메뉴 건너뛰기




Volumn 38, Issue 3, 2015, Pages 313-320

Catabolic metabolism during cancer EMT

Author keywords

Cancer; Catabolism; Epithelial mesenchymal transition (EMT); Survival

Indexed keywords

REACTIVE OXYGEN METABOLITE; GLUCOSE;

EID: 84925533652     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-015-0567-x     Document Type: Review
Times cited : (53)

References (68)
  • 1
    • 0037163688 scopus 로고    scopus 로고
    • Evaluation of 2-deoxy-d-glucose as a chemotherapeutic agent: Mechanism of cell death
    • 1:CAS:528:DC%2BD38XmvF2ks7o%3D 12232767
    • Aft, R.L., F.W. Zhang, and D. Gius. 2002. Evaluation of 2-deoxy-d-glucose as a chemotherapeutic agent: mechanism of cell death. British Journal of Cancer 87(7): 805-812. doi: 10.1038/sj.bjc.6600547.
    • (2002) British Journal of Cancer , vol.87 , Issue.7 , pp. 805-812
    • Aft, R.L.1    Zhang, F.W.2    Gius, D.3
  • 2
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • 1:CAS:528:DC%2BD3cXhtVyltLo%3D 10655587
    • Batlle, E., E. Sancho, C. Franci, D. Dominguez, M. Monfar, J. Baulida, and A. Garcia De Herreros. 2000. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature Cell Biology 2(2): 84-89. doi: 10.1038/35000034.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3    Dominguez, D.4    Monfar, M.5    Baulida, J.6    Garcia De Herreros, A.7
  • 3
    • 41649119370 scopus 로고    scopus 로고
    • Snail is a repressor of RKIP transcription in metastatic prostate cancer cells
    • 1:CAS:528:DC%2BD1cXktFCnsL4%3D 17952120
    • Beach, S., H. Tang, S. Park, A.S. Dhillon, E.T. Keller, W. Kolch, and K.C. Yeung. 2008. Snail is a repressor of RKIP transcription in metastatic prostate cancer cells. Oncogene 27(15): 2243-2248. doi: 10.1038/sj.onc.1210860.
    • (2008) Oncogene , vol.27 , Issue.15 , pp. 2243-2248
    • Beach, S.1    Tang, H.2    Park, S.3    Dhillon, A.S.4    Keller, E.T.5    Kolch, W.6    Yeung, K.C.7
  • 4
    • 84871433609 scopus 로고    scopus 로고
    • Global profiling strategies for mapping dysregulated metabolic pathways in cancer
    • 1:CAS:528:DC%2BC38XhsV2qtbzJ 23063552
    • Benjamin, D.I., B.F. Cravatt, and D.K. Nomura. 2012. Global profiling strategies for mapping dysregulated metabolic pathways in cancer. Cell Metabolism 16(5): 565-577. doi: 10.1016/j.cmet.2012.09.013.
    • (2012) Cell Metabolism , vol.16 , Issue.5 , pp. 565-577
    • Benjamin, D.I.1    Cravatt, B.F.2    Nomura, D.K.3
  • 6
    • 84906936187 scopus 로고    scopus 로고
    • Cancer cell survival during detachment from the ECM: Multiple barriers to tumour progression
    • 1:CAS:528:DC%2BC2cXht12nu7vI 25098270
    • Buchheit, C.L., K.J. Weigel, and Z.T. Schafer. 2014. Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression. Nature Reviews Cancer 14(9): 632-641. doi: 10.1038/nrc3789.
    • (2014) Nature Reviews Cancer , vol.14 , Issue.9 , pp. 632-641
    • Buchheit, C.L.1    Weigel, K.J.2    Schafer, Z.T.3
  • 7
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • 1:CAS:528:DC%2BD3cXhtVyltLw%3D 10655586
    • Cano, A., M.A. Perez-Moreno, I. Rodrigo, A. Locascio, M.J. Blanco, M.G. del Barrio, F. Portillo, and M.A. Nieto. 2000. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biology 2(2): 76-83. doi: 10.1038/35000025.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    Del Barrio, M.G.6    Portillo, F.7    Nieto, M.A.8
  • 8
    • 84875465199 scopus 로고    scopus 로고
    • Cancer metabolism: Fatty acid oxidation in the limelight
    • 1:CAS:528:DC%2BC3sXjtFWhu7o%3D 23446547
    • Carracedo, A., L.C. Cantley, and P.P. Pandolfi. 2013. Cancer metabolism: fatty acid oxidation in the limelight. Nature Reviews Cancer 13(4): 227-232. doi: 10.1038/nrc3483.
    • (2013) Nature Reviews Cancer , vol.13 , Issue.4 , pp. 227-232
    • Carracedo, A.1    Cantley, L.C.2    Pandolfi, P.P.3
  • 10
    • 84860319933 scopus 로고    scopus 로고
    • MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling
    • 1:CAS:528:DC%2BC38XnsVSqsrk%3D 22421157
    • Cha, Y.H., N.H. Kim, C. Park, I. Lee, H.S. Kim, and J.I. Yook. 2012. MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle 11(7): 1273-1281. doi: 10.4161/cc.19618.
    • (2012) Cell Cycle , vol.11 , Issue.7 , pp. 1273-1281
    • Cha, Y.H.1    Kim, N.H.2    Park, C.3    Lee, I.4    Kim, H.S.5    Yook, J.I.6
  • 11
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • 1:CAS:528:DC%2BD38XlslGqsLw%3D 12154349
    • Chambers, A.F., A.C. Groom, and I.C. MacDonald. 2002. Dissemination and growth of cancer cells in metastatic sites. Nature Reviews Cancer 2(8): 563-572. doi: 10.1038/nrc865.
    • (2002) Nature Reviews Cancer , vol.2 , Issue.8 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    Macdonald, I.C.3
  • 12
    • 83355163333 scopus 로고    scopus 로고
    • Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models
    • 1:CAS:528:DC%2BC3MXhsFylurbE 21992792
    • Cheong, J.H., E.S. Park, J. Liang, J.B. Dennison, D. Tsavachidou, C. Nguyen-Charles, K. Wa Cheng, et al. 2011. Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models. Molecular Cancer Therapeutics 10(12): 2350-2362. doi: 10.1158/1535-7163.MCT-11-0497.
    • (2011) Molecular Cancer Therapeutics , vol.10 , Issue.12 , pp. 2350-2362
    • Cheong, J.H.1    Park, E.S.2    Liang, J.3    Dennison, J.B.4    Tsavachidou, D.5    Nguyen-Charles, C.6    Wa Cheng, K.7
  • 15
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • 1:CAS:528:DC%2BD28Xhslelt78%3D 16453012
    • Cully, M., H. You, A.J. Levine, and T.W. Mak. 2006. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nature Reviews Cancer 6(3): 184-192. doi: 10.1038/nrc1819.
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 16
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • 1:CAS:528:DC%2BD1cXisVOjtQ%3D%3D
    • DeBerardinis, R.J., A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, and C.B. Thompson. 2007. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. The Proceedings of the National Academy of Sciences USA 104(49): 19345-19350. doi: 10.1073/pnas.0709747104.
    • (2007) The Proceedings of the National Academy of Sciences USA , vol.104 , Issue.49 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 17
  • 18
    • 55349136976 scopus 로고    scopus 로고
    • A history of cancer chemotherapy
    • 1:CAS:528:DC%2BD1cXhtlSktbbJ 18974103
    • DeVita Jr., V.T., and E. Chu. 2008. A history of cancer chemotherapy. Cancer Research 68(21): 8643-8653. doi: 10.1158/0008-5472.CAN-07-6611.
    • (2008) Cancer Research , vol.68 , Issue.21 , pp. 8643-8653
    • Devita, Jr.V.T.1    Chu, E.2
  • 19
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i
    • 1:CAS:528:DC%2BD3cXjvVGrtA%3D%3D 10617608
    • El-Mir, M.Y., V. Nogueira, E. Fontaine, N. Averet, M. Rigoulet, and X. Leverve. 2000. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. Journal of Biological Chemistry 275(1): 223-228.
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.1 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 20
    • 40749151542 scopus 로고    scopus 로고
    • Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis
    • 1:CAS:528:DC%2BD1cXivVajt74%3D 18172008
    • Escriva, M., S. Peiro, N. Herranz, P. Villagrasa, N. Dave, B. Montserrat-Sentis, S.A. Murray, et al. 2008. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Molecular and Cellular Biology 28(5): 1528-1540. doi: 10.1128/MCB.02061-07.
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.5 , pp. 1528-1540
    • Escriva, M.1    Peiro, S.2    Herranz, N.3    Villagrasa, P.4    Dave, N.5    Montserrat-Sentis, B.6    Murray, S.A.7
  • 21
    • 20444461067 scopus 로고    scopus 로고
    • Metformin and reduced risk of cancer in diabetic patients
    • Evans, J.M., L.A. Donnelly, A.M. Emslie-Smith, D.R. Alessi, and A.D. Morris. 2005. Metformin and reduced risk of cancer in diabetic patients. BMJ 330(7503): 1304-1305. doi: 10.1136/bmj.38415.708634.F7.
    • (2005) BMJ , vol.330 , Issue.7503 , pp. 1304-1305
    • Evans, J.M.1    Donnelly, L.A.2    Emslie-Smith, A.M.3    Alessi, D.R.4    Morris, A.D.5
  • 22
    • 84902332213 scopus 로고    scopus 로고
    • Quantitative flux analysis reveals folate-dependent NADPH production
    • 1:CAS:528:DC%2BC2cXps1WmtLc%3D 24805240
    • Fan, J., J. Ye, J.J. Kamphorst, T. Shlomi, C.B. Thompson, and J.D. Rabinowitz. 2014. Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510(7504): 298-302. doi: 10.1038/nature13236.
    • (2014) Nature , vol.510 , Issue.7504 , pp. 298-302
    • Fan, J.1    Ye, J.2    Kamphorst, J.J.3    Shlomi, T.4    Thompson, C.B.5    Rabinowitz, J.D.6
  • 23
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • 1:CAS:528:DC%2BD2MXlsV2mt74%3D
    • Feng, Z., H. Zhang, A.J. Levine, and S. Jin. 2005. The coordinate regulation of the p53 and mTOR pathways in cells. The Proceedings of the National Academy of Sciences USA 102(23): 8204-8209. doi: 10.1073/pnas.0502857102.
    • (2005) The Proceedings of the National Academy of Sciences USA , vol.102 , Issue.23 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 25
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • 1:CAS:528:DC%2BD1cXlslemsr8%3D 18094039
    • Fung, C., R. Lock, S. Gao, E. Salas, and J. Debnath. 2008. Induction of autophagy during extracellular matrix detachment promotes cell survival. Molecular Biology of the Cell 19(3): 797-806. doi: 10.1091/mbc.E07-10-1092.
    • (2008) Molecular Biology of the Cell , vol.19 , Issue.3 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5
  • 26
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • 1:CAS:528:DC%2BD1MXhsVCjs73E 19682730
    • Gupta, P.B., T.T. Onder, G. Jiang, K. Tao, C. Kuperwasser, R.A. Weinberg, and E.S. Lander. 2009. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138(4): 645-659. doi: 10.1016/j.cell.2009.06.034.
    • (2009) Cell , vol.138 , Issue.4 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 27
    • 79960845901 scopus 로고    scopus 로고
    • Evidence for biological effects of metformin in operable breast cancer: A pre-operative, window-of-opportunity, randomized trial
    • 1:CAS:528:DC%2BC3MXoslahu7o%3D 21655990
    • Hadad, S., T. Iwamoto, L. Jordan, C. Purdie, S. Bray, L. Baker, G. Jellema, et al. 2011. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Research and Treatment 128(3): 783-794. doi: 10.1007/s10549-011-1612-1.
    • (2011) Breast Cancer Research and Treatment , vol.128 , Issue.3 , pp. 783-794
    • Hadad, S.1    Iwamoto, T.2    Jordan, L.3    Purdie, C.4    Bray, S.5    Baker, L.6    Jellema, G.7
  • 28
    • 84876320551 scopus 로고    scopus 로고
    • LKB1 and AMPK and the cancer-metabolism link - Ten years after
    • Hardie, D.G., and D.R. Alessi. 2013. LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC Biology 11: 36. doi: 10.1186/1741-7007-11-36.
    • (2013) BMC Biology , vol.11 , pp. 36
    • Hardie, D.G.1    Alessi, D.R.2
  • 29
    • 84869077946 scopus 로고    scopus 로고
    • Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
    • 1:CAS:528:DC%2BC38Xhs1Kls73N 23153533
    • Hitosugi, T., L. Zhou, S. Elf, J. Fan, H.B. Kang, J.H. Seo, C. Shan, et al. 2012. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 22(5): 585-600. doi: 10.1016/j.ccr.2012.09.020.
    • (2012) Cancer Cell , vol.22 , Issue.5 , pp. 585-600
    • Hitosugi, T.1    Zhou, L.2    Elf, S.3    Fan, J.4    Kang, H.B.5    Seo, J.H.6    Shan, C.7
  • 30
    • 77956411030 scopus 로고    scopus 로고
    • Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial
    • 1:CAS:528:DC%2BC3cXht1Gju77K
    • Hosono, K., H. Endo, H. Takahashi, M. Sugiyama, E. Sakai, T. Uchiyama, K. Suzuki, et al. 2010. Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prevention Research (Phila) 3(9): 1077-1083. doi: 10.1158/1940-6207.CAPR-10-0186.
    • (2010) Cancer Prevention Research (Phila) , vol.3 , Issue.9 , pp. 1077-1083
    • Hosono, K.1    Endo, H.2    Takahashi, H.3    Sugiyama, M.4    Sakai, E.5    Uchiyama, T.6    Suzuki, K.7
  • 31
    • 84868632060 scopus 로고    scopus 로고
    • A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
    • 1:CAS:528:DC%2BC38Xht1WktLfL 22902876
    • Ito, K., A. Carracedo, D. Weiss, F. Arai, U. Ala, D.E. Avigan, Z.T. Schafer, et al. 2012. A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nature Medicine 18(9): 1350-1358. doi: 10.1038/nm.2882.
    • (2012) Nature Medicine , vol.18 , Issue.9 , pp. 1350-1358
    • Ito, K.1    Carracedo, A.2    Weiss, D.3    Arai, F.4    Ala, U.5    Avigan, D.E.6    Schafer, Z.T.7
  • 32
    • 84863763440 scopus 로고    scopus 로고
    • AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    • 1:CAS:528:DC%2BC38XnvVykt7k%3D 22660331
    • Jeon, S.M., N.S. Chandel, and N. Hay. 2012. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 485(7400): 661-665. doi: 10.1038/nature11066.
    • (2012) Nature , vol.485 , Issue.7400 , pp. 661-665
    • Jeon, S.M.1    Chandel, N.S.2    Hay, N.3
  • 33
    • 84867527044 scopus 로고    scopus 로고
    • Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer
    • 1:CAS:528:DC%2BC38Xhs1ynt7jK 22986741
    • Jerby, L., L. Wolf, C. Denkert, G.Y. Stein, M. Hilvo, M. Oresic, T. Geiger, and E. Ruppin. 2012. Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer. Cancer Research 72(22): 5712-5720. doi: 10.1158/0008-5472.CAN-12-2215.
    • (2012) Cancer Research , vol.72 , Issue.22 , pp. 5712-5720
    • Jerby, L.1    Wolf, L.2    Denkert, C.3    Stein, G.Y.4    Hilvo, M.5    Oresic, M.6    Geiger, T.7    Ruppin, E.8
  • 34
    • 84885586152 scopus 로고    scopus 로고
    • Life history trade-offs at a single locus maintain sexually selected genetic variation
    • 1:CAS:528:DC%2BC3sXhtlCntLbP 23965625
    • Johnston, S.E., J. Gratten, C. Berenos, J.G. Pilkington, T.H. Clutton-Brock, J.M. Pemberton, and J. Slate. 2013. Life history trade-offs at a single locus maintain sexually selected genetic variation. Nature 502(7469): 93-95. doi: 10.1038/nature12489.
    • (2013) Nature , vol.502 , Issue.7469 , pp. 93-95
    • Johnston, S.E.1    Gratten, J.2    Berenos, C.3    Pilkington, J.G.4    Clutton-Brock, T.H.5    Pemberton, J.M.6    Slate, J.7
  • 35
    • 84877979327 scopus 로고    scopus 로고
    • P53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells
    • 1:CAS:528:DC%2BC3sXhsVSgtLrF 23624843
    • Kim, N.H., Y.H. Cha, S.E. Kang, Y. Lee, I. Lee, S.Y. Cha, J.K. Ryu, et al. 2013. p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. Cell Cycle 12(10): 1578-1587. doi: 10.4161/cc.24739.
    • (2013) Cell Cycle , vol.12 , Issue.10 , pp. 1578-1587
    • Kim, N.H.1    Cha, Y.H.2    Kang, S.E.3    Lee, Y.4    Lee, I.5    Cha, S.Y.6    Ryu, J.K.7
  • 36
    • 80455137130 scopus 로고    scopus 로고
    • P53 and microRNA-34 are suppressors of canonical Wnt signaling
    • Kim, N.H., H.S. Kim, N.G. Kim, I. Lee, H.S. Choi, X.Y. Li, S.E. Kang, et al. 2011a. p53 and microRNA-34 are suppressors of canonical Wnt signaling. Sci Signal 4(197): ra71. doi: 10.1126/scisignal.2001744.
    • (2011) Sci Signal , vol.4 , Issue.197 , pp. 71
    • Kim, N.H.1    Kim, H.S.2    Kim, N.G.3    Lee, I.4    Choi, H.S.5    Li, X.Y.6    Kang, S.E.7
  • 37
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    • 1:CAS:528:DC%2BC3MXhsVeit7jP 22024162
    • Kim, N.H., H.S. Kim, X.Y. Li, I. Lee, H.S. Choi, S.E. Kang, S.Y. Cha, et al. 2011b. A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. Journal of Cell Biology 195(3): 417-433. doi: 10.1083/jcb.201103097.
    • (2011) Journal of Cell Biology , vol.195 , Issue.3 , pp. 417-433
    • Kim, N.H.1    Kim, H.S.2    Li, X.Y.3    Lee, I.4    Choi, H.S.5    Kang, S.E.6    Cha, S.Y.7
  • 38
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • 1:CAS:528:DC%2BC3MXks1ags70%3D 21508971
    • Koppenol, W.H., P.L. Bounds, and C.V. Dang. 2011. Otto Warburg's contributions to current concepts of cancer metabolism. Nature Reviews Cancer 11(5): 325-337. doi: 10.1038/nrc3038.
    • (2011) Nature Reviews Cancer , vol.11 , Issue.5 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 39
    • 84870599239 scopus 로고    scopus 로고
    • LKB1-AMPK axis revisited
    • 1:CAS:528:DC%2BC38XhslKrsbrF 22801477
    • Kottakis, F., and N. Bardeesy. 2012. LKB1-AMPK axis revisited. Cell Research 22(12): 1617-1620. doi: 10.1038/cr.2012.108.
    • (2012) Cell Research , vol.22 , Issue.12 , pp. 1617-1620
    • Kottakis, F.1    Bardeesy, N.2
  • 40
    • 84920616812 scopus 로고    scopus 로고
    • PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
    • 1:CAS:528:DC%2BC2cXhsFyhs77M 25241037
    • LeBleu, V.S., J.T. O'Connell, K.N. Gonzalez Herrera, H. Wikman, K. Pantel, M.C. Haigis, F.M. de Carvalho, et al. 2014. PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nature Cell Biology 16(10): 992-1003. doi: 10.1038/ncb3039.
    • (2014) Nature Cell Biology , vol.16 , Issue.10 , pp. 992-1003
    • Lebleu, V.S.1    O'Connell, J.T.2    Gonzalez Herrera, K.N.3    Wikman, H.4    Pantel, K.5    Haigis, M.C.6    De Carvalho, F.M.7
  • 41
    • 80052258995 scopus 로고    scopus 로고
    • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
    • 1:CAS:528:DC%2BC3MXpsFKqsLw%3D 21804546
    • Locasale, J.W., A.R. Grassian, T. Melman, C.A. Lyssiotis, K.R. Mattaini, A.J. Bass, G. Heffron, et al. 2011. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics 43(9): 869-874. doi: 10.1038/ng.890.
    • (2011) Nature Genetics , vol.43 , Issue.9 , pp. 869-874
    • Locasale, J.W.1    Grassian, A.R.2    Melman, T.3    Lyssiotis, C.A.4    Mattaini, K.R.5    Bass, A.J.6    Heffron, G.7
  • 42
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • 1:STN:280:DyaK1cvgsFCnsA%3D%3D 9736035
    • Luzzi, K.J., I.C. MacDonald, E.E. Schmidt, N. Kerkvliet, V.L. Morris, A.F. Chambers, and A.C. Groom. 1998. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. American Journal of Pathology 153(3): 865-873. doi: 10.1016/S0002-9440(10)65628-3.
    • (1998) American Journal of Pathology , vol.153 , Issue.3 , pp. 865-873
    • Luzzi, K.J.1    Macdonald, I.C.2    Schmidt, E.E.3    Kerkvliet, N.4    Morris, V.L.5    Chambers, A.F.6    Groom, A.C.7
  • 43
    • 84903524608 scopus 로고    scopus 로고
    • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
    • 1:CAS:528:DC%2BC2cXpslGitLg%3D 24847880
    • Madiraju, A.K., D.M. Erion, Y. Rahimi, X.M. Zhang, D.T. Braddock, R.A. Albright, B.J. Prigaro, et al. 2014. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510(7506): 542-546. doi: 10.1038/nature13270.
    • (2014) Nature , vol.510 , Issue.7506 , pp. 542-546
    • Madiraju, A.K.1    Erion, D.M.2    Rahimi, Y.3    Zhang, X.M.4    Braddock, D.T.5    Albright, R.A.6    Prigaro, B.J.7
  • 44
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • 1:CAS:528:DC%2BD1cXmsVOru7w%3D 18485877
    • Mani, S.A., W. Guo, M.J. Liao, E.N. Eaton, A. Ayyanan, A.Y. Zhou, M. Brooks, et al. 2008. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133(4): 704-715. doi: 10.1016/j.cell.2008.03.027.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6    Brooks, M.7
  • 46
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • 1:CAS:528:DC%2BD2sXhtVOnsr3P 17882277
    • Menendez, J.A., and R. Lupu. 2007. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nature Reviews Cancer 7(10): 763-777. doi: 10.1038/nrc2222.
    • (2007) Nature Reviews Cancer , vol.7 , Issue.10 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 47
    • 1542513774 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
    • 1:CAS:528:DC%2BD2cXisFWmsLs%3D
    • Mills, K.R., M. Reginato, J. Debnath, B. Queenan, and J.S. Brugge. 2004. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. The Proceedings of the National Academy of Sciences USA 101(10): 3438-3443. doi: 10.1073/pnas.0400443101.
    • (2004) The Proceedings of the National Academy of Sciences USA , vol.101 , Issue.10 , pp. 3438-3443
    • Mills, K.R.1    Reginato, M.2    Debnath, J.3    Queenan, B.4    Brugge, J.S.5
  • 48
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • 1:CAS:528:DC%2BD1cXisFWjt78%3D 18305538
    • Mizushima, N., B. Levine, A.M. Cuervo, and D.J. Klionsky. 2008. Autophagy fights disease through cellular self-digestion. Nature 451(7182): 1069-1075. doi: 10.1038/nature06639.
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 49
    • 82255192310 scopus 로고    scopus 로고
    • Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
    • Ni Chonghaile, T., K.A. Sarosiek, T.T. Vo, J.A. Ryan, A. Tammareddi, G. Moore Vdel, J. Deng, et al. 2011. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 334(6059): 1129-1133. doi: 10.1126/science.1206727.
    • (2011) Science , vol.334 , Issue.6059 , pp. 1129-1133
    • Ni Chonghaile, T.1    Sarosiek, K.A.2    Vo, T.T.3    Ryan, J.A.4    Tammareddi, A.5    Moore Vdel, G.6    Deng, J.7
  • 50
    • 84866538325 scopus 로고    scopus 로고
    • Metformin in early breast cancer: A prospective window of opportunity neoadjuvant study
    • 1:CAS:528:DC%2BC38XhtlGmtr7P 22933030
    • Niraula, S., R.J. Dowling, M. Ennis, M.C. Chang, S.J. Done, N. Hood, J. Escallon, et al. 2012. Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study. Breast Cancer Research and Treatment 135(3): 821-830. doi: 10.1007/s10549-012-2223-1.
    • (2012) Breast Cancer Research and Treatment , vol.135 , Issue.3 , pp. 821-830
    • Niraula, S.1    Dowling, R.J.2    Ennis, M.3    Chang, M.C.4    Done, S.J.5    Hood, N.6    Escallon, J.7
  • 51
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • 1:CAS:528:DC%2BD3cXlt1Sms7g%3D 10839993
    • Owen, M.R., E. Doran, and A.P. Halestrap. 2000. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochemical Journal 348(Pt 3): 607-614.
    • (2000) Biochemical Journal , vol.348 , Issue.PART 3 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 52
    • 84866322945 scopus 로고    scopus 로고
    • Investigating metformin for cancer prevention and treatment: The end of the beginning
    • 1:CAS:528:DC%2BC38XhtlGgsb3O 22926251
    • Pollak, M.N. 2012. Investigating metformin for cancer prevention and treatment: the end of the beginning. Cancer Discov 2(9): 778-790. doi: 10.1158/2159-8290.CD-12-0263.
    • (2012) Cancer Discov , vol.2 , Issue.9 , pp. 778-790
    • Pollak, M.N.1
  • 53
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • 1:CAS:528:DC%2BC38XhtFKgtr8%3D 22265420
    • Rhim, A.D., E.T. Mirek, N.M. Aiello, A. Maitra, J.M. Bailey, F. McAllister, M. Reichert, et al. 2012. EMT and dissemination precede pancreatic tumor formation. Cell 148(1-2): 349-361. doi: 10.1016/j.cell.2011.11.025.
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 349-361
    • Rhim, A.D.1    Mirek, E.T.2    Aiello, N.M.3    Maitra, A.4    Bailey, J.M.5    McAllister, F.6    Reichert, M.7
  • 54
    • 69949101473 scopus 로고    scopus 로고
    • Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
    • 1:CAS:528:DC%2BD1MXhtVWhsbjK 19693011
    • Schafer, Z.T., A.R. Grassian, L. Song, Z. Jiang, Z. Gerhart-Hines, H.Y. Irie, S. Gao, P. Puigserver, and J.S. Brugge. 2009. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 461(7260): 109-113. doi: 10.1038/nature08268.
    • (2009) Nature , vol.461 , Issue.7260 , pp. 109-113
    • Schafer, Z.T.1    Grassian, A.R.2    Song, L.3    Jiang, Z.4    Gerhart-Hines, Z.5    Irie, H.Y.6    Gao, S.7    Puigserver, P.8    Brugge, J.S.9
  • 56
    • 84859768059 scopus 로고    scopus 로고
    • Lipophagy: Connecting autophagy and lipid metabolism
    • Singh, R., and A.M. Cuervo. 2012. Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol 2012: 282041. doi: 10.1155/2012/282041.
    • (2012) Int J Cell Biol , vol.2012 , pp. 282041
    • Singh, R.1    Cuervo, A.M.2
  • 57
    • 0021227896 scopus 로고
    • Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts
    • 1:STN:280:DyaL2c3lvFSrtQ%3D%3D 6744281
    • Tarin, D., J.E. Price, M.G. Kettlewell, R.G. Souter, A.C. Vass, and B. Crossley. 1984. Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts. Cancer Research 44(8): 3584-3592.
    • (1984) Cancer Research , vol.44 , Issue.8 , pp. 3584-3592
    • Tarin, D.1    Price, J.E.2    Kettlewell, M.G.3    Souter, R.G.4    Vass, A.C.5    Crossley, B.6
  • 58
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • 1:CAS:528:DC%2BD1MXmtVKlsbg%3D 19460998
    • Vander Heiden, M.G., L.C. Cantley, and C.B. Thompson. 2009. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324(5930): 1029-1033. doi: 10.1126/science.1160809.
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 59
    • 77956674635 scopus 로고    scopus 로고
    • Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    • 1:CAS:528:DC%2BC3cXhtFGjtLrK 20847263
    • Vander Heiden, M.G., J.W. Locasale, K.D. Swanson, H. Sharfi, G.J. Heffron, D. Amador-Noguez, H.R. Christofk, et al. 2010. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 329(5998): 1492-1499. doi: 10.1126/science.1188015.
    • (2010) Science , vol.329 , Issue.5998 , pp. 1492-1499
    • Vander Heiden, M.G.1    Locasale, J.W.2    Swanson, K.D.3    Sharfi, H.4    Heffron, G.J.5    Amador-Noguez, D.6    Christofk, H.R.7
  • 60
    • 2442705493 scopus 로고    scopus 로고
    • Snail blocks the cell cycle and confers resistance to cell death
    • 1:CAS:528:DC%2BD2cXktlCqs74%3D
    • Vega, S., A.V. Morales, O.H. Ocana, F. Valdes, I. Fabregat, and M.A. Nieto. 2004. Snail blocks the cell cycle and confers resistance to cell death. Genes & Development 18(10): 1131-1143. doi: 10.1101/gad.294104.
    • (2004) Genes & Development , vol.18 , Issue.10 , pp. 1131-1143
    • Vega, S.1    Morales, A.V.2    Ocana, O.H.3    Valdes, F.4    Fabregat, I.5    Nieto, M.A.6
  • 61
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • 1:STN:280:DyaG28%2FltV2ktQ%3D%3D 13298683
    • Warburg, O. 1956. On the origin of cancer cells. Science 123(3191): 309-314.
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 62
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • 1:CAS:528:DC%2BC38Xkt1ylsbc%3D 22439925
    • Ward, P.S., and C.B. Thompson. 2012. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 21(3): 297-308. doi: 10.1016/j.ccr.2012.02.014.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 64
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: A new therapeutic target in cancer
    • 1:CAS:528:DC%2BC3cXpvFKqs7s%3D 20570523
    • Wise, D.R., and C.B. Thompson. 2010. Glutamine addiction: a new therapeutic target in cancer. Trends in Biochemical Sciences 35(8): 427-433. doi: 10.1016/j.tibs.2010.05.003.
    • (2010) Trends in Biochemical Sciences , vol.35 , Issue.8 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 65
    • 84867371728 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression
    • 1:CAS:528:DC%2BC38XhsFKhsLzM
    • Wu, Z.Q., X.Y. Li, C.Y. Hu, M. Ford, C.G. Kleer, and S.J. Weiss. 2012. Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. The Proceedings of the National Academy of Sciences USA 109(41): 16654-16659. doi: 10.1073/pnas.1205822109.
    • (2012) The Proceedings of the National Academy of Sciences USA , vol.109 , Issue.41 , pp. 16654-16659
    • Wu, Z.Q.1    Li, X.Y.2    Hu, C.Y.3    Ford, M.4    Kleer, C.G.5    Weiss, S.J.6
  • 66
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • 1:CAS:528:DC%2BC3cXks1SrtL4%3D 20034776
    • Yang, Z., and D.J. Klionsky. 2010. Mammalian autophagy: core molecular machinery and signaling regulation. Current Opinion in Cell Biology 22(2): 124-131. doi: 10.1016/j.ceb.2009.11.014.
    • (2010) Current Opinion in Cell Biology , vol.22 , Issue.2 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 67
    • 15744374449 scopus 로고    scopus 로고
    • Wnt-dependent regulation of the E-cadherin repressor snail
    • 1:CAS:528:DC%2BD2MXisVyjtLY%3D 15647282
    • Yook, J.I., X.Y. Li, I. Ota, E.R. Fearon, and S.J. Weiss. 2005. Wnt-dependent regulation of the E-cadherin repressor snail. Journal of Biological Chemistry 280(12): 11740-11748. doi: 10.1074/jbc.M413878200.
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.12 , pp. 11740-11748
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Fearon, E.R.4    Weiss, S.J.5
  • 68
    • 33751514601 scopus 로고    scopus 로고
    • A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
    • 1:CAS:528:DC%2BD28Xht1Kju7rE 17072303
    • Yook, J.I., X.Y. Li, I. Ota, C. Hu, H.S. Kim, N.H. Kim, S.Y. Cha, et al. 2006. A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biology 8(12): 1398-1406. doi: 10.1038/ncb1508.
    • (2006) Nature Cell Biology , vol.8 , Issue.12 , pp. 1398-1406
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Hu, C.4    Kim, H.S.5    Kim, N.H.6    Cha, S.Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.