EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 13, 2009, Pages 5324-5329

  Richter, Günther H S ^a   Plehm, Stephanie ^a   Fasan, Annette ^a   Rössler, Sabine ^a   Unland, Rebekka ^b   Bennani Baiti, Idriss M ^c   Hotfilder, Marc ^b   Löwel, Diana ^a   Von Luettichau, Irene ^a   Mossbrugger, Ilona ^d   Quintanilla Martinez, Leticia ^d   Kovar, Heinrich ^c   Staege, Martin S ^e   Müller Tidow, Carsten ^b   Burdach, Stefan ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Epigenetic regulation; Ewing tumor; Stemness

Indexed keywords

DNA BINDING PROTEIN; NERVE GROWTH FACTOR RECEPTOR; PROTEIN EZH2; RAG2 PROTEIN; RNA BINDING PROTEIN EWS; TRANSCRIPTION FACTOR FLI 1; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; METASTASIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HISTONE DEACETYLASES; HUMANS; MESENCHYMAL STEM CELLS; MICE; NEOPLASM METASTASIS; NEURAL PLATE; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEIN C-FLI-1; SARCOMA, EWING'S; TRANSCRIPTION FACTORS;

MUS;

EID: 65249101694     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810759106     Document Type: Article

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