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Volumn 43, Issue 3, 2015, Pages 158-167

Role of toll-like receptors in multiple myeloma and recent advances

Author keywords

[No Author keywords available]

Indexed keywords

AGATOLIMOD; AS 04; AS 15; BCG VACCINE; BORTEZOMIB; C 792; COMPOUND 852A; CORTICOSTEROID; CYTOTOXIC AGENT; GNKG 168; HILTONOL; IMIQUIMOD; IMM 101; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMO 2055; IMO 8400; INTERFERON; MELPHALAN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

EID: 84924960274     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2014.11.003     Document Type: Review
Times cited : (20)

References (103)
  • 1
    • 33846967820 scopus 로고    scopus 로고
    • Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk
    • Nieters A., Beckmann L., Deeg E., Becker N. Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk. Genes Immun 2006, 7:615-624.
    • (2006) Genes Immun , vol.7 , pp. 615-624
    • Nieters, A.1    Beckmann, L.2    Deeg, E.3    Becker, N.4
  • 2
    • 84876000935 scopus 로고    scopus 로고
    • Characterization of the Toll-like receptor expression profile in human multiple myeloma cells
    • Abdi J., Mutis T., Garssen J., Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS One 2013, 8:e60671.
    • (2013) PLoS One , vol.8 , pp. e60671
    • Abdi, J.1    Mutis, T.2    Garssen, J.3    Redegeld, F.4
  • 3
    • 78751518366 scopus 로고    scopus 로고
    • Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack
    • Bao H., Lu P., Li Y., et al. Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack. Cancer Biol Ther 2011, 11:58-67.
    • (2011) Cancer Biol Ther , vol.11 , pp. 58-67
    • Bao, H.1    Lu, P.2    Li, Y.3
  • 4
    • 33744465220 scopus 로고    scopus 로고
    • Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors
    • Jego G., Bataille R., Geffroy-Luseau A., Descamps G., Pellat-Deceunynck C. Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors. Leukemia 2006, 20:1130-1137.
    • (2006) Leukemia , vol.20 , pp. 1130-1137
    • Jego, G.1    Bataille, R.2    Geffroy-Luseau, A.3    Descamps, G.4    Pellat-Deceunynck, C.5
  • 5
    • 77955804238 scopus 로고    scopus 로고
    • Expression and function of toll-like receptors in multiple myeloma patients: toll-like receptor ligands promote multiple myeloma cell growth and survival via activation of nuclear factor-kappaB
    • Xu Y., Zhao Y., Huang H., et al. Expression and function of toll-like receptors in multiple myeloma patients: toll-like receptor ligands promote multiple myeloma cell growth and survival via activation of nuclear factor-kappaB. Br J Haematol 2010, 150:543-553.
    • (2010) Br J Haematol , vol.150 , pp. 543-553
    • Xu, Y.1    Zhao, Y.2    Huang, H.3
  • 6
    • 34347400169 scopus 로고    scopus 로고
    • Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway
    • Liu J., Hamrouni A., Wolowiec D., et al. Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood 2007, 110:296-304.
    • (2007) Blood , vol.110 , pp. 296-304
    • Liu, J.1    Hamrouni, A.2    Wolowiec, D.3
  • 7
    • 84878316176 scopus 로고    scopus 로고
    • Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells
    • Abdi J., Mutis T., Garssen J., Redegeld F. Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells. Blood Cancer J 2013, 3:e119.
    • (2013) Blood Cancer J , vol.3 , pp. e119
    • Abdi, J.1    Mutis, T.2    Garssen, J.3    Redegeld, F.4
  • 8
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: back to Virchow?
    • Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 2001, 357:539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 9
    • 70449371316 scopus 로고    scopus 로고
    • Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production
    • Dorner M., Brandt S., Tinguely M., et al. Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production. Immunology 2009, 128:573-579.
    • (2009) Immunology , vol.128 , pp. 573-579
    • Dorner, M.1    Brandt, S.2    Tinguely, M.3
  • 10
    • 34250020832 scopus 로고    scopus 로고
    • Th2-mediated anti-tumour immunity: friend or foe?
    • Ellyard J.I., Simson L., Parish C.R. Th2-mediated anti-tumour immunity: friend or foe?. Tissue Antigens 2007, 70:1-11.
    • (2007) Tissue Antigens , vol.70 , pp. 1-11
    • Ellyard, J.I.1    Simson, L.2    Parish, C.R.3
  • 11
    • 0034671803 scopus 로고    scopus 로고
    • Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses
    • Wyllie D.H., Kiss-Toth E., Visintin A., et al. Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. JImmunol 2000, 165:7125-7132.
    • (2000) JImmunol , vol.165 , pp. 7125-7132
    • Wyllie, D.H.1    Kiss-Toth, E.2    Visintin, A.3
  • 12
    • 84979858768 scopus 로고    scopus 로고
    • Toll-like receptor and accessory molecule mRNA expression in humans and mice as well as in murine autoimmunity, transient inflammation, and progressive fibrosis
    • Ramaiah S.K., Gunthner R., Lech M., Anders H.J. Toll-like receptor and accessory molecule mRNA expression in humans and mice as well as in murine autoimmunity, transient inflammation, and progressive fibrosis. Int J Mol Sci 2013, 14:13213-13230.
    • (2013) Int J Mol Sci , vol.14 , pp. 13213-13230
    • Ramaiah, S.K.1    Gunthner, R.2    Lech, M.3    Anders, H.J.4
  • 13
    • 84885528644 scopus 로고    scopus 로고
    • Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines
    • Butt A.Q., Mills K.H. Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines. Oncogene 2014, 33:4623-4631.
    • (2014) Oncogene , vol.33 , pp. 4623-4631
    • Butt, A.Q.1    Mills, K.H.2
  • 14
    • 56149118396 scopus 로고    scopus 로고
    • Acute modulation of toll-like receptors by insulin
    • Ghanim H., Mohanty P., Deopurkar R., et al. Acute modulation of toll-like receptors by insulin. Diabetes Care 2008, 31:1827-1831.
    • (2008) Diabetes Care , vol.31 , pp. 1827-1831
    • Ghanim, H.1    Mohanty, P.2    Deopurkar, R.3
  • 15
    • 84866398771 scopus 로고    scopus 로고
    • Variation at innate immunity Toll-like receptor genes in a bottlenecked population of a New Zealand robin
    • Grueber C.E., Wallis G.P., King T.M., Jamieson I.G. Variation at innate immunity Toll-like receptor genes in a bottlenecked population of a New Zealand robin. PLoS One 2012, 7:e45011.
    • (2012) PLoS One , vol.7 , pp. e45011
    • Grueber, C.E.1    Wallis, G.P.2    King, T.M.3    Jamieson, I.G.4
  • 16
    • 78650494568 scopus 로고    scopus 로고
    • The application of Toll like receptors for cancer therapy
    • So E.Y., Ouchi T. The application of Toll like receptors for cancer therapy. Int J Biol Sci 2010, 6:675-681.
    • (2010) Int J Biol Sci , vol.6 , pp. 675-681
    • So, E.Y.1    Ouchi, T.2
  • 17
    • 0035336425 scopus 로고    scopus 로고
    • A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression
    • Sweet M.J., Leung B.P., Kang D., et al. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J Immunol 2001, 166:6633-6639.
    • (2001) J Immunol , vol.166 , pp. 6633-6639
    • Sweet, M.J.1    Leung, B.P.2    Kang, D.3
  • 18
    • 37849010503 scopus 로고    scopus 로고
    • Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies
    • Spaner D.E., Foley R., Galipeau J., Bramson J. Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies. Oncogene 2008, 27:208-217.
    • (2008) Oncogene , vol.27 , pp. 208-217
    • Spaner, D.E.1    Foley, R.2    Galipeau, J.3    Bramson, J.4
  • 19
    • 64249114110 scopus 로고    scopus 로고
    • TLR3 ligand induces NF-{kappa}B activation and various fates of multiple myeloma cells depending on IFN-{alpha} production
    • Chiron D., Pellat-Deceunynck C., Amiot M., Bataille R., Jego G. TLR3 ligand induces NF-{kappa}B activation and various fates of multiple myeloma cells depending on IFN-{alpha} production. J Immunol 2009, 182:4471-4478.
    • (2009) J Immunol , vol.182 , pp. 4471-4478
    • Chiron, D.1    Pellat-Deceunynck, C.2    Amiot, M.3    Bataille, R.4    Jego, G.5
  • 20
    • 0036679732 scopus 로고    scopus 로고
    • Of mice and men: species variations of Toll-like receptor expression
    • Rehli M. Of mice and men: species variations of Toll-like receptor expression. Trends Immunol 2002, 23:375-378.
    • (2002) Trends Immunol , vol.23 , pp. 375-378
    • Rehli, M.1
  • 21
    • 0024299087 scopus 로고
    • The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
    • Hashimoto C., Hudson K.L., Anderson K.V. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 1988, 52:269-279.
    • (1988) Cell , vol.52 , pp. 269-279
    • Hashimoto, C.1    Hudson, K.L.2    Anderson, K.V.3
  • 22
    • 80052688676 scopus 로고    scopus 로고
    • The role of intermediary domain of MyD88 in cell activation and therapeutic inhibition of TLRs
    • Avbelj M., Horvat S., Jerala R. The role of intermediary domain of MyD88 in cell activation and therapeutic inhibition of TLRs. J Immunol 2011, 187:2394-2404.
    • (2011) J Immunol , vol.187 , pp. 2394-2404
    • Avbelj, M.1    Horvat, S.2    Jerala, R.3
  • 23
    • 77955742528 scopus 로고    scopus 로고
    • Recent insights into the role of Toll-like receptors in viral infection
    • Carty M., Bowie A.G. Recent insights into the role of Toll-like receptors in viral infection. Clin Exp Immunol 2010, 161:397-406.
    • (2010) Clin Exp Immunol , vol.161 , pp. 397-406
    • Carty, M.1    Bowie, A.G.2
  • 24
    • 79953813107 scopus 로고    scopus 로고
    • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    • Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117:3720-3732.
    • (2011) Blood , vol.117 , pp. 3720-3732
    • Dinarello, C.A.1
  • 25
    • 0142031430 scopus 로고    scopus 로고
    • Role of Toll-like receptors in pathogen recognition
    • Janssens S., Beyaert R. Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 2003, 16:637-646.
    • (2003) Clin Microbiol Rev , vol.16 , pp. 637-646
    • Janssens, S.1    Beyaert, R.2
  • 26
    • 84865969361 scopus 로고    scopus 로고
    • Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma
    • Onnis A., Navari M., Antonicelli G., et al. Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma. Blood Cancer J 2012, 2:e84.
    • (2012) Blood Cancer J , vol.2 , pp. e84
    • Onnis, A.1    Navari, M.2    Antonicelli, G.3
  • 27
    • 55249107642 scopus 로고    scopus 로고
    • Toll-like receptors: lessons to learn from normal and malignant human B cells
    • Chiron D., Bekeredjian-Ding I., Pellat-Deceunynck C., Bataille R., Jego G. Toll-like receptors: lessons to learn from normal and malignant human B cells. Blood 2008, 112:2205-2213.
    • (2008) Blood , vol.112 , pp. 2205-2213
    • Chiron, D.1    Bekeredjian-Ding, I.2    Pellat-Deceunynck, C.3    Bataille, R.4    Jego, G.5
  • 29
    • 84869105188 scopus 로고    scopus 로고
    • Isolated Toll-like receptor transmembrane domains are capable of oligomerization
    • Godfroy J.I., Roostan M., Moroz Y.S., Korendovych I.V., Yin H. Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS One 2012, 7:e48875.
    • (2012) PLoS One , vol.7 , pp. e48875
    • Godfroy, J.I.1    Roostan, M.2    Moroz, Y.S.3    Korendovych, I.V.4    Yin, H.5
  • 30
    • 84900463570 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)-1/2 triggering of multiple myeloma cells modulates their adhesion to bone marrow stromal cells and enhances bortezomib-induced apoptosis
    • Abdi J., Mutis T., Garssen J., Redegeld F.A. Toll-like receptor (TLR)-1/2 triggering of multiple myeloma cells modulates their adhesion to bone marrow stromal cells and enhances bortezomib-induced apoptosis. PLoS One 2014, 9:e96608.
    • (2014) PLoS One , vol.9 , pp. e96608
    • Abdi, J.1    Mutis, T.2    Garssen, J.3    Redegeld, F.A.4
  • 31
    • 0041331693 scopus 로고    scopus 로고
    • Subcellular localization of Toll-like receptor 3 in human dendritic cells
    • Matsumoto M., Funami K., Tanabe M., et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol 2003, 171:3154-3162.
    • (2003) J Immunol , vol.171 , pp. 3154-3162
    • Matsumoto, M.1    Funami, K.2    Tanabe, M.3
  • 32
    • 78149361152 scopus 로고    scopus 로고
    • Toll-like receptors: expression and involvement in multiple myeloma
    • Chiron D., Jego G., Pellat-Deuceunynck C. Toll-like receptors: expression and involvement in multiple myeloma. Leuk Res 2010, 34:1545-1550.
    • (2010) Leuk Res , vol.34 , pp. 1545-1550
    • Chiron, D.1    Jego, G.2    Pellat-Deuceunynck, C.3
  • 33
    • 84864700392 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation
    • Reynolds J.M., Martinez G.J., Chung Y., Dong C. Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation. Proc Natl Acad Sci U S A 2012, 109:13064-13069.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 13064-13069
    • Reynolds, J.M.1    Martinez, G.J.2    Chung, Y.3    Dong, C.4
  • 34
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    • Hayashi F., Smith K.D., Ozinsky A., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001, 410:1099-1103.
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1    Smith, K.D.2    Ozinsky, A.3
  • 35
    • 84862897364 scopus 로고    scopus 로고
    • TLR5, a novel and unidentified inflammatory mediator in rheumatoid arthritis that correlates with disease activity score and joint TNF-alpha levels
    • Chamberlain N.D., Vila O.M., Volin M.V., et al. TLR5, a novel and unidentified inflammatory mediator in rheumatoid arthritis that correlates with disease activity score and joint TNF-alpha levels. JImmunol 2012, 189:475-483.
    • (2012) JImmunol , vol.189 , pp. 475-483
    • Chamberlain, N.D.1    Vila, O.M.2    Volin, M.V.3
  • 36
    • 84897557011 scopus 로고    scopus 로고
    • TLR5 activation by flagellin induces doxorubicin resistance via interleukin-6 (IL-6) expression in two multiple myeloma cells
    • Cho H.Y., Lee S.W. TLR5 activation by flagellin induces doxorubicin resistance via interleukin-6 (IL-6) expression in two multiple myeloma cells. Cell Immunol 2014, 289:27-35.
    • (2014) Cell Immunol , vol.289 , pp. 27-35
    • Cho, H.Y.1    Lee, S.W.2
  • 37
    • 84861577379 scopus 로고    scopus 로고
    • An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
    • Lehmann S.M., Kruger C., Park B., et al. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci 2012, 15:827-835.
    • (2012) Nat Neurosci , vol.15 , pp. 827-835
    • Lehmann, S.M.1    Kruger, C.2    Park, B.3
  • 38
    • 84885410480 scopus 로고    scopus 로고
    • Roles of TLR7 in activation of NF-kappaB signaling of keratinocytes by imiquimod
    • Li Z.J., Sohn K.C., Choi D.K., et al. Roles of TLR7 in activation of NF-kappaB signaling of keratinocytes by imiquimod. PLoS One 2013, 8:e77159.
    • (2013) PLoS One , vol.8 , pp. e77159
    • Li, Z.J.1    Sohn, K.C.2    Choi, D.K.3
  • 39
    • 84887194808 scopus 로고    scopus 로고
    • Evidence for a detrimental role of TLR8 in ischemic stroke
    • Tang S.C., Yeh S.J., Li Y.I., et al. Evidence for a detrimental role of TLR8 in ischemic stroke. Exp Neurol 2013, 250:341-347.
    • (2013) Exp Neurol , vol.250 , pp. 341-347
    • Tang, S.C.1    Yeh, S.J.2    Li, Y.I.3
  • 40
    • 84887504831 scopus 로고    scopus 로고
    • An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing
    • Onji M., Kanno A., Saitoh S., et al. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun 2013, 4:1949.
    • (2013) Nat Commun , vol.4 , pp. 1949
    • Onji, M.1    Kanno, A.2    Saitoh, S.3
  • 41
    • 84894572850 scopus 로고    scopus 로고
    • Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice
    • Koulis C., Chen Y.C., Hausding C., et al. Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2014, 34:516-525.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 516-525
    • Koulis, C.1    Chen, Y.C.2    Hausding, C.3
  • 42
    • 84876304588 scopus 로고    scopus 로고
    • Cutting-edge report: TLR10 plays a role in mediating bacterial peptidoglycan-induced trophoblast apoptosis
    • Mulla M.J., Myrtolli K., Tadesse S., et al. Cutting-edge report: TLR10 plays a role in mediating bacterial peptidoglycan-induced trophoblast apoptosis. Am J Reprod Immunol 2013, 69:449-453.
    • (2013) Am J Reprod Immunol , vol.69 , pp. 449-453
    • Mulla, M.J.1    Myrtolli, K.2    Tadesse, S.3
  • 43
    • 84896277732 scopus 로고    scopus 로고
    • Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection
    • Lee S.M., Kok K.H., Jaume M., et al. Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. Proc Natl Acad Sci U S A 2014, 111:3793-3798.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 3793-3798
    • Lee, S.M.1    Kok, K.H.2    Jaume, M.3
  • 44
    • 84893115383 scopus 로고    scopus 로고
    • Innate immunity to Toxoplasma gondii infection
    • Yarovinsky F. Innate immunity to Toxoplasma gondii infection. Nat Rev Immunol 2014, 14:109-121.
    • (2014) Nat Rev Immunol , vol.14 , pp. 109-121
    • Yarovinsky, F.1
  • 45
    • 0042679529 scopus 로고    scopus 로고
    • Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    • Hoebe K., Du X., Georgel P., et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003, 424:743-748.
    • (2003) Nature , vol.424 , pp. 743-748
    • Hoebe, K.1    Du, X.2    Georgel, P.3
  • 46
    • 84888436208 scopus 로고    scopus 로고
    • Prophylactic broad spectrum antibiotics as a new anti-myeloma therapy
    • Valkovic T., Nacinovic A.D., Petranovic D. Prophylactic broad spectrum antibiotics as a new anti-myeloma therapy. Med Hypotheses 2013, 81:1137-1140.
    • (2013) Med Hypotheses , vol.81 , pp. 1137-1140
    • Valkovic, T.1    Nacinovic, A.D.2    Petranovic, D.3
  • 47
    • 33644829447 scopus 로고    scopus 로고
    • Early mortality after diagnosis of multiple myeloma: analysis of patients entered onto the United kingdom Medical Research Council trials between 1980 and 2002-Medical Research Council Adult Leukaemia Working Party
    • Augustson B.M., Begum G., Dunn J.A., et al. Early mortality after diagnosis of multiple myeloma: analysis of patients entered onto the United kingdom Medical Research Council trials between 1980 and 2002-Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2005, 23:9219-9226.
    • (2005) J Clin Oncol , vol.23 , pp. 9219-9226
    • Augustson, B.M.1    Begum, G.2    Dunn, J.A.3
  • 48
    • 84925000911 scopus 로고    scopus 로고
    • Multiple myeloma andinfections: A population-based study based on 9,610 multiple myeloma patients
    • Abstract 945. Presented December 11
    • Blimark C, Mellqvist UH, Landgren O, et al. Multiple myeloma andinfections: A population-based study based on 9,610 multiple myeloma patients. 2012 ASH Annual Meeting. Abstract 945. Presented December 11, 2012.
    • (2012) 2012 ASH Annual Meeting
    • Blimark, C.1    Mellqvist, U.H.2    Landgren, O.3
  • 49
    • 77957675974 scopus 로고    scopus 로고
    • High early mortality rate in elderly patients with multiple myeloma receiving a vincristine-doxorubicin-dexamethasone regimen
    • Teng H.W., Teng C.J., Wang W.S., et al. High early mortality rate in elderly patients with multiple myeloma receiving a vincristine-doxorubicin-dexamethasone regimen. Am J Hematol 2010, 85:812-815.
    • (2010) Am J Hematol , vol.85 , pp. 812-815
    • Teng, H.W.1    Teng, C.J.2    Wang, W.S.3
  • 50
    • 84889084599 scopus 로고    scopus 로고
    • Pneumococcal vaccine responses in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance
    • Karlsson J., Hogevik H., Andersson K., Roshani L., Andréasson B., Wennerås C. Pneumococcal vaccine responses in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance. Trials Vaccinol 2013, 2:31-38.
    • (2013) Trials Vaccinol , vol.2 , pp. 31-38
    • Karlsson, J.1    Hogevik, H.2    Andersson, K.3    Roshani, L.4    Andréasson, B.5    Wennerås, C.6
  • 51
    • 78649344532 scopus 로고    scopus 로고
    • Treating atherosclerosis: the potential of Toll-like receptors as therapeutic targets
    • Cole J.E., Mitra A.T., Monaco C. Treating atherosclerosis: the potential of Toll-like receptors as therapeutic targets. Expert Rev Cardiovasc Ther 2010, 8:1619-1635.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , pp. 1619-1635
    • Cole, J.E.1    Mitra, A.T.2    Monaco, C.3
  • 52
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V., Rothenfusser S., Britsch S., et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002, 168:4531-4537.
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3
  • 53
    • 67649209791 scopus 로고    scopus 로고
    • Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype
    • Romieu-Mourez R., Francois M., Boivin M.N., Bouchentouf M., Spaner D.E., Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol 2009, 182:7963-7973.
    • (2009) J Immunol , vol.182 , pp. 7963-7973
    • Romieu-Mourez, R.1    Francois, M.2    Boivin, M.N.3    Bouchentouf, M.4    Spaner, D.E.5    Galipeau, J.6
  • 55
    • 33744459726 scopus 로고    scopus 로고
    • Toll-like receptors mediate proliferation and survival of multiple myeloma cells
    • Bohnhorst J., Rasmussen T., Moen S.H., et al. Toll-like receptors mediate proliferation and survival of multiple myeloma cells. Leukemia 2006, 20:1138-1144.
    • (2006) Leukemia , vol.20 , pp. 1138-1144
    • Bohnhorst, J.1    Rasmussen, T.2    Moen, S.H.3
  • 56
    • 69149086044 scopus 로고    scopus 로고
    • Toll gates to periodontal host modulation and vaccine therapy
    • Hajishengallis G. Toll gates to periodontal host modulation and vaccine therapy. Periodontol 2000 2009, 51:181-207.
    • (2009) Periodontol 2000 , vol.51 , pp. 181-207
    • Hajishengallis, G.1
  • 57
    • 0034651023 scopus 로고    scopus 로고
    • Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma
    • Tinhofer I., Marschitz I., Henn T., Egle A., Greil R. Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma. Blood 2000, 95:610-618.
    • (2000) Blood , vol.95 , pp. 610-618
    • Tinhofer, I.1    Marschitz, I.2    Henn, T.3    Egle, A.4    Greil, R.5
  • 58
    • 84908667838 scopus 로고    scopus 로고
    • NF-kappaB Activation in T Helper 17 Cell Differentiation
    • Park S.H., Cho G., Park S.G. NF-kappaB Activation in T Helper 17 Cell Differentiation. Immune Netw 2014, 14:14-20.
    • (2014) Immune Netw , vol.14 , pp. 14-20
    • Park, S.H.1    Cho, G.2    Park, S.G.3
  • 59
    • 0034881738 scopus 로고    scopus 로고
    • Deregulated cytokine network and defective Th1 immune response in multiple myeloma
    • Frassanito M.A., Cusmai A., Dammacco F. Deregulated cytokine network and defective Th1 immune response in multiple myeloma. Clin Exp Immunol 2001, 125:190-197.
    • (2001) Clin Exp Immunol , vol.125 , pp. 190-197
    • Frassanito, M.A.1    Cusmai, A.2    Dammacco, F.3
  • 60
    • 33845542139 scopus 로고    scopus 로고
    • Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia
    • Spaner D.E., Masellis A. Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia. Leukemia 2007, 21:53-60.
    • (2007) Leukemia , vol.21 , pp. 53-60
    • Spaner, D.E.1    Masellis, A.2
  • 61
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    • Yamamoto M., Sato S., Hemmi H., et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003, 301:640-643.
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3
  • 62
    • 79953674746 scopus 로고    scopus 로고
    • The role of toll-like receptor mediated signalling in the pathogenesis of multiple myeloma
    • Abdi J., Engels F., Garssen J., Redegeld F. The role of toll-like receptor mediated signalling in the pathogenesis of multiple myeloma. Crit Rev Oncol Hematol 2011, 80:225-240.
    • (2011) Crit Rev Oncol Hematol , vol.80 , pp. 225-240
    • Abdi, J.1    Engels, F.2    Garssen, J.3    Redegeld, F.4
  • 63
    • 84862291416 scopus 로고    scopus 로고
    • Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions
    • Danylesko I., Beider K., Shimoni A., Nagler A. Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions. Clin Dev Immunol 2012, 2012:753407.
    • (2012) Clin Dev Immunol , vol.2012 , pp. 753407
    • Danylesko, I.1    Beider, K.2    Shimoni, A.3    Nagler, A.4
  • 64
    • 78649854748 scopus 로고    scopus 로고
    • CpG-oligodeoxynucleotide inhibits Smad-dependent bone morphogenetic protein signaling: effects on myeloma cell apoptosis and invitro osteoblastogenesis
    • Norgaard N.N., Holien T., Jonsson S., et al. CpG-oligodeoxynucleotide inhibits Smad-dependent bone morphogenetic protein signaling: effects on myeloma cell apoptosis and invitro osteoblastogenesis. JImmunol 2010, 185:3131-3139.
    • (2010) JImmunol , vol.185 , pp. 3131-3139
    • Norgaard, N.N.1    Holien, T.2    Jonsson, S.3
  • 65
    • 36049033394 scopus 로고    scopus 로고
    • Signaling to NF-kappaB by Toll-like receptors
    • Kawai T., Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 2007, 13:460-469.
    • (2007) Trends Mol Med , vol.13 , pp. 460-469
    • Kawai, T.1    Akira, S.2
  • 66
    • 37549058765 scopus 로고    scopus 로고
    • Toll-like receptors' two-edged sword: when immunity meets apoptosis
    • Salaun B., Romero P., Lebecque S. Toll-like receptors' two-edged sword: when immunity meets apoptosis. Eur J Immunol 2007, 37:3311-3318.
    • (2007) Eur J Immunol , vol.37 , pp. 3311-3318
    • Salaun, B.1    Romero, P.2    Lebecque, S.3
  • 67
    • 45449094567 scopus 로고    scopus 로고
    • Activation-dependent induction of Blimp-1
    • Calame K. Activation-dependent induction of Blimp-1. Curr Opin Immunol 2008, 20:259-264.
    • (2008) Curr Opin Immunol , vol.20 , pp. 259-264
    • Calame, K.1
  • 68
    • 28544444025 scopus 로고    scopus 로고
    • Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
    • Shapiro-Shelef M., Lin K.I., Savitsky D., Liao J., Calame K. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med 2005, 202:1471-1476.
    • (2005) J Exp Med , vol.202 , pp. 1471-1476
    • Shapiro-Shelef, M.1    Lin, K.I.2    Savitsky, D.3    Liao, J.4    Calame, K.5
  • 69
    • 84903177242 scopus 로고    scopus 로고
    • TPL2 kinase regulates the inflammatory milieu of the myeloma niche
    • Hope C., Ollar S.J., Heninger E., et al. TPL2 kinase regulates the inflammatory milieu of the myeloma niche. Blood 2014, 123:3305-3315.
    • (2014) Blood , vol.123 , pp. 3305-3315
    • Hope, C.1    Ollar, S.J.2    Heninger, E.3
  • 70
    • 61849148751 scopus 로고    scopus 로고
    • Cancer stem cells in multiple myeloma
    • Ghosh N., Matsui W. Cancer stem cells in multiple myeloma. Cancer Lett 2009, 277:1-7.
    • (2009) Cancer Lett , vol.277 , pp. 1-7
    • Ghosh, N.1    Matsui, W.2
  • 71
    • 84875583581 scopus 로고    scopus 로고
    • Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1
    • Hawley T.S., Riz I., Yang W., et al. Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Am J Hematol 2013, 88:265-272.
    • (2013) Am J Hematol , vol.88 , pp. 265-272
    • Hawley, T.S.1    Riz, I.2    Yang, W.3
  • 72
    • 84903747411 scopus 로고    scopus 로고
    • The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells
    • Staudinger M., Glorius P., Burger R., et al. The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells. Blood Cancer J 2014, 4:e219.
    • (2014) Blood Cancer J , vol.4 , pp. e219
    • Staudinger, M.1    Glorius, P.2    Burger, R.3
  • 73
    • 37749027492 scopus 로고    scopus 로고
    • Mechanisms of dexamethasone-mediated inhibition of Toll-like receptor signaling induced by Neisseria meningitidis and Streptococcus pneumoniae
    • Mogensen T.H., Berg R.S., Paludan S.R., Ostergaard L. Mechanisms of dexamethasone-mediated inhibition of Toll-like receptor signaling induced by Neisseria meningitidis and Streptococcus pneumoniae. Infect Immun 2008, 76:189-197.
    • (2008) Infect Immun , vol.76 , pp. 189-197
    • Mogensen, T.H.1    Berg, R.S.2    Paludan, S.R.3    Ostergaard, L.4
  • 74
    • 84868640245 scopus 로고    scopus 로고
    • The tumor microenvironment controls drug sensitivity
    • Ostman A. The tumor microenvironment controls drug sensitivity. Nat Med 2012, 18:1332-1334.
    • (2012) Nat Med , vol.18 , pp. 1332-1334
    • Ostman, A.1
  • 75
    • 79952720734 scopus 로고    scopus 로고
    • Treatment options for relapsed and refractory multiple myeloma
    • Lonial S., Mitsiades C.S., Richardson P.G. Treatment options for relapsed and refractory multiple myeloma. Clin Cancer Res 2011, 17:1264-1277.
    • (2011) Clin Cancer Res , vol.17 , pp. 1264-1277
    • Lonial, S.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 76
    • 84905676418 scopus 로고    scopus 로고
    • A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib
    • Ray A., Tian Z., Das D.S., et al. A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib. Leukemia 2014, 28:1716-1724.
    • (2014) Leukemia , vol.28 , pp. 1716-1724
    • Ray, A.1    Tian, Z.2    Das, D.S.3
  • 77
    • 84878156984 scopus 로고    scopus 로고
    • Monoclonal antibodies: potential new therapeutic treatment against multiple myeloma
    • Allegra A., Penna G., Alonci A., et al. Monoclonal antibodies: potential new therapeutic treatment against multiple myeloma. Eur J Haematol 2013, 90:441-468.
    • (2013) Eur J Haematol , vol.90 , pp. 441-468
    • Allegra, A.1    Penna, G.2    Alonci, A.3
  • 78
    • 37849035627 scopus 로고    scopus 로고
    • TLR signaling by tumor and immune cells: a double-edged sword
    • Huang B., Zhao J., Unkeless J.C., Feng Z.H., Xiong H. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene 2008, 27:218-224.
    • (2008) Oncogene , vol.27 , pp. 218-224
    • Huang, B.1    Zhao, J.2    Unkeless, J.C.3    Feng, Z.H.4    Xiong, H.5
  • 79
    • 84860293001 scopus 로고    scopus 로고
    • Toll-like receptors are potential therapeutic targets in rheumatoid arthritis
    • Shotorbani S.S., Su Z.L., Xu H.X. Toll-like receptors are potential therapeutic targets in rheumatoid arthritis. World J Biol Chem 2011, 2:167-172.
    • (2011) World J Biol Chem , vol.2 , pp. 167-172
    • Shotorbani, S.S.1    Su, Z.L.2    Xu, H.X.3
  • 80
    • 84894404830 scopus 로고    scopus 로고
    • RANKing bone resorption versus inflammation: Infection makes the decision
    • Ferrari-Lacraz S., Burger D. RANKing bone resorption versus inflammation: Infection makes the decision. IBMS BoneKEy 2010, 7:156-160.
    • (2010) IBMS BoneKEy , vol.7 , pp. 156-160
    • Ferrari-Lacraz, S.1    Burger, D.2
  • 81
    • 84878805816 scopus 로고    scopus 로고
    • Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis
    • Lundberg A.M., Ketelhuth D.F., Johansson M.E., et al. Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis. Cardiovasc Res 2013, 99:364-373.
    • (2013) Cardiovasc Res , vol.99 , pp. 364-373
    • Lundberg, A.M.1    Ketelhuth, D.F.2    Johansson, M.E.3
  • 82
    • 67649422321 scopus 로고    scopus 로고
    • Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    • O'Neill L.A., Bryant C.E., Doyle S.L. Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 2009, 61:177-197.
    • (2009) Pharmacol Rev , vol.61 , pp. 177-197
    • O'Neill, L.A.1    Bryant, C.E.2    Doyle, S.L.3
  • 83
    • 70350689747 scopus 로고    scopus 로고
    • The potential use of Toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents
    • Makkouk A., Abdelnoor A.M. The potential use of Toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents. Immunopharmacol Immunotoxicol 2009, 31:331-338.
    • (2009) Immunopharmacol Immunotoxicol , vol.31 , pp. 331-338
    • Makkouk, A.1    Abdelnoor, A.M.2
  • 84
    • 84866754613 scopus 로고    scopus 로고
    • Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies
    • Weigel B.J., Cooley S., DeFor T., et al. Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies. Am J Hematol 2012, 87:953-956.
    • (2012) Am J Hematol , vol.87 , pp. 953-956
    • Weigel, B.J.1    Cooley, S.2    DeFor, T.3
  • 85
    • 84874449237 scopus 로고    scopus 로고
    • TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells invivo
    • Zhang Q., Hossain D.M., Nechaev S., et al. TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells invivo. Blood 2013, 121:1304-1315.
    • (2013) Blood , vol.121 , pp. 1304-1315
    • Zhang, Q.1    Hossain, D.M.2    Nechaev, S.3
  • 87
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K., Akira S. Toll-like receptors in innate immunity. Int Immunol 2005, 17:1-14.
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 88
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: clinical applications
    • Hideshima T., Bergsagel P.L., Kuehl W.M., Anderson K.C. Advances in biology of multiple myeloma: clinical applications. Blood 2004, 104:607-618.
    • (2004) Blood , vol.104 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 89
    • 77951196379 scopus 로고    scopus 로고
    • Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
    • Cherfils-Vicini J., Platonova S., Gillard M., et al. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest 2010, 120:1285-1297.
    • (2010) J Clin Invest , vol.120 , pp. 1285-1297
    • Cherfils-Vicini, J.1    Platonova, S.2    Gillard, M.3
  • 90
    • 56249098670 scopus 로고    scopus 로고
    • Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors
    • Goto Y., Arigami T., Kitago M., et al. Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors. Mol Cancer Ther 2008, 7:3642-3653.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3642-3653
    • Goto, Y.1    Arigami, T.2    Kitago, M.3
  • 91
    • 84880181922 scopus 로고    scopus 로고
    • The regulation of Toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells
    • Guo H., Chen Y., Hu X., Qian G., Ge S., Zhang J. The regulation of Toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells. Mol Cancer 2013, 12:77.
    • (2013) Mol Cancer , vol.12 , pp. 77
    • Guo, H.1    Chen, Y.2    Hu, X.3    Qian, G.4    Ge, S.5    Zhang, J.6
  • 92
    • 63449126998 scopus 로고    scopus 로고
    • Toll-like receptors and their role in carcinogenesis and anti-tumor treatment
    • Wolska A., Lech-Maranda E., Robak T. Toll-like receptors and their role in carcinogenesis and anti-tumor treatment. Cell Mol Biol Lett 2009, 14:248-272.
    • (2009) Cell Mol Biol Lett , vol.14 , pp. 248-272
    • Wolska, A.1    Lech-Maranda, E.2    Robak, T.3
  • 93
    • 33750208645 scopus 로고    scopus 로고
    • Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis
    • Chen H., Li M., Campbell R.A., Burkhardt K., Zhu D. Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis. Oncogene 2006, 25:6520-6527.
    • (2006) Oncogene , vol.25 , pp. 6520-6527
    • Chen, H.1    Li, M.2    Campbell, R.A.3    Burkhardt, K.4    Zhu, D.5
  • 95
    • 38649123396 scopus 로고    scopus 로고
    • The future of toll-like receptor therapeutics
    • Parkinson T. The future of toll-like receptor therapeutics. Curr Opin Mol Ther 2008, 10:21-31.
    • (2008) Curr Opin Mol Ther , vol.10 , pp. 21-31
    • Parkinson, T.1
  • 97
    • 84870189452 scopus 로고    scopus 로고
    • Therapeutic applications of nucleic acids and their analogues in toll-like receptor signaling
    • Gosu V., Basith S., Kwon O.P., Choi S. Therapeutic applications of nucleic acids and their analogues in toll-like receptor signaling. Molecules 2012, 17:13503-13529.
    • (2012) Molecules , vol.17 , pp. 13503-13529
    • Gosu, V.1    Basith, S.2    Kwon, O.P.3    Choi, S.4
  • 98
    • 84860491259 scopus 로고    scopus 로고
    • An intra-patient placebo-controlled phase I trial to evaluate the safety and tolerability of intradermal IMM-101 in melanoma
    • Stebbing J., Dalgleish A., Gifford-Moore A., et al. An intra-patient placebo-controlled phase I trial to evaluate the safety and tolerability of intradermal IMM-101 in melanoma. Ann Oncol 2012, 23:1314-1319.
    • (2012) Ann Oncol , vol.23 , pp. 1314-1319
    • Stebbing, J.1    Dalgleish, A.2    Gifford-Moore, A.3
  • 99
    • 77249176352 scopus 로고    scopus 로고
    • AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity
    • Didierlaurent A.M., Morel S., Lockman L., et al. AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J Immunol 2009, 183:6186-6197.
    • (2009) J Immunol , vol.183 , pp. 6186-6197
    • Didierlaurent, A.M.1    Morel, S.2    Lockman, L.3
  • 101
    • 84893535667 scopus 로고    scopus 로고
    • Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
    • Suárez-Fariñas M., Arbeit R., Jiang W., et al. Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation. PLoS One 2013, 8:e84634.
    • (2013) PLoS One , vol.8 , pp. e84634
    • Suárez-Fariñas, M.1    Arbeit, R.2    Jiang, W.3
  • 102
    • 84906791645 scopus 로고    scopus 로고
    • Antitumor activity and safety of combination therapy with the Toll-like receptor 9 agonist IMO-2055, erlotinib, and bevacizumab in advanced or metastatic non-small cell lung cancer patients who have progressed following chemotherapy
    • Smith D.A., Conkling P., Richards D.A., Nemunaitis J.J., Boyd T.E. Antitumor activity and safety of combination therapy with the Toll-like receptor 9 agonist IMO-2055, erlotinib, and bevacizumab in advanced or metastatic non-small cell lung cancer patients who have progressed following chemotherapy. Cancer Immunol Immunother 2014, 63:787-796.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 787-796
    • Smith, D.A.1    Conkling, P.2    Richards, D.A.3    Nemunaitis, J.J.4    Boyd, T.E.5
  • 103
    • 84881121899 scopus 로고    scopus 로고
    • Phase 2 trial of erlotinib with or without PF-3512676 (CPG 7909, a Toll-like receptor 9 agonist) in patients with advanced recurrent EGFR-positive non-small cell lung cancer
    • Belani C.P., Nemunaitis J.J., Chachoua A., et al. Phase 2 trial of erlotinib with or without PF-3512676 (CPG 7909, a Toll-like receptor 9 agonist) in patients with advanced recurrent EGFR-positive non-small cell lung cancer. Cancer Biol Ther 2013, 14:557-563.
    • (2013) Cancer Biol Ther , vol.14 , pp. 557-563
    • Belani, C.P.1    Nemunaitis, J.J.2    Chachoua, A.3


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