The human EZH2 gene: Genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders

European Journal of Human Genetics

Volumn 8, Issue 3, 2000, Pages 174-180

  Cardoso, Carlos ^a   Mignon, Cecile ^a   Hetet, Gilles ^b   Grandchamps, Bernard ^b   Fontes, Michel ^a   Colleaux, Laurence ^a  

^a TIMONE HOSPITAL   (France)

^b INSERM   (France)

Author keywords

7q35; EZH2; Genomic structure; Malignant myeloid disorders; Pseudogene

Indexed keywords

ONCOPROTEIN;

ARTICLE; CENTRAL NERVOUS SYSTEM; CHROMOSOME 21Q; CHROMOSOME 7Q; COMB; DEVELOPMENTAL GENETICS; DOWN SYNDROME; DROSOPHILA; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETIC ORGANIZATION; HEMATOPOIETIC SYSTEM; HOMEOBOX; HUMAN; HUMAN CELL; MYELOID LEUKEMIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTO ONCOGENE; PSEUDOGENE; SEQUENCE HOMOLOGY;

EID: 0034070298     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200439     Document Type: Article

References (24)

1. Pirotta V: Chromatin complexes regulating gene expression in Drosophila. Curr Opin Genet Dev 1995; 5: 466-472.
2. Pirotta V: PcG complexes and chromatin silencing. Curr Opin Genet Dev 1997; 7: 249-258.
3. Korf I, Fan Y, Strome S: The polycomb group in Caenorhabditis elegans and maternal control of germline development. Development 1998; 125: 2469-2478.
4. Schumacher A, Magnuson T: Murine Polycomb and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet 1997; 13: 167-170.
5. Laible G, Wolf A, Dorn R et al: Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J 1997; 16: 3219-3232.
6. Hobert O, Jallal B, Ullrich A: Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol Cell Biol 1996; 16: 3066-3073.
7. Chen H, Rossier C, Antonorakis SE: Cloning of a human homolog of the drosophila Enhancer of zests gene (EZH2) that maps to chromosome 21q22.2. Genomics 1996; 38: 30-37.
8. Cardoso C, Timsit S, Villard L, Khrestchatisky M, Fontes M, Colleaux L: Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. Hum Mol Genet 1998; 7: 679-684.
9. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J Mol Biol 1990; 215: 403-410.
10. Sambrook T, Fritsch EF, Maniatis T: Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, 1989.
11. Pinkel D, Straume T, Gray JW: Cytogenetics analysis using quantitative, high sensitivity, fluorescence hybridization. Proc Natl Acad Sci USA 1986; 83: 2934-2938.
12. Lemieux N, Dutrillaux B, Viegas-Pequignot E: A simple method for simultaneous R- or G- banding and fluorescence in situ hybridization of small single-copy gene. Cytogenet Cell Genet 1992; 59: 311-312.
13. Cave H, Gerard B, Martin E et al: Loss of heterozygosity in the chromosomal region 12p12-13 is very common in childhood acute lymphoblastic leukemia and permits the precise localization of a tumor-suppressor gene distinct from p27KIP1. Blood 1995; 86: 3869-3875.
14. El Kassar N, Hetet G, Briere J, Grandchamp B: X-chromosome inactivation in healthy females: incidence of excessive lyonization with age and comparison of assays involving DNA methylation and transcript polymorphisms. Clin Chem 1998; 44: 61-67.
15. Raynaud S, Cave H, Baens M et al: The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia. Blood 1996; 87: 2891-2899.
16. Breathnach R, Chambon P: Organisation and expression of eucaryotic split genes coding for proteins. Anna Rev Biochem 1981; 50: 349-383.
17. Shapiro MB, Senepathy P: RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res 1987; 15: 7155-7174.
18. Michel JJ, Xiong Y: Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. Cell Growth Differ 1998; 9: 435-449.
19. Dohner K, Brown J, Hehmann U et al: Molecular cytogenetic characterization of a critical region in bands 7q35-q36 commonly deleted in malignant myeloid disorders. Blood 1998; 92: 4031-4035.
20. Laible G, Haynes AR, Lebersorger A et al: The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosome 11 and 6. Mamm Gen 1999; 10: 311-314.
21. Jenuwein T, Laible G, Dorn R, Reuter G: SET-domain proteins modulate chromatin domains in eu- and heterochromatin. Cell Mol Life Sci 1998; 54: 80-93.
22. Djabali M, Selleri L, Parry P et al: A trithorax-like gene is interrupted by 11q23 translocations in acute leukemia. Nat Genet 1992; 2: 113-118.
23. Tkachuk DC, Kohler S, Cleary ML: Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 1992; 71: 691-700.
24. Van der Lugt NM, Domen J, Linders K et al: Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 protooncogene. Genes Dev 1994; 8: 757-769.