Toll-like receptor (TLR)-1/2 triggering of multiple myeloma cells modulates their adhesion to bone marrow stromal cells and enhances bortezomib-induced apoptosis

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Abdi, Jahangir ^a   Mutis, Tuna ^b   Garssen, Johan ^a   Redegeld, Frank A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; BETA7 INTEGRIN; BORTEZOMIB; CASPASE 3; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; VITRONECTIN RECEPTOR; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; INTEGRIN; LIPOPEPTIDE; PAM(3)CSK(4) PEPTIDE; PYRAZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ADHESION; CELL INTERACTION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG TARGETING; FLUORESCENCE ACTIVATED CELL SORTING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LIGAND BINDING; MICROENVIRONMENT; MULTIPLE MYELOMA CELL LINE; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UPREGULATION; AGONISTS; BONE MARROW CELL; DRUG EFFECTS; IMMUNOLOGY; MULTIPLE MYELOMA; STROMA CELL; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BONE MARROW CELLS; BORONIC ACIDS; CELL ADHESION; CELL LINE, TUMOR; HUMANS; INTEGRINS; LIPOPEPTIDES; MULTIPLE MYELOMA; PYRAZINES; STROMAL CELLS; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 2;

EID: 84900463570     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096608     Document Type: Article

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