HDAC4 controls histone methylation in response to elevated cardiac load

Journal of Clinical Investigation

Volumn 123, Issue 3, 2013, Pages 1359-1370

  Hohl, Mathias ^a   Wagner, Michael ^a   Reil, Jan Christian ^a   Müller, Sarah Anne ^a   Tauchnitz, Marcus ^a   Zimmer, Angela M ^a   Lehmann, Lorenz H ^b   Thiel, Gerald ^a   Böhm, Michael ^a   Backs, Johannes ^b   Maack, Christoph ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; HETEROCHROMATIN PROTEIN 1; HISTONE; HISTONE DEACETYLASE 4; HISTONE H3; LYSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DEMETHYLATION; DISSOCIATION; GENE DELETION; HEART FAILURE; HEART PRELOAD; HEART WORK; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; HUMAN TISSUE; ISOLATED HEART; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN TRANSPORT; RAT; UPREGULATION;

ACETYLATION; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ATRIAL NATRIURETIC FACTOR; BLOOD PRESSURE; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CARDIOMYOPATHY, DILATED; CASE-CONTROL STUDIES; CELLS, CULTURED; ENZYME INDUCTION; EPIGENESIS, GENETIC; GENE EXPRESSION; HEART FAILURE; HEART VENTRICLES; HISTONE DEACETYLASES; HISTONES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MALE; METHYLATION; METHYLTRANSFERASES; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; NATRIURETIC PEPTIDE, BRAIN; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 84874589977     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61084     Document Type: Article

References (45)

1. Kannel WB. Incidence and epidemiology of heart failure. Heart Fail Rev. 2000;5(2):167-173.
2. Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. 2006;7(8):589-600. (Pubitemid 44325350)
3. Saito Y, et al. Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart. J Clin Invest. 1989;83(1):298-305. (Pubitemid 19048436)
4. Feldman AM, Ray PE, Silan CM, Mercer JA, Minobe W, Bristow MR. Selective gene expression in failing human heart. Quantification of steady-state levels of messenger RNA in endomyocardial biopsies using the polymerase chain reaction. Circulation. 1991;83(6):1866-1872.
5. Kögler H, et al. Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression. Circulation. 2006;113(23):2724-2732. (Pubitemid 43947990)
6. Lorch Y, LaPointe JW, Kornberg RD. Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones. Cell. 1987;49(2):203-210.
7. Lee DY, Hayes JJ, Pruss D, Wolffe AP. A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell. 1993;72(1):73-84. (Pubitemid 23029694)
8. Backs J, Olson EN. Control of cardiac growth by histone acetylation/deacetylation. Circ Res. 2006; 98(1):15-24. (Pubitemid 43977219)
9. Shi Y, Whetstine Jr. Dynamic regulation of histone lysine methylation by demethylases. Mol Cell. 2007;25(1):1-14. (Pubitemid 46049067)
10. Barski A, et al. High-resolution profiling of histone methylations in the human genome. Cell. 2007; 129(4):823-837. (Pubitemid 46802390)
11. Bannister AJ, et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature. 2001;410(6824):120-124. (Pubitemid 32225848)
12. Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293(5532):1074-1080. (Pubitemid 32758077)
13. Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet. 2009;10(1):32-42.
14. Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, Olson EN. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell. 2002;110(4):479-488. (Pubitemid 35232291)
15. Chang S, McKinsey TA, Zhang CL, Richardson JA, Hill JA, Olson EN. Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol. 2004;24(19):8467-8476. (Pubitemid 39245069)
16. McKinsey TA, Zhang CL, Lu J, Olson EN. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408(6808):106-111.
17. Backs J, Song K, Bezprozvannaya S, Chang S, Olson EN. CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest. 2006;116(7):1853-1864. (Pubitemid 44033310)
18. Wu X, et al. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. 2006;116(3):675-682. (Pubitemid 43326876)
19. Ago T, et al. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell. 2008;133(6):978-993. (Pubitemid 351787743)
20. Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T. HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J. 1999;18(18):5099-5107. (Pubitemid 29443811)
21. Lu J, McKinsey TA, Nicol RL, Olson EN. Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. Proc Natl Acad Sci U S A. 2000;97(8):4070-4075. (Pubitemid 30226088)
22. Martin C, Zhang Y. The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol. 2005; 6(11):838-849. (Pubitemid 41568733)
23. Shi Y, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004;119(7):941-953. (Pubitemid 40037608)
24. Tsukada Y, et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2006;439(7078):811-816. (Pubitemid 43255695)
25. Bannister AJ, Kouzarides T. Reversing histone methylation. Nature. 2005;436(7054):1103-1106. (Pubitemid 41232281)
26. Saccani S, Natoli G. Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev. 2002;16(17):2219-2224. (Pubitemid 35013084)
27. Brasacchio D, et al. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes. 2009;58(5):1229- 1236.
28. Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci U S A. 2008; 105(26):9047-9052.
29. Kaneda R, et al. Genome-wide histone methylation profile for heart failure. Genes Cells. 2009;14(1):69-77.
30. Zhang QJ, Chen HZ, Wang L, Liu DP, Hill JA, Liu ZP. The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest. 2011; 121(6):2447-2456.
31. Kuwahara K, et al. NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J. 2003;22(23):6310-6321. (Pubitemid 37522588)
32. Ooi L, Wood IC. Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet. 2007;8(7):544-554. (Pubitemid 46955208)
33. Zhang CL, McKinsey TA, Olson EN. Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol Cell Biol. 2002; 22(20):7302-7312.
34. Aagaard L, et al. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999;18(7):1923-1938. (Pubitemid 29158536)
35. Kirchhefer U, Schmitz W, Scholz H, Neumann J. Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts. Cardiovasc Res. 1999;42(1):254-261. (Pubitemid 29167092)
36. Stein AB, et al. Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest. 2011;121(7):2641-2650.
37. Lockman K, Taylor JM, Mack CP. The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression. Circ Res. 2007;101(12):e115-123. (Pubitemid 350294652)
38. Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 2001; 410(6824):116-120. (Pubitemid 32225847)
39. Backs J, et al. The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A. 2009;106(7):2342-2347.
40. Potthoff MJ, et al. Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007; 117(9):2459-2467. (Pubitemid 47494347)
41. Agah R, Frenkel PA, French BA, Michael LH, Overbeek PA, Schneider MD. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J Clin Invest. 1997;100(1):169-179. (Pubitemid 27311255)
42. Reil JC, et al. Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling. Cardiovasc Res. 2010;87(3):485-493.
43. Custodis F, Eberl M, Kilter H, Böhm M, Laufs U. Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy. Cardiovasc Res. 2006;71(2):342-351.
44. Maack C, Dabew ER, Hohl M, Schäfers HJ, Böhm M. Endogenous activation of mitochondrial KATP channels protects human failing myocardium from hydroxyl radical-induced stunning. Circ Res. 2009;105(8):811-817.
45. Kohlhaas M, Maack C. Adverse bioenergetic consequences of Na+-Ca2+ exchanger-mediated Ca2+ influx in cardiac myocytes. Circulation. 2010; 122(22):2273-2280.