-
1
-
-
84872601036
-
Histone acetylation: Molecular mnemonics on the chromatin
-
Gräff J, Tsai L-H (2013) Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci 14:97-111. doi: 10.1038/nrn3427
-
(2013)
Nat Rev Neurosci
, vol.14
, pp. 97-111
-
-
Gräff, J.1
Tsai, L.-H.2
-
2
-
-
84886808679
-
Chromatin proteins and modifications as drug targets
-
Helin K, Dhanak D (2013) Chromatin proteins and modifications as drug targets. Nature 502:480-488. doi: 10.1038/nature12751
-
(2013)
Nature
, vol.502
, pp. 480-488
-
-
Helin, K.1
Dhanak, D.2
-
3
-
-
79958769268
-
Epigenetic aberrations during oncogenesis
-
Hatziapostolou M, Iliopoulos D (2011) Epigenetic aberrations during oncogenesis. Cell Mol Life Sci 68:1681-1702. doi: 10.1007/s00018-010-0624-z
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 1681-1702
-
-
Hatziapostolou, M.1
Iliopoulos, D.2
-
4
-
-
84863621527
-
Cancer epigenetics: From mechanism to therapy
-
Dawson MA, Kouzarides T (2012) Cancer epigenetics: from mechanism to therapy. Cell 150:12-27. doi: 10.1016/j.cell.2012.06.013
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
5
-
-
69449102464
-
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
-
Wang Z, Zang C, Cui K et al (2009) Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138:1019-1031. doi: 10.1016/j.cell.2009.06.049
-
(2009)
Cell
, vol.138
, pp. 1019-1031
-
-
Wang, Z.1
Zang, C.2
Cui, K.3
-
6
-
-
79955815135
-
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
-
Mihaylova MM, Vasquez DS, Ravnskjaer K et al (2011) Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145:607-621. doi: 10.1016/j.cell.2011.03.043
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
Vasquez, D.S.2
Ravnskjaer, K.3
-
7
-
-
39749127166
-
The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men
-
Yang X-J, Seto E (2008) The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 9:206-218. doi: 10.1038/nrm2346
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 206-218
-
-
Yang, X.-J.1
Seto, E.2
-
8
-
-
84860257685
-
Roles of histone deacetylases in epigenetic regulation: Emerging paradigms from studies with inhibitors
-
Delcuve G, Khan D, Davie J (2012) Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors. Clin Epigenenetics 4:5. doi: 10.1186/1868-7083-4-5
-
(2012)
Clin Epigenenetics
, vol.4
, pp. 5
-
-
Delcuve, G.1
Khan, D.2
Davie, J.3
-
9
-
-
79952268809
-
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
-
Di Micco R, Sulli G, Dobreva M et al (2011) Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol 13:292-302. doi: 10.1038/ncb2170
-
(2011)
Nat Cell Biol
, vol.13
, pp. 292-302
-
-
Di Micco, R.1
Sulli, G.2
Dobreva, M.3
-
10
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
Bolden JE, Peart MJ, Johnstone RW (2006) Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5:769-784. doi: 10.1038/nrd2133
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
11
-
-
0344306402
-
Apoptotic pathways activated by histone deacetylase inhibitors: Implications for the drug-resistant phenotype
-
Henderson C, Brancolini C (2003) Apoptotic pathways activated by histone deacetylase inhibitors: implications for the drug-resistant phenotype. Drug Resist Updat 6:247-256. doi: 10.1016/S1368-7646(03)00067-0
-
(2003)
Drug Resist Updat
, vol.6
, pp. 247-256
-
-
Henderson, C.1
Brancolini, C.2
-
12
-
-
80052180405
-
Class IIa HDACs: From important roles in differentiation to possible implications in tumourigenesis
-
Clocchiatti A, Florean C, Brancolini C (2011) Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis. J Cell Mol Med 15:1833-1846. doi: 10.1111/j.1582-4934.2011.01321.x
-
(2011)
J Cell Mol Med
, vol.15
, pp. 1833-1846
-
-
Clocchiatti, A.1
Florean, C.2
Brancolini, C.3
-
13
-
-
85027919146
-
HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin
-
Aygün O, Mehta S, Grewal SIS (2013) HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin. Nat Struct Mol Biol 20:547-554. doi: 10.1038/nsmb.2565
-
(2013)
Nat Struct Mol Biol
, vol.20
, pp. 547-554
-
-
Aygün, O.1
Mehta, S.2
Grewal, S.I.S.3
-
14
-
-
67449127082
-
Clinical studies of histone deacetylase inhibitors
-
Prince HM, Bishton MJ, Harrison SJ (2009) Clinical studies of histone deacetylase inhibitors. Clin Cancer Res 15:3958-3969. doi: 10.1158/1078-0432.CCR-08-2785
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3958-3969
-
-
Prince, H.M.1
Bishton, M.J.2
Harrison, S.J.3
-
15
-
-
67349227787
-
Isoform-specific histone deacetylase inhibitors: The next step?
-
Balasubramanian S, Verner E, Buggy JJ (2009) Isoform-specific histone deacetylase inhibitors: the next step? Cancer Lett 280:211-221. doi: 10.1016/j.canlet.2009.02.013
-
(2009)
Cancer Lett
, vol.280
, pp. 211-221
-
-
Balasubramanian, S.1
Verner, E.2
Buggy, J.J.3
-
16
-
-
77950860448
-
Inside HDAC with HDAC inhibitors
-
Bertrand P (2010) Inside HDAC with HDAC inhibitors. Eur J Med Chem 45:2095-2116. doi: 10.1016/j.ejmech.2010.02.030
-
(2010)
Eur J Med Chem
, vol.45
, pp. 2095-2116
-
-
Bertrand, P.1
-
17
-
-
84864722456
-
Histone deacetylase inhibitors in the treatment of cancer: Overview and perspectives
-
Giannini G, Cabri W, Fattorusso C, Rodriquez M (2012) Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives. Future Med Chem 4:1439-1460. doi: 10.4155/fmc.12.80
-
(2012)
Future Med Chem
, vol.4
, pp. 1439-1460
-
-
Giannini, G.1
Cabri, W.2
Fattorusso, C.3
Rodriquez, M.4
-
18
-
-
84896703864
-
Towards selective inhibition of histone deacetylase isoforms: What has been achieved, where we are and what will be next
-
Thaler F, Mercurio C (2014) Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next. Chem Med Chem 9:523-536. doi: 10.1002/cmdc.201300413
-
(2014)
Chem Med Chem
, vol.9
, pp. 523-536
-
-
Thaler, F.1
Mercurio, C.2
-
19
-
-
84901493375
-
Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases
-
Dekker FJ, van den Bosch T, Martin NI (2014) Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. Drug Discov Today 19:654-660. doi: 10.1016/j.drudis.2013.11.012
-
(2014)
Drug Discov Today
, vol.19
, pp. 654-660
-
-
Dekker, F.J.1
Van Den Bosch, T.2
Martin, N.I.3
-
20
-
-
36048958965
-
Histone deacetylase inhibitors: Overview and perspectives
-
Dokmanovic M, Clarke C, Marks PA (2007) Histone deacetylase inhibitors: overview and perspectives. Mol Cancer Res 5:981-989. doi: 10.1158/1541-7786.MCR-07-0324
-
(2007)
Mol Cancer Res
, vol.5
, pp. 981-989
-
-
Dokmanovic, M.1
Clarke, C.2
Marks, P.A.3
-
21
-
-
84892942381
-
New and emerging HDAC inhibitors for cancer treatment
-
West AC, Johnstone RW (2014) New and emerging HDAC inhibitors for cancer treatment. J Clin Invest 124:30-39. doi: 10.1172/JCI69738
-
(2014)
J Clin Invest
, vol.124
, pp. 30-39
-
-
West, A.C.1
Johnstone, R.W.2
-
22
-
-
84910019636
-
Histone deacetylase inhibitors and cell death
-
Zhang J, Zhong Q (2014) Histone deacetylase inhibitors and cell death. Cell Mol Life Sci. doi: 10.1007/s00018-014-1656-6
-
(2014)
Cell Mol Life Sci
-
-
Zhang, J.1
Zhong, Q.2
-
23
-
-
57749170458
-
The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
-
Haberland M, Montgomery RL, Olson EN (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10:32-42. doi: 10.1038/nrg2485
-
(2009)
Nat Rev Genet
, vol.10
, pp. 32-42
-
-
Haberland, M.1
Montgomery, R.L.2
Olson, E.N.3
-
24
-
-
0036161439
-
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
-
Fischle W, Dequiedt F, Hendzel MJ et al (2002) Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell 9:45-57. doi: 10.1016/S1097-2765(01)00429-4
-
(2002)
Mol Cell
, vol.9
, pp. 45-57
-
-
Fischle, W.1
Dequiedt, F.2
Hendzel, M.J.3
-
25
-
-
36849004821
-
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
-
Lahm A, Paolini C, Pallaoro M et al (2007) Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci USA 104:17335-17340. doi: 10.1073/pnas.0706487104
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 17335-17340
-
-
Lahm, A.1
Paolini, C.2
Pallaoro, M.3
-
26
-
-
84879092346
-
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
-
Lobera M, Madauss KP, Pohlhaus DT et al (2013) Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol 9:319-325. doi: 10.1038/nchembio.1223
-
(2013)
Nat Chem Biol
, vol.9
, pp. 319-325
-
-
Lobera, M.1
Madauss, K.P.2
Pohlhaus, D.T.3
-
27
-
-
34547919621
-
Class IIa histone deacetylases: Regulating the regulators
-
Martin M, Kettmann R, Dequiedt F (2007) Class IIa histone deacetylases: regulating the regulators. Oncogene 26:5450-5467. doi: 10.1038/sj.onc.1210613
-
(2007)
Oncogene
, vol.26
, pp. 5450-5467
-
-
Martin, M.1
Kettmann, R.2
Dequiedt, F.3
-
28
-
-
84895440984
-
HDAC4: Mechanism of regulation and biological functions
-
Wang Z, Qin G, Zhao TC (2014) HDAC4: mechanism of regulation and biological functions. Epigenomics 6:139-150. doi: 10.2217/epi.13.73
-
(2014)
Epigenomics
, vol.6
, pp. 139-150
-
-
Wang, Z.1
Qin, G.2
Zhao, T.C.3
-
29
-
-
45549095066
-
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity
-
Schuetz A, Min J, Allali-Hassani A et al (2008) Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J Biol Chem 283:11355-11363. doi: 10.1074/jbc.M707362200
-
(2008)
J Biol Chem
, vol.283
, pp. 11355-11363
-
-
Schuetz, A.1
Min, J.2
Allali-Hassani, A.3
-
30
-
-
6344222799
-
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
-
Vannini A, Volpari C, Filocamo G et al (2004) Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. Proc Natl Acad Sci USA 101:15064-15069. doi: 10.1073/pnas.0404603101
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15064-15069
-
-
Vannini, A.1
Volpari, C.2
Filocamo, G.3
-
31
-
-
55549094833
-
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain
-
Bottomley MJ, Lo Surdo P, Di Giovine P et al (2008) Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain. J Biol Chem 283:26694-26704. doi: 10.1074/jbc.M803514200
-
(2008)
J Biol Chem
, vol.283
, pp. 26694-26704
-
-
Bottomley, M.J.1
Lo Surdo, P.2
Di Giovine, P.3
-
32
-
-
0035845539
-
Cloning and characterization of a histone deacetylase, HDAC9
-
Zhou X, Marks PA, Rifkind RA, Richon VM (2001) Cloning and characterization of a histone deacetylase, HDAC9. Proc Natl Acad Sci USA 98:10572-10577. doi: 10.1073/pnas.191375098
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10572-10577
-
-
Zhou, X.1
Marks, P.A.2
Rifkind, R.A.3
Richon, V.M.4
-
33
-
-
1842578986
-
Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
-
Gregoretti IV, Lee YM, Goodson HV (2004) Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol 338:17-31. doi: 10.1016/j.jmb.2004.02.006
-
(2004)
J Mol Biol
, vol.338
, pp. 17-31
-
-
Gregoretti, I.V.1
Lee, Y.M.2
Goodson, H.V.3
-
34
-
-
0033957792
-
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
-
Huang EY, Zhang J, Miska EA et al (2000) Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes Dev 14:45-54. doi: 10.1101/gad.14.1.45
-
(2000)
Genes Dev
, vol.14
, pp. 45-54
-
-
Huang, E.Y.1
Zhang, J.2
Miska, E.A.3
-
35
-
-
0035724413
-
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
-
Guenther MG, Barak O, Lazar MA (2001) The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 21:6091-6101. doi: 10.1128/MCB.21.18.6091-6101.2001
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6091-6101
-
-
Guenther, M.G.1
Barak, O.2
Lazar, M.A.3
-
36
-
-
0035929621
-
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo
-
Fischle W, Dequiedt F, Fillion M et al (2001) Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem 276:35826-35835. doi: 10.1074/jbc.M104935200
-
(2001)
J Biol Chem
, vol.276
, pp. 35826-35835
-
-
Fischle, W.1
Dequiedt, F.2
Fillion, M.3
-
38
-
-
84886996928
-
MEF2 is a converging hub for HDAC4 and PI3K/Akt-induced transformation
-
Di Giorgio E, Clocchiatti A, Piccinin S et al (2013) MEF2 is a converging hub for HDAC4 and PI3K/Akt-induced transformation. Mol Cell Biol 33:4473-4491. doi: 10.1128/MCB.01050-13
-
(2013)
Mol Cell Biol
, vol.33
, pp. 4473-4491
-
-
Di Giorgio, E.1
Clocchiatti, A.2
Piccinin, S.3
-
39
-
-
0036787922
-
Association of class II histone deacetylases with heterochromatin protein 1: Potential role for histone methylation in control of muscle differentiation
-
Zhang C, McKinsey T, Olson E (2002) Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol Cell Biol 22:7302-7312. doi: 10.1128/MCB.22.20.7302
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7302-7312
-
-
Zhang, C.1
McKinsey, T.2
Olson, E.3
-
40
-
-
0033539092
-
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
-
Finnin MS, Donigian JR, Cohen A et al (1999) Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 401:188-193. doi: 10.1038/43710
-
(1999)
Nature
, vol.401
, pp. 188-193
-
-
Finnin, M.S.1
Donigian, J.R.2
Cohen, A.3
-
41
-
-
0037088643
-
Functional domains of histone deacetylase-3
-
Yang W-M, Tsai S-C, Wen Y-D et al (2002) Functional domains of histone deacetylase-3. J Biol Chem 277:9447-9454. doi: 10.1074/jbc.M105993200
-
(2002)
J Biol Chem
, vol.277
, pp. 9447-9454
-
-
Yang, W.-M.1
Tsai, S.-C.2
Wen, Y.-D.3
-
42
-
-
44649184557
-
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy
-
Ago T, Liu T, Zhai P et al (2008) A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell 133:978-993. doi: 10.1016/j.cell.2008.04.041
-
(2008)
Cell
, vol.133
, pp. 978-993
-
-
Ago, T.1
Liu, T.2
Zhai, P.3
-
43
-
-
84874342427
-
Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment
-
Isaacs JT, Antony L, Dalrymple SL et al (2013) Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res 73:1386-1399. doi: 10.1158/0008-5472.CAN-12-2730
-
(2013)
Cancer Res
, vol.73
, pp. 1386-1399
-
-
Isaacs, J.T.1
Antony, L.2
Dalrymple, S.L.3
-
45
-
-
58249119457
-
The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity
-
Cohen TJ, Barrientos T, Hartman ZC et al (2009) The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity. FASEB J 23:99-106. doi: 10.1096/fj.08-115931
-
(2009)
FASEB J
, vol.23
, pp. 99-106
-
-
Cohen, T.J.1
Barrientos, T.2
Hartman, Z.C.3
-
46
-
-
77957244932
-
Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases
-
Moresi V, Williams AH, Meadows E et al (2010) Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell 143:35-45. doi: 10.1016/j.cell.2010.09.004
-
(2010)
Cell
, vol.143
, pp. 35-45
-
-
Moresi, V.1
Williams, A.H.2
Meadows, E.3
-
47
-
-
84863823498
-
A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program
-
Choi MC, Cohen TJ, Barrientos T et al (2012) A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. Mol Cell 47:122-132. doi: 10.1016/j.molcel.2012.04.025
-
(2012)
Mol Cell
, vol.47
, pp. 122-132
-
-
Choi, M.C.1
Cohen, T.J.2
Barrientos, T.3
-
48
-
-
0038491472
-
ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons
-
Liu L, Cavanaugh JE, Wang Y et al (2003) ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc Natl Acad Sci USA 100:8532-8537. doi: 10.1073/pnas.1332804100
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8532-8537
-
-
Liu, L.1
Cavanaugh, J.E.2
Wang, Y.3
-
49
-
-
33645224990
-
Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation
-
Grégoire S, Tremblay AM, Xiao L et al (2006) Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. J Biol Chem 281:4423-4433. doi: 10.1074/jbc.M509471200
-
(2006)
J Biol Chem
, vol.281
, pp. 4423-4433
-
-
Grégoire, S.1
Tremblay, A.M.2
Xiao, L.3
-
50
-
-
33846940901
-
Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2
-
Grégoire S, Xiao L, Nie J et al (2007) Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol 27:1280-1295. doi: 10.1128/MCB.00882-06
-
(2007)
Mol Cell Biol
, vol.27
, pp. 1280-1295
-
-
Grégoire, S.1
Xiao, L.2
Nie, J.3
-
51
-
-
4644304383
-
Histone deacetylase inhibitors specifically kill nonproliferating tumour cells
-
Burgess A, Ruefli A, Beamish H et al (2004) Histone deacetylase inhibitors specifically kill nonproliferating tumour cells. Oncogene 23:6693-6701. doi: 10.1038/sj.onc.1207893
-
(2004)
Oncogene
, vol.23
, pp. 6693-6701
-
-
Burgess, A.1
Ruefli, A.2
Beamish, H.3
-
52
-
-
84875978060
-
HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
-
Bolden JE, Shi W, Jankowski K et al (2013) HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses. Cell Death Dis 4:e519. doi: 10.1038/cddis.2013.9
-
(2013)
Cell Death Dis
, vol.4
, pp. e519
-
-
Bolden, J.E.1
Shi, W.2
Jankowski, K.3
-
53
-
-
0033604457
-
Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53
-
Vrana JA, Decker RH, Johnson CR et al (1999) Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53. Oncogene 18:7016-7025. doi: 10.1038/sj.onc.1203176
-
(1999)
Oncogene
, vol.18
, pp. 7016-7025
-
-
Vrana, J.A.1
Decker, R.H.2
Johnson, C.R.3
-
54
-
-
0034730127
-
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
-
Richon VM, Sandhoff TW, Rifkind RA, Marks PA (2000) Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci USA 97:10014-10019. doi: 10.1073/pnas.180316197
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10014-10019
-
-
Richon, V.M.1
Sandhoff, T.W.2
Rifkind, R.A.3
Marks, P.A.4
-
55
-
-
84860135029
-
Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death
-
Gammoh N, Lam D, Puente C et al (2012) Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci 109:6561-6565. doi: 10.1073/pnas.1204429109
-
(2012)
Proc Natl Acad Sci
, vol.109
, pp. 6561-6565
-
-
Gammoh, N.1
Lam, D.2
Puente, C.3
-
56
-
-
0038485588
-
Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA)
-
Henderson C, Mizzau M, Paroni G et al (2003) Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). J Biol Chem 278:12579-12589. doi: 10.1074/jbc.M213093200
-
(2003)
J Biol Chem
, vol.278
, pp. 12579-12589
-
-
Henderson, C.1
Mizzau, M.2
Paroni, G.3
-
57
-
-
0034548836
-
Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells
-
1:CAS:528:DC%2BD3cXosVGntbk%3D 11090069
-
Maeda T, Towatari M, Kosugi H, Saito H (2000) Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells. Blood 96:3847-3856
-
(2000)
Blood
, vol.96
, pp. 3847-3856
-
-
Maeda, T.1
Towatari, M.2
Kosugi, H.3
Saito, H.4
-
58
-
-
0034671618
-
Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors
-
1:CAS:528:DC%2BD3cXovFygsrs%3D 11120829
-
Magner WJ, Kazim AL, Stewart C et al (2000) Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. J Immunol 165:7017-7024
-
(2000)
J Immunol
, vol.165
, pp. 7017-7024
-
-
Magner, W.J.1
Kazim, A.L.2
Stewart, C.3
-
59
-
-
0036842460
-
Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis
-
Rossig L, Li H, Fisslthaler B et al (2002) Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. Circ Res 91:837-844. doi: 10.1161/01.RES.0000037983.07158.B1
-
(2002)
Circ Res
, vol.91
, pp. 837-844
-
-
Rossig, L.1
Li, H.2
Fisslthaler, B.3
-
60
-
-
85047699941
-
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
-
Deroanne CF, Bonjean K, Servotte S et al (2002) Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene 21:427-436. doi: 10.1038/sj.onc.1205108
-
(2002)
Oncogene
, vol.21
, pp. 427-436
-
-
Deroanne, C.F.1
Bonjean, K.2
Servotte, S.3
-
61
-
-
73949128107
-
Histone deacetylase inhibitors in cancer therapy
-
Lane AA, Chabner BA (2009) Histone deacetylase inhibitors in cancer therapy. J Clin Oncol 27:5459-5468. doi: 10.1200/JCO.2009.22.1291
-
(2009)
J Clin Oncol
, vol.27
, pp. 5459-5468
-
-
Lane, A.A.1
Chabner, B.A.2
-
62
-
-
54349100901
-
HDAC4 promotes growth of colon cancer cells via repression of p21
-
Wilson AJ, Byun D-S, Nasser S et al (2008) HDAC4 promotes growth of colon cancer cells via repression of p21. Mol Biol Cell 19:4062-4075. doi: 10.1091/mbc.E08-02-0139
-
(2008)
Mol Biol Cell
, vol.19
, pp. 4062-4075
-
-
Wilson, A.J.1
Byun, D.-S.2
Nasser, S.3
-
63
-
-
58249096131
-
HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
-
Mottet D, Pirotte S, Lamour V et al (2009) HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene 28:243-256. doi: 10.1038/onc.2008.371
-
(2009)
Oncogene
, vol.28
, pp. 243-256
-
-
Mottet, D.1
Pirotte, S.2
Lamour, V.3
-
64
-
-
78449294626
-
PiggyBac transposon mutagenesis: A tool for cancer gene discovery in mice
-
Rad R, Rad L, Wang W et al (2010) PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science 330:1104-1107. doi: 10.1126/science.1193004
-
(2010)
Science
, vol.330
, pp. 1104-1107
-
-
Rad, R.1
Rad, L.2
Wang, W.3
-
65
-
-
84874589977
-
HDAC4 controls histone methylation in response to elevated cardiac load
-
Hohl M, Wagner M, Reil J et al (2013) HDAC4 controls histone methylation in response to elevated cardiac load. J Clin Invest 123:1359-1370. doi: 10.1172/JCI61084
-
(2013)
J Clin Invest
, vol.123
, pp. 1359-1370
-
-
Hohl, M.1
Wagner, M.2
Reil, J.3
-
66
-
-
40849086606
-
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases
-
Jones P, Altamura S, De Francesco R et al (2008) Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases. Bioorg Med Chem Lett 18:1814-1819. doi: 10.1016/j.bmcl.2008.02.025
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 1814-1819
-
-
Jones, P.1
Altamura, S.2
De Francesco, R.3
-
67
-
-
42049121320
-
2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors
-
Jones P, Bottomley MJ, Carfí A et al (2008) 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors. Bioorg Med Chem Lett 18:3456-3461. doi: 10.1016/j.bmcl.2008.02.026
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 3456-3461
-
-
Jones, P.1
Bottomley, M.J.2
Carfí, A.3
-
68
-
-
77249087051
-
Chemical phylogenetics of histone deacetylases
-
Bradner JE, West N, Grachan ML et al (2010) Chemical phylogenetics of histone deacetylases. Nat Chem Biol 6:238-243. doi: 10.1038/nchembio.313
-
(2010)
Nat Chem Biol
, vol.6
, pp. 238-243
-
-
Bradner, J.E.1
West, N.2
Grachan, M.L.3
-
69
-
-
0035961036
-
Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin
-
Sternson SM, Wong JC, Grozinger CM, Schreiber SL (2001) Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin. Org Lett 3:4239-4242. doi: 10.1021/ol016915f
-
(2001)
Org Lett
, vol.3
, pp. 4239-4242
-
-
Sternson, S.M.1
Wong, J.C.2
Grozinger, C.M.3
Schreiber, S.L.4
-
70
-
-
84855776224
-
Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases
-
Henkes LM, Haus P, Jäger F et al (2012) Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases. Bioorg Med Chem 20:985-995. doi: 10.1016/j.bmc.2011.11.041
-
(2012)
Bioorg Med Chem
, vol.20
, pp. 985-995
-
-
Henkes, L.M.1
Haus, P.2
Jäger, F.3
-
71
-
-
84872823252
-
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells
-
Marek L, Hamacher A, Hansen FK et al (2013) Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem 56:427-436. doi: 10.1021/jm301254q
-
(2013)
J Med Chem
, vol.56
, pp. 427-436
-
-
Marek, L.1
Hamacher, A.2
Hansen, F.K.3
-
72
-
-
84894034702
-
Improved synthesis and structural reassignment of MC1568: A class IIa selective HDAC inhibitor
-
Fleming CL, Ashton TD, Gaur V et al (2014) Improved synthesis and structural reassignment of MC1568: a class IIa selective HDAC inhibitor. J Med Chem 57:1132-1135. doi: 10.1021/jm401945k
-
(2014)
J Med Chem
, vol.57
, pp. 1132-1135
-
-
Fleming, C.L.1
Ashton, T.D.2
Gaur, V.3
-
73
-
-
20944435415
-
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides
-
Mai A, Massa S, Pezzi R et al (2005) Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. J Med Chem 48:3344-3353. doi: 10.1021/jm049002a
-
(2005)
J Med Chem
, vol.48
, pp. 3344-3353
-
-
Mai, A.1
Massa, S.2
Pezzi, R.3
-
74
-
-
57749101152
-
Specific activity of class II histone deacetylases in human breast cancer cells
-
Duong V, Bret C, Altucci L et al (2008) Specific activity of class II histone deacetylases in human breast cancer cells. Mol Cancer Res 6:1908-1919. doi: 10.1158/1541-7786.MCR-08-0299
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1908-1919
-
-
Duong, V.1
Bret, C.2
Altucci, L.3
-
75
-
-
77957824326
-
HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation
-
Nebbioso A, Dell'Aversana C, Bugge A et al (2010) HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation. J Mol Endocrinol 45:219-228. doi: 10.1677/JME-10-0043
-
(2010)
J Mol Endocrinol
, vol.45
, pp. 219-228
-
-
Nebbioso, A.1
Dell'Aversana, C.2
Bugge, A.3
-
76
-
-
84874349294
-
Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells
-
Venza I, Visalli M, Oteri R et al (2013) Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res 26:193-204. doi: 10.1111/pcmr.12049
-
(2013)
Pigment Cell Melanoma Res
, vol.26
, pp. 193-204
-
-
Venza, I.1
Visalli, M.2
Oteri, R.3
-
77
-
-
84895070874
-
Identifying targets for the restoration and reactivation of BRM
-
Kahali B, Gramling SJ, Marquez SB et al (2014) Identifying targets for the restoration and reactivation of BRM. Oncogene 33:653-664. doi: 10.1038/onc.2012.613
-
(2014)
Oncogene
, vol.33
, pp. 653-664
-
-
Kahali, B.1
Gramling, S.J.2
Marquez, S.B.3
-
78
-
-
67650083046
-
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes
-
Nebbioso A, Manzo F, Miceli M et al (2009) Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO Rep 10:776-782. doi: 10.1038/embor.2009.88
-
(2009)
EMBO Rep
, vol.10
, pp. 776-782
-
-
Nebbioso, A.1
Manzo, F.2
Miceli, M.3
-
79
-
-
71049156256
-
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy
-
Ontoria JM, Altamura S, Di Marco A, Ferrigno F, Laufer R, Muraglia E, Palumbi MC, Rowley M, Scarpelli R, Schultz-Fademrecht C, Serafini S, Steinkühler CJP (2009) Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy. J Med Chem 52:6782-6789. doi: 10.1021/jm900555u
-
(2009)
J Med Chem
, vol.52
, pp. 6782-6789
-
-
Ontoria, J.M.1
Altamura, S.2
Di Marco, A.3
Ferrigno, F.4
Laufer, R.5
Muraglia, E.6
Palumbi, M.C.7
Rowley, M.8
Scarpelli, R.9
Schultz-Fademrecht, C.10
Serafini, S.11
Steinkühler, C.J.P.12
-
80
-
-
69949090550
-
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
-
Tessier P, Smil DV, Wahhab A et al (2009) Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett 19:5684-5688. doi: 10.1016/j.bmcl.2009.08.010
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5684-5688
-
-
Tessier, P.1
Smil, D.V.2
Wahhab, A.3
-
81
-
-
83455178133
-
Identification of selective class II histone deacetylase inhibitors using a novel dual-parameter binding assay based on fluorescence anisotropy and lifetime
-
Haus P, Korbus M, Schröder M, Meyer-Almes F-J (2011) Identification of selective class II histone deacetylase inhibitors using a novel dual-parameter binding assay based on fluorescence anisotropy and lifetime. J Biomol Screen 16:1206-1216. doi: 10.1177/1087057111424605
-
(2011)
J Biomol Screen
, vol.16
, pp. 1206-1216
-
-
Haus, P.1
Korbus, M.2
Schröder, M.3
Meyer-Almes, F.-J.4
-
82
-
-
77952223624
-
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors
-
Olsson A, Björk A, Vallon-Christersson J et al (2010) Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer 9:107. doi: 10.1186/1476-4598-9-107
-
(2010)
Mol Cancer
, vol.9
, pp. 107
-
-
Olsson, A.1
Björk, A.2
Vallon-Christersson, J.3
-
83
-
-
84858745199
-
Tasquinimod prevents the angiogenic rebound induced by fractionated radiation resulting in an enhanced therapeutic response of prostate cancer xenografts
-
Dalrymple SL, Becker RE, Zhou H et al (2012) Tasquinimod prevents the angiogenic rebound induced by fractionated radiation resulting in an enhanced therapeutic response of prostate cancer xenografts. Prostate 72:638-648. doi: 10.1002/pros.21467
-
(2012)
Prostate
, vol.72
, pp. 638-648
-
-
Dalrymple, S.L.1
Becker, R.E.2
Zhou, H.3
-
84
-
-
78149330949
-
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
-
Corzo CA, Condamine T, Lu L et al (2010) HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 207:2439-2453. doi: 10.1084/jem.20100587
-
(2010)
J Exp Med
, vol.207
, pp. 2439-2453
-
-
Corzo, C.A.1
Condamine, T.2
Lu, L.3
-
85
-
-
80052768852
-
Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitor
-
Kong Y, Jung M, Wang K et al (2011) Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitor. Mol Cancer Ther 10:1591-1599. doi: 10.1158/1535-7163.MCT-10-0779
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1591-1599
-
-
Kong, Y.1
Jung, M.2
Wang, K.3
-
86
-
-
0037416151
-
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
-
Zhang Y, Li N, Caron C et al (2003) HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J 22:1168-1179. doi: 10.1093/emboj/cdg115
-
(2003)
EMBO J
, vol.22
, pp. 1168-1179
-
-
Zhang, Y.1
Li, N.2
Caron, C.3
-
87
-
-
33845741562
-
Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer
-
Geng L, Cuneo KC, Fu A et al (2006) Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer. Cancer Res 66:11298-11304. doi: 10.1158/0008-5472.CAN-06-0049
-
(2006)
Cancer Res
, vol.66
, pp. 11298-11304
-
-
Geng, L.1
Cuneo, K.C.2
Fu, A.3
-
88
-
-
34248344283
-
Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains
-
Guo L, Han A, Bates DL et al (2007) Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains. Proc Natl Acad Sci USA 104:4297-4302. doi: 10.1073/pnas.0608041104
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 4297-4302
-
-
Guo, L.1
Han, A.2
Bates, D.L.3
-
89
-
-
0033568028
-
HDAC4 deacetylase associates with and represses the MEF2 transcription factor
-
Miska EA, Karlsson C, Langley E et al (1999) HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J 18:5099-5107. doi: 10.1093/emboj/18.18.5099
-
(1999)
EMBO J
, vol.18
, pp. 5099-5107
-
-
Miska, E.A.1
Karlsson, C.2
Langley, E.3
-
90
-
-
8344261349
-
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
-
Vega RB, Matsuda K, Oh J et al (2004) Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119:555-566. doi: 10.1016/j.cell.2004.10.024
-
(2004)
Cell
, vol.119
, pp. 555-566
-
-
Vega, R.B.1
Matsuda, K.2
Oh, J.3
-
91
-
-
4544358659
-
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
-
Chang S, McKinsey TA, Zhang CL et al (2004) Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol 24:8467-8476. doi: 10.1128/MCB.24.19.8467-8476.2004
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8467-8476
-
-
Chang, S.1
McKinsey, T.A.2
Zhang, C.L.3
-
92
-
-
33746228132
-
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10
-
Chang S, Young BD, Li S et al (2006) Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell 126:321-334. doi: 10.1016/j.cell.2006.05.040
-
(2006)
Cell
, vol.126
, pp. 321-334
-
-
Chang, S.1
Young, B.D.2
Li, S.3
-
93
-
-
79955515703
-
Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins
-
Kehat I, Accornero F, Aronow BJ, Molkentin JD (2011) Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins. J Cell Biol 193:21-29. doi: 10.1083/jcb.201101046
-
(2011)
J Cell Biol
, vol.193
, pp. 21-29
-
-
Kehat, I.1
Accornero, F.2
Aronow, B.J.3
Molkentin, J.D.4
-
94
-
-
34250320926
-
Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases
-
Barrett A, Santangelo S, Tan K et al (2007) Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int J Cancer 121:265-275. doi: 10.1002/ijc.22673
-
(2007)
Int J Cancer
, vol.121
, pp. 265-275
-
-
Barrett, A.1
Santangelo, S.2
Tan, K.3
-
95
-
-
84863194158
-
Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2
-
Jayathilaka N, Han A, Gaffney KJ et al (2012) Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res 40:5378-5388. doi: 10.1093/nar/gks189
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 5378-5388
-
-
Jayathilaka, N.1
Han, A.2
Gaffney, K.J.3
-
96
-
-
9644265333
-
Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2
-
Han A, He J, Wu Y et al (2005) Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. J Mol Biol 345:91-102. doi: 10.1016/j.jmb.2004.10.033
-
(2005)
J Mol Biol
, vol.345
, pp. 91-102
-
-
Han, A.1
He, J.2
Wu, Y.3
-
97
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S, Pelicci PG (2006) Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6:38-51. doi: 10.1038/nrc1779
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
98
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi Y, Lan F, Matson C et al (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119:941-953. doi: 10.1016/j.cell.2004.12.012
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
Lan, F.2
Matson, C.3
-
99
-
-
24144462170
-
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
-
Metzger E, Wissmann M, Yin N et al (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437:436-439. doi: 10.1038/nature04020
-
(2005)
Nature
, vol.437
, pp. 436-439
-
-
Metzger, E.1
Wissmann, M.2
Yin, N.3
-
100
-
-
84869871771
-
The role of histone demethylases in cancer therapy
-
Hoffmann I, Roatsch M, Schmitt ML et al (2012) The role of histone demethylases in cancer therapy. Mol Oncol 6:683-703. doi: 10.1016/j.molonc.2012.07.004
-
(2012)
Mol Oncol
, vol.6
, pp. 683-703
-
-
Hoffmann, I.1
Roatsch, M.2
Schmitt, M.L.3
-
101
-
-
84876904061
-
Class IIa histone deacetylases and myocyte enhancer factor 2 proteins regulate the mesenchymal-to-epithelial transition of somatic cell reprogramming
-
Zhuang Q, Qing X, Ying Y et al (2013) Class IIa histone deacetylases and myocyte enhancer factor 2 proteins regulate the mesenchymal-to-epithelial transition of somatic cell reprogramming. J Biol Chem 288:12022-12031. doi: 10.1074/jbc.M113.460766
-
(2013)
J Biol Chem
, vol.288
, pp. 12022-12031
-
-
Zhuang, Q.1
Qing, X.2
Ying, Y.3
-
102
-
-
42449161465
-
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5
-
McGee SL, van Denderen BJW, Howlett KF et al (2008) AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes 57:860-867. doi: 10.2337/db07-0843
-
(2008)
Diabetes
, vol.57
, pp. 860-867
-
-
McGee, S.L.1
Van Denderen, B.J.W.2
Howlett, K.F.3
-
103
-
-
43149104404
-
GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes
-
Sparling DP, Griesel BA, Weems J, Olson AL (2008) GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes. J Biol Chem 283:7429-7437. doi: 10.1074/jbc.M800481200
-
(2008)
J Biol Chem
, vol.283
, pp. 7429-7437
-
-
Sparling, D.P.1
Griesel, B.A.2
Weems, J.3
Olson, A.L.4
-
104
-
-
78650932686
-
Class II histone deacetylases limit GLUT4 gene expression during adipocyte differentiation
-
Weems J, Olson AL (2011) Class II histone deacetylases limit GLUT4 gene expression during adipocyte differentiation. J Biol Chem 286:460-468. doi: 10.1074/jbc.M110.157107
-
(2011)
J Biol Chem
, vol.286
, pp. 460-468
-
-
Weems, J.1
Olson, A.L.2
-
105
-
-
84867909223
-
Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells
-
Raichur S, Hooi Teh S, Ohwaki K et al (2012) Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells. J Mol Endocrinol 49:203-211. doi: 10.1530/JME-12-0095
-
(2012)
J Mol Endocrinol
, vol.49
, pp. 203-211
-
-
Raichur, S.1
Hooi Teh, S.2
Ohwaki, K.3
-
106
-
-
21744447354
-
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases
-
Kumar A, Lin Z, SenBanerjee S, Jain MK (2005) Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol 25:5893-5903. doi: 10.1128/MCB.25.14.5893-5903.2005
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5893-5903
-
-
Kumar, A.1
Lin, Z.2
SenBanerjee, S.3
Jain, M.K.4
-
107
-
-
65449174979
-
Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells
-
Baek Y-S, Haas S, Hackstein H et al (2009) Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells. BMC Immunol 10:18. doi: 10.1186/1471-2172-10-18
-
(2009)
BMC Immunol
, vol.10
, pp. 18
-
-
Baek, Y.-S.1
Haas, S.2
Hackstein, H.3
-
108
-
-
35748960519
-
The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2
-
Bolger TA, Zhao X, Cohen TJ et al (2007) The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. J Biol Chem 282:29186-29192. doi: 10.1074/jbc.M704182200
-
(2007)
J Biol Chem
, vol.282
, pp. 29186-29192
-
-
Bolger, T.A.1
Zhao, X.2
Cohen, T.J.3
-
109
-
-
34548301409
-
Histone deacetylases: Focus on the nervous system
-
Morrison BE, Majdzadeh N, D'Mello SR (2007) Histone deacetylases: focus on the nervous system. Cell Mol Life Sci 64:2258-2269. doi: 10.1007/s00018-007-7035-9
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 2258-2269
-
-
Morrison, B.E.1
Majdzadeh, N.2
D'Mello, S.R.3
-
110
-
-
84855754333
-
Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction
-
West AE (2012) Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction. Neuron 73:1-3. doi: 10.1016/j.neuron.2011.12.016
-
(2012)
Neuron
, vol.73
, pp. 1-3
-
-
West, A.E.1
-
111
-
-
84860692938
-
Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia
-
Li J, Chen J, Ricupero CL et al (2012) Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nat Med 18:783-790. doi: 10.1038/nm.2709
-
(2012)
Nat Med
, vol.18
, pp. 783-790
-
-
Li, J.1
Chen, J.2
Ricupero, C.L.3
-
112
-
-
84891858918
-
Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes
-
Hara N, Alkanani AK, Dinarello CA, Zipris D (2014) Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes. J Mol Med 92:93-102. doi: 10.1007/s00109-013-1078-1
-
(2014)
J Mol Med
, vol.92
, pp. 93-102
-
-
Hara, N.1
Alkanani, A.K.2
Dinarello, C.A.3
Zipris, D.4
-
113
-
-
33748778745
-
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia
-
Herman D, Jenssen K, Burnett R et al (2006) Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol 2:551-558. doi: 10.1038/nchembio815
-
(2006)
Nat Chem Biol
, vol.2
, pp. 551-558
-
-
Herman, D.1
Jenssen, K.2
Burnett, R.3
-
114
-
-
84891304904
-
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease
-
Burli RW, Luckhurst CA, Aziz O et al (2013) Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. J Med Chem 56:9934-9954. doi: 10.1021/jm4011884
-
(2013)
J Med Chem
, vol.56
, pp. 9934-9954
-
-
Burli, R.W.1
Luckhurst, C.A.2
Aziz, O.3
-
115
-
-
35948980739
-
Deacetylase inhibition promotes the generation and function of regulatory T cells
-
Tao R, de Zoeten EF, Ozkaynak E et al (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 13:1299-1307. doi: 10.1038/nm1652
-
(2007)
Nat Med
, vol.13
, pp. 1299-1307
-
-
Tao, R.1
De Zoeten, E.F.2
Ozkaynak, E.3
-
116
-
-
73449117582
-
Immunomodulatory effects of deacetylase inhibitors: Therapeutic targeting of FOXP3+ regulatory T cells
-
Wang L, de Zoeten EF, Greene MI, Hancock WW (2009) Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov 8:969-981. doi: 10.1038/nrd3031
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 969-981
-
-
Wang, L.1
De Zoeten, E.F.2
Greene, M.I.3
Hancock, W.W.4
-
117
-
-
75449114277
-
Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice
-
de Zoeten EF, Wang L, Sai H et al (2010) Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology 138:583-594. doi: 10.1053/j.gastro.2009.10.037
-
(2010)
Gastroenterology
, vol.138
, pp. 583-594
-
-
De Zoeten, E.F.1
Wang, L.2
Sai, H.3
-
118
-
-
79952396960
-
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
-
Bantscheff M, Hopf C, Savitski MM et al (2011) Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol 29:255-265. doi: 10.1038/nbt.175
-
(2011)
Nat Biotechnol
, vol.29
, pp. 255-265
-
-
Bantscheff, M.1
Hopf, C.2
Savitski, M.M.3
|