The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2

Cancer Research

Volumn 69, Issue 6, 2009, Pages 2623-2629

  Friedman, Jeffrey M ^a   Liang, Gangning ^a   Liu, Chun Chi ^b   Wolff, Erika M ^a   Tsai, Yvonne C ^a   Ye, Wei ^a   Zhou, Xianghong ^b   Jones, Peter A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; POLYCOMB GROUP PROTEIN; POLYCOMB GROUP PROTEIN EZH2; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; EZH2 PROTEIN, HUMAN; MIRN101 MICRORNA, HUMAN; N DEMETHYLASE; TRANSCRIPTION FACTOR;

ARTICLE; BLADDER CARCINOMA; BLADDER TRANSITIONAL CELL CARCINOMA; CANCER CELL CULTURE; CANCER GENETICS; CARCINOGENESIS; CELL PROLIFERATION; CHROMATIN STRUCTURE; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MODULATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAMPLE; TRANSITIONAL CELL CARCINOMA; TUMOR SUPPRESSOR GENE; BIOSYNTHESIS; BLADDER TUMOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TUMOR CELL LINE;

CARCINOMA, TRANSITIONAL CELL; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; MICRORNAS; OXIDOREDUCTASES, N-DEMETHYLATING; TRANSCRIPTION FACTORS; URINARY BLADDER NEOPLASMS;

EID: 65549083102     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-3114     Document Type: Article

References (34)

1. Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006;6:846-56.
2. Pasini D, Bracken AP, HelÏn K. Polycomb group proteins in cell cycle progression and cancer. Cell Cycle 2004;3:396-400.
3. Kleer CG, Cao Q, Varambally S, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 2003;100:11606-11.
4. Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Heiin K, EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003;22:5323-35.
5. Raman JD, Mongan NP, Tickoo SK, Boorjian SA, Scherr DS, Gudas LJ. Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin Cancer Res 2005;11:8570-6.
6. Varambally S, Dhanasekaran SM, Zhou M, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002;419:624-9.
7. Rhodes DR, Yu J, Shanker K, et al. Large-scale metaanalysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci USA 2004;101: 9309-14.
8. Gal-Yam EN, Egger G, Iniguez L, et al. Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc Natl Acad Sci U S A 2008;105:12979-84.
9. Kondo Y, Shen L, Cheng AS, et al. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet 2008;40: 741-50.
10. Yu j, Yu J, Rhodes DR, et al. A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. Cancer Res 2007;67:10657-63.
11. Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007;128:683-92.
12. Valencia-Sanchez MA, Liu J, Harmon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006;20:515-24.
13. Ambros V. The functions of animal microRNAs. Nature 2004;431:350-5.
14. Esquela-Kerscher A, Slack FJ, Oncomirs - microRNAs with a role in cancer. Mat Rev Cancer 2006;6:259-69.
15. Hermeking H. p53 enters the microRNA world Cancer Cell 2007;12:414-8.
16. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-66.
17. Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the protooncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006;9:435-43.
18. Robertson KD, Jones PA. Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. Oncogene 1999;18:3810-20.
19. Kim TY, Zhong S, Fields CR, Kim JH, Robertson KD. Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res 2006;66:7490-501.
20. Datta J, Kutay H, Nasser MW, et al. Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res 2008;68: 5049-58.
21. Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 2007;104:15805-10.
22. Iorio MV, Ferracin M, Liu CG, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005;65:7065-70.
23. Yanaihara N, Caplen N, Bowman F, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006;9:189-98.
24. Ragnarsson G, Eiriksdottir G, Johannsdottir JT, Jonasson JG, Egilsson V, Ingvarsson S. Loss of heterozygosity at chromosome lp in different solid human tumours: association with survival. Br J Cancer 1999;79: 1468-74.
25. Wolff EM, Liang G, Jones PA. Mechanisms of disease: genetic and epigenetic alterations that drive bladder cancer. Nat Clin Pract Urol 2005;2:502-10.
26. Varambally S, Cao Q, Mani RS, et al. Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer. Science 2008;322:1695-9.
27. Lewis BP, Shih IH, jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003;115:787-98.
28. Lee ER, Murdoch EE, Fritseh MR. High histone acetylation and decreased polycomb repressive complex 2 member levels regulate gene specific transcriptional changes during early embryonic stem cell differentiation induced by retinoic acid. Stem Cells 2007;25:2191-9.
29. Bar M, Wyman SR, Fritz BR, et al. MicroRNA Discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries. Stem Cells 2008;26:2496-505.
30. Lakshmipathy U, Love B, Goff LA, et al. MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells. Stem Cells Dev 2007;16: 1003-16.
31. Sinkkonen L, Hugenschmidt T, Berninger P, et al. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat Struct Mol Biol 2008;15:259-67.
32. Benetti R, Gonzalo S, jaco I, et al. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol 2008;15: 268-79.
33. Porkka KP, Pfeiffer MJ, Waltering KR, Vessella RL, Tammela TL, Visakorpi T. MicroRNA expression profiling in prostate cancer. Cancer Res 2007;67:6130-5.
34. Schepeler T, Reinert JT, Ostenfeld MS, et al. Diagnostic and prognostic mieroRNAs in stage II colon cancer. Cancer Res 2008;68:6416-24.