • 27
    • 0037305488 scopus 로고    scopus 로고
    • Effects of aging and caloric restriction on mitochondrial energy production in Gastrocnemius muscle and heart
    • COI: 1:CAS:528:DC%2BD3sXhtlOqtrg%3D, PID: 12388443
    • Drew B, Phaneuf S, Driks A, Selman C, Gredilla R, Lezza A et al (2003) Effects of aging and caloric restriction on mitochondrial energy production in Gastrocnemius muscle and heart. Am J Physiol Regul Integr Comp Physiol 284:R474–R480
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284 , pp. 474-480
    • Drew, B.1    Phaneuf, S.2    Driks, A.3    Selman, C.4    Gredilla, R.5    Lezza, A.6
  • 28
    • 84873378527 scopus 로고    scopus 로고
    • Exercise metabolism and the molecular regulation of skeletal muscle adaptation
    • COI: 1:CAS:528:DC%2BC3sXitFCnsb4%3D, PID: 23395166
    • Egan B, Zierath JR (2013) Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab 17:162–184
    • (2013) Cell Metab , vol.17 , pp. 162-184
    • Egan, B.1    Zierath, J.R.2
  • 29
    • 11144288788 scopus 로고    scopus 로고
    • Aerobic power and insulin action improve in response to endurance exercise training in healthy 77–78 year olds
    • PID: 15591302
    • Evans EM, Racette SB, Petersen LR, Villareal DT, Greiwe JS, Holloszy JO (2005) Aerobic power and insulin action improve in response to endurance exercise training in healthy 77–78 year olds. J Appl Physiol 98:40–45
    • (2005) J Appl Physiol , vol.98 , pp. 40-45
    • Evans, E.M.1    Racette, S.B.2    Petersen, L.R.3    Villareal, D.T.4    Greiwe, J.S.5    Holloszy, J.O.6
  • 31
    • 79953210362 scopus 로고    scopus 로고
    • Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
    • Fernadnez-Marcos PJ, Auwerx J (2011) Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 93:884S–890S
    • (2011) Am J Clin Nutr , vol.93 , pp. 884-890
    • Fernadnez-Marcos, P.J.1    Auwerx, J.2
  • 32
    • 33746012931 scopus 로고    scopus 로고
    • Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuli
    • COI: 1:CAS:528:DC%2BD28XnvF2gsrk%3D, PID: 16731801
    • Fluck M (2006) Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuli. J Exp Biol 209:2239–2248
    • (2006) J Exp Biol , vol.209 , pp. 2239-2248
    • Fluck, M.1
  • 33
    • 84892369382 scopus 로고    scopus 로고
    • How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo
    • COI: 1:CAS:528:DC%2BC3sXhtVCgtrfN, PID: 23747930
    • Forman HJ, Davies KJA, Ursini F (2014) How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med 66:24–35
    • (2014) Free Radic Biol Med , vol.66 , pp. 24-35
    • Forman, H.J.1    Davies, K.J.A.2    Ursini, F.3
  • 34
    • 0025998579 scopus 로고
    • A cross-sectional study of muscle strength and mass in 45–78 year old men and women
    • COI: 1:STN:280:DyaK38%2FktFeltQ%3D%3D, PID: 1938738
    • Frontera WR, Hughes VA, Lutz KJ, Evans WJ (1991) A cross-sectional study of muscle strength and mass in 45–78 year old men and women. J Appl Physiol 71:644–650
    • (1991) J Appl Physiol , vol.71 , pp. 644-650
    • Frontera, W.R.1    Hughes, V.A.2    Lutz, K.J.3    Evans, W.J.4
  • 35
    • 80052830501 scopus 로고    scopus 로고
    • Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance
    • COI: 1:CAS:528:DC%2BC3MXhtValurjE, PID: 21677280
    • Ghosh S, Lertwattanarak R, Lefort N, Molina-Carrion M, Joya-Galeana J, Bowen BP et al (2011) Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance. Diabetes 60:2051–2060
    • (2011) Diabetes , vol.60 , pp. 2051-2060
    • Ghosh, S.1    Lertwattanarak, R.2    Lefort, N.3    Molina-Carrion, M.4    Joya-Galeana, J.5    Bowen, B.P.6
  • 36
    • 84857672185 scopus 로고    scopus 로고
    • Physiological adaptations to low-volume, high-intensity interval training in health and disease
    • COI: 1:CAS:528:DC%2BC38XkslSmsrs%3D, PID: 22289907
    • Gibala M, Little JP, MacDonald MJ, Hawley JA (2012) Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol 590:1077–1084
    • (2012) J Physiol , vol.590 , pp. 1077-1084
    • Gibala, M.1    Little, J.P.2    MacDonald, M.J.3    Hawley, J.A.4
  • 37
    • 78049460582 scopus 로고    scopus 로고
    • Intensity-dependent activation of intracellular signaling pathways in skeletal muscle: role of fibre type recruitment during exercise
    • COI: 1:CAS:528:DC%2BC3cXhsVKltbfP, PID: 21037317
    • Godin R, Ascah A, Daussin FN (2010) Intensity-dependent activation of intracellular signaling pathways in skeletal muscle: role of fibre type recruitment during exercise. J Physiol 588:4073–4074
    • (2010) J Physiol , vol.588 , pp. 4073-4074
    • Godin, R.1    Ascah, A.2    Daussin, F.N.3
  • 38
    • 84901049780 scopus 로고    scopus 로고
    • Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans
    • Gousillou G, Sgarioto N, Kapchinksy S, Purves-Smith F, Norris B, Pion CH et al (2014) Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans. FASEB J 28:1621–1633
    • (2014) FASEB J , vol.28 , pp. 1621-1633
    • Gousillou, G.1    Sgarioto, N.2    Kapchinksy, S.3    Purves-Smith, F.4    Norris, B.5    Pion, C.H.6
  • 39
    • 77949485324 scopus 로고    scopus 로고
    • Antioxidants: molecules, medicines, and myths
    • COI: 1:CAS:528:DC%2BC3cXjs1Onsb8%3D, PID: 20171167
    • Gutteridge JMC, Halliwell B (2010) Antioxidants: molecules, medicines, and myths. Biochem Biophys Res Commun 393:561–564
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 561-564
    • Gutteridge, J.M.C.1    Halliwell, B.2
  • 41
    • 2942572700 scopus 로고    scopus 로고
    • Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?
    • COI: 1:CAS:528:DC%2BD2cXkvVyks7w%3D, PID: 15155533
    • Halliwell B, Whiteman M (2004) Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 142:231–255
    • (2004) Br J Pharmacol , vol.142 , pp. 231-255
    • Halliwell, B.1    Whiteman, M.2
  • 42
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • COI: 1:STN:280:DyaG28%2FosVygsw%3D%3D, PID: 13332224
    • Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298–300
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 43
    • 0019387984 scopus 로고
    • A physiological comparison of young and older endurance athletes
    • COI: 1:STN:280:DyaL387hvFKqsQ%3D%3D, PID: 7327965
    • Heath GW, Hagberg JM, Ehsani AA, Holloszy JO (1981) A physiological comparison of young and older endurance athletes. J Appl Physiol 51:634–640
    • (1981) J Appl Physiol , vol.51 , pp. 634-640
    • Heath, G.W.1    Hagberg, J.M.2    Ehsani, A.A.3    Holloszy, J.O.4
  • 44
    • 37049016418 scopus 로고    scopus 로고
    • The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging
    • Hiona A, Leeuwenburgh C (2008) The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Exp Gerontol 43:23–33
    • (2008) Exp Gerontol , vol.43 , pp. 23-33
    • Hiona, A.1    Leeuwenburgh, C.2
  • 45
    • 0021343295 scopus 로고
    • Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
    • COI: 1:CAS:528:DyaL2cXhvV2hur4%3D, PID: 6373687
    • Holloszy JO, Coyle EF (1984) Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56:831–838
    • (1984) J Appl Physiol , vol.56 , pp. 831-838
    • Holloszy, J.O.1    Coyle, E.F.2
  • 46
    • 84901316606 scopus 로고    scopus 로고
    • Cellular mechanisms and physiological consequences of redox-dependent signalling
    • COI: 1:CAS:528:DC%2BC2cXosV2ls7g%3D, PID: 24854789
    • Holmstrom KM, Finkel T (2014) Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 15:411–421
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 411-421
    • Holmstrom, K.M.1    Finkel, T.2
  • 47
    • 0035112481 scopus 로고    scopus 로고
    • Contractile activity-induced mitochondrial biogenesis in skeletal muscle
    • COI: 1:CAS:528:DC%2BD3MXjsVWmu7s%3D, PID: 11181630
    • Hood DA (2001) Contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol 90:1137–1157
    • (2001) J Appl Physiol , vol.90 , pp. 1137-1157
    • Hood, D.A.1
  • 48
    • 67651237067 scopus 로고    scopus 로고
    • Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle
    • COI: 1:CAS:528:DC%2BD1MXmtFSnurw%3D, PID: 19448716
    • Hood DA (2009) Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle. Appl Physiol Nutr Metab 34:465–472
    • (2009) Appl Physiol Nutr Metab , vol.34 , pp. 465-472
    • Hood, D.A.1
  • 49
    • 58349118928 scopus 로고    scopus 로고
    • Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells
    • COI: 1:CAS:528:DC%2BD1MXpsFCitw%3D%3D, PID: 19005163
    • Irrcher R, Ljubicic V, Hood DA (2009) Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells. Am J Physiol Cell Physiol 296:C116–C123
    • (2009) Am J Physiol Cell Physiol , vol.296 , pp. 116-123
    • Irrcher, R.1    Ljubicic, V.2    Hood, D.A.3
  • 51
    • 70349804298 scopus 로고    scopus 로고
    • Redox regulation of adaptive responses of skeletal muscle to contractile activity
    • COI: 1:CAS:528:DC%2BD1MXht1yjtbjK, PID: 19748570
    • Jackson MJ (2009) Redox regulation of adaptive responses of skeletal muscle to contractile activity. Free Radic Biol Med 47:1267–1275
    • (2009) Free Radic Biol Med , vol.47 , pp. 1267-1275
    • Jackson, M.J.1
  • 52
    • 79955425933 scopus 로고    scopus 로고
    • Age-related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species
    • COI: 1:CAS:528:DC%2BC3MXmslOhtLg%3D, PID: 21320885
    • Jackson MJ, McArdle A (2011) Age-related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species. J Physiol 589:2139–2145
    • (2011) J Physiol , vol.589 , pp. 2139-2145
    • Jackson, M.J.1    McArdle, A.2
  • 53
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
    • PID: 17609368
    • Jager S, Handschin C, St-Pierre J, Spiegelman BM (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proc Natl Acad Sci USA 104:12017–12022
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12017-12022
    • Jager, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 54
    • 62349116477 scopus 로고    scopus 로고
    • The mitochondrial theory of aging: insight from transgenic and knockout mouse models
    • COI: 1:CAS:528:DC%2BD1MXjsVOnur8%3D, PID: 19171187
    • Jang YC, Van Remmen H (2009) The mitochondrial theory of aging: insight from transgenic and knockout mouse models. Exp Gerontol 44:256–260
    • (2009) Exp Gerontol , vol.44 , pp. 256-260
    • Jang, Y.C.1    Van Remmen, H.2
  • 55
    • 78751704988 scopus 로고    scopus 로고
    • Age-associated alterations of the neuromuscular junction
    • Jang YC, Van Remmen H (2011) Age-associated alterations of the neuromuscular junction. Exp Gerontol 46:193–198
    • (2011) Exp Gerontol , vol.46 , pp. 193-198
    • Jang, Y.C.1    Van Remmen, H.2
  • 58
    • 5044227528 scopus 로고    scopus 로고
    • Acute exercise activates nuclear factor (NF)-KB signalling pathway in rat skeletal muscle
    • COI: 1:CAS:528:DC%2BD2cXotFOmsLY%3D, PID: 15466358
    • Ji LL, Gomez-Cabrera MC, Steinhafel N, Vina J (2004) Acute exercise activates nuclear factor (NF)-KB signalling pathway in rat skeletal muscle. FASEB J 18:1499–1506
    • (2004) FASEB J , vol.18 , pp. 1499-1506
    • Ji, L.L.1    Gomez-Cabrera, M.C.2    Steinhafel, N.3    Vina, J.4
  • 59
    • 33744468523 scopus 로고    scopus 로고
    • Exercise and hormesis: activation of cellular antioxidant signalling pathway
    • COI: 1:CAS:528:DC%2BD28Xms1Okt7k%3D, PID: 16804022
    • Ji LL, Gomez-Cabrera MC, Vina J (2006) Exercise and hormesis: activation of cellular antioxidant signalling pathway. Ann NY Acad Sci 1067:425–435
    • (2006) Ann NY Acad Sci , vol.1067 , pp. 425-435
    • Ji, L.L.1    Gomez-Cabrera, M.C.2    Vina, J.3
  • 60
    • 84866444702 scopus 로고    scopus 로고
    • The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low functioning elderly individuals
    • Joesph AM, Adhihttey PJ, Buford TW, Wohlgemuth SE, Lees HA, Nguen LM et al (2012) The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low functioning elderly individuals. Aging Cell 11:801–809
    • (2012) Aging Cell , vol.11 , pp. 801-809
    • Joesph, A.M.1    Adhihttey, P.J.2    Buford, T.W.3    Wohlgemuth, S.E.4    Lees, H.A.5    Nguen, L.M.6
  • 61
    • 84655163961 scopus 로고    scopus 로고
    • Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations
    • COI: 1:CAS:528:DC%2BC38Xitlyjtw%3D%3D, PID: 22027063
    • Kalyanaraman B, Usmar V, Davies KJA, Dennery PA, Forman RJ, Grisham MB et al (2012) Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med 52:1–6
    • (2012) Free Radic Biol Med , vol.52 , pp. 1-6
    • Kalyanaraman, B.1    Usmar, V.2    Davies, K.J.A.3    Dennery, P.A.4    Forman, R.J.5    Grisham, M.B.6
  • 62
    • 53649099811 scopus 로고    scopus 로고
    • The exercise-induced stress response in skeletal muscle: failure during aging
    • COI: 1:CAS:528:DC%2BD1cXht1aqsLjP, PID: 18923581
    • Kayani AC, Morton JP, McArdle A (2008) The exercise-induced stress response in skeletal muscle: failure during aging. Appl Physiol Nutr Metab 33:1033–1041
    • (2008) Appl Physiol Nutr Metab , vol.33 , pp. 1033-1041
    • Kayani, A.C.1    Morton, J.P.2    McArdle, A.3
  • 63
    • 0035109475 scopus 로고    scopus 로고
    • Time course of adaptive responses of human skeletal muscle to oxidative stress induced by non-damaging exercise
    • COI: 1:CAS:528:DC%2BD3MXjsVWmurc%3D, PID: 11181616
    • Khassaf M, Child RB, McArdle A, Brodie DA, Esanu C, Jackson MJ (2001) Time course of adaptive responses of human skeletal muscle to oxidative stress induced by non-damaging exercise. J Appl Physiol 90:1031–1036
    • (2001) J Appl Physiol , vol.90 , pp. 1031-1036
    • Khassaf, M.1    Child, R.B.2    McArdle, A.3    Brodie, D.A.4    Esanu, C.5    Jackson, M.J.6
  • 64
    • 77952903562 scopus 로고    scopus 로고
    • Cell signalling ballet in space and time
    • COI: 1:CAS:528:DC%2BC3cXmsVWmsL8%3D, PID: 20495582
    • Kholodenko B, Hancock JF, Kolch W (2010) Cell signalling ballet in space and time. Nat Rev Mol Cell Biol 11:414–426
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 414-426
    • Kholodenko, B.1    Hancock, J.F.2    Kolch, W.3
  • 65
    • 84863952749 scopus 로고    scopus 로고
    • Age-associated declines in mitochondrial biogenesis are minimised by exercise training
    • COI: 1:CAS:528:DC%2BC38XhtlOmt7%2FO, PID: 22573103
    • Koltai E, Hart N, Taylor AW, Goto S, Nyo JK, Davies KJ et al (2012) Age-associated declines in mitochondrial biogenesis are minimised by exercise training. Am J Physiol Regul Integr Comp Physiol 303:R127–R134
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.303 , pp. 127-134
    • Koltai, E.1    Hart, N.2    Taylor, A.W.3    Goto, S.4    Nyo, J.K.5    Davies, K.J.6
  • 66
    • 84884530383 scopus 로고    scopus 로고
    • Mitochondrial and skeletal muscle health with advancing age
    • COI: 1:CAS:528:DC%2BC3sXptV2nsbw%3D, PID: 23684888
    • Konopka AR, Nair SK (2013) Mitochondrial and skeletal muscle health with advancing age. Mol Cell Endocrinol 379:19–29
    • (2013) Mol Cell Endocrinol , vol.379 , pp. 19-29
    • Konopka, A.R.1    Nair, S.K.2
  • 67
    • 84898974238 scopus 로고    scopus 로고
    • Markers of human skeletal muscle mitochondrial biogenesis and quality control. Effects of age and aerobic exercise training
    • COI: 1:CAS:528:DC%2BC2cXjvVygtbs%3D, PID: 23873965
    • Konopka AR, Suer MK, Wolff CA, Harber MP (2014) Markers of human skeletal muscle mitochondrial biogenesis and quality control. Effects of age and aerobic exercise training. J Gerontol A Biol Sci Med Sci 69:371–378
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 371-378
    • Konopka, A.R.1    Suer, M.K.2    Wolff, C.A.3    Harber, M.P.4
  • 68
    • 77954335451 scopus 로고    scopus 로고
    • Regulation of skeletal muscle mitochondrial function: genes to proteins
    • COI: 1:CAS:528:DC%2BC3cXpvVOrs7s%3D
    • Lanza IR, Nair KS (2010) Regulation of skeletal muscle mitochondrial function: genes to proteins. Acta Physiol 199:529–547
    • (2010) Acta Physiol , vol.199 , pp. 529-547
    • Lanza, I.R.1    Nair, K.S.2
  • 70
    • 38949196761 scopus 로고    scopus 로고
    • PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle
    • COI: 1:CAS:528:DC%2BD1cXit1ykurY%3D, PID: 18073319
    • Leick L, Wojtaszewski JFP, Johansen ST, Kiilerich K, Gomes G, Hellsten Y et al (2008) PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. Am J Physiol Endocrinol Metab 294:E463–E474
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. 463-474
    • Leick, L.1    Wojtaszewski, J.F.P.2    Johansen, S.T.3    Kiilerich, K.4    Gomes, G.5    Hellsten, Y.6
  • 71
    • 0023856536 scopus 로고
    • What is the cause of ageing atrophy? Total number, size and proportion of different fibre types studied in whole vastus lateralis muscle from 15 to 83 year old men
    • COI: 1:STN:280:DyaL1c3ksVOltA%3D%3D, PID: 3379447
    • Lexell J, Taylor CC, Sjostrum M (1988) What is the cause of ageing atrophy? Total number, size and proportion of different fibre types studied in whole vastus lateralis muscle from 15 to 83 year old men. J Neurol Sci 84:275–294
    • (1988) J Neurol Sci , vol.84 , pp. 275-294
    • Lexell, J.1    Taylor, C.C.2    Sjostrum, M.3
  • 72
    • 77949856117 scopus 로고    scopus 로고
    • Acute endurance exercise increases the nuclear abundance of PGC-1α in trained human skeletal muscle
    • COI: 1:CAS:528:DC%2BC3cXkvVSjtrs%3D, PID: 20106991
    • Little JP, Safdar A, Cermak N, Tarnopolsky MA, Gibala MJ (2010a) Acute endurance exercise increases the nuclear abundance of PGC-1α in trained human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 298:R912–R917
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298 , pp. 912-917
    • Little, J.P.1    Safdar, A.2    Cermak, N.3    Tarnopolsky, M.A.4    Gibala, M.J.5
  • 73
    • 77951738458 scopus 로고    scopus 로고
    • A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms
    • COI: 1:CAS:528:DC%2BC3cXktVSlurs%3D, PID: 20100740
    • Little JP, Safdar A, Wilkin GP, Tranopolsky MA, Gibala MJ (2010b) A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms. J Physiol 588:1011–1022
    • (2010) J Physiol , vol.588 , pp. 1011-1022
    • Little, J.P.1    Safdar, A.2    Wilkin, G.P.3    Tranopolsky, M.A.4    Gibala, M.J.5
  • 74
    • 67651174518 scopus 로고    scopus 로고
    • Diminished contraction-induced intracellular signalling towards mitochondrial biogenesis in aged skeletal muscle
    • COI: 1:CAS:528:DC%2BD1MXhtVSjtbnL, PID: 19416128
    • Ljubicic V, Hood DA (2009a) Diminished contraction-induced intracellular signalling towards mitochondrial biogenesis in aged skeletal muscle. Aging Cell 8:394–404
    • (2009) Aging Cell , vol.8 , pp. 394-404
    • Ljubicic, V.1    Hood, D.A.2
  • 75
    • 69049102233 scopus 로고    scopus 로고
    • Specific attenuation of protein kinase phosphorylation in muscle with a high mitochondrial content
    • COI: 1:CAS:528:DC%2BD1MXht1ykur3E, PID: 19549794
    • Ljubicic V, Hood DA (2009b) Specific attenuation of protein kinase phosphorylation in muscle with a high mitochondrial content. Am J Physiol Endocrinol Metab 297:E749–E758
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. 749-758
    • Ljubicic, V.1    Hood, D.A.2
  • 76
    • 77952590840 scopus 로고    scopus 로고
    • Molecular basis for an attenuated mitochondrial plasticity in aged skeletal muscle
    • Ljubicic V, Joesph A, Adhihetty PJ, Huang JH, Saleem A, Uguccioni G et al (2009) Molecular basis for an attenuated mitochondrial plasticity in aged skeletal muscle. Aging 9:818–830
    • (2009) Aging , vol.9 , pp. 818-830
    • Ljubicic, V.1    Joesph, A.2    Adhihetty, P.J.3    Huang, J.H.4    Saleem, A.5    Uguccioni, G.6
  • 77
    • 76749087887 scopus 로고    scopus 로고
    • Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging
    • COI: 1:CAS:528:DC%2BC3cXitlWisbs%3D, PID: 19682549
    • Ljubicic V, Joseph AM, Saleem A, Uguccioni G, Collu-Marchese M, Lai RY et al (2010) Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging. Biochim Biophys Acta 1800:223–234
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 223-234
    • Ljubicic, V.1    Joseph, A.M.2    Saleem, A.3    Uguccioni, G.4    Collu-Marchese, M.5    Lai, R.Y.6
  • 78
    • 49649128985 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and healthy aging
    • COI: 1:CAS:528:DC%2BD1cXhtVart7rJ, PID: 18662766
    • Lopez-Lluch G, Irusta PM, Navas P, de Cabo R (2008) Mitochondrial biogenesis and healthy aging. Exp Gerontol 43:813–819
    • (2008) Exp Gerontol , vol.43 , pp. 813-819
    • Lopez-Lluch, G.1    Irusta, P.M.2    Navas, P.3    de Cabo, R.4
  • 79
    • 24644478044 scopus 로고    scopus 로고
    • Analysis of global mRNA expression from human skeletal muscle during recovery from endurance exercise
    • COI: 1:CAS:528:DC%2BD2MXpvFKhtbo%3D, PID: 15985525
    • Mahoney DJ, Praise G, Melov S, Safdar A, Tarnopolsky MA (2005) Analysis of global mRNA expression from human skeletal muscle during recovery from endurance exercise. FASEB J 19:1498–1500
    • (2005) FASEB J , vol.19 , pp. 1498-1500
    • Mahoney, D.J.1    Praise, G.2    Melov, S.3    Safdar, A.4    Tarnopolsky, M.A.5
  • 81
    • 79957933470 scopus 로고    scopus 로고
    • Nitric oxide signalling: classical, less classical and nonclassical mechanisms
    • COI: 1:CAS:528:DC%2BC3MXntFSktb8%3D, PID: 21549190
    • Martinez-Ruiz A, Cadenas S, Lamas S (2011) Nitric oxide signalling: classical, less classical and nonclassical mechanisms. Free Radic Biol Med 51:17–29
    • (2011) Free Radic Biol Med , vol.51 , pp. 17-29
    • Martinez-Ruiz, A.1    Cadenas, S.2    Lamas, S.3
  • 82
    • 0035018106 scopus 로고    scopus 로고
    • Contractile-activity induced oxidative stress: cellular origin and adaptive responses
    • COI: 1:CAS:528:DC%2BD3MXjtVWrurY%3D, PID: 11171582
    • McArdle A, Patwell D, Vasilaki A, Griffiths RD, Jackson MJ (2001) Contractile-activity induced oxidative stress: cellular origin and adaptive responses. Am J Physiol Cell Physiol 280:C621–C627
    • (2001) Am J Physiol Cell Physiol , vol.280 , pp. 621-627
    • McArdle, A.1    Patwell, D.2    Vasilaki, A.3    Griffiths, R.D.4    Jackson, M.J.5
  • 83
    • 84908895052 scopus 로고    scopus 로고
    • Differential cysteine labelling and global label-free proteomics reveals an altered metabolic state in skeletal muscle aging
    • McDonagh B, Sakellariou GK, Smith N, Brownridge P, Jackson MJ (2014) Differential cysteine labelling and global label-free proteomics reveals an altered metabolic state in skeletal muscle aging. J Prot Res. doi:10.1021/pr5006394
    • (2014) J Prot Res
    • McDonagh, B.1    Sakellariou, G.K.2    Smith, N.3    Brownridge, P.4    Jackson, M.J.5
  • 84
    • 84901256992 scopus 로고    scopus 로고
    • Application of the [gamma-P-32] ATP kinase assay to study anabolic signaling in human skeletal muscle
    • COI: 1:CAS:528:DC%2BC2cXosVSmtL4%3D, PID: 24436296
    • McGlory C, White A, Treins C, Drust B, Close GL, MacLaren DPM et al (2014) Application of the [gamma-P-32] ATP kinase assay to study anabolic signaling in human skeletal muscle. J Appl Physiol 116:504–513
    • (2014) J Appl Physiol , vol.116 , pp. 504-513
    • McGlory, C.1    White, A.2    Treins, C.3    Drust, B.4    Close, G.L.5    MacLaren, D.P.M.6
  • 85
    • 0036239678 scopus 로고    scopus 로고
    • Mitochondrial DNA deletion mutations: a causal role in sarcopenia
    • COI: 1:CAS:528:DC%2BD38XjsFWlt7o%3D
    • McKenzie D, Bua E, McKiernan S, Cao Z, Wanagat J, Aiken JM (2002) Mitochondrial DNA deletion mutations: a causal role in sarcopenia. Euro J Biochem 269:2010–2015
    • (2002) Euro J Biochem , vol.269 , pp. 2010-2015
    • McKenzie, D.1    Bua, E.2    McKiernan, S.3    Cao, Z.4    Wanagat, J.5    Aiken, J.M.6
  • 88
    • 84857310052 scopus 로고    scopus 로고
    • A perspective on the determination of mitochondrial biogenesis
    • COI: 1:CAS:528:DC%2BC38XkslSrt7o%3D, PID: 22205627
    • Miller BF, Hamilton KL (2012) A perspective on the determination of mitochondrial biogenesis. Am J Physiol Endocrinol Metab 302:E496–E499
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. 496-499
    • Miller, B.F.1    Hamilton, K.L.2
  • 89
    • 33745830817 scopus 로고    scopus 로고
    • Time-course and differential responses of the major heat shock protein families in human skeletal muscle following acute non-damaging treadmill exercise
    • COI: 1:CAS:528:DC%2BD28XnsFWjsLo%3D, PID: 16565353
    • Morton JP, MacLaren DPM, Cable NT, Bongers T, Griffiths RD, Campbell IT et al (2006) Time-course and differential responses of the major heat shock protein families in human skeletal muscle following acute non-damaging treadmill exercise. J Appl Physiol 101:176–182
    • (2006) J Appl Physiol , vol.101 , pp. 176-182
    • Morton, J.P.1    MacLaren, D.P.M.2    Cable, N.T.3    Bongers, T.4    Griffiths, R.D.5    Campbell, I.T.6
  • 90
    • 67651120134 scopus 로고    scopus 로고
    • The exercise-induced stress response of skeletal muscle with specific emphasis on humans
    • PID: 19769414
    • Morton JP, Kayani AC, McArdle A, Drust B (2009) The exercise-induced stress response of skeletal muscle with specific emphasis on humans. Sports Med 39:643–662
    • (2009) Sports Med , vol.39 , pp. 643-662
    • Morton, J.P.1    Kayani, A.C.2    McArdle, A.3    Drust, B.4
  • 92
    • 77954067388 scopus 로고    scopus 로고
    • Relative workload determine exercise-induced increases in PGC-1alpaha mRNA
    • COI: 1:CAS:528:DC%2BC3cXptVyltLg%3D, PID: 20139785
    • Nordsborg NB, Lundby C, Leick L, Pilegaard H (2010) Relative workload determine exercise-induced increases in PGC-1alpaha mRNA. Med Sci Sports Exerc 42:1477–1484
    • (2010) Med Sci Sports Exerc , vol.42 , pp. 1477-1484
    • Nordsborg, N.B.1    Lundby, C.2    Leick, L.3    Pilegaard, H.4
  • 93
    • 84868104223 scopus 로고    scopus 로고
    • Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans
    • COI: 1:CAS:528:DC%2BC38XhvVahur7O, PID: 22890714
    • Nyberg M, Blackwell JR, Damsgaard R, Jones AM, Hellsten Y, Mortensen SP (2012) Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans. J Physiol 590:5361–5370
    • (2012) J Physiol , vol.590 , pp. 5361-5370
    • Nyberg, M.1    Blackwell, J.R.2    Damsgaard, R.3    Jones, A.M.4    Hellsten, Y.5    Mortensen, S.P.6
  • 94
    • 84902269966 scopus 로고    scopus 로고
    • Role of sedentary aging and lifelong physical activity on exchange of glutathione across exercising human skeletal muscle
    • COI: 1:CAS:528:DC%2BC2cXht1SksrrL, PID: 24858720
    • Nyberg M, Mortensen SP, Cabo H, Gomez-Cabrera MC, Vina J, Hellensten Y (2014) Role of sedentary aging and lifelong physical activity on exchange of glutathione across exercising human skeletal muscle. Free Radic Biol Med 73:166–173
    • (2014) Free Radic Biol Med , vol.73 , pp. 166-173
    • Nyberg, M.1    Mortensen, S.P.2    Cabo, H.3    Gomez-Cabrera, M.C.4    Vina, J.5    Hellensten, Y.6
  • 95
    • 33845929020 scopus 로고    scopus 로고
    • Effects of a physical activity intervention on measures of physical activity intervention on measures of physical performance: results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study
    • PID: 17167156
    • Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralink JM et al (2006) Effects of a physical activity intervention on measures of physical activity intervention on measures of physical performance: results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci 61:1157–1165
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 1157-1165
    • Pahor, M.1    Blair, S.N.2    Espeland, M.3    Fielding, R.4    Gill, T.M.5    Guralink, J.M.6
  • 96
    • 51749101734 scopus 로고    scopus 로고
    • In situ detection and measurement of intracellular reactive oxygen species in single isolated mature skeletal muscle fibres by real-time fluorescence microscopy
    • COI: 1:CAS:528:DC%2BD1cXms1eqs7s%3D, PID: 18407749
    • Palomero J, Pye D, Kabayo T, Spiller DG, Jackson MJ (2008) In situ detection and measurement of intracellular reactive oxygen species in single isolated mature skeletal muscle fibres by real-time fluorescence microscopy. Antioxid Redox Signal 10:1463–1474
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1463-1474
    • Palomero, J.1    Pye, D.2    Kabayo, T.3    Spiller, D.G.4    Jackson, M.J.5
  • 97
    • 84881655593 scopus 로고    scopus 로고
    • Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal muscle fibres at rest, but not during contractions
    • COI: 1:CAS:528:DC%2BC3sXhsVegsr7N, PID: 23697797
    • Palomero J, Vasilaki A, Pye D, McArdle A, Jackson MJ (2013) Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal muscle fibres at rest, but not during contractions. Am J Physiol Regul Integr Comp Physiol 305:R351–R358
    • (2013) Am J Physiol Regul Integr Comp Physiol , vol.305 , pp. 351-358
    • Palomero, J.1    Vasilaki, A.2    Pye, D.3    McArdle, A.4    Jackson, M.J.5
  • 99
    • 84913580822 scopus 로고    scopus 로고
    • Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide
    • PID: 25462644
    • Pearson T, McArdle A, Jackson MJ (2014) Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide. Free Radic Biol Med. doi:10.1016/j.freeradbiomed.2014.10.505i
    • (2014) Free Radic Biol Med
    • Pearson, T.1    McArdle, A.2    Jackson, M.J.3
  • 100
    • 78649710608 scopus 로고    scopus 로고
    • Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle
    • COI: 1:CAS:528:DC%2BC3cXhsFOmsb7O, PID: 20921196
    • Perry CGR, Lally J, Holloway GP, Heigenhauser GJF, Bonen A, Spriet LL (2010) Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol 588:4795–4810
    • (2010) J Physiol , vol.588 , pp. 4795-4810
    • Perry, C.G.R.1    Lally, J.2    Holloway, G.P.3    Heigenhauser, G.J.F.4    Bonen, A.5    Spriet, L.L.6
  • 101
    • 84868277570 scopus 로고    scopus 로고
    • Skeletal muscle mitochondria and aging: a review
    • PID: 22888430
    • Peterson CM, Johannsen DL, Ravussin E (2012) Skeletal muscle mitochondria and aging: a review. J Aging Res 2012:194821
    • (2012) J Aging Res , vol.2012 , pp. 194821
    • Peterson, C.M.1    Johannsen, D.L.2    Ravussin, E.3
  • 102
    • 80052193535 scopus 로고    scopus 로고
    • Sirtuin 1 (SIRT1) deactylase activity is not required for mitochondrial biogenesis or peroxisome proliferator activate receptor-γ co-activator-1α (PGC-1α) deactylation following exercise
    • COI: 1:CAS:528:DC%2BC3MXhtVOkt7fF, PID: 21757760
    • Philp A, Chen A, Lan D, Meyer GA, Murphy A, Knapp AE et al (2011) Sirtuin 1 (SIRT1) deactylase activity is not required for mitochondrial biogenesis or peroxisome proliferator activate receptor-γ co-activator-1α (PGC-1α) deactylation following exercise. J Biol Chem 286:30561–30570
    • (2011) J Biol Chem , vol.286 , pp. 30561-30570
    • Philp, A.1    Chen, A.2    Lan, D.3    Meyer, G.A.4    Murphy, A.5    Knapp, A.E.6
  • 103
    • 78249257768 scopus 로고    scopus 로고
    • Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permealised fibres
    • Picard M, Ritchie D, Wright KJ, Romestaing C, Thomas MM, Rowan SL et al (2010) Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permealised fibres. Aging Cell 6:1032–1046
    • (2010) Aging Cell , vol.6 , pp. 1032-1046
    • Picard, M.1    Ritchie, D.2    Wright, K.J.3    Romestaing, C.4    Thomas, M.M.5    Rowan, S.L.6
  • 105
    • 81155138284 scopus 로고    scopus 로고
    • Alterations in intrinsic mitochondrial function with aging are fibre type-specific and do not explain differential atrophy between muscles
    • COI: 1:CAS:528:DC%2BC3MXhs1Sqt7vO, PID: 21933339
    • Picard M, Ritchie D, Thomas MM, Wright KJ, Hepple RT (2011b) Alterations in intrinsic mitochondrial function with aging are fibre type-specific and do not explain differential atrophy between muscles. Aging Cell 10:1047–1055
    • (2011) Aging Cell , vol.10 , pp. 1047-1055
    • Picard, M.1    Ritchie, D.2    Thomas, M.M.3    Wright, K.J.4    Hepple, R.T.5
  • 106
    • 84877105774 scopus 로고    scopus 로고
    • Mitochondrial morphology transitions and functions: implications for retrograde signalling
    • COI: 1:CAS:528:DC%2BC3sXlvVKgtrk%3D, PID: 23364527
    • Picard M, Shirihai OS, Gentil BJ, Burelle Y (2013) Mitochondrial morphology transitions and functions: implications for retrograde signalling. Am J Physiol Regul Integr Comp Physiol 304:R393–R406
    • (2013) Am J Physiol Regul Integr Comp Physiol , vol.304 , pp. 393-406
    • Picard, M.1    Shirihai, O.S.2    Gentil, B.J.3    Burelle, Y.4
  • 107
    • 0037322888 scopus 로고    scopus 로고
    • Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle
    • COI: 1:CAS:528:DC%2BD3sXitlSmtrg%3D, PID: 12563009
    • Pilegaard H, Saltin B, Neufer DP (2003) Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle. J Physiol 546:851–858
    • (2003) J Physiol , vol.546 , pp. 851-858
    • Pilegaard, H.1    Saltin, B.2    Neufer, D.P.3
  • 108
    • 55949118714 scopus 로고    scopus 로고
    • Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    • COI: 1:CAS:528:DC%2BD1cXhtlGgtbnP, PID: 18923182
    • Powers SK, Jackson MJ (2008) Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88:1243–1276
    • (2008) Physiol Rev , vol.88 , pp. 1243-1276
    • Powers, S.K.1    Jackson, M.J.2
  • 109
    • 34248161046 scopus 로고    scopus 로고
    • Real-time measurement of nitric oxide in single mature mouse skeletal muscle fibres during contractions
    • COI: 1:CAS:528:DC%2BD2sXls1Khu7k%3D, PID: 17331997
    • Pye D, Palomero J, Kabayo T, Jackson MJ (2007) Real-time measurement of nitric oxide in single mature mouse skeletal muscle fibres during contractions. J Physiol 581:309–318
    • (2007) J Physiol , vol.581 , pp. 309-318
    • Pye, D.1    Palomero, J.2    Kabayo, T.3    Jackson, M.J.4
  • 110
    • 79959347376 scopus 로고    scopus 로고
    • Age-dependent changes in 8-oxoguanine-DNA glyocloase activity are modulated by the adaptive response to physical exercise in human muscle
    • COI: 1:CAS:528:DC%2BC3MXnslKgt7s%3D, PID: 21569841
    • Radak Z, Bori Z, Kolati E, Fatourous GI, Jamaturas AZ, Douroudos II et al (2011) Age-dependent changes in 8-oxoguanine-DNA glyocloase activity are modulated by the adaptive response to physical exercise in human muscle. Free Radic Biol Med 51:417–423
    • (2011) Free Radic Biol Med , vol.51 , pp. 417-423
    • Radak, Z.1    Bori, Z.2    Kolati, E.3    Fatourous, G.I.4    Jamaturas, A.Z.5    Douroudos, I.I.6
  • 111
    • 75649150185 scopus 로고    scopus 로고
    • Facts noise and wishful thinking: muscle protein turnover in aging and human disuse atrophy
    • COI: 1:STN:280:DC%2BC3czkvVGjtg%3D%3D
    • Rennie MJ, Selby A, Atherton P, Smith K, Glover EL, Phillips SM (2010) Facts noise and wishful thinking: muscle protein turnover in aging and human disuse atrophy. Scand J Med Sci Sport 20:5–9
    • (2010) Scand J Med Sci Sport , vol.20 , pp. 5-9
    • Rennie, M.J.1    Selby, A.2    Atherton, P.3    Smith, K.4    Glover, E.L.5    Phillips, S.M.6
  • 112
    • 33846580517 scopus 로고    scopus 로고
    • Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
    • COI: 1:CAS:528:DC%2BD2sXitlSqtrk%3D, PID: 17276357
    • Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ et al (2007) Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab 5:151–156
    • (2007) Cell Metab , vol.5 , pp. 151-156
    • Reznick, R.M.1    Zong, H.2    Li, J.3    Morino, K.4    Moore, I.K.5    Yu, H.J.6
  • 114
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
    • COI: 1:CAS:528:DC%2BD2MXhslClsb0%3D, PID: 15744310
    • Rodgers JT, Lerin C, Haas W, Gygy SP, Spiegelman BM, Puigserver P (2005) Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434:113–118
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygy, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 115
    • 84864186432 scopus 로고    scopus 로고
    • PGC-1α is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle
    • COI: 1:CAS:528:DC%2BC38XhtFWisbvL, PID: 22848618
    • Rowe GC, El-Khoury R, Patten IS, Rustin P, Arany Z (2012) PGC-1α is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle. PLoS ONE 7:e41817
    • (2012) PLoS ONE , vol.7 , pp. 41817
    • Rowe, G.C.1    El-Khoury, R.2    Patten, I.S.3    Rustin, P.4    Arany, Z.5
  • 116
    • 10744228606 scopus 로고    scopus 로고
    • Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1α in skeletal muscle
    • COI: 1:CAS:528:DC%2BD3sXpsFagsL0%3D, PID: 14633846
    • Russell AP, Feilchenfeldt J, Schreiber S, Praz M, Crettenand A, Gobelet C et al (2003) Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1α in skeletal muscle. Diabetes 52:2874–28812
    • (2003) Diabetes , vol.52 , pp. 2874-28812
    • Russell, A.P.1    Feilchenfeldt, J.2    Schreiber, S.3    Praz, M.4    Crettenand, A.5    Gobelet, C.6
  • 117
    • 77957756428 scopus 로고    scopus 로고
    • Dysfunctional Nrf2-Keap1 redox signalling in skeletal muscle of the sedentary old
    • COI: 1:CAS:528:DC%2BC3cXht1Oms7vI, PID: 20708680
    • Safdar A, DeBeer J, Tarnopolsky MA (2010a) Dysfunctional Nrf2-Keap1 redox signalling in skeletal muscle of the sedentary old. Free Radic Biol Med 49:1487–1493
    • (2010) Free Radic Biol Med , vol.49 , pp. 1487-1493
    • Safdar, A.1    DeBeer, J.2    Tarnopolsky, M.A.3
  • 119
    • 79953232671 scopus 로고    scopus 로고
    • Exercise increases mitochondrial PGC-1α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis
    • COI: 1:CAS:528:DC%2BC3MXjsVyqs7s%3D, PID: 21245132
    • Safdar A, Little JP, Stokl AJ, Hettinga BP, Akhtar M, Tarnopolsky MA (2011) Exercise increases mitochondrial PGC-1α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J Biol Chem 286:10605–10617
    • (2011) J Biol Chem , vol.286 , pp. 10605-10617
    • Safdar, A.1    Little, J.P.2    Stokl, A.J.3    Hettinga, B.P.4    Akhtar, M.5    Tarnopolsky, M.A.6
  • 120
    • 84872433353 scopus 로고    scopus 로고
    • Studies of mitochondrial and non-mitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase (s) in the increase skeletal muscle superoxide generation that occurs following contractile activity
    • COI: 1:CAS:528:DC%2BC3sXpt1GltQ%3D%3D
    • Sakellariou GK, Vasilaki A, Palomero J, Kayani A, Zibrik L, McArdle A et al (2013) Studies of mitochondrial and non-mitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase (s) in the increase skeletal muscle superoxide generation that occurs following contractile activity. Antiox Redox Signal 18:603–621
    • (2013) Antiox Redox Signal , vol.18 , pp. 603-621
    • Sakellariou, G.K.1    Vasilaki, A.2    Palomero, J.3    Kayani, A.4    Zibrik, L.5    McArdle, A.6
  • 121
    • 84890084174 scopus 로고    scopus 로고
    • Redefining the major contributors to superoxide production in contracting skeletal muscle. Role of NAD(P)H oxidases
    • COI: 1:CAS:528:DC%2BC3sXhvVyqs7vK, PID: 23915064
    • Sakellariou GK, Jackson MJ, Vasilaki A (2014) Redefining the major contributors to superoxide production in contracting skeletal muscle. Role of NAD(P)H oxidases. Free Radic Res 48:12–29
    • (2014) Free Radic Res , vol.48 , pp. 12-29
    • Sakellariou, G.K.1    Jackson, M.J.2    Vasilaki, A.3
  • 122
    • 84880746018 scopus 로고    scopus 로고
    • Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle
    • COI: 1:CAS:528:DC%2BC3sXht1CltrrK, PID: 23690562
    • Saleem A, Hood DA (2013) Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle. J Physiol 591:3625–3636
    • (2013) J Physiol , vol.591 , pp. 3625-3636
    • Saleem, A.1    Hood, D.A.2
  • 123
    • 75149165994 scopus 로고    scopus 로고
    • Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
    • COI: 1:CAS:528:DC%2BC3cXhtlGhtbo%3D, PID: 20036736
    • Salmon AB, Richardson A, Perez VI (2010) Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med 48:642–655
    • (2010) Free Radic Biol Med , vol.48 , pp. 642-655
    • Salmon, A.B.1    Richardson, A.2    Perez, V.I.3
  • 124
    • 33750825245 scopus 로고    scopus 로고
    • PGC-1alpha protects form atrophy by suppressing FOXO3 action and atrophy-specific gene transcription
    • COI: 1:CAS:528:DC%2BD28Xht1WmsL3L, PID: 17053067
    • Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH et al (2006) PGC-1alpha protects form atrophy by suppressing FOXO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci USA 103:16260–16265
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16260-16265
    • Sandri, M.1    Lin, J.2    Handschin, C.3    Yang, W.4    Arany, Z.P.5    Lecker, S.H.6
  • 125
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • COI: 1:CAS:528:DC%2BD1cXls1KhsLw%3D, PID: 18391175
    • Scarpulla RC (2008) Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 88:611–638
    • (2008) Physiol Rev , vol.88 , pp. 611-638
    • Scarpulla, R.C.1
  • 126
    • 0042266366 scopus 로고    scopus 로고
    • Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
    • COI: 1:CAS:528:DC%2BD3sXlvFCgtr0%3D, PID: 12882902
    • Short KR, Vittone JL, Brigelow ML, Proctor DN, Rizza RA, Coenen-Schimke JM et al (2003) Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52:1888–1896
    • (2003) Diabetes , vol.52 , pp. 1888-1896
    • Short, K.R.1    Vittone, J.L.2    Brigelow, M.L.3    Proctor, D.N.4    Rizza, R.A.5    Coenen-Schimke, J.M.6
  • 128
    • 84897444272 scopus 로고    scopus 로고
    • 2 generation: redox signalling and oxidative stress
    • PID: 24515117
    • 2 generation: redox signalling and oxidative stress. J Biol Chem. doi:10.1074/jbc.R113.544635
    • (2014) J Biol Chem
    • Sies, H.1
  • 130
    • 37749043558 scopus 로고    scopus 로고
    • Endurance exercise and performance in masters athletes: age-associated changes and underlying physiological mechanisms
    • COI: 1:CAS:528:DC%2BD1cXhtFaqtbY%3D, PID: 17717011
    • Tanaka H, Seals DR (2008) Endurance exercise and performance in masters athletes: age-associated changes and underlying physiological mechanisms. J Physiol 586:55–63
    • (2008) J Physiol , vol.586 , pp. 55-63
    • Tanaka, H.1    Seals, D.R.2
  • 131
    • 0031441068 scopus 로고    scopus 로고
    • Greater decline in maximal aerobic capacity with age in physically active vs sedentary healthy women
    • COI: 1:STN:280:DyaK1c%2FmslWhug%3D%3D, PID: 9390967
    • Tanaka H, DeSouza CA, Jones PP, Stevenson ET, Davy KP, Seals DR (1997) Greater decline in maximal aerobic capacity with age in physically active vs sedentary healthy women. J Appl Physiol 83:1947–1953
    • (1997) J Appl Physiol , vol.83 , pp. 1947-1953
    • Tanaka, H.1    DeSouza, C.A.2    Jones, P.P.3    Stevenson, E.T.4    Davy, K.P.5    Seals, D.R.6
  • 132
    • 79954590152 scopus 로고    scopus 로고
    • Variability in training-induced skeletal muscle adaptation
    • PID: 21030666
    • Timmons JA (2011) Variability in training-induced skeletal muscle adaptation. J Appl Physiol 110:846–853
    • (2011) J Appl Physiol , vol.110 , pp. 846-853
    • Timmons, J.A.1
  • 133
    • 0030059437 scopus 로고    scopus 로고
    • Aging among elite distance runners: a 22 year longitudinal study
    • COI: 1:STN:280:DyaK28vgtlSntw%3D%3D, PID: 8847316
    • Trappe SW, Costill DL, Vukovich MD, Jones J, Melham T (1996) Aging among elite distance runners: a 22 year longitudinal study. J Appl Physiol 80:285–290
    • (1996) J Appl Physiol , vol.80 , pp. 285-290
    • Trappe, S.W.1    Costill, D.L.2    Vukovich, M.D.3    Jones, J.4    Melham, T.5
  • 134
    • 84871752629 scopus 로고    scopus 로고
    • New records in aerobic power among octogenarian lifelong endurance athletes
    • PID: 23065759
    • Trappe S, Hayes E, Galpin A, Kaminsky L, Jemiolo B, Fink W et al (2013) New records in aerobic power among octogenarian lifelong endurance athletes. J Appl Physiol 114:3–10
    • (2013) J Appl Physiol , vol.114 , pp. 3-10
    • Trappe, S.1    Hayes, E.2    Galpin, A.3    Kaminsky, L.4    Jemiolo, B.5    Fink, W.6
  • 135
    • 84922463601 scopus 로고    scopus 로고
    • Protein carbonylation and heat shock proteins in human skeletal muscle: relationships to age and sarcopenia
    • Valls MRB, Wilkinson DJ, Narici M, Smith K, Phillips BE et al (2014) Protein carbonylation and heat shock proteins in human skeletal muscle: relationships to age and sarcopenia. J Gerontol A Biol Sci Med Sci. doi:10.1093/gerona/glu007
    • (2014) J Gerontol A Biol Sci Med Sci
    • Valls, M.R.B.1    Wilkinson, D.J.2    Narici, M.3    Smith, K.4    Phillips, B.E.5
  • 136
    • 0036266110 scopus 로고    scopus 로고
    • Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity
    • COI: 1:CAS:528:DC%2BD38XkvVynur0%3D, PID: 12115981
    • Vasilaki A, Jackson MJ, McArdle A (2002) Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity. Muscle Nerve 25:902–905
    • (2002) Muscle Nerve , vol.25 , pp. 902-905
    • Vasilaki, A.1    Jackson, M.J.2    McArdle, A.3
  • 137
    • 0242584804 scopus 로고    scopus 로고
    • Skeletal muscle of aged male mice fail to adapt following contractile activity
    • COI: 1:CAS:528:DC%2BD3sXisFGjtLw%3D, PID: 12653661
    • Vasilaki A, Iwanejko I, McArdle F, Broome CS, Jackson MJ, McArdle A (2003) Skeletal muscle of aged male mice fail to adapt following contractile activity. Biochem Soc Trans 31:455–456
    • (2003) Biochem Soc Trans , vol.31 , pp. 455-456
    • Vasilaki, A.1    Iwanejko, I.2    McArdle, F.3    Broome, C.S.4    Jackson, M.J.5    McArdle, A.6
  • 138
    • 33750161128 scopus 로고    scopus 로고
    • Adaptive response of mouse skeletal muscle to contractile activity: the effect of age
    • COI: 1:CAS:528:DC%2BD28XhtFektLvL, PID: 16996110
    • Vasilaki A, McArdle F, Iwanejko LM, McArdle A (2006a) Adaptive response of mouse skeletal muscle to contractile activity: the effect of age. Mech Ageing Dev 127:830–839
    • (2006) Mech Ageing Dev , vol.127 , pp. 830-839
    • Vasilaki, A.1    McArdle, F.2    Iwanejko, L.M.3    McArdle, A.4
  • 139
    • 33646933518 scopus 로고    scopus 로고
    • Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity
    • COI: 1:CAS:528:DC%2BD28XktVOiu7Y%3D, PID: 16626390
    • Vasilaki A, Mansouri A, Van Remmen H, Van Der Meulen JH, Larkin L, Richardson AG et al (2006b) Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity. Aging Cell 5:109–117
    • (2006) Aging Cell , vol.5 , pp. 109-117
    • Vasilaki, A.1    Mansouri, A.2    Van Remmen, H.3    Van Der Meulen, J.H.4    Larkin, L.5    Richardson, A.G.6
  • 140
    • 84875246546 scopus 로고    scopus 로고
    • Regulation of mitochondrial biogenesis and PGC-1α under cellular stress
    • COI: 1:CAS:528:DC%2BC3sXitlams7k%3D, PID: 23347985
    • Wenz T (2013) Regulation of mitochondrial biogenesis and PGC-1α under cellular stress. Mitochondrion 13:134–142
    • (2013) Mitochondrion , vol.13 , pp. 134-142
    • Wenz, T.1
  • 141
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease
    • COI: 1:CAS:528:DC%2BC3cXjtFWjtw%3D%3D, PID: 19918075
    • Wenz T, Rosse SG, Rotundo RL, Spiegelman BM, Moraes CT (2009) Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease. Proc Natl Acad Sci USA 106:20405–20410
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rosse, S.G.2    Rotundo, R.L.3    Spiegelman, B.M.4    Moraes, C.T.5
  • 142
    • 78649413837 scopus 로고    scopus 로고
    • Mitochondrial fusion and fission in cell life and death
    • COI: 1:CAS:528:DC%2BC3cXhsVGrurnN, PID: 21102612
    • Westermann B (2010) Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 11:872–884
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 872-884
    • Westermann, B.1
  • 143
    • 42249088093 scopus 로고    scopus 로고
    • Reconciling the chemistry and biology of reactive oxygen species
    • COI: 1:CAS:528:DC%2BD1cXkvVSmtLo%3D, PID: 18421291
    • Winterbourn CC (2008) Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol 4:278–286
    • (2008) Nat Chem Biol , vol.4 , pp. 278-286
    • Winterbourn, C.C.1
  • 144
    • 84924119180 scopus 로고    scopus 로고
    • Are free radicals involved in thiol-based redox signalling?
    • Winterbourn CC (2014a) Are free radicals involved in thiol-based redox signalling? Free Radic Biol Med. doi:10.1016/j.freeradbiolmed.2014.08.017i
    • (2014) Free Radic Biol Med
    • Winterbourn, C.C.1
  • 145
    • 84890114880 scopus 로고    scopus 로고
    • The challenges of using fluorescent probes to detect and quantify specific reactive oxygen species in living cells
    • COI: 1:CAS:528:DC%2BC3sXptFOjur4%3D, PID: 23665586
    • Winterbourn CC (2014b) The challenges of using fluorescent probes to detect and quantify specific reactive oxygen species in living cells. Biochim Biophys Acta 1840:730–738
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 730-738
    • Winterbourn, C.C.1
  • 146
    • 33846992686 scopus 로고    scopus 로고
    • Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression
    • COI: 1:CAS:528:DC%2BD2sXks1Or, PID: 17099248
    • Wright DC, Han DH, Garcia-Roves PM, Geiger PC, Jones TE, Holloszy JO (2007) Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression. J Biol Chem 282:194–199
    • (2007) J Biol Chem , vol.282 , pp. 194-199
    • Wright, D.C.1    Han, D.H.2    Garcia-Roves, P.M.3    Geiger, P.C.4    Jones, T.E.5    Holloszy, J.O.6


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