An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation

Archives of Biochemistry and Biophysics

Volumn 464, Issue 1, 2007, Pages 130-137

  Rominger, Cynthia M ^a   Schaber, Michael D ^a   Yang, Jingsong ^a   Gontarek, Richard R ^a   Weaver, Kurt L ^a   Broderick, Timothy ^a   Carter, Luke ^a   Copeland, Robert A ^a   May, Earl W ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

ERK; Inhibitor; Intrinsic ATPase; Kinase; MAPK signal transduction; MEK; Raf; Screening assay

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHO MITOGEN ACTIVATED PROTEIN KINASE 1; PYRUVATE KINASE; RAF PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; DIAGNOSTIC ACCURACY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HYDROLYSIS; PRIORITY JOURNAL; REACTION ANALYSIS; SENSITIVITY ANALYSIS; STEADY STATE;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; BUTADIENES; ESCHERICHIA COLI; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYDROLYSIS; KINETICS; MAP KINASE KINASE 1; NITRILES; PHOSPHATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS B-RAF; RABBITS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 34447617694     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.04.004     Document Type: Article

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