Catalytic mechanisms and regulation of protein kinases

Methods in Enzymology

Volumn 548, Issue C, 2014, Pages 1-21

  Wang, Zhihong ^a   Cole, Philip A ^b  

^a UNIVERSITY OF THE SCIENCES   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

B Raf; Bisubstrate analog; Chemical rescue; EGFR; Erlotinib; Inhibitor; Lapatinib; Src; Transition state

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; B RAF KINASE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE; PROTEIN KINASE; PROTEIN TYROSINE KINASE; RAP1 PROTEIN; PROTEIN KINASE INHIBITOR;

ARTICLE; BINDING SITE; CARCINOGENESIS; CATALYSIS; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; STEADY STATE; ANALOGS AND DERIVATIVES; ANIMAL; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOCATALYSIS; HUMANS; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY;

EID: 84925452389     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-397918-6.00001-X     Document Type: Chapter

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